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Select item 112467431.

The ENL YEATS epigenetic reader domain critically links MLL-ENL to leukemic stem cell frequency in t(11;19) Leukemia

Hsiangyu Hu, Nirmalya Saha, Yuting Yang, Ejaz Ahmad, Lauren Lachowski, Uttar Shrestha, Vidhya Premkumar, James Ropa, Lili Chen, Blaine Teahan, Sierrah Grigsby, Rolf Marschalek, Zaneta Nikolovska-Coleska, Andrew G. Muntean

Leukemia. Author manuscript; available in PMC 2024 Jul 14.

Published in final edited form as: Leukemia. 2023 Jan; 37(1): 190–201. Published online 2022 Nov 26. doi: 10.1038/s41375-022-01765-0

PMCID:: PMC11246743

Abstract Article PDF–2.2M

Select item 111732732.

Distinct Responses to Menin Inhibition and Synergy with DOT1L Inhibition in KMT2A-Rearranged Acute Lymphoblastic and Myeloid Leukemia

Fabienne R. S. Adriaanse, Pauline Schneider, Susan T. C. J. M. Arentsen-Peters, Ana M. Neves da Fonseca, Janine Stutterheim, Rob Pieters, C. Michel Zwaan, Ronald W. Stam

Int J Mol Sci. 2024 Jun; 25(11): 6020. Published online 2024 May 30. doi: 10.3390/ijms25116020

PMCID:: PMC11173273

Abstract Article PDF–4.5M

Select item 110789783.

Regulation of cytokine and chemokine expression by histone lysine methyltransferase MLL1 in rheumatoid arthritis synovial fibroblasts

Keita Okamoto, Yasuto Araki, Yoshimi Aizaki, Shinya Tanaka, Yuho Kadono, Toshihide Mimura

Sci Rep. 2024; 14: 10610. Published online 2024 May 9. doi: 10.1038/s41598-024-60860-7

PMCID:: PMC11078978

Abstract Article PDF–1.1M

Select item 110732444.

RhoC in association with TET2/WDR5 regulates cancer stem cells by epigenetically modifying the expression of pluripotency genes

Pavana Thomas, Sweta Srivastava, Avinash H. Udayashankara, Samyuktha Damodaran, Lokendra Yadav, Boby Mathew, Srinag Bangalore Suresh, Amit Kumar Mandal, Nirmala Srikantia

Cell Mol Life Sci. 2023 Jan; 80(1): 1. Published online 2022 Dec 5. doi: 10.1007/s00018-022-04645-z

PMCID:: PMC11073244

Abstract Article PDF–12M

Select item 109332675.

Interaction network of human early embryonic transcription factors

Lisa Gawriyski, Zenglai Tan, Xiaonan Liu, Iftekhar Chowdhury, Dicle Malaymar Pinar, Qin Zhang, Jere Weltner, Eeva-Mari Jouhilahti, Gong-Hong Wei, Juha Kere, Markku Varjosalo

EMBO Rep. 2024 Mar; 25(3): 1589–1622. Published online 2024 Jan 31. doi: 10.1038/s44319-024-00074-0

PMCID:: PMC10933267

Abstract Article PDF–2.9M

Select item 109184936.

Functional relevance of circRNA aberrant expression in pediatric acute leukemia with KMT2A::AFF1 fusion

Caterina Tretti Parenzan, Anna Dal Molin, Giorgia Longo, Enrico Gaffo, Alessia Buratin, Alice Cani, Elena Boldrin, Valentina Serafin, Paola Guglielmelli, Alessandro M. Vannucchi, Giovanni Cazzaniga, Andrea Biondi, Franco Locatelli, Lueder H. Meyer, Barbara Buldini, Geertruij te Kronnie, Silvia Bresolin, Stefania Bortoluzzi

Blood Adv. 2024 Mar 12; 8(5): 1305–1319. Published online 2023 Dec 1. doi: 10.1182/bloodadvances.2023011291

PMCID:: PMC10918493

Abstract Article PDF–2.3M

Select item 108457647.

Epigenetic drug screening for trophoblast syncytialization reveals a novel role for MLL1 in regulating fetoplacental growth

Jiayi Wu, Chuanmei Qin, Fuju Tian, Xueqing Liu, Jianing Hu, Fan Wu, Cailian Chen, Yi Lin

BMC Med. 2024; 22: 57. Published online 2024 Feb 5. doi: 10.1186/s12916-024-03264-8

PMCID:: PMC10845764

Abstract Article PDF–17M

Select item 106803278.

