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Select item 99415101.

TIM-4 orchestrates mitochondrial homeostasis to promote lung cancer progression via ANXA2/PI3K/AKT/OPA1 axis

Yuzhen Wang, Yingchun Wang, Wen Liu, Lu Ding, Xiaodi Zhang, Bo Wang, Zheng Tong, Xuetian Yue, Chunyang Li, Liyun Xu, Zhuanchang Wu, Xiaohong Liang, Chunhong Ma, Lifen Gao

Cell Death Dis. 2023 Feb; 14(2): 141. Published online 2023 Feb 20. doi: 10.1038/s41419-023-05678-3

PMCID:: PMC9941510

Abstract Article PDF–6.1M

Select item 93890142.

TIM-4 in macrophages contributes to nasal polyp formation through the TGF-β1–mediated epithelial to mesenchymal transition in nasal epithelial cells

Danxue Qin, Peiqiang Liu, Huiqin Zhou, Jing Jin, Wanyang Gong, Kunyu Liu, Siyuan Chen, Jingyu Huang, Wenjun Fan, Zezhang Tao, Yu Xu

Front Immunol. 2022; 13: 941608. Published online 2022 Aug 5. doi: 10.3389/fimmu.2022.941608

PMCID:: PMC9389014

Abstract Article PDF–10M

Select item 91156043.

Tim-4⁺ Cavity-Resident Macrophages Impair Anti-Tumor CD8⁺ T cell Immunity

Andrew Chow, Sara Schad, Michael D. Green, Matthew D. Hellmann, Viola Allaj, Nicholas Ceglia, Giulia Zago, Nisargbhai S. Shah, Sai Kiran Sharma, Marissa Mattar, Joseph Chan, Hira Rizvi, Hong Zhong, Cailian Liu, Yonina Bykov, Dmitriy Zamarin, Hongyu Shi, Sadna Budhu, Corrin Wohlhieter, Fathema Uddin, Aditi Gupta, Inna Khodos, Jessica J. Waninger, Angel Qin, Geoffrey J. Markowitz, Vivek Mittal, Vinod Balachandran, Jennifer N. Durham, Dung T. Le, Weiping Zou, Sohrab P. Shah, Andrew McPherson, Katherine Panageas, Jason S. Lewis, Justin S.A. Perry, Elisa de Stanchina, Triparna Sen, John Thomas Poirier, Jedd D. Wolchok, Charles M. Rudin, Taha Merghoub

Cancer Cell. Author manuscript; available in PMC 2022 Jul 12.

Published in final edited form as: Cancer Cell. 2021 Jul 12; 39(7): 973–988.e9. Published online 2021 Jun 10. doi: 10.1016/j.ccell.2021.05.006

PMCID:: PMC9115604

Abstract Article PDF–3.8M

Select item 88421654.

CFTR interactome mapping using the mammalian membrane two‐hybrid high‐throughput screening system

Sang Hyun Lim, Jamie Snider, Liron Birimberg‐Schwartz, Wan Ip, Joana C Serralha, Hugo M Botelho, Miquéias Lopes‐Pacheco, Madalena C Pinto, Mohamed Taha Moutaoufik, Mara Zilocchi, Onofrio Laselva, Mohsen Esmaeili, Max Kotlyar, Anna Lyakisheva, Priscilla Tang, Lucía López Vázquez, Indira Akula, Farzaneh Aboualizadeh, Victoria Wong, Ingrid Grozavu, Teuta Opacak‐Bernardi, Zhong Yao, Meg Mendoza, Mohan Babu, Igor Jurisica, Tanja Gonska, Christine E Bear, Margarida D Amaral, Igor Stagljar

Mol Syst Biol. 2022 Feb; 18(2): e10629. Published online 2022 Feb 14. doi: 10.15252/msb.202110629

PMCID:: PMC8842165

Abstract Article PDF–3.0M

Select item 82245645.

EphA2 Interacts with Tim-4 through Association between Its FN3 Domain and the IgV Domain of Tim-4

Byeongjin Moon, Susumin Yang, Kwangwoo Kim, Juyeon Lee, Dongtak Jeong, Daeho Park

Cells. 2021 Jun; 10(6): 1290. Published online 2021 May 22. doi: 10.3390/cells10061290

PMCID:: PMC8224564

Abstract Article PDF–1.9M

Select item 81650306.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 79312257.

