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Select item 93989941.

Ttc21b deficiency attenuates autosomal dominant polycystic kidney disease in a kidney tubular- and maturation-dependent manner

Wei Wang, Luciane M. Silva, Henry H. Wang, Matthew A. Kavanaugh, Tana S. Pottorf, Bailey A. Allard, Damon T. Jacobs, Rouchen Dong, Joseph T. Cornelius, Aakriti Chaturvedi, Katherine I. Swenson-Fields, Timothy A Fields, Michele T. Pritchard, Madhulika Sharma, Chad Slawson, Darren P. Wallace, James P. Calvet, Pamela V. Tran

Kidney Int. Author manuscript; available in PMC 2023 Sep 1.

Published in final edited form as: Kidney Int. 2022 Sep; 102(3): 577–591. Published online 2022 May 27. doi: 10.1016/j.kint.2022.04.034

Correction in:: Kidney Int. 2023 Jun; 103(6): 1202.

PMCID:: PMC9398994

Abstract Article PDF–3.3M

Select item 92784832.

Thm2 interacts with paralog, Thm1, and sensitizes to Hedgehog signaling in postnatal skeletogenesis

Bailey A. Allard, Wei Wang, Tana S. Pottorf, Hammad Mumtaz, Brittany M. Jack, Henry H. Wang, Luciane M. Silva, Damon T. Jacobs, Jinxi Wang, Erin E. Bumann, Pamela V. Tran

Cell Mol Life Sci. 2021 Apr; 78(7): 3743–3762. Published online 2021 Mar 8. doi: 10.1007/s00018-021-03806-w

PMCID:: PMC9278483

Abstract Article PDF–3.8M

Select item 91499323.

Genetic Interaction of Thm2 and Thm1 Shapes Postnatal Craniofacial Bone

Erin E. Bumann, Portia Hahn Leat, Henry H. Wang, Brittany M. Hufft-Martinez, Wei Wang, Pamela V. Tran

J Dev Biol. 2022 Jun; 10(2): 17. Published online 2022 May 11. doi: 10.3390/jdb10020017

PMCID:: PMC9149932

Abstract Article PDF–3.2M

Select item 86654504.

IFT-A deficiency in juvenile mice impairs biliary development and exacerbates ADPKD liver disease

Wei Wang, Tana S Pottorf, Henry H Wang, Ruochen Dong, Matthew A Kavanaugh, Joseph T Cornelius, Katie L Dennis, Udayan Apte, Michele T Pritchard, Madhulika Sharma, Pamela V Tran

J Pathol. Author manuscript; available in PMC 2021 Dec 11.

Published in final edited form as: J Pathol. 2021 Jul; 254(3): 289–302. Published online 2021 May 21. doi: 10.1002/path.5685

PMCID:: PMC8665450

Abstract Article PDF–3.6M

Select item 79387705.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 76551036.

Sonic hedgehog signaling directs patterned cell remodeling during cranial neural tube closure

Eric R Brooks, Mohammed Tarek Islam, Kathryn V Anderson, Jennifer A Zallen

eLife. 2020; 9: e60234. Published online 2020 Oct 26. doi: 10.7554/eLife.60234

PMCID:: PMC7655103

Abstract Article PDF–13M

Select item 72788857.

Intraflagellar-transport A dysfunction causes hyperphagia-induced systemic insulin resistance in a pre-obese state

Damon T Jacobs, Bailey A Allard, Tana S Pottorf, Luciane M Silva, Wei Wang, Aisha Al-Naamani, Ewud Agborbesong, Tao Wang, Dajanae A Carr, Pamela V Tran

FASEB J. Author manuscript; available in PMC 2021 Jan 1.

Published in final edited form as: FASEB J. 2020 Jan; 34(1): 148–160. Published online 2019 Nov 19. doi: 10.1096/fj.201900751R

PMCID:: PMC7278885

Abstract Article PDF–2.0M

Select item 72002948.

Genetic interaction of mammalian IFT-A paralogs regulates cilia disassembly, ciliary entry of membrane protein, Hedgehog signaling and embryogenesis

Wei Wang, Bailey A. Allard, Tana S. Pottorf, Henry H. Wang, Jay L. Vivian, Pamela V. Tran

FASEB J. Author manuscript; available in PMC 2021 May 1.

Published in final edited form as: FASEB J. 2020 May; 34(5): 6369–6381. Published online 2020 Mar 13. doi: 10.1096/fj.201902611R

PMCID:: PMC7200294

Abstract Article PDF–2.4M

Select item 70987139.

MetAP2 inhibition reduces food intake and body weight in a ciliopathy mouse model of obesity

Tana S. Pottorf, Micaella P. Fagan, Bryan F. Burkey, David J. Cho, James E. Vath, Pamela V. Tran

JCI Insight. 2020 Jan 30; 5(2): e134278. Published online 2020 Jan 30. doi: 10.1172/jci.insight.134278

PMCID:: PMC7098713

Abstract Article PDF–2.8M

Select item 688107410.

Gpr63 is a modifier of microcephaly in Ttc21b mouse mutants

John Snedeker, William J. Gibbons, Jr., David F. Paulding, Zakia Abdelhamed, Daniel R. Prows, Rolf W. Stottmann

PLoS Genet. 2019 Nov; 15(11): e1008467. Published online 2019 Nov 15. doi: 10.1371/journal.pgen.1008467

PMCID:: PMC6881074

Abstract Article PDF–2.7M

Select item 583179911.

