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Select item 92738681.

Identification of Therapeutic Targets for Amyotrophic Lateral Sclerosis Using PandaOmics – An AI-Enabled Biological Target Discovery Platform

Frank W. Pun, Bonnie Hei Man Liu, Xi Long, Hoi Wing Leung, Geoffrey Ho Duen Leung, Quinlan T. Mewborne, Junli Gao, Anastasia Shneyderman, Ivan V. Ozerov, Ju Wang, Feng Ren, Alexander Aliper, Evelyne Bischof, Evgeny Izumchenko, Xiaoming Guan, Ke Zhang, Bai Lu, Jeffrey D. Rothstein, Merit E. Cudkowicz, Alex Zhavoronkov

Front Aging Neurosci. 2022; 14: 914017. Published online 2022 Jun 28. doi: 10.3389/fnagi.2022.914017

PMCID:: PMC9273868

Abstract Article PDF–3.6M

Select item 70379312.

Genetic Dissection of Alzheimer’s Disease Using Drosophila Models

Youngjae Jeon, Jae Ha Lee, Byoungyun Choi, So-Yoon Won, Kyoung Sang Cho

Int J Mol Sci. 2020 Feb; 21(3): 884. Published online 2020 Jan 30. doi: 10.3390/ijms21030884

PMCID:: PMC7037931

Abstract Article PDF–9.3M

Select item 69949443.

Analysis of a cellular structure observed in the compound eyes of Drosophila white; yata mutants and white mutants

Eri Arimoto, Yutaro Kawashima, Taein Choi, Mami Unagami, Shintaro Akiyama, Mizuki Tomizawa, Hiroyuki Yano, Emiko Suzuki, Masaki Sone

Biol Open. 2020 Jan 15; 9(1): bio047043. Published online 2020 Jan 13. doi: 10.1242/bio.047043

PMCID:: PMC6994944

Abstract Article PDF–9.4M

Select item 69615784.

CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans

Ping Wei, Wen Xue, Yun Zhao, Guang Ning, Jiwu Wang

Genome Res. 2020 Jan; 30(1): 95–106. doi: 10.1101/gr.250811.119

PMCID:: PMC6961578

Abstract Article PDF–3.6M

Select item 61432675.

Suppression of the synaptic localization of a subset of proteins including APP partially ameliorates phenotypes of the Drosophila Alzheimer's disease model

Koto Furotani, Keisuke Kamimura, Takaaki Yajima, Minoru Nakayama, Rena Enomoto, Takuya Tamura, Hitoshi Okazawa, Masaki Sone

PLoS One. 2018; 13(9): e0204048. Published online 2018 Sep 18. doi: 10.1371/journal.pone.0204048

PMCID:: PMC6143267

Abstract Article PDF–6.0M

Select item 59313696.

A Whole Animal Platform to Advance A Clinical Kinase Inhibitor Into New Disease Space

Masahiro Sonoshita, Alex P. Scopton, Peter M-U. Ung, Matthew A. Murray, Lisa Silber, Andres Y. Maldonado, Alexander Real, Avner Schlessinger, Ross L. Cagan, Arvin C. Dar

Nat Chem Biol. Author manuscript; available in PMC 2018 Jul 22.

Published in final edited form as: Nat Chem Biol. 2018 Mar; 14(3): 291–298. Published online 2018 Jan 22. doi: 10.1038/nchembio.2556

PMCID:: PMC5931369

Abstract Article PDF–2.9M

Select item 57078057.

Landscape and evolution of tissue-specific alternative polyadenylation across Drosophila species

Piero Sanfilippo, Jiayu Wen, Eric C. Lai

Genome Biol. 2017; 18: 229. Published online 2017 Nov 30. doi: 10.1186/s13059-017-1358-0

PMCID:: PMC5707805

Abstract Article PDF–3.2M

Select item 56890028.