Platelet‐derived extracellular vesicles are increased in sera of Alzheimer's disease patients, as revealed by Tim4‐based assays

Haruki Odaka, Keiko Hiemori, Asako Shimoda, Kazunari Akiyoshi, Hiroaki Tateno

FEBS Open Bio. 2021 Mar; 11(3): 741–752. Published online 2021 Feb 3. doi: 10.1002/2211-5463.13068

PMCID:: PMC7931225

Abstract Article PDF–789K

Select item 75265478.

Autophagic adaptation to oxidative stress alters peritoneal residential macrophage survival and ovarian cancer metastasis

Houjun Xia, Shasha Li, Xiong Li, Weichao Wang, Yingjie Bian, Shuang Wei, Sara Grove, Weimin Wang, Linda Vatan, J. Rebecca Liu, Karen McLean, Ramandeep Rattan, Adnan Munkarah, Jun-Lin Guan, Ilona Kryczek, Weiping Zou

JCI Insight. 2020 Sep 17; 5(18): e141115. Published online 2020 Sep 17. doi: 10.1172/jci.insight.141115

PMCID:: PMC7526547

Abstract Article PDF–4.9M

Select item 74086109.

Mertk Interacts with Tim-4 to Enhance Tim-4-Mediated Efferocytosis

Byeongjin Moon, Juyeon Lee, Sang-Ah Lee, Chanhyuk Min, Hyunji Moon, Deokhwan Kim, Susumin Yang, Heera Moon, Jaeseon Jeon, Young-Eun Joo, Daeho Park

Cells. 2020 Jul; 9(7): 1625. Published online 2020 Jul 6. doi: 10.3390/cells9071625

PMCID:: PMC7408610

Abstract Article PDF–8.2M

Select item 710696210.

IL‐6 promotes metastasis of non‐small‐cell lung cancer by up‐regulating TIM‐4 via NF‐κB

Wen Liu, Hongxing Wang, Fuxiang Bai, Lu Ding, Yanyan Huang, Changchang Lu, Siyuan Chen, Chunyang Li, Xuetian Yue, Xiaohong Liang, Chunhong Ma, Liyun Xu, Lifen Gao

Cell Prolif. 2020 Mar; 53(3): e12776. Published online 2020 Feb 5. doi: 10.1111/cpr.12776

PMCID:: PMC7106962

Abstract Article PDF–2.7M

Select item 674811711.

A scaffold for signaling of Tim-4-mediated efferocytosis is formed by fibronectin

Juyeon Lee, Boyeon Park, Byeongjin Moon, Jeongjun Park, Hyunji Moon, Kwanhyeong Kim, Sang-Ah Lee, Deokhwan Kim, Chanhyuk Min, Dae-Hee Lee, Gwangrog Lee, Daeho Park

Cell Death Differ. 2019 Sep; 26(9): 1646–1655. Published online 2018 Nov 19. doi: 10.1038/s41418-018-0238-9

PMCID:: PMC6748117

Abstract Article PDF–1.9M

Select item 664310712.

TIMD4 rs6882076 SNP Is Associated with Decreased Levels of Triglycerides and the Risk of Coronary Heart Disease and Ischemic Stroke

Eksavang Khounphinith, Rui-Xing Yin, Xiao-Li Cao, Feng Huang, Jin-Zhen Wu, Hui Li

Int J Med Sci. 2019; 16(6): 864–871. Published online 2019 Jun 2. doi: 10.7150/ijms.31729

PMCID:: PMC6643107

Abstract Article PDF–375K

Select item 650395213.

Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing

Tiina Viita, Salla Kyheröinen, Bina Prajapati, Jori Virtanen, Mikko J. Frilander, Markku Varjosalo, Maria K. Vartiainen

J Cell Sci. 2019 Apr 15; 132(8): jcs226852. Published online 2019 Apr 17. doi: 10.1242/jcs.226852

PMCID:: PMC6503952

Abstract Article

Select item 577382214.

