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Select item 112451611.

Interruption of KLF5 acetylation promotes PTEN-deficient prostate cancer progression by reprogramming cancer-associated fibroblasts

Baotong Zhang, Mingcheng Liu, Fengyi Mai, Xiawei Li, Wenzhou Wang, Qingqing Huang, Xiancai Du, Weijian Ding, Yixiang Li, Benjamin G. Barwick, Jianping Jenny Ni, Adeboye O. Osunkoya, Yuanli Chen, Wei Zhou, Siyuan Xia, Jin-Tang Dong

J Clin Invest. 2024 Jul 15; 134(14): e175949. Published online 2024 May 23. doi: 10.1172/JCI175949

PMCID:: PMC11245161

Abstract Article PDF–22M

Select item 103735702.

Knockdown of KLF5 ameliorates renal fibrosis in MRL/lpr mice via inhibition of MX1 transcription

Shanshan Tao, Xiao Tan, Wen Chai, Xiaojie Peng, Weimin Zheng, Rui Fu, Meihui Deng

Immun Inflamm Dis. 2023 Jul; 11(7): e937. Published online 2023 Jul 27. doi: 10.1002/iid3.937

PMCID:: PMC10373570

Abstract Article PDF–15M

Select item 103567713.

Opposing gene regulatory programs governing myofiber development and maturation revealed at single nucleus resolution

Matthieu Dos Santos, Akansha M. Shah, Yichi Zhang, Svetlana Bezprozvannaya, Kenian Chen, Lin Xu, Weichun Lin, John R. McAnally, Rhonda Bassel-Duby, Ning Liu, Eric N. Olson

Nat Commun. 2023; 14: 4333. Published online 2023 Jul 19. doi: 10.1038/s41467-023-40073-8

PMCID:: PMC10356771

Abstract Article PDF–4.9M

Select item 102316674.

Formation and function of the meningeal arachnoid barrier around the developing mouse brain

Julia Derk, Christina N. Como, Hannah E. Jones, Luke R. Joyce, Sol Kim, Brady L. Spencer, Stephanie Bonney, Rebecca O’Rourke, Brad Pawlikowski, Kelly S. Doran, Julie A. Siegenthaler

Dev Cell. Author manuscript; available in PMC 2024 Apr 24.

Published in final edited form as: Dev Cell. 2023 Apr 24; 58(8): 635–644.e4. Published online 2023 Mar 29. doi: 10.1016/j.devcel.2023.03.005

PMCID:: PMC10231667

Abstract Article PDF–2.4M

Select item 94808525.

KLF5 governs sphingolipid metabolism and barrier function of the skin

Ying Lyu, Yinglu Guan, Lisa Deliu, Ericka Humphrey, Joanna K. Frontera, Youn Joo Yang, Daniel Zamler, Kun Hee Kim, Vakul Mohanty, Kevin Jin, Virginia Liu, Jinzhuang Dou, Lucas J. Veillon, Shwetha V. Kumar, Philip L. Lorenzi, Yang Chen, Kathleen M. McAndrews, Sergei Grivennikov, Xingzhi Song, Jianhua Zhang, Yuanxin Xi, Jing Wang, Ken Chen, Priyadharsini Nagarajan, Yejing Ge

Genes Dev. 2022 Jul 1; 36(13-14): 822–842. doi: 10.1101/gad.349662.122

PMCID:: PMC9480852

Abstract Article PDF–19M

Select item 94236696.

Deep learning-based approach to the characterization and quantification of histopathology in mouse models of colitis

Soma Kobayashi, Jason Shieh, Ainara Ruiz de Sabando, Julie Kim, Yang Liu, Sui Y. Zee, Prateek Prasanna, Agnieszka B. Bialkowska, Joel H. Saltz, Vincent W. Yang

PLoS One. 2022; 17(8): e0268954. Published online 2022 Aug 29. doi: 10.1371/journal.pone.0268954

PMCID:: PMC9423669

Abstract Article PDF–3.3M

Select item 93584747.

A WWP2–PTEN–KLF5 signaling axis regulates odontoblast differentiation and dentinogenesis in mice

Jing Fu, Xiaobo Zhang, Huiwen Zheng, Guobin Yang, Zhi Chen, Guohua Yuan

J Biol Chem. 2022 Aug; 298(8): 102220. Published online 2022 Jul 1. doi: 10.1016/j.jbc.2022.102220

PMCID:: PMC9358474

Abstract Article PDF–3.7M

Select item 93167668.

Krüppel-like factor 5 accelerates the pathogenesis of Alzheimer’s disease via BACE1-mediated APP processing

Yaqi Wang, Yuting Cui, Jing Liu, Qiao Song, Min Cao, Yuli Hou, Xiaomin Zhang, Peichang Wang

Alzheimers Res Ther. 2022; 14: 103. Published online 2022 Jul 26. doi: 10.1186/s13195-022-01050-3

PMCID:: PMC9316766

Abstract Article PDF–7.1M

Select item 92135529.

NANOG initiates epiblast fate through the coordination of pluripotency genes expression

Nicolas Allègre, Sabine Chauveau, Cynthia Dennis, Yoan Renaud, Dimitri Meistermann, Lorena Valverde Estrella, Pierre Pouchin, Michel Cohen-Tannoudji, Laurent David, Claire Chazaud

Nat Commun. 2022; 13: 3550. Published online 2022 Jun 21. doi: 10.1038/s41467-022-30858-8

PMCID:: PMC9213552

Abstract Article PDF–4.4M

Select item 905763110.

