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Items: 1 to 20 of 46

1.
Pde5 Inhibition Reduced Blood Pressure and Alleviated Target Organ Damage in Chronic Intermittent Hypoxia
Siyi Li, Qingjie Xin, Yan Yan, Xiao Wang, Hui Ai, Bin Que, Wei Gong, Shaoping Nie
J Cardiovasc Pharmacol. 2024 Jul; 84(1): e81–e91. Published online 2023 Nov 22. doi: 10.1097/FJC.0000000000001519
PMCID:
PMC11230658
AbstractArticlePDF–1.0M
2.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
3.
Structural Characterization of Murine Phosphodiesterase 5 Isoforms and Involvement of Cysteine Residues in Supramolecular Assembly
Mauro Giorgi, Adriana Erica Miele, Silvia Cardarelli, Alessandra Giorgi, Mara Massimi, Stefano Biagioni, Michele Saliola
Int J Mol Sci. 2023 Jan; 24(2): 1108. Published online 2023 Jan 6. doi: 10.3390/ijms24021108
PMCID:
PMC9862819
AbstractArticlePDF–24M
4.
Inhibition of Phosphodiesterase 5 Promotes the Aromatase-Mediated Estrogen Biosynthesis in Osteoblastic Cells by Activation of cGMP/PKG/SHP2 Pathway
Wisanee Wisanwattana, Kanjana Wongkrajang, Dong-yi Cao, Xiao-ke Shi, Zhong-hui Zhang, Zong-yuan Zhou, Fu Li, Qing-gang Mei, Chun Wang, Apichart Suksamrarn, Guo-lin Zhang, Fei Wang
Front Endocrinol (Lausanne) 2021; 12: 636784. Published online 2021 Mar 12. doi: 10.3389/fendo.2021.636784
PMCID:
PMC7995890
AbstractArticlePDF–3.8M
5.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
6.
Rearrangement of the Protein Phosphatase 1 Interactome during Heart Failure Progression
David Y. Chiang, Katherina M. Alsina, Eleonora Corradini, Martin Fitzpatrick, Li Ni, Satadru K. Lahiri, Julia Reynolds, Xiaolu Pan, Larry Scott, Jr, Albert J.R. Heck, Xander H.T. Wehrens
Circulation. Author manuscript; available in PMC 2019 Oct 9.
Published in final edited form as: Circulation. 2018 Oct 9; 138(15): 1569–1581. doi: 10.1161/CIRCULATIONAHA.118.034361
PMCID:
PMC6193872
AbstractArticlePDF–2.4M
7.
MicroRNA-19a/b-3p protect the heart from hypertension-induced pathological cardiac hypertrophy through PDE5A
Kun Liu, Qiongyu Hao, Jie Wei, Gong-Hao Li, Yong Wu, Yun-Feng Zhao
J Hypertens. 2018 Sep; 36(9): 1847–1857. Published online 2018 Apr 16. doi: 10.1097/HJH.0000000000001769
PMCID:
PMC6080882
AbstractArticlePDF–553K
8.
Luteinizing hormone signaling phosphorylates and activates the cyclic GMP phosphodiesterase PDE5 in mouse ovarian follicles, contributing an additional component to the hormonally induced decrease in cyclic GMP that reinitiates meiosis
Jeremy R. Egbert, Siu-Pok Yee, Laurinda A. Jaffe
Dev Biol. Author manuscript; available in PMC 2019 Mar 1.
Published in final edited form as: Dev Biol. 2018 Mar 1; 435(1): 6–14. Published online 2018 Jan 16. doi: 10.1016/j.ydbio.2018.01.008
PMCID:
PMC5818284
AbstractArticlePDF–1005K
9.
Transcriptional Architecture of Synaptic Communication Delineates GABAergic Neuron Identity
Anirban Paul, Megan Crow, Ricardo Raudales, Miao He, Jesse Gillis, Z. Josh Huang
Cell. Author manuscript; available in PMC 2018 Oct 19.