Transcription elongation rate has a tissue-specific impact on alternative cleavage and polyadenylation in Drosophila melanogaster

Xiaochuan Liu, Jaime Freitas, Dinghai Zheng, Marta S. Oliveira, Mainul Hoque, Torcato Martins, Telmo Henriques, Bin Tian, Alexandra Moreira

RNA. 2017 Dec; 23(12): 1807–1816. doi: 10.1261/rna.062661.117

PMCID:: PMC5689002

Abstract Article PDF–4.0M

Select item 51268649.

Latitudinal clines in gene expression and cis-regulatory element variation in Drosophila melanogaster

Punita Juneja, Andrew Quinn, Francis M. Jiggins

BMC Genomics. 2016; 17: 981. Published online 2016 Nov 28. doi: 10.1186/s12864-016-3333-7

PMCID:: PMC5126864

Abstract Article PDF–1.1M

Select item 496024710.

Analysis of Amyloid Precursor Protein Function in Drosophila melanogaster

Marlène Cassar, Doris Kretzschmar

Front Mol Neurosci. 2016; 9: 61. Published online 2016 Jul 26. doi: 10.3389/fnmol.2016.00061

PMCID:: PMC4960247

Abstract Article PDF–700K

Select item 473800511.

Proteome-wide dataset supporting the study of ancient metazoan macromolecular complexes

Sadhna Phanse, Cuihong Wan, Blake Borgeson, Fan Tu, Kevin Drew, Greg Clark, Xuejian Xiong, Olga Kagan, Julian Kwan, Alexandr Bezginov, Kyle Chessman, Swati Pal, Graham Cromar, Ophelia Papoulas, Zuyao Ni, Daniel R. Boutz, Snejana Stoilova, Pierre C. Havugimana, Xinghua Guo, Ramy H. Malty, Mihail Sarov, Jack Greenblatt, Mohan Babu, W. Brent Derry, Elisabeth R. Tillier, John B. Wallingford, John Parkinson, Edward M. Marcotte, Andrew Emili

Data Brief. 2016 Mar; 6: 715–721. Published online 2015 Dec 12. doi: 10.1016/j.dib.2015.11.062

PMCID:: PMC4738005

Abstract Article PDF–205K

Select item 453277612.

The Hippo pathway promotes cell survival in response to chemical stress

F Di Cara, T M Maile, B D Parsons, A Magico, S Basu, N Tapon, K King-Jones

Cell Death Differ. 2015 Sep; 22(9): 1526–1539. Published online 2015 Mar 13. doi: 10.1038/cdd.2015.10

PMCID:: PMC4532776

Abstract Article PDF–2.5M

Select item 452833013.

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders

Madeline A. Crosby, L. Sian Gramates, Gilberto dos Santos, Beverley B. Matthews, Susan E. St. Pierre, Pinglei Zhou, Andrew J. Schroeder, Kathleen Falls, David B. Emmert, Susan M. Russo, William M. Gelbart, the FlyBase Consortium

G3 (Bethesda) 2015 Aug; 5(8): 1737–1749. Published online 2015 Jun 24. doi: 10.1534/g3.115.018937

PMCID:: PMC4528330

Abstract Article PDF–2.2M

Select item 452832914.

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data

Beverley B. Matthews, Gilberto dos Santos, Madeline A. Crosby, David B. Emmert, Susan E. St. Pierre, L. Sian Gramates, Pinglei Zhou, Andrew J. Schroeder, Kathleen Falls, Victor Strelets, Susan M. Russo, William M. Gelbart, the FlyBase Consortium

G3 (Bethesda) 2015 Aug; 5(8): 1721–1736. Published online 2015 Jun 24. doi: 10.1534/g3.115.018929

PMCID:: PMC4528329

Abstract Article PDF–4.9M

Select item 445871415.

