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Items: 1 to 20 of 74

1.
The AHR repressor limits expression of antimicrobial genes but not AHR-dependent genes in intestinal eosinophils
Heike Weighardt, Michael Shapiro, Michelle Mayer, Irmgard Förster, Brigitta Stockinger, Nicola Laura Diny
J Leukoc Biol. 2024 Aug; 116(2): 369–378. Published online 2024 May 3. doi: 10.1093/jleuko/qiae105
PMCID:
PMC11271977
AbstractArticlePDF–1.1M
2.
Early-life exposure to cigarette smoke primes lung function and DNA methylation changes at Cyp1a1 upon exposure later in life
Chinonye Doris Onuzulu, Samantha Lee, Sujata Basu, Jeannette Comte, Yan Hai, Nikho Hizon, Shivam Chadha, Maria Shenna Fauni, Shana Kahnamoui, Bo Xiang, Andrew J. Halayko, Vernon W. Dolinsky, Christopher D. Pascoe, Meaghan J. Jones
Am J Physiol Lung Cell Mol Physiol. 2023 Nov 1; 325(5): L552–L567. Published online 2023 Aug 29. doi: 10.1152/ajplung.00192.2023
PMCID:
PMC11068412
AbstractArticle
3.
Inhibition of CYP1A1 Alleviates Colchicine-Induced Hepatotoxicity
Ruoyue Huang, Jingyi Duan, Wen Huang, Yan Cheng, Beiwei Zhu, Fei Li
Toxins (Basel) 2024 Jan; 16(1): 35. Published online 2024 Jan 9. doi: 10.3390/toxins16010035
PMCID:
PMC10818746
AbstractArticlePDF–5.8M
4.
Monoterpenoid aryl hydrocarbon receptor allosteric antagonists protect against ultraviolet skin damage in female mice
Karolína Ondrová, Iveta Zůvalová, Barbora Vyhlídalová, Kristýna Krasulová, Eva Miková, Radim Vrzal, Petr Nádvorník, Binod Nepal, Sandhya Kortagere, Martina Kopečná, David Kopečný, Marek Šebela, Fraydoon Rastinejad, Hua Pu, Miroslav Soural, Katharina Maria Rolfes, Thomas Haarmann-Stemmann, Hao Li, Sridhar Mani, Zdeněk Dvořák
Nat Commun. 2023; 14: 2728. Published online 2023 May 11. doi: 10.1038/s41467-023-38478-6
PMCID:
PMC10174618
AbstractArticlePDF–3.4M
5.
Cytochrome P450 1A1 is essential for the microbial metabolite, Urolithin A-mediated protection against colitis
Sweta Ghosh, Bhagavatula Moorthy, Bodduluri Haribabu, Venkatakrishna Rao Jala
Front Immunol. 2022; 13: 1004603. Published online 2022 Sep 8. doi: 10.3389/fimmu.2022.1004603
PMCID:
PMC9493474
AbstractArticlePDF–18M
6.
Lung Epithelial CYP1 Activity Regulates Aryl Hydrocarbon Receptor Dependent Allergic Airway Inflammation
Francesca Alessandrini, Renske de Jong, Maria Wimmer, Ann-Marie Maier, Isis Fernandez, Miriam Hils, Jeroen T. Buters, Tilo Biedermann, Ulrich M. Zissler, Christian Hoffmann, Julia Esser-von-Bieren, Carsten B. Schmidt-Weber, Caspar Ohnmacht
Front Immunol. 2022; 13: 901194. Published online 2022 Jun 6. doi: 10.3389/fimmu.2022.901194
PMCID:
PMC9207268
AbstractArticlePDF–6.0M
7.
Molecular Mechanisms of Pulmonary Carcinogenesis by Polycyclic Aromatic Hydrocarbons (PAHs): Implications for Human Lung Cancer
Rachel Stading, Grady Gastelum, Chun Chu, Weiwu Jiang, Bhagavatula Moorthy
Semin Cancer Biol. Author manuscript; available in PMC 2022 Jan 5.