Published in final edited form as: Cell. 2017 Oct 19; 171(3): 522–539.e20. Published online 2017 Sep 21. doi: 10.1016/j.cell.2017.08.032
PMCID:
PMC5772785
AbstractArticlePDF–4.0M
10.
Phosphodiesterase-5 inhibition preserves renal hemodynamics and function in mice with diabetic kidney disease by modulating miR-22 and BMP7
Riccardo Pofi, Daniela Fiore, Rita De Gaetano, Giuseppe Panio, Daniele Gianfrilli, Carlotta Pozza, Federica Barbagallo, Yang Kevin Xiang, Konstantinos Giannakakis, Susanna Morano, Andrea Lenzi, Fabio Naro, Andrea M. Isidori, Mary Anna Venneri
Sci Rep. 2017; 7: 44584. Published online 2017 Mar 15. doi: 10.1038/srep44584
PMCID:
PMC5353686
AbstractArticlePDF–1.3M
11.
Sub-acute hemolysis in sickle cell mice causes priapism secondary to NO imbalance and PDE5 dysregulation
Nikolai A. Sopko, Hotaka Matsui, Johanna L. Hannan, Dan Berkowitz, Hunter C. Champion, Lewis L. Hsu, Biljana Musicki, Arthur L. Burnett, Trinity J. Bivalacqua
J Sex Med. Author manuscript; available in PMC 2016 Sep 7.
Published in final edited form as: J Sex Med. 2015 Sep; 12(9): 1878–1885. Published online 2015 Sep 7. doi: 10.1111/jsm.12976
PMCID:
PMC4600325
AbstractArticlePDF–263K
12.
A high resolution spatiotemporal atlas of gene expression of the developing mouse brain
Carol L. Thompson, Lydia Ng, Vilas Menon, Salvador Martinez, Chang-Kyu Lee, Katie Glattfelder, Susan M. Sunkin, Alex Henry, Christopher Lau, Chinh Dang, Raquel Garcia-Lopez, Almudena Martinez-Ferre, Ana Pombero, John L.R. Rubenstein, Wayne B. Wakeman, John Hohmann, Nick Dee, Andrew J. Sodt, Rob Young, Kimberly Smith, Thuc-Nghi Nguyen, Jolene Kidney, Leonard Kuan, Andreas Jeromin, Ajamete Kaykas, Jeremy Miller, Damon Page, Geri Orta, Amy Bernard, Zackery Riley, Simon Smith, Paul Wohnoutka, Mike Hawrylycz, Luis Puelles, Allan R. Jones
Neuron. Author manuscript; available in PMC 2015 Jul 16.
Published in final edited form as: Neuron. 2014 Jul 16; 83(2): 309–323. Published online 2014 Jun 19. doi: 10.1016/j.neuron.2014.05.033
PMCID:
PMC4319559
AbstractArticlePDF–3.0M
13.
Roles of cGMP-dependent protein kinase I (cGKI) and PDE5 in the regulation of Ang II-induced cardiac hypertrophy and fibrosis
Enrico Patrucco, Katrin Domes, Mauro Sbroggió, Anne Blaich, Jens Schlossmann, Matthias Desch, Sergei D. Rybalkin, Joseph A. Beavo, Robert Lukowski, Franz Hofmann
Proc Natl Acad Sci U S A. 2014 Sep 2; 111(35): 12925–12929. Published online 2014 Aug 19. doi: 10.1073/pnas.1414364111
PMCID:
PMC4156763
AbstractArticlePDF–1.3M
14.
Sildenafil reduces respiratory muscle weakness and fibrosis in the mdx mouse model of Duchenne muscular dystrophy
Justin M Percival, Nicholas P Whitehead, Marvin E Adams, Candace M Adamo, Joseph A Beavo, Stanley C Froehner
J Pathol. Author manuscript; available in PMC 2014 Jun 23.
Published in final edited form as: J Pathol. 2012 Sep; 228(1): 77–87. Published online 2012 Jul 18. doi: 10.1002/path.4054
PMCID:
PMC4067455
AbstractArticlePDF–1.1M
15.