Cooperation of MLL1 and Jun in controlling H3K4me3 on enhancers in colorectal cancer

Xiang Lin, Ji-Dong Chen, Chen-Yu Wang, Zhen Cai, Rui Zhan, Chen Yang, La-Ying Zhang, Lian-Yun Li, Yong Xiao, Ming-Kai Chen, Min Wu

Genome Biol. 2023; 24: 268. Published online 2023 Nov 27. doi: 10.1186/s13059-023-03108-3

PMCID:: PMC10680327

Abstract Article PDF–6.7M

Select item 106709869.

Dependency of B-Cell Acute Lymphoblastic Leukemia and Multiple Myeloma Cell Lines on MEN1 Extends beyond MEN1–KMT2A Interaction

Tatjana Magdalena Wolffhardt, Franz Ketzer, Stefano Telese, Thomas Wirth, Alexey Ushmorov

Int J Mol Sci. 2023 Nov; 24(22): 16472. Published online 2023 Nov 17. doi: 10.3390/ijms242216472

PMCID:: PMC10670986

Abstract Article PDF–6.1M

Select item 1065246410.

Epigenetic-focused CRISPR/Cas9 screen identifies (absent, small, or homeotic)2-like protein (ASH2L) as a regulator of glioblastoma cell survival

Ezgi Ozyerli-Goknar, Ezgi Yagmur Kala, Ali Cenk Aksu, Ipek Bulut, Ahmet Cingöz, Sheikh Nizamuddin, Martin Biniossek, Fidan Seker-Polat, Tunc Morova, Can Aztekin, Sonia H. Y. Kung, Hamzah Syed, Nurcan Tuncbag, Mehmet Gönen, Martin Philpott, Adam P. Cribbs, Ceyda Acilan, Nathan A. Lack, Tamer T. Onder, H. T. Marc Timmers, Tugba Bagci-Onder

Cell Commun Signal. 2023; 21: 328. Published online 2023 Nov 16. doi: 10.1186/s12964-023-01335-6

PMCID:: PMC10652464

Abstract Article PDF–8.0M

Select item 1058490411.

MLL1 inhibits the neurogenic potential of SCAPs by interacting with WDR5 and repressing HES1

Chen Zhang, Weilong Ye, Mengyao Zhao, Lujue Long, Dengsheng Xia, Zhipeng Fan

Int J Oral Sci. 2023; 15: 48. Published online 2023 Oct 18. doi: 10.1038/s41368-023-00253-0

PMCID:: PMC10584904

Abstract Article PDF–7.9M

Select item 1056587612.

Pulse-SILAC and Interactomics Reveal Distinct DDB1-CUL4–Associated Factors, Cellular Functions, and Protein Substrates

Jennifer Raisch, Marie-Line Dubois, Marika Groleau, Dominique Lévesque, Thomas Burger, Carla-Marie Jurkovic, Romain Brailly, Gwendoline Marbach, Alyson McKenna, Catherine Barrette, Pierre-Étienne Jacques, François-Michel Boisvert

Mol Cell Proteomics. 2023 Oct; 22(10): 100644. Published online 2023 Sep 7. doi: 10.1016/j.mcpro.2023.100644

PMCID:: PMC10565876

Abstract Article PDF–3.7M

Select item 1033567713.

MLL methyltransferases regulate H3K4 methylation to ensure CENP-A assembly at human centromeres

Kausika Kumar Malik, Sreerama Chaitanya Sridhara, Kaisar Ahmad Lone, Payal Deepakbhai Katariya, Deepshika Pulimamidi, Shweta Tyagi

PLoS Biol. 2023 Jun; 21(6): e3002161. Published online 2023 Jun 28. doi: 10.1371/journal.pbio.3002161

PMCID:: PMC10335677

Abstract Article PDF–3.5M

Select item 1023742214.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 1016963615.

