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Select item 106563271.

Mutant p53^R211* ameliorates inflammatory arthritis in AIA rats via inhibition of TBK1-IRF3 innate immune response

Yaling Zeng, Jerome P. L. Ng, Linna Wang, Xiongfei Xu, Betty Yuen Kwan Law, Guobing Chen, Hang Hong Lo, Lijun Yang, Jiujie Yang, Lei Zhang, Liqun Qu, Xiaoyun Yun, Jing Zhong, Ruihong Chen, Dingqi Zhang, Yuping Wang, Weidan Luo, Congling Qiu, Baixiong Huang, Wenfeng liu, Liang Liu, Vincent Kam Wai Wong

Inflamm Res. 2023; 72(12): 2199–2219. Published online 2023 Nov 8. doi: 10.1007/s00011-023-01809-w

PMCID:: PMC10656327

Abstract Article PDF–13M

Select item 71144342.

Elucidating the molecular physiopathology of acute respiratory distress syndrome in severe acute respiratory syndrome patients

Say Li Kong, Paul Chui, Bing Lim, Manuel Salto-Tellez

Virus Res. 2009 Nov; 145(2): 260–269. Published online 2009 Jul 25. doi: 10.1016/j.virusres.2009.07.014

PMCID:: PMC7114434

Abstract Article PDF–1.8M

Select item 52784633.

Chronic innate immune activation of TBK1 suppresses mTORC1 activity and dysregulates cellular metabolism

Maroof Hasan, Vijay K. Gonugunta, Nicole Dobbs, Aktar Ali, Guillermo Palchik, Maria A. Calvaruso, Ralph J. DeBerardinis, Nan Yan

Proc Natl Acad Sci U S A. 2017 Jan 24; 114(4): 746–751. Published online 2017 Jan 9. doi: 10.1073/pnas.1611113114

PMCID:: PMC5278463

Abstract Article PDF–1.3M

Select item 52264884.

IRF3 is an important molecule in the UII/UT system and mediates immune inflammatory injury in acute liver failure

Liang-ming Liu, Wen-juan Tu, Tong Zhu, Xiao-ting Wang, Zhi-li Tan, Huan Zhong, De-yong Gao, Dong-yu Liang

Oncotarget. 2016 Aug 2; 7(31): 49027–49041. Published online 2016 Jul 19. doi: 10.18632/oncotarget.10717

PMCID:: PMC5226488

Abstract Article PDF–3.1M

Select item 49332345.

The Type I Interferon-IRF7 Axis Mediates Transcriptional Expression of Usp25 Gene

Yujie Ren, Yin Zhao, Dandan Lin, Ximing Xu, Qiyun Zhu, Jing Yao, Hong-Bing Shu, Bo Zhong

J Biol Chem. 2016 Jun 17; 291(25): 13206–13215. Published online 2016 Apr 27. doi: 10.1074/jbc.M116.718080

PMCID:: PMC4933234

Abstract Article PDF–3.7M

Select item 43321506.

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes

Xu Li, Wenqi Wang, Jiadong Wang, Anna Malovannaya, Yuanxin Xi, Wei Li, Rudy Guerra, David H Hawke, Jun Qin, Junjie Chen

Mol Syst Biol. 2015 Jan; 11(1): 775. Published online 2015 Jan 21. doi: 10.15252/msb.20145504

PMCID:: PMC4332150

Abstract Article PDF–2.8M

Select item 40543667.

Murine Gammaherpesvirus 68 Encoding Open Reading Frame 11 Targets TANK Binding Kinase 1 To Negatively Regulate the Host Type I Interferon Response

Hye-Ri Kang, Woo-Chang Cheong, Ji-Eun Park, Seungbo Ryu, Hye-Jeong Cho, Hyunyee Youn, Jin-Hyun Ahn, Moon Jung Song

J Virol. 2014 Jun; 88(12): 6832–6846. doi: 10.1128/JVI.03460-13

PMCID:: PMC4054366

Abstract Article PDF–2.8M

Select item 37743638.

Inducible Interleukin 32 (IL-32) Exerts Extensive Antiviral Function via Selective Stimulation of Interferon λ1 (IFN-λ1)

Yongkui Li, Jiajia Xie, Xiupeng Xu, Li Liu, Yushun Wan, Yingle Liu, Chengliang Zhu, Ying Zhu

J Biol Chem. 2013 Jul 19; 288(29): 20927–20941. Published online 2013 May 31. doi: 10.1074/jbc.M112.440115

PMCID:: PMC3774363

Abstract Article PDF–2.7M

Select item 37182859.

The transcription factor IRF3 triggers “defensive suicide” necrosis in response to viral and bacterial pathogens

Nelson C. Di Paolo, Konstantin Doronin, Lisa K. Baldwin, Thalia Papayannopoulou, Dmitry M. Shayakhmetov

Cell Rep. Author manuscript; available in PMC 2013 Jul 22.

Published in final edited form as: Cell Rep. 2013 Jun 27; 3(6): 1840–1846. Published online 2013 Jun 13. doi: 10.1016/j.celrep.2013.05.025

PMCID:: PMC3718285

Abstract Article PDF–3.4M

Select item 370263110.

Structural Insights into the Functions of TBK1 in Innate Antimicrobial Immunity

Chang Shu, Banumathi Sankaran, Catherine T. Chaton, Andrew B. Herr, Ashutosh Mishra, Junmin Peng, Pingwei Li

Structure. Author manuscript; available in PMC 2014 Jul 2.

