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Select item 111970631.

Recessively Inherited Deficiency of Secreted WFDC2 (HE4) Causes Nasal Polyposis and Bronchiectasis

Gerard W. Dougherty, Lawrence E. Ostrowski, Tabea Nöthe-Menchen, Johanna Raidt, Andre Schramm, Heike Olbrich, Weining Yin, Patrick R. Sears, Hong Dang, Amanda J. Smith, Achim G. Beule, Rim Hjeij, Niels Rutjes, Eric G. Haarman, Saskia M. Maas, Thomas W. Ferkol, Peadar G. Noone, Kenneth N. Olivier, Diana C. Bracht, Pascal Barbry, Laure-Emmanuelle Zaragosi, Morgane Fierville, Sabine Kliesch, Kai Wohlgemuth, Julia König, Sebastian George, Niki T. Loges, Agathe Ceppe, Matthew R. Markovetz, Hong Luo, Ting Guo, Hoda Rizk, Tarek Eldesoky, Katrin Dahlke, Karsten Boldt, Marius Ueffing, David B. Hill, Yuan-Ping Pang, Michael R. Knowles, Maimoona A. Zariwala, Heymut Omran

Am J Respir Crit Care Med. 2024 Jul 1; 210(1): 63–76. Published online 2024 Apr 16. doi: 10.1164/rccm.202308-1370OC

PMCID:: PMC11197063

Abstract Article PDF–2.8M

Select item 111668032.

Silencing HE4 alleviates the renal fibrosis in lupus nephritis mice by regulating the C3/MMPs/prss axis

Yixia Li, Xiaorong Zhong, Feng Yang

Naunyn Schmiedebergs Arch Pharmacol. 2024; 397(7): 4823–4831. Published online 2023 Dec 29. doi: 10.1007/s00210-023-02883-x

PMCID:: PMC11166803

Abstract Article PDF–1.1M

Select item 111366913.

Knockdown of HE4 suppresses tumor growth and invasiveness in lung adenocarcinoma through regulation of EGFR signaling

YUE ZHANG, WENYU YANG, XIAOWANG HAN, YUE QIAO, HAITAO WANG, TING CHEN, TIANYING LI, WEN-BIN OU

Oncol Res. 2024; 32(6): 1119–1128. Published online 2024 May 23. doi: 10.32604/or.2024.045025

PMCID:: PMC11136691

Abstract Article PDF–22M

Select item 109117364.

Human Epididymis Protein 4 (HE4) and Cancer Antigen 125 (CA125) for Prediction of Optimal Primary Surgery in Non-Mucinous Epithelial Ovarian Cancer

Kanokwan Promchit, Shina Oranratanaphan

Asian Pac J Cancer Prev. 2024; 25(1): 281–286. doi: 10.31557/APJCP.2024.25.1.281

PMCID:: PMC10911736

Abstract Article PDF–410K

Select item 107255895.

Elevated level of serum human epididymis protein 4 (HE4) predicts disease severity and mortality in COVID-19 pneumonia

Renáta Sütő, Marianna Pócsi, Zsolt Szabó, Zsolt Fejes, Gergely Ivády, György Kerekes, Miklós Fagyas, Attila Nagy, Zoltán Szentkereszty, János Kappelmayer, Béla Nagy, Jr.

BMC Pulm Med. 2023; 23: 512. Published online 2023 Dec 16. doi: 10.1186/s12890-023-02811-y

PMCID:: PMC10725589

Abstract Article PDF–1.4M

Select item 107049826.

Combination of serum CST1 and HE4 for early diagnosis of endometrial cancer

Wenhui Zhong, Yunliang Liu, Liangming Zhang, Wanzhen Zhuang, Jianlin Chen, Zhixin Huang, Yue Zheng, Yi Huang

PeerJ. 2023; 11: e16424. Published online 2023 Dec 5. doi: 10.7717/peerj.16424

PMCID:: PMC10704982

Abstract Article PDF–9.0M

Select item 104437497.

Diagnostic value of serum human epididymis protein 4, carbohydrate antigen 125 and their combination in endometrial cancer: A meta-analysis

Qi Wu, Su-ning Bai, Li-yun Song, Wen-fei Wu, Li-na Han

Medicine (Baltimore) 2023 Aug 18; 102(33): e34737. Published online 2023 Aug 18. doi: 10.1097/MD.0000000000034737

PMCID:: PMC10443749

Abstract Article PDF–2.3M

Select item 101336308.

Effect of Serum Level of Human Epididymis Protein 4 and Interleukin-6 as Biomarkers in Patients with Adnexal Mass

Hameed S, Abdulqader Jasim H, Sharief M

Arch Razi Inst. 2022 Oct; 77(5): 1659–1671. Published online 2022 Oct 31. doi: 10.22092/ARI.2022.358329.2194

PMCID:: PMC10133630

Abstract Article PDF–429K

Select item 98877679.

Secreted proteins MDK, WFDC2, and CXCL14 as candidate biomarkers for early diagnosis of lung adenocarcinoma

Junfeng Li, Jianjie Li, Huifeng Hao, Fangliang Lu, Jia Wang, Menglei Ma, Bo Jia, Minglei Zhuo, Jingjing Wang, Yujia Chi, Xiaoyu Zhai, Yuyan Wang, Meina Wu, Tongtong An, Jun Zhao, Fan Yang, Ziping Wang

BMC Cancer. 2023; 23: 110. Published online 2023 Jan 31. doi: 10.1186/s12885-023-10523-z

PMCID:: PMC9887767

Abstract Article PDF–3.0M

Select item 933856810.

