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Select item 115248251.

Inhibition of P2RX7 contributes to cytotoxicity by suppression of glycolysis and AKT activation in human hepatocellular carcinoma

Jae Kook Yang, Junhyung Kim, Young Hyeon Ahn, Sang Ho Bae, Moo-Jun Baek, Sae Hwan Lee, Jong-Seok Moon

BMB Rep. 2024 Oct 31; 57(10): 459–464. Published online 2024 Oct 4. doi: 10.5483/BMBRep.2024-0070

PMCID:: PMC11524825

Abstract Article PDF–8.0M

Select item 112342052.

P2X7R Modulates NEK7-NLRP3 Interaction to Exacerbate Experimental Autoimmune Prostatitis via GSDMD-mediated Prostate Epithelial Cell Pyroptosis

Lei Chen, Yi Liu, Shaoyu Yue, Hui Wang, Jia Chen, Wenming Ma, Wenlong Xu, Muyang Xu, Ziqi Chen, Xianguo Chen, Li Zhang, Chaozhao Liang

Int J Biol Sci. 2024; 20(9): 3393–3411. Published online 2024 Jun 11. doi: 10.7150/ijbs.94704

PMCID:: PMC11234205

Abstract Article PDF–15M

Select item 112042173.

P2X7 Variants in Pathophysiology

Anna Pegoraro, Marianna Grignolo, Luigia Ruo, Ludovica Ricci, Elena Adinolfi

Int J Mol Sci. 2024 Jun; 25(12): 6673. Published online 2024 Jun 18. doi: 10.3390/ijms25126673

PMCID:: PMC11204217

Abstract Article PDF–571K

Select item 111893784.

Functional expression of the ATP-gated P2X7 receptor in human iPSC-derived astrocytes

Jaideep Kesavan, Orla Watters, Laura de Diego-Garcia, Aida Menéndez Méndez, Mariana Alves, Klaus Dinkel, Michael Hamacher, Jochen H. M. Prehn, David C. Henshall, Tobias Engel

Purinergic Signal. 2024 Jun; 20(3): 303–309. Published online 2023 Jul 15. doi: 10.1007/s11302-023-09957-8

PMCID:: PMC11189378

Abstract Article PDF–1.8M

Select item 111893705.

Potential role of the P2X7 receptor in the proliferation of human diffused large B-cell lymphoma

Xiao Yang, Yuanyuan Ji, Lin Mei, Wenwen Jing, Xin Yang, Qianwei Liu

Purinergic Signal. 2024 Jun; 20(3): 273–284. Published online 2023 May 24. doi: 10.1007/s11302-023-09947-w

PMCID:: PMC11189370

Abstract Article PDF–2.3M

Select item 111754436.

Extracellular ATP/P2X7 receptor, a regulatory axis of migration in ovarian carcinoma-derived cells

José David Nuñez-Ríos, Mauricio Reyna-Jeldes, Esperanza Mata-Martínez, Anaí del Rocío Campos-Contreras, Iván Lazcano-Sánchez, Adriana González-Gallardo, Mauricio Díaz-Muñoz, Claudio Coddou, Francisco G. Vázquez-Cuevas

PLoS One. 2024; 19(6): e0304062. Published online 2024 Jun 13. doi: 10.1371/journal.pone.0304062

PMCID:: PMC11175443

Abstract Article PDF–3.5M

Select item 111733067.

Genetic Polymorphisms of P2RX7 but Not of ADORA2A Are Associated with the Severity of SARS-CoV-2 Infection

Jorge Lindo, Célia Nogueira, Rui Soares, Nuno Cunha, Maria Rosário Almeida, Lisa Rodrigues, Patrícia Coelho, Francisco Rodrigues, Rodrigo A. Cunha, Teresa Gonçalves

Int J Mol Sci. 2024 Jun; 25(11): 6135. Published online 2024 Jun 2. doi: 10.3390/ijms25116135

PMCID:: PMC11173306

Abstract Article PDF–295K

Select item 109317478.

P2X7 Receptor in Dendritic Cells and Macrophages: Implications in Antigen Presentation and T Lymphocyte Activation

Claudio Acuña-Castillo, Alejandro Escobar, Moira García-Gómez, Vivienne C. Bachelet, Juan Pablo Huidobro-Toro, Daniela Sauma, Carlos Barrera-Avalos

Int J Mol Sci. 2024 Mar; 25(5): 2495. Published online 2024 Feb 21. doi: 10.3390/ijms25052495

PMCID:: PMC10931747

Abstract Article PDF–3.5M

Select item 109168669.