Ttc21b Is Required in Bergmann Glia for Proper Granule Cell Radial Migration

Ashley M. Driver, Christopher Shumrick, Rolf W. Stottmann

J Dev Biol. 2017 Dec; 5(4): 18. Published online 2017 Dec 19. doi: 10.3390/jdb5040018

PMCID:: PMC5831799

Abstract Article PDF–3.9M

Select item 582026512.

Aberrant Regulation of Notch3 Signaling Pathway in Polycystic Kidney Disease

Jessica Idowu, Trisha Home, Nisha Patel, Brenda Magenheimer, Pamela V. Tran, Robin L. Maser, Christopher J. Ward, James P. Calvet, Darren P. Wallace, Madhulika Sharma

Sci Rep. 2018; 8: 3340. Published online 2018 Feb 20. doi: 10.1038/s41598-018-21132-3

PMCID:: PMC5820265

Abstract Article PDF–2.5M

Select item 536771013.

A tissue-specific role for intraflagellar transport genes during craniofacial development

Elizabeth N. Schock, Jaime N. Struve, Ching-Fang Chang, Trevor J. Williams, John Snedeker, Aria C. Attia, Rolf W. Stottmann, Samantha A. Brugmann

PLoS One. 2017; 12(3): e0174206. Published online 2017 Mar 27. doi: 10.1371/journal.pone.0174206

PMCID:: PMC5367710

Abstract Article PDF–3.7M

Select item 534961314.

Unique spatiotemporal requirements for intraflagellar transport genes during forebrain development

John Snedeker, Elizabeth N. Schock, Jamie N. Struve, Ching-Fang Chang, Megan Cionni, Pamela V. Tran, Samantha A. Brugmann, Rolf W. Stottmann

PLoS One. 2017; 12(3): e0173258. Published online 2017 Mar 14. doi: 10.1371/journal.pone.0173258

PMCID:: PMC5349613

Abstract Article PDF–3.3M

Select item 512388815.

Role for the IFT-A complex in selective transport to the primary cilium

Wenxiang Fu, Lei Wang, Sehyun Kim, Ji Li, Brian David Dynlacht

Cell Rep. Author manuscript; available in PMC 2016 Nov 25.

Published in final edited form as: Cell Rep. 2016 Nov 1; 17(6): 1505–1517. doi: 10.1016/j.celrep.2016.10.018

PMCID:: PMC5123888

Abstract Article PDF–3.0M

Select item 495831416.

Dysfunction of intraflagellar transport-A causes hyperphagia-induced obesity and metabolic syndrome

Damon T. Jacobs, Luciane M. Silva, Bailey A. Allard, Michael P. Schonfeld, Anindita Chatterjee, George C. Talbott, David R. Beier, Pamela V. Tran

Dis Model Mech. 2016 Jul 1; 9(7): 789–798. doi: 10.1242/dmm.025791

PMCID:: PMC4958314

Abstract Article

Select item 481772017.

THM1 negatively modulates mouse sonic hedgehog signal transduction and affects retrograde intraflagellar transport in cilia

Pamela V Tran, Courtney J Haycraft, Tatiana Y Besschetnova, Annick Turbe-Doan, Rolf W Stottmann, Bruce J Herron, Allyson L Chesebro, Haiyan Qiu, Paul J Scherz, Jagesh V Shah, Bradley K Yoder, David R Beier

Nat Genet. Author manuscript; available in PMC 2016 Apr 1.

Published in final edited form as: Nat Genet. 2008 Apr; 40(4): 403–410. Published online 2008 Mar 9. doi: 10.1038/ng.105

PMCID:: PMC4817720

Abstract Article PDF–1.3M

Select item 417843318.

Downregulating Hedgehog Signaling Reduces Renal Cystogenic Potential of Mouse Models

Pamela V. Tran, George C. Talbott, Annick Turbe-Doan, Damon T. Jacobs, Michael P. Schonfeld, Luciane M. Silva, Anindita Chatterjee, Mary Prysak, Bailey A. Allard, David R. Beier

J Am Soc Nephrol. 2014 Oct; 25(10): 2201–2212. Published online 2014 Apr 3. doi: 10.1681/ASN.2013070735

PMCID:: PMC4178433

Abstract Article

Select item 407349419.

The Central Role of EED in the Orchestration of Polycomb Group Complexes

Qi Cao, Xiaoju Wang, Meng Zhao, Rendong Yang, Rohit Malik, Yuanyuan Qiao, Anton Poliakov, Anastasia K. Yocum, Yong Li, Wei Chen, Xuhong Cao, Xia Jiang, Arun Dahiya, Clair Harris, Felix Y. Feng, Sundeep Kalantry, Zhaohui S. Qin, Saravana M. Dhanasekaran, Arul M. Chinnaiyan

Nat Commun. Author manuscript; available in PMC 2014 Jul 24.

Published in final edited form as: Nat Commun. 2014; 5: 3127. doi: 10.1038/ncomms4127

PMCID:: PMC4073494

Abstract Article PDF–2.1M

Select item 357241020.

A conditional knockout resource for the genome–wide study of mouse gene function

William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley

Nature. Author manuscript; available in PMC 2013 Feb 14.

Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163

PMCID:: PMC3572410

Abstract Article PDF–1.1M

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