Association between the TIMD4-HAVCR1 variants and serum lipid levels, coronary heart disease and ischemic stroke risk and atorvastatin lipid-lowering efficacy

Qing-Hui Zhang, Rui-Xing Yin, Wu-Xian Chen, Xiao-Li Cao, Yu-Ming Chen

Biosci Rep. 2018 Feb 28; 38(1): BSR20171058. Prepublished online 2018 Jan 19. Published online 2018 Jan 19. doi: 10.1042/BSR20171058

PMCID:: PMC5773822

Abstract Article PDF–1.7M

Select item 550562115.

Role of TIM-4 in exosome-dependent entry of HIV-1 into human immune cells

Brian Sims, Anitra L Farrow, Sparkle D Williams, Anju Bansal, Alexandre Krendelchtchikov, Linlin Gu, Qiana L Matthews

Int J Nanomedicine. 2017; 12: 4823–4833. Published online 2017 Jul 6. doi: 10.2147/IJN.S132762

PMCID:: PMC5505621

Abstract Article PDF–747K

Select item 490723016.

Characterization of Human and Murine T-Cell Immunoglobulin Mucin Domain 4 (TIM-4) IgV Domain Residues Critical for Ebola Virus Entry

Bethany A. Rhein, Rachel B. Brouillette, Grace A. Schaack, John A. Chiorini, Wendy Maury

J Virol. 2016 Jul 1; 90(13): 6097–6111. Prepublished online 2016 Apr 27. Published online 2016 Jun 10. doi: 10.1128/JVI.00100-16

PMCID:: PMC4907230

Abstract Article PDF–2.9M

Select item 488219017.

Widespread expansion of protein interaction capabilities by alternative splicing

Xinping Yang, Jasmin Coulombe-Huntington, Shuli Kang, Gloria M. Sheynkman, Tong Hao, Aaron Richardson, Song Sun, Fan Yang, Yun A. Shen, Ryan R. Murray, Kerstin Spirohn, Bridget E. Begg, Miquel Duran-Frigola, Andrew MacWilliams, Samuel J. Pevzner, Quan Zhong, Shelly A. Wanamaker, Stanley Tam, Lila Ghamsari, Nidhi Sahni, Song Yi, Maria D. Rodriguez, Dawit Balcha, Guihong Tan, Michael Costanzo, Brenda Andrews, Charles Boone, Xianghong J. Zhou, Kourosh Salehi-Ashtiani, Benoit Charloteaux, Alyce A. Chen, Michael A. Calderwood, Patrick Aloy, Frederick P. Roth, David E. Hill, Lilia M. Iakoucheva, Yu Xia, Marc Vidal

Cell. Author manuscript; available in PMC 2017 Feb 11.

Published in final edited form as: Cell. 2016 Feb 11; 164(4): 805–817. doi: 10.1016/j.cell.2016.01.029

PMCID:: PMC4882190

Abstract Article PDF–1.9M

Select item 481588418.

TIM-4 promotes the growth of non-small-cell lung cancer in a RGD motif-dependent manner

Qianqian Zhang, Hongxing Wang, Xiaodong Wu, Bing Liu, Wen Liu, Rong Wang, Xiaohong Liang, Chunhong Ma, Lifen Gao

Br J Cancer. 2015 Nov 17; 113(10): 1484–1492. Published online 2015 Oct 29. doi: 10.1038/bjc.2015.323

PMCID:: PMC4815884

Abstract Article PDF–2.3M

Select item 471019519.

Expression of Tim4 in Glioma and its Regulatory Role in LN-18 Glioma Cells

Weiguo Li, Xingang Li, Shujun Xu, Xiangyu Ma, Qiujie Zhang

Med Sci Monit. 2016; 22: 77–82. Published online 2016 Jan 7. doi: 10.12659/MSM.894963

PMCID:: PMC4710195

Abstract Article PDF–827K

Select item 464794120.

hORFeome v3.1: A resource of human open reading frames representing over 10,000 human genes

Philippe Lamesch, Ning Li, Stuart Milstein, Changyu Fan, Tong Hao, Gabor Szabo, Zhenjun Hu, Kavitha Venkatesan, Graeme Bethel, Paul Martin, Jane Rogers, Stephanie Lawlor, Stuart McLaren, Amélie Dricot, Heather Borick, Michael E. Cusick, Jean Vandenhaute, Ian Dunham, David E. Hill, Marc Vidal

Genomics. 2007 Mar; 89(3): 307–315. doi: 10.1016/j.ygeno.2006.11.012

PMCID:: PMC4647941

Abstract Article

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