The KMT2A recombinome of acute leukemias in 2023

C. Meyer, P. Larghero, B. Almeida Lopes, T. Burmeister, D. Gröger, R. Sutton, N. C. Venn, G. Cazzaniga, L. Corral Abascal, G. Tsaur, L. Fechina, M. Emerenciano, M. S. Pombo-de-Oliveira, T. Lund-Aho, T. Lundán, M. Montonen, V. Juvonen, J. Zuna, J. Trka, P. Ballerini, H. Lapillonne, V. H. J. Van der Velden, E. Sonneveld, E. Delabesse, R. R. C. de Matos, M. L. M. Silva, S. Bomken, K. Katsibardi, M. Keernik, N. Grardel, J. Mason, R. Price, J. Kim, C. Eckert, L. Lo Nigro, C. Bueno, P. Menendez, U. zur Stadt, P. Gameiro, L. Sedék, T. Szczepański, A. Bidet, V. Marcu, K. Shichrur, S. Izraeli, H. O. Madsen, B. W. Schäfer, S. Kubetzko, R. Kim, E. Clappier, H. Trautmann, M. Brüggemann, P. Archer, J. Hancock, J. Alten, A. Möricke, M. Stanulla, J. Lentes, A. K. Bergmann, S. Strehl, S. Köhrer, K. Nebral, M. N. Dworzak, O. A. Haas, C. Arfeuille, A. Caye-Eude, H. Cavé, R. Marschalek

Leukemia. 2023; 37(5): 988–1005. Published online 2023 Apr 5. doi: 10.1038/s41375-023-01877-1

PMCID:: PMC10169636

Abstract Article PDF–3.7M

Select item 1013893116.

Analysis of Ku70 S155 Phospho-Specific BioID2 Interactome Identifies Ku Association with TRIP12 in Response to DNA Damage

Sanna Abbasi, Laila Bayat, Caroline Schild-Poulter

Int J Mol Sci. 2023 Apr; 24(8): 7041. Published online 2023 Apr 11. doi: 10.3390/ijms24087041

PMCID:: PMC10138931

Abstract Article PDF–4.0M

Select item 1013243317.

The EGR3 regulome of infant KMT2A-r acute lymphoblastic leukemia identifies differential expression of B-lineage genes predictive for outcome

Marius Külp, Patrizia Larghero, Julia Alten, Gunnar Cario, Cornelia Eckert, Aurélie Caye-Eude, Hélène Cavé, Tessa Schmachtel, Michela Bardini, Giovanni Cazzaniga, Paola De Lorenzo, Maria Grazia Valsecchi, Halvard Bonig, Claus Meyer, Michael A. Rieger, Rolf Marschalek

Leukemia. 2023; 37(6): 1216–1233. Published online 2023 Apr 26. doi: 10.1038/s41375-023-01895-z

PMCID:: PMC10132433

Abstract Article PDF–5.3M

Select item 1011541518.

RNA binding induces an allosteric switch in Cyp33 to repress MLL1-mediated transcription

Markus Blatter, Charlotte Meylan, Antoine Cléry, Roberto Giambruno, Yaroslav Nikolaev, Michel Heidecker, Jessica Arvindbhai Solanki, Manuel O. Diaz, Davide Gabellini, Frédéric H.-T. Allain

Sci Adv. 2023 Apr; 9(16): eadf5330. Published online 2023 Apr 19. doi: 10.1126/sciadv.adf5330

PMCID:: PMC10115415

Abstract Article PDF–3.3M

Select item 1007290619.

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity

Martin Golkowski, Andrea Lius, Tanmay Sapre, Ho-Tak Lau, Taylor Moreno, Dustin J. Maly, Shao-En Ong

Mol Cell. Author manuscript; available in PMC 2023 Apr 4.

Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 803–818.e8. Published online 2023 Feb 2. doi: 10.1016/j.molcel.2023.01.015

PMCID:: PMC10072906

Abstract Article PDF–4.2M

Select item 996871920.

Integrative phosphoproteomics defines two biologically distinct groups of KMT2A rearranged acute myeloid leukaemia with different drug response phenotypes

Pedro Casado, Ana Rio-Machin, Juho J. Miettinen, Findlay Bewicke-Copley, Kevin Rouault-Pierre, Szilvia Krizsan, Alun Parsons, Vinothini Rajeeve, Farideh Miraki-Moud, David C. Taussig, Csaba Bödör, John Gribben, Caroline Heckman, Jude Fitzgibbon, Pedro R. Cutillas

Signal Transduct Target Ther. 2023; 8: 80. Published online 2023 Feb 27. doi: 10.1038/s41392-022-01288-1

PMCID:: PMC9968719

Abstract Article PDF–5.4M

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