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Select item 110112021.

Numerous Serine/Threonine Kinases Affect Blood Cell Homeostasis in Drosophila melanogaster

Sebastian Deichsel, Bernd M. Gahr, Helena Mastel, Anette Preiss, Anja C. Nagel

Cells. 2024 Apr; 13(7): 576. Published online 2024 Mar 26. doi: 10.3390/cells13070576

PMCID:: PMC11011202

Abstract Article PDF–5.5M

Select item 105932262.

Unanticipated domain requirements for Drosophila Wnk kinase in vivo

Prathibha Yarikipati, Sima Jonusaite, John M. Pleinis, Carihann Dominicci Cotto, David Sanchez-Hernandez, Daryl E. Morrison, Suhani Goyal, Jeffrey Schellinger, Clothilde Pénalva, Jennifer Curtiss, Aylin R. Rodan, Andreas Jenny

PLoS Genet. 2023 Oct; 19(10): e1010975. Published online 2023 Oct 11. doi: 10.1371/journal.pgen.1010975

PMCID:: PMC10593226

Abstract Article PDF–3.6M

Select item 105593053.

Hydrostatic Pressure Sensing by WNK kinases

John M. Humphreys, Liliana R. Teixeira, Radha Akella, Haixia He, Ashari R. Kannangara, Kamil Sekulski, John Pleinis, Joanna Liwocha, Jenny Jiou, Kelly A. Servage, Kim Orth, Lukasz Joachimiak, Josep Rizo, Melanie H. Cobb, Chad A. Brautigam, Aylin R. Rodan, Elizabeth J. Goldsmith

Mol Biol Cell. 2023 Oct 1; 34(11): ar109. Published online 2023 Sep 21. doi: 10.1091/mbc.E23-03-0113

PMCID:: PMC10559305

Abstract Article PDF–2.1M

Select item 104425444.

A nerve-wracking buzz: lessons from Drosophila models of peripheral neuropathy and axon degeneration

Martha R. C. Bhattacharya

Front Aging Neurosci. 2023; 15: 1166146. Published online 2023 Aug 8. doi: 10.3389/fnagi.2023.1166146

PMCID:: PMC10442544

Abstract Article PDF–841K

Select item 100901375.

Adult expression of Semaphorins and Plexins is essential for motor neuron survival

Aarya Vaikakkara Chithran, Douglas W. Allan, Timothy P. O’Connor

Sci Rep. 2023; 13: 5894. Published online 2023 Apr 11. doi: 10.1038/s41598-023-32943-4

PMCID:: PMC10090137

Abstract Article PDF–5.0M

Select item 99815356.

A large-scale RNAi screen reveals that mitochondrial function is important for meiotic chromosome organization in oocytes

Karen Jule Nieken, Kathryn O’Brien, Alexander McDonnell, Liudmila Zhaunova, Hiroyuki Ohkura

Chromosoma. 2023; 132(1): 1–18. Published online 2023 Jan 17. doi: 10.1007/s00412-023-00784-9

PMCID:: PMC9981535

Abstract Article PDF–3.4M

Select item 98701067.

SIK3 and Wnk converge on Fray to regulate glial K⁺ buffering and seizure susceptibility

Lorenzo Lones, Aaron DiAntonio

PLoS Genet. 2023 Jan; 19(1): e1010581. Published online 2023 Jan 10. doi: 10.1371/journal.pgen.1010581

PMCID:: PMC9870106

Abstract Article PDF–2.5M

Select item 96992838.

WNK kinases sense molecular crowding and rescue cell volume via phase separation

Cary R. Boyd-Shiwarski, Daniel J. Shiwarski, Shawn E. Griffiths, Rebecca T. Beacham, Logan Norrell, Daryl E. Morrison, Jun Wang, Jacob Mann, William Tennant, Eric N. Anderson, Jonathan Franks, Michael Calderon, Kelly A. Connolly, Muhammad Umar Cheema, Claire J. Weaver, Lubika J. Nkashama, Claire C. Weckerly, Katherine E. Querry, Udai Bhan Pandey, Christopher J. Donnelly, Dandan Sun, Aylin R. Rodan, Arohan R. Subramanya

Cell. Author manuscript; available in PMC 2023 Nov 23.

Published in final edited form as: Cell. 2022 Nov 23; 185(24): 4488–4506.e20. Published online 2022 Oct 31. doi: 10.1016/j.cell.2022.09.042

PMCID:: PMC9699283

Abstract Article PDF–3.7M

Select item 95868799.

Updates on ion and water transport by the Malpighian tubule

Julian A T Dow, Sue Ann Krause, Pawel Herzyk

Curr Opin Insect Sci. 2021 Oct; 47: 31–37. doi: 10.1016/j.cois.2021.02.018

PMCID:: PMC9586879

Abstract Article

Select item 933649510.

Chromatin and transcriptomic profiling uncover dysregulation of the Tip60 HAT/HDAC2 epigenomic landscape in the neurodegenerative brain

Mariah Beaver, Bhanu Chandra Karisetty, Haolin Zhang, Akanksha Bhatnagar, Ellen Armour, Visha Parmar, Reshma Brown, Merry Xiang, Felice Elefant

Epigenetics. 2022; 17(7): 786–807. Published online 2021 Aug 9. doi: 10.1080/15592294.2021.1959742

PMCID:: PMC9336495

Abstract Article PDF–3.5M

Select item 897208311.