Excess adenosine A2B receptor signaling contributes to priapism through HIF-1α mediated reduction of PDE5 gene expression
Chen Ning, Jiaming Wen, Yujin Zhang, Yingbo Dai, Wei Wang, Weiru Zhang, Lin Qi, Almut Grenz, Holger K. Eltzschig, Michael R. Blackburn, Rodney E. Kellems, Yang Xia
FASEB J. 2014 Jun; 28(6): 2725–2735. doi: 10.1096/fj.13-247833
PMCID:
PMC4021439
AbstractArticle
16.
Increased PDE5 activity and decreased Rho kinase and PKC activities in colonic muscle from caveolin-1−/− mice impair the peristaltic reflex and propulsion
Sunila Mahavadi, Sayak Bhattacharya, Divya P. Kumar, Chereena Clay, Gracious Ross, Hamid I. Akbarali, John R. Grider, Karnam S. Murthy
Am J Physiol Gastrointest Liver Physiol. 2013 Dec 15; 305(12): G964–G974. Published online 2013 Oct 24. doi: 10.1152/ajpgi.00165.2013
PMCID:
PMC3882438
AbstractArticle
17.
Phosphodiesterase 5 Attenuates the Vasodilatory Response in Renovascular Hypertension
Johannes Stegbauer, Sebastian Friedrich, Sebastian A. Potthoff, Kathrin Broekmans, Miriam M. Cortese-Krott, Ivo Quack, Lars Christian Rump, Doris Koesling, Evanthia Mergia
PLoS One. 2013; 8(11): e80674. Published online 2013 Nov 15. doi: 10.1371/journal.pone.0080674
PMCID:
PMC3829872
AbstractArticlePDF–468K
18.
Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates
Jeremy A. Miller, Jason Nathanson, Daniel Franjic, Sungbo Shim, Rachel A. Dalley, Sheila Shapouri, Kimberly A. Smith, Susan M. Sunkin, Amy Bernard, Jeffrey L. Bennett, Chang-Kyu Lee, Michael J. Hawrylycz, Allan R. Jones, David G. Amaral, Nenad Sestan, Fred H. Gage, Ed S. Lein
Development. 2013 Nov 15; 140(22): 4633–4644. doi: 10.1242/dev.097212
PMCID:
PMC3817946
AbstractArticle
19.
Ventricular phosphodiesterase 5 expression is increased in patients with advanced heart failure and contributes to adverse ventricular remodeling after myocardial infarction in mice
Peter Pokreisz, Sara Vandenwijngaert, Virginie Bito, An Van den Bergh, Ilse Lenaerts, Cornelius Busch, Glenn Marsboom, Olivier Gheysens, Pieter Vermeersch, Liesbeth Biesmans, Xiaoshun Liu, Hilde Gillijns, Marijke Pellens, Alfons Van Lommel, Emmanuel Buys, Luc Schoonjans, Johan Vanhaecke, Erik Verbeken, Karin Sipido, Paul Herijgers, Kenneth D. Bloch, Stefan Janssens
Circulation. Author manuscript; available in PMC 2013 Oct 5.
Published in final edited form as: Circulation. 2009 Jan 27; 119(3): 408–416. Published online 2009 Jan 12. doi: 10.1161/CIRCULATIONAHA.108.822072
PMCID:
PMC3791110
AbstractArticlePDF–5.0M
20.
Sildenafil Citrate-Restored eNOS and PDE5 Regulation in Sickle Cell Mouse Penis Prevents Priapism Via Control of Oxidative/Nitrosative Stress
Trinity J. Bivalacqua, Biljana Musicki, Lewis L. Hsu, Dan E. Berkowitz, Hunter C. Champion, Arthur L. Burnett
PLoS One. 2013; 8(7): e68028. Published online 2013 Jul 2. doi: 10.1371/journal.pone.0068028
PMCID:
PMC3699477
AbstractArticlePDF–2.6M

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