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Items: 1 to 20 of 29

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
2.
MELK predicts poor prognosis and promotes metastasis in esophageal squamous cell carcinoma via activating the NF-κB pathway
Jiecheng Ye, Wanying Deng, Ying Zhong, Hui Liu, Baoyin Guo, Zixi Qin, Peiwen Li, Xueyun Zhong, Lihui Wang
Int J Oncol. 2022 Aug; 61(2): 94. Published online 2022 Jun 21. doi: 10.3892/ijo.2022.5384
PMCID:
PMC9256079
AbstractArticlePDF–2.4M
3.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
4.
BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING)
Kou Motani, Hidetaka Kosako
J Biol Chem. 2020 Aug 7; 295(32): 11174–11183. Published online 2020 Jun 17. doi: 10.1074/jbc.RA120.014323
PMCID:
PMC7415991
AbstractArticlePDF–2.0M
5.
Thr55 phosphorylation of p21 by MPK38/MELK ameliorates defects in glucose, lipid, and energy metabolism in diet-induced obese mice
Hyun-A. Seong, Hyunjung Ha
Cell Death Dis. 2019 Jun; 10(6): 380. Published online 2019 May 16. doi: 10.1038/s41419-019-1616-z
PMCID:
PMC6522503
AbstractArticlePDF–2.6M
6.
Mouse screen reveals multiple new genes underlying mouse and human hearing loss
Neil J. Ingham, Selina A. Pearson, Valerie E. Vancollie, Victoria Rook, Morag A. Lewis, Jing Chen, Annalisa Buniello, Elisa Martelletti, Lorenzo Preite, Chi Chung Lam, Felix D. Weiss, Zӧe Powis, Pim Suwannarat, Christopher J. Lelliott, Sally J. Dawson, Jacqueline K. White, Karen P. Steel
PLoS Biol. 2019 Apr; 17(4): e3000194. Published online 2019 Apr 11. doi: 10.1371/journal.pbio.3000194
PMCID:
PMC6459510
AbstractArticlePDF–5.1M
7.
Smad proteins differentially regulate obesity-induced glucose and lipid abnormalities and inflammation via class-specific control of AMPK-related kinase MPK38/MELK activity
Hyun-A Seong, Ravi Manoharan, Hyunjung Ha
Cell Death Dis. 2018 May; 9(5): 471. Published online 2018 Apr 27. doi: 10.1038/s41419-018-0489-x
PMCID:
PMC5920110
AbstractArticlePDF–2.6M
8.
Maternal embryonic leucine zipper kinase regulates pancreatic ductal, but not β‐cell, regeneration
Cheng‐Ho Chung, Amber Miller, Andreas Panopoulos, Ergeng Hao, Robert Margolis, Alexey Terskikh, Fred Levine
Physiol Rep. 2014 Sep; 2(9): e12131. Published online 2014 Sep 4. doi: 10.14814/phy2.12131
PMCID:
PMC4270240
AbstractArticlePDF–3.6M
9.
Maternal embryonic leucine zipper kinase enhances gastric cancer progression via the FAK/Paxillin pathway
Tao Du, Ying Qu, Jianfang Li, Hao Li, Liping Su, Quan Zhou, Min Yan, Chen Li, Zhenggang Zhu, Bingya Liu
Mol Cancer. 2014; 13: 100. Published online 2014 May 4. doi: 10.1186/1476-4598-13-100
PMCID:
PMC4113179
AbstractArticlePDF–2.3M
10.
MELK is an oncogenic kinase essential for mitotic progression in basal-like breast cancer cells
Yubao Wang, Young-Mi Lee, Lukas Baitsch, Alan Huang, Yi Xiang, Haoxuan Tong, Ana Lako, Thanh Von, Christine Choi, Elgene Lim, Junxia Min, Li Li, Frank Stegmeier, Robert Schlegel, Michael J Eck, Nathanael S Gray, Timothy J Mitchison, Jean J Zhao
eLife. 2014; 3: e01763. Published online 2014 May 20. doi: 10.7554/eLife.01763
Correction in:
eLife. 2018; 7: e36414.
PMCID:
PMC4059381
AbstractArticlePDF–4.0M
11.
MELK is Upregulated and Required in Mammary Tumor Initiating Cells In Vivo
Lionel Hebbard, Jochen Maurer, Amber Miller, Jacqueline Lesperance, John Hassell, Robert G. Oshima, Alexey Terskikh
Cancer Res. Author manuscript; available in PMC 2014 Apr 17.
Published in final edited form as: Cancer Res. 2010 Nov 1; 70(21): 8863–8873. Published online 2010 Sep 22. doi: 10.1158/0008-5472.CAN-10-1295
PMCID:
PMC3990264
AbstractArticlePDF–1.7M
12.
