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Select item 109665181.

BMP‐ACVR1 Axis is Critical for Efficacy of PRC2 Inhibitors in B‐Cell Lymphoma

Dongdong Liu, Zhen Li, Dongxia Tan, Yang An, Liping Chu, Tiancheng Chen, Weijia Li, Ailin Zhou, Ruijie Xiang, Liye Zhang, Yuxiu Qu, Wei Qi

Adv Sci (Weinh) 2024 Mar; 11(12): 2306499. Published online 2024 Jan 16. doi: 10.1002/advs.202306499

PMCID:: PMC10966518

Abstract Article PDF–14M

Select item 105264562.

AAV-Mediated Targeting of the Activin A-ACVR1^R206H Signaling in Fibrodysplasia Ossificans Progressiva

Yeon-Suk Yang, Chujiao Lin, Hong Ma, Jun Xie, Frederick S. Kaplan, Guangping Gao, Jae-Hyuck Shim

Biomolecules. 2023 Sep; 13(9): 1364. Published online 2023 Sep 8. doi: 10.3390/biom13091364

PMCID:: PMC10526456

Abstract Article PDF–3.5M

Select item 103117973.

Functional comparison of human ACVR1 and zebrafish Acvr1l FOP-associated variants in embryonic zebrafish

Robert L. Lalonde, Hannah A. Nicolas, Rowan S. Cutler, Irene Pantekidis, Weibo Zhang, Pamela C. Yelick

Dev Dyn. Author manuscript; available in PMC 2024 May 1.

Published in final edited form as: Dev Dyn. 2023 May; 252(5): 605–628. Published online 2023 Jan 26. doi: 10.1002/dvdy.566

PMCID:: PMC10311797

Abstract Article PDF–3.1M

Select item 102129224.

A blocking monoclonal antibody reveals dimerization of intracellular domains of ALK2 associated with genetic disorders

Takenobu Katagiri, Sho Tsukamoto, Mai Kuratani, Shinnosuke Tsuji, Kensuke Nakamura, Satoshi Ohte, Yoshiro Kawaguchi, Kiyosumi Takaishi

Nat Commun. 2023; 14: 2960. Published online 2023 May 25. doi: 10.1038/s41467-023-38746-5

Correction in:: Nat Commun. 2023; 14: 6054.

PMCID:: PMC10212922

Abstract Article PDF–5.4M

Select item 100729065.

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity

Martin Golkowski, Andrea Lius, Tanmay Sapre, Ho-Tak Lau, Taylor Moreno, Dustin J. Maly, Shao-En Ong

Mol Cell. Author manuscript; available in PMC 2023 Apr 4.

Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 803–818.e8. Published online 2023 Feb 2. doi: 10.1016/j.molcel.2023.01.015

PMCID:: PMC10072906

Abstract Article PDF–4.2M

Select item 98857066.

FKBP12 is a major regulator of ALK2 activity in multiple myeloma cells

Ingrid Quist-Løkken, Clara Andersson-Rusch, Martin Haugrud Kastnes, Jürgen Markus Kolos, Jerome Jatzlau, Hanne Hella, Oddrun Elise Olsen, Anders Sundan, Petra Knaus, Felix Hausch, Toril Holien

Cell Commun Signal. 2023; 21: 25. Published online 2023 Jan 30. doi: 10.1186/s12964-022-01033-9

PMCID:: PMC9885706

Abstract Article PDF–4.7M

Select item 94948707.

Recapitulation of pro-inflammatory signature of monocytes with ACVR1A mutation using FOP patient-derived iPSCs

Hirotsugu Maekawa, Yonghui Jin, Megumi Nishio, Shunsuke Kawai, Sanae Nagata, Takeshi Kamakura, Hiroyuki Yoshitomi, Akira Niwa, Megumu K. Saito, Shuichi Matsuda, Junya Toguchida

Orphanet J Rare Dis. 2022; 17: 364. Published online 2022 Sep 21. doi: 10.1186/s13023-022-02506-3

PMCID:: PMC9494870

Abstract Article PDF–9.6M

Select item 89738608.

MicroRNA-137 inhibits the inflammatory response and extracellular matrix degradation in lipopolysaccharide-stimulated human nucleus pulposus cells by targeting activin a receptor type I

Bin Yu, Ziqi Zhu, Beiduo Shen, Jiawei Lu, Kai Guo, Weidong Zhao, Desheng Wu

Bioengineered. 2022; 13(3): 6396–6408. Published online 2022 Mar 2. doi: 10.1080/21655979.2022.2042987

PMCID:: PMC8973860

Abstract Article PDF–2.8M

Select item 88032619.

ACVR1^R206H extends inflammatory responses in human induced pluripotent stem cell-derived macrophages

Koji Matsuo, Abigail Lepinski, Robert D. Chavez, Emilie Barruet, Ashley Pereira, Tania A. Moody, Amy N. Ton, Aditi Sharma, Judith Hellman, Kiichiro Tomoda, Mary C. Nakamura, Edward C. Hsiao

Bone. Author manuscript; available in PMC 2022 Dec 1.

Published in final edited form as: Bone. 2021 Dec; 153: 116129. Published online 2021 Jul 24. doi: 10.1016/j.bone.2021.116129

Correction in:: Bone. 2022 Feb 28 : 116325.

PMCID:: PMC8803261

Abstract Article PDF–2.5M

Select item 869183210.

Modeling the ACVR1^R206H mutation in human skeletal muscle stem cells

Emilie Barruet, Steven M Garcia, Jake Wu, Blanca M Morales, Stanley Tamaki, Tania Moody, Jason H Pomerantz, Edward C Hsiao

eLife. 2021; 10: e66107. Published online 2021 Nov 10. doi: 10.7554/eLife.66107

PMCID:: PMC8691832

Abstract Article PDF–16M

Select item 836810011.

