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Select item 108897761.

Loss of 15-Lipoxygenase in Retinodegenerative RCS Rats

Andrew James Mead, Kabir Ahluwalia, Brandon Ebright, Zeyu Zhang, Priyal Dave, Zeyang Li, Eugene Zhou, Aditya Anil Naik, Rachael Ngu, Catherine Chester, Angela Lu, Isaac Asante, Dimitrios Pollalis, Juan Carlos Martinez, Mark Humayun, Stan Louie

Int J Mol Sci. 2024 Feb; 25(4): 2309. Published online 2024 Feb 15. doi: 10.3390/ijms25042309

PMCID:: PMC10889776

Abstract Article PDF–3.2M

Select item 58203762.

Distribution of Alox15 in the Rat Brain and Its Role in Prefrontal Cortical Resolvin D1 Formation and Spatial Working Memory

Suku-Maran Shalini, Christabel Fung-Yih Ho, Yee-Kong Ng, Jie-Xin Tong, Eng-Shi Ong, Deron R. Herr, Gavin S. Dawe, Wei-Yi Ong

Mol Neurobiol. 2018; 55(2): 1537–1550. Published online 2017 Feb 8. doi: 10.1007/s12035-017-0413-x

PMCID:: PMC5820376

Abstract Article PDF–2.4M

Select item 47523243.

Key Role of ROS in the Process of 15-Lipoxygenase/15-Hydroxyeicosatetraenoiccid-Induced Pulmonary Vascular Remodeling in Hypoxia Pulmonary Hypertension

Qian Li, Min Mao, Yanli Qiu, Gaofeng Liu, Tingting Sheng, Xiufeng Yu, Shuang Wang, Daling Zhu

PLoS One. 2016; 11(2): e0149164. Published online 2016 Feb 12. doi: 10.1371/journal.pone.0149164

PMCID:: PMC4752324

Abstract Article PDF–12M

Select item 43402994.

12/15-Lipoxygenase metabolites of arachidonic acid activate PPARγ: a possible neuroprotective effect in ischemic brain

Li Sun, Yan-Wei Xu, Jing Han, Hao Liang, Ning Wang, Yan Cheng

J Lipid Res. 2015 Mar; 56(3): 502–514. doi: 10.1194/jlr.M053058

PMCID:: PMC4340299

Abstract Article PDF–1.7M

Select item 42424515.

Lipoxygenase-catalyzed transformation of epoxy fatty acids to hydroxy-endoperoxides: a potential P450 and lipoxygenase interaction

Tarvi Teder, William E. Boeglin, Alan R. Brash

J Lipid Res. 2014 Dec; 55(12): 2587–2596. doi: 10.1194/jlr.M054072

PMCID:: PMC4242451

Abstract Article PDF–959K

Select item 38976116.

Microarray Analysis of Rat Pancreas Reveals Altered Expression of Alox15 and Regenerating Islet-Derived Genes in Response to Iron Deficiency and Overload

Richard Coffey, Hyeyoung Nam, Mitchell D. Knutson

PLoS One. 2014; 9(1): e86019. Published online 2014 Jan 21. doi: 10.1371/journal.pone.0086019

PMCID:: PMC3897611

Abstract Article PDF–423K

Select item 38400047.

Functional characterization of genetic enzyme variations in human lipoxygenases

Thomas Horn, Kumar Reddy Kakularam, Monika Anton, Constanze Richter, Pallu Reddanna, Hartmut Kuhn

Redox Biol. 2013; 1(1): 566–577. Published online 2013 Nov 11. doi: 10.1016/j.redox.2013.11.001

PMCID:: PMC3840004

Abstract Article PDF–4.2M

Select item 36338138.

Systematic analysis of rat 12/15-lipoxygenase enzymes reveals critical role for spinal eLOX3 hepoxilin synthase activity in inflammatory hyperalgesia

Ann M. Gregus, Darren S. Dumlao, Spencer C. Wei, Paul C. Norris, Laura C. Catella, Flore G. Meyerstein, Matthew W. Buczynski, Joanne J. Steinauer, Bethany L. Fitzsimmons, Tony L. Yaksh, Edward A. Dennis

FASEB J. 2013 May; 27(5): 1939–1949. doi: 10.1096/fj.12-217414

PMCID:: PMC3633813

Abstract Article

Select item 36179499.

Biosynthesis, isolation, and NMR analysis of leukotriene A epoxides: substrate chirality as a determinant of the cis or trans epoxide configuration

Jing Jin, Yuxiang Zheng, William E. Boeglin, Alan R. Brash

J Lipid Res. 2013 Mar; 54(3): 754–761. doi: 10.1194/jlr.M033746

PMCID:: PMC3617949

Abstract Article PDF–1.0M

Select item 331129310.

12/15-Lipoxygenase signaling in the endoplasmic reticulum stress response

Banumathi K. Cole, Norine S. Kuhn, Shamina M. Green-Mitchell, Kendall A. Leone, Rebekah M. Raab, Jerry L. Nadler, Swarup K. Chakrabarti

Am J Physiol Endocrinol Metab. 2012 Mar 15; 302(6): E654–E665. Published online 2012 Jan 3. doi: 10.1152/ajpendo.00373.2011

PMCID:: PMC3311293

Abstract Article

Select item 317805911.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 316157912.