The structures of the kinase domain and UBA domain of MPK38 suggest the activation mechanism for kinase activity
Yong-Soon Cho, Jiho Yoo, Soomin Park, Hyun-Soo Cho
Acta Crystallogr D Biol Crystallogr. 2014 Feb 1; 70(Pt 2): 514–521. Published online 2014 Jan 31. doi: 10.1107/S1399004713027806
PMCID:
PMC3940201
AbstractArticlePDF–1.2M
13.
Novel Protein Interactions with Endoglin and Activin Receptor-like Kinase 1: Potential Role in Vascular Networks
Guoxiong Xu, Miriam Barrios-Rodiles, Mirjana Jerkic, Andrei L. Turinsky, Robert Nadon, Sonia Vera, Despina Voulgaraki, Jeffrey L. Wrana, Mourad Toporsian, Michelle Letarte
Mol Cell Proteomics. 2014 Feb; 13(2): 489–502. Published online 2013 Dec 7. doi: 10.1074/mcp.M113.033464
PMCID:
PMC3916649
AbstractArticlePDF–4.1M
14.
A conditional knockout resource for the genome–wide study of mouse gene function
William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley
Nature. Author manuscript; available in PMC 2013 Feb 14.
Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163
PMCID:
PMC3572410
AbstractArticlePDF–1.1M
15.
PDK1 Protein Phosphorylation at Thr354 by Murine Protein Serine-Threonine Kinase 38 Contributes to Negative Regulation of PDK1 Protein Activity
Hyun-A Seong, Haiyoung Jung, Ravi Manoharan, Hyunjung Ha
J Biol Chem. 2012 Jun 15; 287(25): 20811–20822. Published online 2012 Apr 27. doi: 10.1074/jbc.M111.331827
PMCID:
PMC3375505
AbstractArticlePDF–2.3M
16.
Murine Protein Serine-threonine Kinase 38 Activates p53 Function through Ser15 Phosphorylation
Hyun-A Seong, Hyunjung Ha
J Biol Chem. 2012 Jun 15; 287(25): 20797–20810. Published online 2012 Apr 24. doi: 10.1074/jbc.M112.347757
PMCID:
PMC3375504
AbstractArticlePDF–2.9M
17.
Murine Protein Serine/Threonine Kinase 38 Activates Apoptosis Signal-regulating Kinase 1 via Thr838 Phosphorylation
Haiyoung Jung, Hyun-A Seong, Hyunjung Ha
J Biol Chem. 2008 Dec 12; 283(50): 34541–34553. doi: 10.1074/jbc.M807219200
PMCID:
PMC3259894
AbstractArticlePDF–1.0M
18.
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas
Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042
PMCID:
PMC3178059
AbstractArticlePDF–1.0M
19.
A High-Resolution Anatomical Atlas of the Transcriptome in the Mouse Embryo
Graciana Diez-Roux, Sandro Banfi, Marc Sultan, Lars Geffers, Santosh Anand, David Rozado, Alon Magen, Elena Canidio, Massimiliano Pagani, Ivana Peluso, Nathalie Lin-Marq, Muriel Koch, Marchesa Bilio, Immacolata Cantiello, Roberta Verde, Cristian De Masi, Salvatore A. Bianchi, Juliette Cicchini, Elodie Perroud, Shprese Mehmeti, Emilie Dagand, Sabine Schrinner, Asja Nürnberger, Katja Schmidt, Katja Metz, Christina Zwingmann, Norbert Brieske, Cindy Springer, Ana Martinez Hernandez, Sarah Herzog, Frauke Grabbe, Cornelia Sieverding, Barbara Fischer, Kathrin Schrader, Maren Brockmeyer, Sarah Dettmer, Christin Helbig, Violaine Alunni, Marie-Annick Battaini, Carole Mura, Charlotte N. Henrichsen, Raquel Garcia-Lopez, Diego Echevarria, Eduardo Puelles, Elena Garcia-Calero, Stefan Kruse, Markus Uhr, Christine Kauck, Guangjie Feng, Nestor Milyaev, Chuang Kee Ong, Lalit Kumar, MeiSze Lam, Colin A. Semple, Attila Gyenesei, Stefan Mundlos, Uwe Radelof, Hans Lehrach, Paolo Sarmientos, Alexandre Reymond, Duncan R. Davidson, Pascal Dollé, Stylianos E. Antonarakis, Marie-Laure Yaspo, Salvador Martinez, Richard A. Baldock, Gregor Eichele, Andrea Ballabio
PLoS Biol. 2011 Jan; 9(1): e1000582. Published online 2011 Jan 18. doi: 10.1371/journal.pbio.1000582
PMCID:
PMC3022534
AbstractArticlePDF–3.8M
20.
Murine Protein Serine/Threonine Kinase 38 Stimulates TGF-β Signaling in a Kinase-dependent Manner via Direct Phosphorylation of Smad Proteins
Hyun-A Seong, Haiyoung Jung, Hyunjung Ha
J Biol Chem. 2010 Oct 1; 285(40): 30959–30970. Published online 2010 Jul 21. doi: 10.1074/jbc.M110.138370
PMCID:
PMC2945587
AbstractArticlePDF–2.8M

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