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Items: 1 to 20 of 24

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
2.
Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development
Francesco Bedogni, Robert F. Hevner
Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034
PMCID:
PMC8313239
AbstractArticlePDF–1.6M
3.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
4.
The E3 ubiquitin ligase Idol controls brain LDL receptor expression, ApoE clearance, and Aβ amyloidosis
Jinkuk Choi, Jie Gao, Jaekwang Kim, Cynthia Hong, Jungsu Kim, Peter Tontonoz
Sci Transl Med. Author manuscript; available in PMC 2020 Apr 13.
Published in final edited form as: Sci Transl Med. 2015 Nov 18; 7(314): 314ra184. doi: 10.1126/scitranslmed.aad1904
PMCID:
PMC7153735
AbstractArticlePDF–2.0M
5.
Therapeutic IDOL Reduction Ameliorates Amyloidosis and Improves Cognitive Function in APP/PS1 Mice
Jie Gao, Russell Littman, Graciel Diamante, Xu Xiao, In Sook Ahn, Xia Yang, Tracy A. Cole, Peter Tontonoz
Mol Cell Biol. 2020 Apr; 40(8): e00518-19. Prepublished online 2020 Jan 21. Published online 2020 Mar 30. doi: 10.1128/MCB.00518-19
PMCID:
PMC7108818
AbstractArticlePDF–13M
6.
IDOL regulates systemic energy balance through control of neuronal VLDLR expression
Stephen D. Lee, Christina Priest, Mikael Bjursell, Jie Gao, Douglas V. Arneson, In Sook Ahn, Graciel Diamante, J. Edward van Veen, Megan G. Massa, Anna C. Calkin, Jason Kim, Harriet Andersén, Prashant Rajbhandari, Michelle Porritt, Alba Carreras, Andrea Ahnmark, Frank Seeliger, Ingela Maxvall, Pernilla Eliasson, Magnus Althage, Peter Åkerblad, Daniel Lindén, Tracy A. Cole, Richard Lee, Helen Boyd, Mohammad Bohlooly-Y, Stephanie M. Correa, Xia Yang, Peter Tontonoz, Cynthia Hong
Nat Metab. Author manuscript; available in PMC 2020 May 1.
Published in final edited form as: Nat Metab. 2019 Nov; 1(11): 1089–1100. Published online 2019 Oct 28. doi: 10.1038/s42255-019-0127-7
PMCID:
PMC7028310
AbstractArticlePDF–3.9M
7.
Inactivation of the E3 Ubiquitin Ligase IDOL Attenuates Diet-Induced Obesity and Metabolic Dysfunction in Mice
Nienke M. van Loon, Roelof Ottenhoff, Sander Kooijman, Martina Moeton, Saskia Scheij, Reinout L.P. Roscam Abbing, Marion J.J. Gijbels, Johannes H.M. Levels, Vincenzo Sorrentino, Jimmy F.P. Berbée, Patrick C.N. Rensen, Noam Zelcer
Arterioscler Thromb Vasc Biol. 2018 Aug; 38(8): 1785–1795. Published online 2018 Jun 14. doi: 10.1161/ATVBAHA.118.311168
PMCID:
PMC6092113
AbstractArticlePDF–2.5M
8.