15-Lipoxygenase 1 interacts with phosphatidylethanolamine-binding protein to regulate MAPK signaling in human airway epithelial cells

Jinming Zhao, Valerie B. O'Donnell, Silvana Balzar, Claudette M. St. Croix, John B. Trudeau, Sally E. Wenzel

Proc Natl Acad Sci U S A. 2011 Aug 23; 108(34): 14246–14251. Published online 2011 Aug 9. doi: 10.1073/pnas.1018075108

PMCID:: PMC3161579

Abstract Article PDF–1.3M

Select item 312139313.

15-Lipoxygenase-1-enhanced Src-Janus Kinase 2-Signal Transducer and Activator of Transcription 3 Stimulation and Monocyte Chemoattractant Protein-1 Expression Require Redox-sensitive Activation of Epidermal Growth Factor Receptor in Vascular Wall Remodeling

Nikhlesh K. Singh, Dong Wang, Venkatesh Kundumani-Sridharan, Dong Van Quyen, Jixiao Niu, Gadiparthi N. Rao

J Biol Chem. 2011 Jun 24; 286(25): 22478–22488. Published online 2011 May 2. doi: 10.1074/jbc.M111.225060

PMCID:: PMC3121393

Abstract Article PDF–3.3M

Select item 299332014.

Nonobese Diabetic (NOD) Mice Congenic for a Targeted Deletion of 12/15-Lipoxygenase Are Protected From Autoimmune Diabetes

Marcia McDuffie, Nelly A. Maybee, Susanna R. Keller, Brian K. Stevens, James C. Garmey, Margaret A. Morris, Elizabeth Kropf, Claudia Rival, Kaiwen Ma, Jeffrey D. Carter, Sarah A. Tersey, Craig S. Nunemaker, Jerry L. Nadler

Diabetes. Author manuscript; available in PMC 2010 Nov 29.

Published in final edited form as: Diabetes. 2008 Jan; 57(1): 199–208. Published online 2007 Oct 16. doi: 10.2337/db07-0830

PMCID:: PMC2993320

Abstract Article PDF–1.1M

Select item 292897515.

Different Roles of 12/15-Lipoxygenase in Diabetic Large and Small Fiber Peripheral and Autonomic Neuropathies

Irina G. Obrosova, Roman Stavniichuk, Viktor R. Drel, Hanna Shevalye, Igor Vareniuk, Jerry L. Nadler, Robert. E. Schmidt

Am J Pathol. 2010 Sep; 177(3): 1436–1447. doi: 10.2353/ajpath.2010.100178

PMCID:: PMC2928975

Abstract Article PDF–1.1M

Select item 280226716.

12/15-Lipoxygenase deficiency protects mice from allergic airways inflammation and increases secretory IgA levels

Amanda R. Hajek, Alexa R. Lindley, Silvio Favoreto, Jr, Roderick Carter, Robert P. Schleimer, Douglas A. Kuperman

J Allergy Clin Immunol. Author manuscript; available in PMC 2010 Jan 5.

Published in final edited form as: J Allergy Clin Immunol. 2008 Sep; 122(3): 633–9.e3. Published online 2008 Aug 9. doi: 10.1016/j.jaci.2008.06.021

PMCID:: PMC2802267

Abstract Article PDF–1.1M

Select item 278130917.

15(S)-Lipoxygenase-1 associates with neutral lipid droplets in macrophage foam cells: evidence of lipid droplet metabolism

Ginny L. Weibel, Michelle R. Joshi, Cong Wei, Sandra R. Bates, Ian A. Blair, George H. Rothblat

J Lipid Res. 2009 Dec; 50(12): 2371–2376. doi: 10.1194/jlr.M900081-JLR200

PMCID:: PMC2781309

Abstract Article PDF–700K

Select item 276384318.

Effects of vitamin E on mitochondrial dysfunction and asthma features in an experimental allergic murine model

Ulaganathan Mabalirajan, Jyotirmoi Aich, Geeta Devi Leishangthem, Surendra Kumar Sharma, Amit Kumar Dinda, Balaram Ghosh

J Appl Physiol (1985) 2009 Oct; 107(4): 1285–1292. Prepublished online 2009 Jul 23. doi: 10.1152/japplphysiol.00459.2009

PMCID:: PMC2763843

Abstract Article

Select item 275407219.

Protecting Against Cerebrovascular Injury: Contributions of 12/15-Lipoxygenase to Edema Formation After Transient Focal Ischemia

Guang Jin, Ken Arai, Yoshihiro Murata, Sophia Wang, Monique F. Stins, Eng H. Lo, Klaus van Leyen

Stroke. Author manuscript; available in PMC 2009 Sep 29.

Published in final edited form as: Stroke. 2008 Sep; 39(9): 2538–2543. Published online 2008 Jul 17. doi: 10.1161/STROKEAHA.108.514927

PMCID:: PMC2754072

Abstract Article PDF–1.6M

Select item 275398820.

Improved survival and reduced vascular permeability by eliminating or blocking 12/15-lipoxygenase in mouse models of acute lung injury (ALI).

Alexander Zarbock, Matthew R. DiStasi, Emily Smith, John Sanders, Gerhard Kronke, Brian Harry, Sibylle von Vietinghoff, Konrad Buscher, Jerry L. Nadler, Klaus Ley

J Immunol. Author manuscript; available in PMC 2010 Oct 1.

Published in final edited form as: J Immunol. 2009 Oct 1; 183(7): 4715–4722. Published online 2009 Sep 14. doi: 10.4049/jimmunol.0802592