Published in final edited form as: Structure. 2013 Jul 2; 21(7): 1137–1148. Published online 2013 Jun 6. doi: 10.1016/j.str.2013.04.025

PMCID:: PMC3702631

Abstract Article PDF–4.3M

Select item 367018511.

Peroxisomes are signaling platforms for antiviral innate immunity

Evelyn Dixit, Steeve Boulant, Yijing Zhang, Amy S. Lee, Charlotte Odendall, Bennett Shum, Nir Hacohen, Zhijian J. Chen, Sean P. Whelan, Marc Fransen, Max L. Nibert, Giulio Superti-Furga, Jonathan C. Kagan

Cell. Author manuscript; available in PMC 2013 Jun 3.

Published in final edited form as: Cell. 2010 May 14; 141(4): 668–681. Published online 2010 May 6. doi: 10.1016/j.cell.2010.04.018

PMCID:: PMC3670185

Article PDF–5.5M

Select item 354966912.

STING Specifies IRF3 phosphorylation by TBK1 in the Cytosolic DNA Signaling Pathway

Yasuo Tanaka, Zhijian J. Chen

Sci Signal. Author manuscript; available in PMC 2013 Jan 21.

Published in final edited form as: Sci Signal. 2012 Mar 6; 5(214): ra20. Published online 2012 Mar 6. doi: 10.1126/scisignal.2002521

PMCID:: PMC3549669

Abstract Article PDF–2.1M

Select item 352277213.

Trex1 regulates lysosomal biogenesis and interferon-independent activation of antiviral genes

Maroof Hasan, James Koch, Dinesh Rakheja, Asit K. Pattnaik, James Brugarolas, Igor Dozmorov, Beth Levine, Edward K. Wakeland, Min Ae Lee-kirsch, Nan Yan

Nat Immunol. Author manuscript; available in PMC 2013 Jul 1.

Published in final edited form as: Nat Immunol. 2013 Jan; 14(1): 61–71. Published online 2012 Nov 18. doi: 10.1038/ni.2475

PMCID:: PMC3522772

Abstract Article PDF–1.5M

Select item 339254514.

Structure of STING bound to c-di-GMP Reveals the Mechanism of Cyclic Dinucleotide Recognition by the Immune System

Chang Shu, Guanghui Yi, Tylan Watts, C. Cheng Kao, Pingwei Li

Nat Struct Mol Biol. Author manuscript; available in PMC 2013 Jan 1.

Published in final edited form as: Nat Struct Mol Biol. 2012 Jul; 19(7): 722–724. Published online 2012 Jun 24. doi: 10.1038/nsmb.2331

PMCID:: PMC3392545

Abstract Article PDF–667K

Select item 317991615.

MAVS Forms Functional Prion-Like Aggregates To Activate and Propagate Antiviral Innate Immune Response

Fajian Hou, Lijun Sun, Hui Zheng, Brian Skaug, Qiu-Xing Jiang, Zhijian J. Chen

Cell. Author manuscript; available in PMC 2012 Feb 5.

Published in final edited form as: Cell. 2011 Aug 5; 146(3): 448–461. Published online 2011 Jul 21. doi: 10.1016/j.cell.2011.06.041

Correction in:: volume 146 on page 841

PMCID:: PMC3179916

Abstract Article PDF–2.1M

Select item 317805916.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 311127517.

Glucocorticoids target suppressor of cytokine signaling 1 (SOCS1) and type 1 interferons to regulate Toll-like receptor–induced STAT1 activation

Sandip Bhattacharyya, Yuxing Zhao, Thomas W. H. Kay, Louis J. Muglia

Proc Natl Acad Sci U S A. 2011 Jun 7; 108(23): 9554–9559. Published online 2011 May 23. doi: 10.1073/pnas.1017296108

PMCID:: PMC3111275

Abstract Article PDF–1.0M

Select item 305062718.

The transcription factor MAFB antagonizes anti-viral responses by blockade of coactivator recruitment to IRF3

Hwijin Kim, Brian Seed

Nat Immunol. Author manuscript; available in PMC 2011 Mar 8.

Published in final edited form as: Nat Immunol. 2010 Aug; 11(8): 743–750. Published online 2010 Jun 27. doi: 10.1038/ni.1897

PMCID:: PMC3050627

Abstract Article PDF–1.2M

Select item 291921419.

Reconstitution of the RIG-I Pathway Reveals a Pivotal Role of Unanchored Polyubiquitin Chains in Innate Immunity

Wenwen Zeng, Lijun Sun, Xiaomo Jiang, Xiang Chen, Fajian Hou, Anirban Adhikari, Ming Xu, Zhijian J. Chen

Cell. Author manuscript; available in PMC 2010 Oct 1.

Published in final edited form as: Cell. 2010 Apr 16; 141(2): 315–330. doi: 10.1016/j.cell.2010.03.029

PMCID:: PMC2919214

Abstract Article PDF–5.1M

Select item 276491420.

A selective contribution of the RIG-I-like receptor pathway to type I interferon responses activated by cytosolic DNA

Myoung Kwon Choi, ZhiChao Wang, Tatsuma Ban, Hideyuki Yanai, Yan Lu, Ryuji Koshiba, Yukana Nakaima, Sho Hangai, David Savitsky, Makoto Nakasato, Hideo Negishi, Osamu Takeuchi, Kenya Honda, Shizuo Akira, Tomohiko Tamura, Tadatsugu Taniguchi

Proc Natl Acad Sci U S A. 2009 Oct 20; 106(42): 17870–17875. Published online 2009 Oct 1. doi: 10.1073/pnas.0909545106