Cooperative polarization of MCAM/CD146 and ERM family proteins in melanoma

Suzannah G. Miller, Maria Hoh, Christopher C. Ebmeier, Jian Wei Tay, Natalie G. Ahn

Mol Biol Cell. 2024 Mar 1; 35(3): ar31. Published online 2024 Jan 29. doi: 10.1091/mbc.E23-06-0255

PMCID:: PMC10916866

Abstract Article PDF–4.7M

Select item 1089673810.

P2X₇R influences tau aggregate burden in human tauopathies and shows distinct signalling in microglia and astrocytes

Paula Beltran-Lobo, Martina M. Hughes, Claire Troakes, Cara L. Croft, Huzefa Rupawala, Daniel Jutzi, Marc-David Ruepp, Maria Jimenez-Sanchez, Michael S. Perkinton, Michael Kassiou, Todd E. Golde, Diane P. Hanger, Alexei Verkhratsky, Beatriz G. Perez-Nievas, Wendy Noble

Brain Behav Immun. 2023 Nov; 114: 414–429. doi: 10.1016/j.bbi.2023.09.011

PMCID:: PMC10896738

Abstract Article

Select item 1085580111.

P2X7 Receptor-Induced Human Mast Cell Degranulation Is Enhanced by Interleukin 33

Barbora Salcman, Rajia Bahri, Peter W. West, Chiara Tontini, Karen Affleck, Silvia Bulfone-Paus

Int J Mol Sci. 2024 Feb; 25(3): 1730. Published online 2024 Jan 31. doi: 10.3390/ijms25031730

PMCID:: PMC10855801

Abstract Article PDF–1.9M

Select item 1082815112.

The P2X7 receptor in mucosal adaptive immunity

Fabio Grassi, Rebecca Marino

Purinergic Signal. 2024 Feb; 20(1): 9–19. Published online 2023 Apr 17. doi: 10.1007/s11302-023-09939-w

PMCID:: PMC10828151

Abstract Article PDF–2.0M

Select item 1081585413.

Embers of the Past: Early Childhood Traumas Interact with Variation in P2RX7 Gene Implicated in Neuroinflammation on Markers of Current Suicide Risk

Zsuliet Kristof, Zsofia Gal, Dora Torok, Nora Eszlari, Sara Sutori, Beata Sperlagh, Ian M. Anderson, Bill Deakin, Gyorgy Bagdy, Gabriella Juhasz, Xenia Gonda

Int J Mol Sci. 2024 Jan; 25(2): 865. Published online 2024 Jan 10. doi: 10.3390/ijms25020865

PMCID:: PMC10815854

Abstract Article PDF–2.3M

Select item 1075480014.

P2X7 receptor promotes migration and invasion of non-small cell lung cancer A549 cells through the PI3K/Akt pathways

Xue Bai, Qianqian Li, Xiaoxiang Peng, Xinyu Li, Cuicui Qiao, Yiqing Tang, Ronglan Zhao

Purinergic Signal. 2023 Dec; 19(4): 685–697. Published online 2023 Mar 1. doi: 10.1007/s11302-023-09928-z

PMCID:: PMC10754800

Abstract Article PDF–5.1M

Select item 1071642015.

Purinergic P2X7 receptor expression increases in leukocytes from intra-abdominal septic patients

Helios Martínez-Banaclocha, Carlos García-Palenciano, Laura Martínez-Alarcón, Joaquín Amores-Iniesta, Fátima Martín-Sánchez, Giovanni A. Ercole, Ada González-Lisorge, José Fernández-Pacheco, Piedad Martínez-Gil, Julio Padilla-Rodríguez, Alberto Baroja-Mazo, Pablo Pelegrín, Juan José Martínez-García

Front Immunol. 2023; 14: 1297249. Published online 2023 Nov 29. doi: 10.3389/fimmu.2023.1297249

PMCID:: PMC10716420

Abstract Article PDF–3.6M

Select item 1066642216.

P2X7 receptor activation leads to NLRP3-independent IL-1β release by human macrophages

Judith Bockstiegel, Jonas Engelhardt, Günther Weindl

Cell Commun Signal. 2023; 21: 335. Published online 2023 Nov 23. doi: 10.1186/s12964-023-01356-1

PMCID:: PMC10666422

Abstract Article PDF–2.6M

Select item 1045450917.

P2X7 Receptor Regulates Collagen Expression in Human Intestinal Fibroblasts: Relevance in Intestinal Fibrosis

Lluis Lis-López, Cristina Bauset, Marta Seco-Cervera, Dulce Macias-Ceja, Francisco Navarro, Ángeles Álvarez, Juan Vicente Esplugues, Sara Calatayud, Maria Dolores Barrachina, Dolores Ortiz-Masià, Jesús Cosín-Roger

Int J Mol Sci. 2023 Aug; 24(16): 12936. Published online 2023 Aug 18. doi: 10.3390/ijms241612936