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Items: 1 to 20 of 49

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
2.
Long-term inhibition of ODC1 in APP/PS1 mice rescues amyloid pathology and switches astrocytes from a reactive to active state
Mridula Bhalla, C. Justin Lee
Mol Brain. 2024; 17: 3. Published online 2024 Jan 12. doi: 10.1186/s13041-024-01076-8
PMCID:
PMC10785549
AbstractArticlePDF–5.1M
3.
Ornithine decarboxylase supports ILC3 responses in infectious and autoimmune colitis through positive regulation of IL-22 transcription
Vincent Peng, Siyan Cao, Tihana Trsan, Jennifer K. Bando, Julian Avila-Pacheco, John L. Cleveland, Clary Clish, Ramnik J. Xavier, Marco Colonna
Proc Natl Acad Sci U S A. 2022 Nov 8; 119(45): e2214900119. Published online 2022 Oct 24. doi: 10.1073/pnas.2214900119
PMCID:
PMC9659397
AbstractArticlePDF–3.0M
4.
Metabolic Modeling of Single Th17 Cells Reveals Regulators of Autoimmunity
Allon Wagner, Chao Wang, Johannes Fessler, David DeTomaso, Julian Avila-Pacheco, James Kaminski, Sarah Zaghouani, Elena Christian, Pratiksha Thakore, Brandon Schellhaass, Elliot Akama-Garren, Kerry Pierce, Vasundhara Singh, Noga Ron-Harel, Vivian Paraskevi Douglas, Lloyd Bod, Alexandra Schnell, Daniel Puleston, Raymond A. Sobel, Marcia Haigis, Erika Pearce, Manoocher Soleimani, Clary Clish, Aviv Regev, Vijay K. Kuchroo, Nir Yosef
Cell. Author manuscript; available in PMC 2022 Aug 5.
Published in final edited form as: Cell. 2021 Aug 5; 184(16): 4168–4185.e21. Published online 2021 Jul 2. doi: 10.1016/j.cell.2021.05.045
PMCID:
PMC8621950
AbstractArticlePDF–3.5M
5.
Polyamine metabolism is a central determinant of helper T cell lineage fidelity
Daniel J. Puleston, Francesc Baixauli, David E. Sanin, Joy Edwards-Hicks, Matteo Villa, Agnieszka M. Kabat, Marcin M. Kamiński, Michal Stanckzak, Hauke J. Weiss, Katarzyna M. Grzes, Klara Piletic, Cameron S. Field, Mauro Corrado, Fabian Haessler, Chao Wang, Yaarub Musa, Lena Schimmelpfennig, Lea Flachsmann, Gerhard Mittler, Nir Yosef, Vijay K. Kuchroo, Joerg M. Buescher, Stefan Balabanov, Edward J. Pearce, Douglas R. Green, Erika L. Pearce
Cell. 2021 Aug 5; 184(16): 4186–4202.e20. doi: 10.1016/j.cell.2021.06.007
PMCID:
PMC8358979
AbstractArticle
6.
ODC-Dependent Putrescine Synthesis Maintains MerTK Expression to Drive Resolution
Arif Yurdagul, Jr., Na Kong, Brennan D. Gerlach, Xiaobo Wang, Patrick Ampomah, George Kuriakose, Wei Tao, Jinjun Shi, Ira Tabas
Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2022 Mar 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2021 Mar; 41(3): e144–e159. Published online 2021 Jan 6. doi: 10.1161/ATVBAHA.120.315622
PMCID:
PMC8034502
AbstractArticlePDF–2.8M
7.
Creatine mediated crosstalk between adipocytes and cancer cells regulates obesity-driven breast cancer
Olivia A. Maguire, Sarah E. Ackerman, Sarah K. Szwed, Aarthi V. Maganti, François Marchildon, Xiaojing Huang, Daniel J. Kramer, Adriana Rosas-Villegas, Rebecca G. Gelfer, Lauren E. Turner, Victor Ceballos, Asal Hejazi, Bozena Samborska, Janane F. Rahbani, Christien B. Dykstra, Matthew G. Annis, Ji-Dung Luo, Thomas S. Carroll, Caroline S. Jiang, Andrew J. Dannenberg, Peter M. Siegel, Sarah A. Tersey, Raghavendra G. Mirmira, Lawrence Kazak, Paul Cohen
Cell Metab. Author manuscript; available in PMC 2022 Mar 2.