High-throughput discovery of novel developmental phenotypes
Mary E. Dickinson, Ann M. Flenniken, Xiao Ji, Lydia Teboul, Michael D. Wong, Jacqueline K. White, Terrence F. Meehan, Wolfgang J. Weninger, Henrik Westerberg, Hibret Adissu, Candice N. Baker, Lynette Bower, James M. Brown, L. Brianna Caddle, Francesco Chiani, Dave Clary, James Cleak, Mark J. Daly, James M. Denegre, Brendan Doe, Mary E. Dolan, Sarah M. Edie, Helmut Fuchs, Valerie Gailus-Durner, Antonella Galli, Alessia Gambadoro, Juan Gallegos, Shiying Guo, Neil R. Horner, Chih-wei Hsu, Sara J. Johnson, Sowmya Kalaga, Lance C. Keith, Louise Lanoue, Thomas N. Lawson, Monkol Lek, Manuel Mark, Susan Marschall, Jeremy Mason, Melissa L. McElwee, Susan Newbigging, Lauryl M.J. Nutter, Kevin A. Peterson, Ramiro Ramirez-Solis, Douglas J. Rowland, Edward Ryder, Kaitlin E. Samocha, John R. Seavitt, Mohammed Selloum, Zsombor Szoke-Kovacs, Masaru Tamura, Amanda G Trainor, Ilinca Tudose, Shigeharu Wakana, Jonathan Warren, Olivia Wendling, David B. West, Leeyean Wong, Atsushi Yoshiki, The International Mouse Phenotyping Consortium, Daniel G. MacArthur, Glauco P. Tocchini-Valentini, Xiang Gao, Paul Flicek, Allan Bradley, William C. Skarnes, Monica J. Justice, Helen E. Parkinson, Mark Moore, Sara Wells, Robert E. Braun, Karen L. Svenson, Martin Hrabe de Angelis, Yann Herault, Tim Mohun, Ann-Marie Mallon, R. Mark Henkelman, Steve D.M. Brown, David J. Adams, K.C. Kent Lloyd, Colin McKerlie, Arthur L. Beaudet, Maja Bucan, Stephen A. Murray
Nature. Author manuscript; available in PMC 2017 Mar 14.
Published in final edited form as: Nature. 2016 Sep 22; 537(7621): 508–514. Published online 2016 Sep 14. doi: 10.1038/nature19356
Correction in:
Nature. 2017 Nov 16; 551(7680): 398.
PMCID:
PMC5295821
AbstractArticlePDF–3.0M
9.
Stable liver-specific expression of human IDOL in humanized mice raises plasma cholesterol
Salam Ibrahim, Suryanarayan Somanathan, Jeffrey Billheimer, James M. Wilson, Daniel J. Rader
Cardiovasc Res. 2016 May 1; 110(1): 23–29. Published online 2016 Jan 19. doi: 10.1093/cvr/cvw010
PMCID:
PMC4798044
AbstractArticlePDF–582K
10.
The LXR–Idol axis differentially regulates plasma LDL levels in primates and mice
Cynthia Hong, Stephanie M. Marshall, Allison L. McDaniel, Mark Graham, Joseph D. Layne, Lei Cai, Elena Scotti, Rima Boyadjian, Jason Kim, Brian T. Chamberlain, Rajendra K. Tangirala, Michael E. Jung, Loren Fong, Richard Lee, Stephen G. Young, Ryan E. Temel, Peter Tontonoz
Cell Metab. Author manuscript; available in PMC 2015 Nov 4.
Published in final edited form as: Cell Metab. 2014 Nov 4; 20(5): 910–918. Published online 2014 Nov 4. doi: 10.1016/j.cmet.2014.10.001
PMCID:
PMC4261644
AbstractArticlePDF–1.1M
11.
Structural Basis for Phosphorylation-Dependent Recruitment of Tel2 to Hsp90 by Pih1
Mohinder Pal, Marc Morgan, Sarah E.L. Phelps, S. Mark Roe, Sarah Parry-Morris, Jessica A. Downs, Sigrun Polier, Laurence H. Pearl, Chrisostomos Prodromou
Structure. 2014 Jun 10; 22(6): 805–818. doi: 10.1016/j.str.2014.04.001
PMCID:
PMC4058522
AbstractArticlePDF–4.2M
12.
The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data
Gautier Koscielny, Gagarine Yaikhom, Vivek Iyer, Terrence F. Meehan, Hugh Morgan, Julian Atienza-Herrero, Andrew Blake, Chao-Kung Chen, Richard Easty, Armida Di Fenza, Tanja Fiegel, Mark Grifiths, Alan Horne, Natasha A. Karp, Natalja Kurbatova, Jeremy C. Mason, Peter Matthews, Darren J. Oakley, Asfand Qazi, Jack Regnart, Ahmad Retha, Luis A. Santos, Duncan J. Sneddon, Jonathan Warren, Henrik Westerberg, Robert J. Wilson, David G. Melvin, Damian Smedley, Steve D. M. Brown, Paul Flicek, William C. Skarnes, Ann-Marie Mallon, Helen Parkinson
Nucleic Acids Res. 2014 Jan 1; 42(Database issue): D802–D809. Published online 2013 Nov 3. doi: 10.1093/nar/gkt977
PMCID:
PMC3964955
AbstractArticlePDF–5.7M
13.