Chloride oscillation in pacemaker neurons regulates circadian rhythms through a chloride-sensing WNK kinase signaling cascade

Jeffrey N. Schellinger, Qifei Sun, John M. Pleinis, Sung-Wan An, Jianrui Hu, Gaëlle Mercenne, Iris Titos, Chou-Long Huang, Adrian Rothenfluh, Aylin R. Rodan

Curr Biol. Author manuscript; available in PMC 2023 Mar 28.

Published in final edited form as: Curr Biol. 2022 Mar 28; 32(6): 1429–1438.e6. Published online 2022 Mar 17. doi: 10.1016/j.cub.2022.03.017

PMCID:: PMC8972083

Abstract Article PDF–1.5M

Select item 866448612.

Genome-wide phenotypic RNAi screen in the Drosophila wing: phenotypic description of functional classes

Ana López-Varea, Patricia Vega-Cuesta, Ana Ruiz-Gómez, Cristina M Ostalé, Cristina Molnar, Covadonga F Hevia, Mercedes Martín, Maria F Organista, Jesus de Celis, Joaquín Culí, Nuria Esteban, Jose F de Celis

G3 (Bethesda) 2021 Dec; 11(12): jkab349. Published online 2021 Oct 2. doi: 10.1093/g3journal/jkab349

PMCID:: PMC8664486

Abstract Article PDF–3.1M

Select item 866445513.

Functional requirements of protein kinases and phosphatases in the development of the Drosophila melanogaster wing

Cristina M Ostalé, Nuria Esteban, Ana López-Varea, Jose F de Celis

G3 (Bethesda) 2021 Dec; 11(12): jkab348. Published online 2021 Oct 2. doi: 10.1093/g3journal/jkab348

PMCID:: PMC8664455

Abstract Article PDF–2.9M

Select item 816357614.

WNKs are potassium-sensitive kinases

John M. Pleinis, Logan Norrell, Radha Akella, John M. Humphreys, Haixia He, Qifei Sun, Feng Zhang, Jason Sosa-Pagan, Daryl E. Morrison, Jeffrey N. Schellinger, Laurie K. Jackson, Elizabeth J. Goldsmith, Aylin R. Rodan

Am J Physiol Cell Physiol. 2021 May 1; 320(5): C703–C721. Published online 2021 Jan 13. doi: 10.1152/ajpcell.00456.2020

PMCID:: PMC8163576

Abstract Article

Select item 802294615.

An RNAi screen of the kinome in epithelial follicle cells of the Drosophila melanogaster ovary reveals genes required for proper germline death and clearance

Diane P V Lebo, Alice Chirn, Jeffrey D Taylor, Andre Levan, Valentina Doerre Torres, Emily Agreda, Sandy B Serizier, Allison K Lord, Victoria K Jenkins, Kimberly McCall

G3 (Bethesda) 2021 Feb; 11(2): jkaa066. Published online 2021 Mar 6. doi: 10.1093/g3journal/jkaa066

PMCID:: PMC8022946

Abstract Article PDF–1.3M

Select item 668428516.

Intracellular chloride: a regulator of transepithelial transport in the distal nephron

Aylin R. Rodan

Curr Opin Nephrol Hypertens. Author manuscript; available in PMC 2020 Jul 1.

Published in final edited form as: Curr Opin Nephrol Hypertens. 2019 Jul; 28(4): 360–367. doi: 10.1097/MNH.0000000000000502

PMCID:: PMC6684285

Abstract Article PDF–587K

Select item 666909017.

The Drosophila Malpighian Tubule as a Model for Mammalian Tubule Function

Aylin R. Rodan

Curr Opin Nephrol Hypertens. Author manuscript; available in PMC 2020 Sep 1.

Published in final edited form as: Curr Opin Nephrol Hypertens. 2019 Sep; 28(5): 455–464. doi: 10.1097/MNH.0000000000000521

PMCID:: PMC6669090

Abstract Article PDF–794K

Select item 638550518.

The glial sodium-potassium-2-chloride cotransporter is required for synaptic transmission in the Drosophila visual system

Drew Stenesen, Andrew T. Moehlman, Jeffrey N. Schellinger, Aylin R. Rodan, Helmut Krämer

Sci Rep. 2019; 9: 2475. Published online 2019 Feb 21. doi: 10.1038/s41598-019-38850-x

PMCID:: PMC6385505

Abstract Article PDF–6.4M

Select item 596777619.

Intracellular Chloride and Scaffold Protein Mo25 Cooperatively Regulate Transepithelial Ion Transport through WNK Signaling in the Malpighian Tubule

Qifei Sun, Yipin Wu, Sima Jonusaite, John M. Pleinis, John M. Humphreys, Haixia He, Jeffrey N. Schellinger, Radha Akella, Drew Stenesen, Helmut Krämer, Elizabeth J. Goldsmith, Aylin R. Rodan

J Am Soc Nephrol. 2018 May; 29(5): 1449–1461. Published online 2018 Mar 30. doi: 10.1681/ASN.2017101091

PMCID:: PMC5967776

Abstract Article

Select item 593136920.

A Whole Animal Platform to Advance A Clinical Kinase Inhibitor Into New Disease Space

Masahiro Sonoshita, Alex P. Scopton, Peter M-U. Ung, Matthew A. Murray, Lisa Silber, Andres Y. Maldonado, Alexander Real, Avner Schlessinger, Ross L. Cagan, Arvin C. Dar

Nat Chem Biol. Author manuscript; available in PMC 2018 Jul 22.

Published in final edited form as: Nat Chem Biol. 2018 Mar; 14(3): 291–298. Published online 2018 Jan 22. doi: 10.1038/nchembio.2556

PMCID:: PMC5931369

Abstract Article PDF–2.9M

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