Published in final edited form as: Cell Metab. 2021 Mar 2; 33(3): 499–512.e6. Published online 2021 Feb 16. doi: 10.1016/j.cmet.2021.01.018
PMCID:
PMC7954401
AbstractArticlePDF–1.5M
8.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
9.
De novo synthesis and salvage pathway coordinately regulate polyamine homeostasis and determine T cell proliferation and function
Ruohan Wu, Xuyong Chen, Siwen Kang, Tingting Wang, JN Rashida Gnanaprakasam, Yufeng Yao, Lingling Liu, Gaofeng Fan, Mark R. Burns, Ruoning Wang
Sci Adv. 2020 Dec; 6(51): eabc4275. Published online 2020 Dec 16. doi: 10.1126/sciadv.abc4275
PMCID:
PMC7744078
AbstractArticlePDF–1.9M
10.
Ornithine decarboxylase, the rate-limiting enzyme of polyamine synthesis, modifies brain pathology in a mouse model of tuberous sclerosis complex
David Kapfhamer, James McKenna, III, Caroline J Yoon, Tracy Murray-Stewart, Robert A Casero, Jr, Michael J Gambello
Hum Mol Genet. 2020 Aug 11; 29(14): 2395–2407. Published online 2020 Jun 26. doi: 10.1093/hmg/ddaa121
PMCID:
PMC7424721
AbstractArticlePDF–1.4M
11.
Macrophage Metabolism of Apoptotic Cell-Derived Arginine Promotes Continual Efferocytosis and Resolution of Injury
Arif Yurdagul, Jr., Manikandan Subramanian, Xiaobo Wang, Scott B. Crown, Olga Ilkayeva, Lancia Darville, Gopi K. Kolluru, Christina C. Rymond, Brennan D. Gerlach, Ze Zheng, George Kuriakose, Christopher G. Kevil, John M. Koomen, John L. Cleveland, Deborah M. Muoio, Ira Tabas
Cell Metab. Author manuscript; available in PMC 2021 Mar 3.
Published in final edited form as: Cell Metab. 2020 Mar 3; 31(3): 518–533.e10. Published online 2020 Jan 30. doi: 10.1016/j.cmet.2020.01.001
PMCID:
PMC7173557
AbstractArticlePDF–5.0M
12.
Ornithine Decarboxylase in Macrophages Exacerbates Colitis and Promotes Colitis-Associated Colon Carcinogenesis by Impairing M1 Immune Responses
Kshipra Singh, Lori A. Coburn, Mohammad Asim, Daniel P. Barry, Margaret M. Allaman, Chanjuan Shi, M. Kay Washington, Paula B. Luis, Claus Schneider, Alberto G. Delgado, M. Blanca Piazuelo, John L. Cleveland, Alain P. Gobert, Keith T. Wilson
Cancer Res. Author manuscript; available in PMC 2019 Aug 1.
Published in final edited form as: Cancer Res. 2018 Aug 1; 78(15): 4303–4315. Published online 2018 May 31. doi: 10.1158/0008-5472.CAN-18-0116
PMCID:
PMC6072585
AbstractArticlePDF–1.5M
13.
Ornithine decarboxylase regulates M1 macrophage activation and mucosal inflammation via histone modifications
Dana M. Hardbower, Mohammad Asim, Paula B. Luis, Kshipra Singh, Daniel P. Barry, Chunying Yang, Meredith A. Steeves, John L. Cleveland, Claus Schneider, M. Blanca Piazuelo, Alain P. Gobert, Keith T. Wilson
Proc Natl Acad Sci U S A. 2017 Jan 31; 114(5): E751–E760. Published online 2017 Jan 17. doi: 10.1073/pnas.1614958114
PMCID:
PMC5293075
AbstractArticlePDF–1.9M
14.