The Drosophila Helicase Maleless (MLE) is Implicated in Functions Distinct From its Role in Dosage Compensation

Simona Cugusi, Satish Kallappagoudar, Huiping Ling, John C. Lucchesi

Mol Cell Proteomics. 2015 Jun; 14(6): 1478–1488. Published online 2015 Mar 16. doi: 10.1074/mcp.M114.040667

PMCID:: PMC4458714

Abstract Article PDF–625K

Select item 435288716.

The Release 6 reference sequence of the Drosophila melanogaster genome

Roger A. Hoskins, Joseph W. Carlson, Kenneth H. Wan, Soo Park, Ivonne Mendez, Samuel E. Galle, Benjamin W. Booth, Barret D. Pfeiffer, Reed A. George, Robert Svirskas, Martin Krzywinski, Jacqueline Schein, Maria Carmela Accardo, Elisabetta Damia, Giovanni Messina, María Méndez-Lago, Beatriz de Pablos, Olga V. Demakova, Evgeniya N. Andreyeva, Lidiya V. Boldyreva, Marco Marra, A. Bernardo Carvalho, Patrizio Dimitri, Alfredo Villasante, Igor F. Zhimulev, Gerald M. Rubin, Gary H. Karpen, Susan E. Celniker

Genome Res. 2015 Mar; 25(3): 445–458. doi: 10.1101/gr.185579.114

PMCID:: PMC4352887

Abstract Article PDF–1022K

Select item 426505517.

Screen for mitochondrial DNA copy number maintenance genes reveals essential role for ATP synthase

Atsushi Fukuoh, Giuseppe Cannino, Mike Gerards, Suzanne Buckley, Selena Kazancioglu, Filippo Scialo, Eero Lihavainen, Andre Ribeiro, Eric Dufour, Howard T Jacobs

Mol Syst Biol. 2014 Jun 25; 10(6): 734. Published online 2014 Jul 1. doi: 10.15252/msb.20145117

PMCID:: PMC4265055

Abstract Article PDF–1.4M

Select item 422898218.

Drosophila embryonic ‘fibroblasts’: Extending mutant analysis in vitro

Amanda A. Simcox, Christina L. Austin, Thomas L. Jacobsen, Hamed Jafar-Nejad

Fly (Austin) Author manuscript; available in PMC 2014 Nov 12.

Published in final edited form as: Fly (Austin). 2008 Nov-Dec; 2(6): 306–309. Published online 2008 Nov 15. doi: 10.4161/fly.7427

PMCID:: PMC4228982

Abstract Article PDF–720K

Select item 420866719.

Combining Genetic Perturbations and Proteomics to Examine Kinase-Phosphatase Networks in Drosophila Embryos

Richelle Sopko, Marianna Foos, Arunachalam Vinayagam, Bo Zhai, Richard Binari, Yanhui Hu, Sakara Randklev, Lizabeth A. Perkins, Steven P. Gygi, Norbert Perrimon

Dev Cell. Author manuscript; available in PMC 2015 Oct 13.

Published in final edited form as: Dev Cell. 2014 Oct 13; 31(1): 114–127. Published online 2014 Oct 2. doi: 10.1016/j.devcel.2014.07.027

PMCID:: PMC4208667

Abstract Article PDF–2.4M

Select item 419771020.

Analysis of the expression patterns, subcellular localisations and interaction partners of Drosophila proteins using a pigP protein trap library

Nick Lowe, Johanna S. Rees, John Roote, Ed Ryder, Irina M. Armean, Glynnis Johnson, Emma Drummond, Helen Spriggs, Jenny Drummond, Jose P. Magbanua, Huw Naylor, Bénédicte Sanson, Rebecca Bastock, Sven Huelsmann, Vitor Trovisco, Matthias Landgraf, Seymour Knowles-Barley, J. Douglas Armstrong, Helen White-Cooper, Celia Hansen, Roger G. Phillips, The UK Drosophila Protein Trap Screening Consortium, Kathryn S. Lilley, Steven Russell, Daniel St Johnston

Development. 2014 Oct; 141(20): 3994–4005. doi: 10.1242/dev.111054

PMCID:: PMC4197710

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