HE4 as a serum biomarker for the diagnosis of pelvic masses: a prospective, multicenter study in 965 patients

Elena Ioana Braicu, Catherine Linn Krause, Uwe Torsten, Herbert Mecke, Rolf Richter, Lars Hellmeyer, Malgorzata Lanowska, Bodo Müller, Elisa Koch, Janine Boenneß-Zaloum, Kerstin Ames, Radoslav Chekerov, Kati Hasenbein, Mathias Zimmermann, Mandy Mangler, Frank Chen, Rudolf Tauber, Jalid Sehouli

BMC Cancer. 2022; 22: 831. Published online 2022 Jul 30. doi: 10.1186/s12885-022-09887-5

PMCID:: PMC9338568

Abstract Article PDF–1.1M

Select item 910734811.

A bioinformatic analysis of WFDC2 (HE4) expression in high grade serous ovarian cancer reveals tumor-specific changes in metabolic and extracellular matrix gene expression

Nicole E. James, Megan Gura, Morgan Woodman, Richard N. Freiman, Jennifer R. Ribeiro

Med Oncol. 2022; 39(7): 71. Published online 2022 May 15. doi: 10.1007/s12032-022-01665-4

PMCID:: PMC9107348

Abstract Article PDF–3.5M

Select item 909705312.

Human epididymis protein 4 aggravates airway inflammation and remodeling in chronic obstructive pulmonary disease

Yuan Zhan, Jinkun Chen, Jixing Wu, Yiya Gu, Qian Huang, Zhesong Deng, Shanshan Chen, Xiaojie Wu, Yongman Lv, Zhilin Zeng, Jungang Xie

Respir Res. 2022; 23: 120. Published online 2022 May 12. doi: 10.1186/s12931-022-02040-7

PMCID:: PMC9097053

Abstract Article PDF–4.7M

Select item 862946613.

Serum Human Epididymis Protein-4 (HE4) - A novel Approach to Differentiate Malignant from benign Breast Tumors

K S S Sai Baba, Mohd Abdul Rehman, J Pradeep Kumar, Maira Fatima, G S N Raju, Shantveer G Uppin, Noorjahan Mohammed

Asian Pac J Cancer Prev. 2021 Aug; 22(8): 2509–2513. doi: 10.31557/APJCP.2021.22.8.2509

PMCID:: PMC8629466

Abstract Article PDF–340K

Select item 857832714.

Recurrence monitoring for ovarian cancer using a cell phone-integrated paper device to measure the ovarian cancer biomarker HE4/CRE ratio in urine

Emily C. Kight, Iftak Hussain, Audrey K. Bowden, Frederick R. Haselton

Sci Rep. 2021; 11: 21945. Published online 2021 Nov 9. doi: 10.1038/s41598-021-01544-4

PMCID:: PMC8578327

Abstract Article PDF–2.8M

Select item 856921515.

Serum HE4 and CA125 combined to predict and monitor recurrence of type II endometrial carcinoma

Quan Quan, Qianqian Liao, Wanchun Yin, Shuwei Zhou, Sainan Gong, Xiaoling Mu

Sci Rep. 2021; 11: 21694. Published online 2021 Nov 4. doi: 10.1038/s41598-021-01263-w

PMCID:: PMC8569215

Abstract Article PDF–1010K

Select item 848976316.

HE4 might be a more useful tumor biomarker to detect malignancy in patients with ovarian endometrioma when malignancy is suspected

Mariona Rius, Pere Fusté, Cristina Ros, Ángeles Martínez-Zamora, Cristian deGuirior, Meritxell Gracia, Eduard Mension, Francisco Carmona

J Int Med Res. 2021 Sep; 49(9): 03000605211047701. Published online 2021 Sep 30. doi: 10.1177/03000605211047701

PMCID:: PMC8489763

Abstract Article PDF–274K

Select item 826067817.

Elevated Serum Human Epididymis Protein 4 Is Associated With Disease Activity and Systemic Involvements in Primary Sjögren’s Syndrome

Jiali Chen, Feng Sun, Huizhang Bao, Liu Liang, Minghua Zhan, Haihong Yao, Jing He, Yudong Liu

Front Immunol. 2021; 12: 670642. Published online 2021 Jun 23. doi: 10.3389/fimmu.2021.670642

PMCID:: PMC8260678

Abstract Article PDF–1.6M

Select item 816503018.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 815448619.

Diagnostic value of serum human epididymis protein 4 and cancer antigen 125 in the patients with ovarian carcinoma: A protocol for systematic review and meta-analysis

Hai-Ying Dai, Fang Hu, Yuan Ding

Medicine (Baltimore) 2021 May 28; 100(21): e25981. Published online 2021 May 28. doi: 10.1097/MD.0000000000025981

PMCID:: PMC8154486

Abstract Article PDF–405K

Select item 812706120.

Human epididymis protein 4 promotes P-glycoprotein-mediated chemoresistance in ovarian cancer cells through interactions with Annexin II

Qing Liu, Da-Wo Liu, Ming-Jun Zheng, Lu Deng, Hui-Min Wang, Shan Jin, Juan-Juan Liu, Ying-Ying Hao, Lian-Cheng Zhu, Bei Lin

Mol Med Rep. 2021 Jul; 24(1): 496. Published online 2021 May 5. doi: 10.3892/mmr.2021.12135

PMCID:: PMC8127061

Abstract Article PDF–2.9M

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