Published in final edited form as: Semin Cancer Biol. 2021 Nov; 76: 3–16. Published online 2021 Jul 7. doi: 10.1016/j.semcancer.2021.07.001
PMCID:
PMC8728691
AbstractArticlePDF–1.9M
8.
Streptococcus gallolyticus Increases Expression and Activity of Aryl Hydrocarbon Receptor-Dependent CYP1 Biotransformation Capacity in Colorectal Epithelial Cells
Rahwa Taddese, Rian Roelofs, Derk Draper, Xinqun Wu, Shaoguang Wu, Dorine W. Swinkels, Harold Tjalsma, Annemarie Boleij
Front Cell Infect Microbiol. 2021; 11: 740704. Published online 2021 Oct 27. doi: 10.3389/fcimb.2021.740704
PMCID:
PMC8579041
AbstractArticlePDF–1.7M
9.
CYP1A1 Enzymatic Activity Influences Skin Inflammation Via Regulation of the AHR Pathway
Mariela Kyoreva, Ying Li, Mariyah Hoosenally, Jonathan Hardman-Smart, Kirsten Morrison, Isabella Tosi, Mauro Tolaini, Guillermo Barinaga, Brigitta Stockinger, Ulrich Mrowietz, Frank O. Nestle, Catherine H. Smith, Jonathan N. Barker, Paola Di Meglio
J Invest Dermatol. 2021 Jun; 141(6): 1553–1563.e3. doi: 10.1016/j.jid.2020.11.024
PMCID:
PMC8152917
AbstractArticle
10.
Polycyclic Aromatic Hydrocarbon-induced Pulmonary Carcinogenesis in Cytochrome P450 (CYP)1A1- and 1A2-Null Mice: Roles of CYP1A1 and CYP1A2
Grady Gastelum, Weiwu Jiang, Lihua Wang, Guodong Zhou, Roshan Borkar, Nagireddy Putluri, Bhagavatula Moorthy
Toxicol Sci. 2020 Oct; 177(2): 347–361. Published online 2020 Jul 29. doi: 10.1093/toxsci/kfaa107
PMCID:
PMC7818899
AbstractArticlePDF–1.4M
11.
Knockout of cytochrome P450 1A1 enhances lipopolysaccharide‐induced acute lung injury in mice by targeting NF‐κB activation
Li‐xing Tian, Xin Tang, Wei Ma, Jing Wang, Wei Zhang, Kuan Liu, Tao Chen, Jun‐yu Zhu, Hua‐ping Liang
FEBS Open Bio. 2020 Nov; 10(11): 2316–2328. Published online 2020 Sep 23. doi: 10.1002/2211-5463.12977
PMCID:
PMC7609787
AbstractArticlePDF–6.8M
12.
Trappc9 deficiency causes parent-of-origin dependent microcephaly and obesity
Zhengzheng S. Liang, Irene Cimino, Binnaz Yalcin, Narayanan Raghupathy, Valerie E. Vancollie, Ximena Ibarra-Soria, Helen V. Firth, Debra Rimmington, I. Sadaf Farooqi, Christopher J. Lelliott, Steven C. Munger, Stephen O’Rahilly, Anne C. Ferguson-Smith, Anthony P. Coll, Darren W. Logan
PLoS Genet. 2020 Sep; 16(9): e1008916. Published online 2020 Sep 2. doi: 10.1371/journal.pgen.1008916
PMCID:
PMC7467316
AbstractArticlePDF–3.4M
13.
Dissociation of the AhR/ARNT complex by TGF-β/Smad signaling represses CYP1A1 gene expression and inhibits benze[a]pyrene-mediated cytotoxicity
Naoko Nakano, Nobuo Sakata, Yuki Katsu, Daiki Nochise, Erika Sato, Yuta Takahashi, Saori Yamaguchi, Yoko Haga, Souichi Ikeno, Mitsuyoshi Motizuki, Keigo Sano, Kohei Yamasaki, Keiji Miyazawa, Susumu Itoh
J Biol Chem. 2020 Jul 3; 295(27): 9033–9051. Published online 2020 May 14. doi: 10.1074/jbc.RA120.013596
PMCID:
PMC7335805
AbstractArticlePDF–4.4M
14.