Structural basis for ALK2/BMPR2 receptor complex signaling through kinase domain oligomerization

Christopher Agnew, Pelin Ayaz, Risa Kashima, Hanna S. Loving, Prajakta Ghatpande, Jennifer E. Kung, Eric S. Underbakke, Yibing Shan, David E. Shaw, Akiko Hata, Natalia Jura

Nat Commun. 2021; 12: 4950. Published online 2021 Aug 16. doi: 10.1038/s41467-021-25248-5

PMCID:: PMC8368100

Abstract Article PDF–3.5M

Select item 828079512.

Pathogenic ACVR1^R206H activation by Activin A‐induced receptor clustering and autophosphorylation

Anassuya Ramachandran, Merima Mehić, Laabiah Wasim, Dessislava Malinova, Ilaria Gori, Beata K Blaszczyk, Diana M Carvalho, Eileen M Shore, Chris Jones, Marko Hyvönen, Pavel Tolar, Caroline S Hill

EMBO J. 2021 Jul 15; 40(14): e106317. Published online 2021 May 18. doi: 10.15252/embj.2020106317

PMCID:: PMC8280795

Abstract Article PDF–3.2M

Select item 816503013.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 813108614.

Anti-Müllerian hormone concentration regulates activin receptor-like kinase-2/3 expression levels with opposing effects on ovarian cancer cell survival

Maëva Chauvin, Véronique Garambois, Sylvie Choblet, Pierre-Emmanuel Colombo, Myriam Chentouf, Laurent Gros, David-Paul De Brauwere, Martine Duonor-Cerutti, Karen Dumas, Bruno Robert, Marta Jarlier, Pierre Martineau, Isabelle Navarro-Teulon, David Pépin, Thierry Chardès, André Pèlegrin

Int J Oncol. 2021 Jul; 59(1): 43. Published online 2021 May 17. doi: 10.3892/ijo.2021.5223

PMCID:: PMC8131086

Abstract Article PDF–954K

Select item 734646915.

Association analysis of polymorphisms rs12997 in ACVR1 and rs1043784 in BMP6 genes involved in bone morphogenic protein signaling pathway in primary angle-closure and pseudoexfoliation glaucoma patients of Saudi origin

Altaf A. Kondkar, Tahira Sultan, Taif A. Azad, Essam A. Osman, Faisal A. Almobarak, Saleh A. Al-Obeidan

BMC Med Genet. 2020; 21: 145. Published online 2020 Jul 8. doi: 10.1186/s12881-020-01076-0

PMCID:: PMC7346469

Abstract Article PDF–831K

Select item 724578816.

Prophylactic treatment of rapamycin ameliorates naturally developing and episode -induced heterotopic ossification in mice expressing human mutant ACVR1

Hirotsugu Maekawa, Shunsuke Kawai, Megumi Nishio, Sanae Nagata, Yonghui Jin, Hiroyuki Yoshitomi, Shuichi Matsuda, Junya Toguchida

Orphanet J Rare Dis. 2020; 15: 122. Published online 2020 May 24. doi: 10.1186/s13023-020-01406-8

PMCID:: PMC7245788

Abstract Article PDF–5.4M

Select item 722598917.

Activins as Dual Specificity TGF-β Family Molecules: SMAD-Activation via Activin- and BMP-Type 1 Receptors

Oddrun Elise Olsen, Hanne Hella, Samah Elsaadi, Carsten Jacobi, Erik Martinez-Hackert, Toril Holien

Biomolecules. 2020 Apr; 10(4): 519. Published online 2020 Mar 29. doi: 10.3390/biom10040519

PMCID:: PMC7225989

Abstract Article PDF–2.8M

Select item 714585718.

Differential kinase activity of ACVR1 G328V and R206H mutations with implications to possible TβRI cross-talk in diffuse intrinsic pontine glioma

Hongnan Cao, Miao Jin, Mu Gao, Hongyi Zhou, Yizhi Jane Tao, Jeffrey Skolnick

Sci Rep. 2020; 10: 6140. Published online 2020 Apr 9. doi: 10.1038/s41598-020-63061-0

PMCID:: PMC7145857

Abstract Article PDF–2.7M

Select item 711318719.

The deubiquitinating enzyme PSMD14 facilitates tumor growth and chemoresistance through stabilizing the ALK2 receptor in the initiation of BMP6 signaling pathway

Dongyeob Seo, Su Myung Jung, Jin Seok Park, Jaewon Lee, Jihoon Ha, Minbeom Kim, Seok Hee Park

EBioMedicine. 2019 Nov; 49: 55–71. Published online 2019 Nov 1. doi: 10.1016/j.ebiom.2019.10.039

PMCID:: PMC7113187

Abstract Article PDF–3.5M

Select item 710582020.

Mutant ACVR1 Arrests Glial Cell Differentiation to Drive Tumorigenesis in Pediatric Gliomas

Jerome Fortin, Ruxiao Tian, Ida Zarrabi, Graham Hill, Eleanor Williams, Gonzalo Sanchez-Duffhues, Midory Thorikay, Parameswaran Ramachandran, Robert Siddaway, Jong Fu Wong, Annette Wu, Lorraine N. Apuzzo, Jillian Haight, Annick You-Ten, Bryan E. Snow, Andrew Wakeham, David J. Goldhamer, Daniel Schramek, Alex N. Bullock, Peter ten Dijke, Cynthia Hawkins, Tak W. Mak

Cancer Cell. 2020 Mar 16; 37(3): 308–323.e12. doi: 10.1016/j.ccell.2020.02.002

PMCID:: PMC7105820

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