Ornithine Decarboxylase Is Sufficient for Prostate Tumorigenesis via Androgen Receptor Signaling
Amita Shukla-Dave, Mireia Castillo-Martin, Ming Chen, Jose Lobo, Nataliya Gladoun, Ana Collazo-Lorduy, Faisal M. Khan, Vladimir Ponomarev, Zhengzi Yi, Weijia Zhang, Pier P. Pandolfi, Hedvig Hricak, Carlos Cordon-Cardo
Am J Pathol. 2016 Dec; 186(12): 3131–3145. doi: 10.1016/j.ajpath.2016.08.021
PMCID:
PMC5225291
AbstractArticlePDF–2.3M
15.
Mga is essential for the survival of pluripotent cells during peri-implantation development
Andrew J. Washkowitz, Caroline Schall, Kun Zhang, Wolfgang Wurst, Thomas Floss, Jesse Mager, Virginia E. Papaioannou
Development. 2015 Jan 1; 142(1): 31–40. doi: 10.1242/dev.111104
PMCID:
PMC4299147
AbstractArticle
16.
Structural and degradative aspects of ornithine decarboxylase antizyme inhibitor 2
Bruno Ramos-Molina, Ana Lambertos, Andrés J. Lopez-Contreras, Joanna M. Kasprzak, Anna Czerwoniec, Janusz M. Bujnicki, Asunción Cremades, Rafael Peñafiel
FEBS Open Bio. 2014; 4: 510–521. Published online 2014 Jun 2. doi: 10.1016/j.fob.2014.05.004
PMCID:
PMC4066113
AbstractArticlePDF–2.2M
17.
The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data
Gautier Koscielny, Gagarine Yaikhom, Vivek Iyer, Terrence F. Meehan, Hugh Morgan, Julian Atienza-Herrero, Andrew Blake, Chao-Kung Chen, Richard Easty, Armida Di Fenza, Tanja Fiegel, Mark Grifiths, Alan Horne, Natasha A. Karp, Natalja Kurbatova, Jeremy C. Mason, Peter Matthews, Darren J. Oakley, Asfand Qazi, Jack Regnart, Ahmad Retha, Luis A. Santos, Duncan J. Sneddon, Jonathan Warren, Henrik Westerberg, Robert J. Wilson, David G. Melvin, Damian Smedley, Steve D. M. Brown, Paul Flicek, William C. Skarnes, Ann-Marie Mallon, Helen Parkinson
Nucleic Acids Res. 2014 Jan 1; 42(Database issue): D802–D809. Published online 2013 Nov 3. doi: 10.1093/nar/gkt977
PMCID:
PMC3964955
AbstractArticlePDF–5.7M
18.
Critical Roles of Myc-ODC Axis in the Cellular Transformation Induced by Myeloproliferative Neoplasm-Associated JAK2 V617F Mutant
Megumi Funakoshi-Tago, Kazuya Sumi, Tadashi Kasahara, Kenji Tago
PLoS One. 2013; 8(1): e52844. Published online 2013 Jan 3. doi: 10.1371/journal.pone.0052844
PMCID:
PMC3536786
AbstractArticlePDF–1.4M
19.
Introduction of a Fluorine Atom at C3 of 3-Deazauridine Shifts Its Antimetabolic Activity from Inhibition of CTP Synthetase to Inhibition of Orotidylate Decarboxylase, an Early Event in the de Novo Pyrimidine Nucleotide Biosynthesis Pathway
Jan Balzarini, Federico Gago, Wim Kulik, André B. P. van Kuilenburg, Anna Karlsson, Matt A. Peterson, Morris J. Robins
J Biol Chem. 2012 Aug 31; 287(36): 30444–30454. Published online 2012 Jun 24. doi: 10.1074/jbc.M112.378091
PMCID:
PMC3436294
AbstractArticlePDF–1.6M
20.
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas
Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042
PMCID:
PMC3178059
AbstractArticlePDF–1.0M

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