Application of a novel regulatable Cre recombinase system to define the role of liver and gut metabolism in drug oral bioavailability
Colin J. Henderson, Lesley A. McLaughlin, Maria Osuna-Cabello, Malcolm Taylor, Ian Gilbert, Aileen W. McLaren, C. Roland Wolf
Biochem J. Author manuscript; available in PMC 2020 Jan 8.
Published in final edited form as: Biochem J. 2015 Feb 1; 465(3): 479–488. doi: 10.1042/BJ20140582
PMCID:
PMC6949133
AbstractArticlePDF–1.5M
15.
Defining the Contribution of CYP1A1 and CYP1A2 to Drug Metabolism Using Humanized CYP1A1/1A2 and Cyp1a1/Cyp1a2 Knockout Mice
Y. Kapelyukh, C. J. Henderson, N. Scheer, A. Rode, C. R. Wolf
Drug Metab Dispos. 2019 Aug; 47(8): 907–918. Published online 2019 Jul 19. doi: 10.1124/dmd.119.087718
PMCID:
PMC6657216
AbstractArticlePDF–1.4M
16.
Altered keratinocyte differentiation is an early driver of keratin mutation-based palmoplantar keratoderma
Abigail G Zieman, Brian G Poll, Jingqun Ma, Pierre A Coulombe
Hum Mol Genet. 2019 Jul 1; 28(13): 2255–2270. Published online 2019 Mar 20. doi: 10.1093/hmg/ddz050
PMCID:
PMC6602407
AbstractArticlePDF–3.5M
17.
An Extensively Humanized Mouse Model to Predict Pathways of Drug Disposition and Drug/Drug Interactions, and to Facilitate Design of Clinical Trials
C.J. Henderson, Y. Kapelyukh, N. Scheer, A. Rode, AW. McLaren, A.K. MacLeod, D. Lin, J. Wright, L.A. Stanley, C.R. Wolf
Drug Metab Dispos. 2019 Jun; 47(6): 601–615. Published online 2019 Jun. doi: 10.1124/dmd.119.086397
PMCID:
PMC6505380
AbstractArticlePDF–1.7M
18.
Aberrant CYP1A1 Induction: Discrepancy of CYP1A1 mRNA and Aryl Hydrocarbon Hydroxylase Activity in Mutant Cells of Mouse Hepatoma Line, Hepa‐1
Hideaki Kikuchi, Masahiro Usuda, Ikuko Sagami, Shuntaro Ikawa, Minro Watanabe
Jpn J Cancer Res. 1994 Jul; 85(7): 710–717. doi: 10.1111/j.1349-7006.1994.tb02419.x
PMCID:
PMC5919553
SummaryPDF–493K
19.
Species Difference among Experimental Rodents in Induction of P450IA Family Enzymes by 2‐Amino‐1‐methyl‐6‐phenylimidazo[4,5‐b]pyridine
Masakuni Degawa, Ken‐ichiro Kobayashi, Shin‐ichi Miura, Hiroshi Arai, Hiroyasu Esumi, Takashi Sugimura, Yoshiyuki Hashimoto
Jpn J Cancer Res. 1992 Oct; 83(10): 1047–1051. doi: 10.1111/j.1349-7006.1992.tb02720.x
PMCID:
PMC5918673
SummaryPDF–504K
20.
Serotonin is an endogenous regulator of intestinal CYP1A1 via AhR
Christopher Manzella, Megha Singhal, Waddah A. Alrefai, Seema Saksena, Pradeep K. Dudeja, Ravinder K. Gill
Sci Rep. 2018; 8: 6103. Published online 2018 Apr 17. doi: 10.1038/s41598-018-24213-5
PMCID:
PMC5904159
AbstractArticlePDF–3.0M

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