IDOL Stimulates Clathrin-Independent Endocytosis and Multivesicular Body-Mediated Lysosomal Degradation of the Low-Density Lipoprotein Receptor
Elena Scotti, Martino Calamai, Chris N. Goulbourne, Li Zhang, Cynthia Hong, Ron R. Lin, Jinkuk Choi, Paul F. Pilch, Loren G. Fong, Peng Zou, Alice Y. Ting, Francesco S. Pavone, Stephen G. Young, Peter Tontonoz
Mol Cell Biol. 2013 Apr; 33(8): 1503–1514. doi: 10.1128/MCB.01716-12
PMCID:
PMC3624246
AbstractArticlePDF–4.8M
14.
FERM-dependent E3 ligase recognition is a conserved mechanism for targeted degradation of lipoprotein receptors
Anna C. Calkin, Benjamin T. Goult, Li Zhang, Louise Fairall, Cynthia Hong, John W. R. Schwabe, Peter Tontonoz
Proc Natl Acad Sci U S A. 2011 Dec 13; 108(50): 20107–20112. Published online 2011 Nov 22. doi: 10.1073/pnas.1111589108
PMCID:
PMC3250164
AbstractArticlePDF–1.2M
15.
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas
Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042
PMCID:
PMC3178059
AbstractArticlePDF–1.0M
16.
Targeted Disruption of the Idol Gene Alters Cellular Regulation of the Low-Density Lipoprotein Receptor by Sterols and Liver X Receptor Agonists
Elena Scotti, Cynthia Hong, Yuko Yoshinaga, Yiping Tu, Yan Hu, Noam Zelcer, Rima Boyadjian, Pieter J. de Jong, Stephen G. Young, Loren G. Fong, Peter Tontonoz
Mol Cell Biol. 2011 May; 31(9): 1885–1893. doi: 10.1128/MCB.01469-10
PMCID:
PMC3133228
AbstractArticlePDF–3.1M
17.
Reduced VLDL clearance in Apoe−/−Npc1−/− mice is associated with increased Pcsk9 and Idol expression and decreased hepatic LDL-receptor levels
Minako Ishibashi, David Masson, Marit Westerterp, Nan Wang, Scott Sayers, Rong Li, Carrie L. Welch, Alan R. Tall
J Lipid Res. 2010 Sep; 51(9): 2655–2663. doi: 10.1194/jlr.M006163
PMCID:
PMC2918447
AbstractArticlePDF–1.0M
18.
The E3 Ubiquitin Ligase IDOL Induces the Degradation of the Low Density Lipoprotein Receptor Family Members VLDLR and ApoER2
Cynthia Hong, Sarah Duit, Pilvi Jalonen, Ruud Out, Lilith Scheer, Vincenzo Sorrentino, Rima Boyadjian, Kees W. Rodenburg, Edan Foley, Laura Korhonen, Dan Lindholm, Johannes Nimpf, Theo J. C. van Berkel, Peter Tontonoz, Noam Zelcer
J Biol Chem. 2010 Jun 25; 285(26): 19720–19726. Published online 2010 Apr 28. doi: 10.1074/jbc.M110.123729
PMCID:
PMC2888382
AbstractArticlePDF–971K
19.
LXR Regulates Cholesterol Uptake through Idol-dependent Ubiquitination of the LDL Receptor
Noam Zelcer, Cynthia Hong, Rima Boyadjian, Peter Tontonoz
Science. Author manuscript; available in PMC 2010 Jan 3.
Published in final edited form as: Science. 2009 Jul 3; 325(5936): 100–104. Published online 2009 Jun 11. doi: 10.1126/science.1168974
PMCID:
PMC2777523
AbstractArticlePDF–2.3M
20.
The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)
Genome Res. 2004 Oct; 14(10b): 2121–2127. doi: 10.1101/gr.2596504
Correction in:
Genome Res. 2006 Jun; 16(6): 804.
PMCID:
PMC528928
AbstractArticlePDF–140K

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