KLF5 protects the intestinal epithelium against Th17 immune response in a murine colitis model

Jason Shieh, Timothy H. Chu, Yang Liu, Julie Kim, Ainara Ruiz de Sabando, Soma Kobayashi, Sui Y. Zee, Brian S. Sheridan, Agnieszka B. Bialkowska, Vincent W. Yang

JCI Insight. 2022 Apr 8; 7(7): e153488. Published online 2022 Apr 8. doi: 10.1172/jci.insight.153488

PMCID:: PMC9057631

Abstract Article PDF–23M

Select item 885463311.

The histone demethylase Kdm6b regulates subtype diversification of mouse spinal motor neurons during development

Wenxian Wang, Hyeyoung Cho, Jae W. Lee, Soo-Kyung Lee

Nat Commun. 2022; 13: 958. Published online 2022 Feb 17. doi: 10.1038/s41467-022-28636-7

PMCID:: PMC8854633

Abstract Article PDF–14M

Select item 880654812.

Transcription factor Krüppel-like factor 5-regulated N-myc downstream-regulated gene 2 reduces IL-1β-induced chondrocyte inflammatory injury and extracellular matrix degradation

Xiaoliang Mei, Hao Din, Jianning Zhao, Jian Tong, Wei Zhu

Bioengineered. 2021; 12(1): 7020–7032. Published online 2021 Sep 23. doi: 10.1080/21655979.2021.1971483

PMCID:: PMC8806548

Abstract Article PDF–3.8M

Select item 867406913.

miRNA-576 Alleviates the Malignant Progression of Atherosclerosis through Downregulating KLF5

Jing Wang, Lihui Zhang, Ting Wang, Caige Li, Lijing Jiao, Zhansheng Zhao, Yongjun Li

Dis Markers. 2021; 2021: 5450685. Published online 2021 Dec 8. doi: 10.1155/2021/5450685

PMCID:: PMC8674069

Abstract Article PDF–773K

Select item 853634314.

Identification of a KLF5-dependent program and drug development for skeletal muscle atrophy

Lin Liu, Hiroyuki Koike, Takehito Ono, Shinichiro Hayashi, Fujimi Kudo, Atsushi Kaneda, Hiroyuki Kagechika, Ichiro Manabe, Tomoki Nakashima, Yumiko Oishi

Proc Natl Acad Sci U S A. 2021 Aug 31; 118(35): e2102895118. Published online 2021 Aug 23. doi: 10.1073/pnas.2102895118

PMCID:: PMC8536343

Abstract Article PDF–1.6M

Select item 847872715.

Severe liver disease resembling PSC in mice with K5-Cre mediated deletion of Krüppel-like factor 5 (Klf5)

Åsa Bergström, Marco Gerling, Noémi Van Hul, Carlos Fernández Moro, Björn Rozell, Rune Toftgård, Inderpreet Sur

Transgenic Res. 2021; 30(5): 701–707. Published online 2021 Jun 11. doi: 10.1007/s11248-021-00267-6

PMCID:: PMC8478727

Abstract Article PDF–5.2M

Select item 816859616.

Promoting roles of KLF5 in myocardial infarction in mice involving microRNA-27a suppression and the following GFPT2/TGF-β/Smad2/3 axis activation

Zhen Tian, Yan Zhang, Xueman Lyu

Cell Cycle. 2021; 20(9): 874–893. Published online 2021 Apr 29. doi: 10.1080/15384101.2021.1907512

PMCID:: PMC8168596

Abstract Article PDF–6.1M

Select item 787000517.

KLF5 Is Induced by FOXO1 and Causes Oxidative Stress and Diabetic Cardiomyopathy

Ioannis D. Kyriazis, Matthew Hoffman, Lea Gaignebet, Anna Maria Lucchese, Eftychia Markopoulou, Dimitra Palioura, Chao Wang, Thomas D. Bannister, Melpo Christofidou-Solomidou, Shin-ichi Oka, Junichi Sadoshima, Walter J. Koch, Ira J. Goldberg, Vincent W. Yang, Agnieszka B. Bialkowska, Georgios Kararigas, Konstantinos Drosatos

Circ Res. Author manuscript; available in PMC 2022 Feb 5.

Published in final edited form as: Circ Res. 2021 Feb 5; 128(3): 335–357. Published online 2020 Dec 2. doi: 10.1161/CIRCRESAHA.120.316738

PMCID:: PMC7870005

Abstract Article PDF–3.1M

Select item 748374718.

Transcriptional analysis of cleft palate in TGFβ3 mutant mice

J. Liu, S. K. Chanumolu, K. M. White, M. Albahrani, H. H. Otu, A. Nawshad

Sci Rep. 2020; 10: 14940. Published online 2020 Sep 10. doi: 10.1038/s41598-020-71636-0

PMCID:: PMC7483747

Abstract Article PDF–4.1M

Select item 746230419.

Klf5 down-regulation induces vascular senescence through eIF5a depletion and mitochondrial fission

Dong Ma, Bin Zheng, He-liang Liu, Yong-bo Zhao, Xiao Liu, Xin-hua Zhang, Qiang Li, Wei-bo Shi, Toru Suzuki, Jin-kun Wen

PLoS Biol. 2020 Aug; 18(8): e3000808. Published online 2020 Aug 20. doi: 10.1371/journal.pbio.3000808

PMCID:: PMC7462304

Abstract Article PDF–4.9M

Select item 728281520.

Delineating the early transcriptional specification of the mammalian trachea and esophagus

Akela Kuwahara, Ace E Lewis, Coohleen Coombes, Fang-Shiuan Leung, Michelle Percharde, Jeffrey O Bush

eLife. 2020; 9: e55526. Published online 2020 Jun 9. doi: 10.7554/eLife.55526

PMCID:: PMC7282815

Abstract Article PDF–4.9M

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