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Items: 1 to 20 of 33

1.
Functionally diverse thymic medullary epithelial cells interplay to direct central tolerance
Aya Ushio, Mami Matsuda-Lennikov, Felix Kalle-Youngoue, Akihide Shimizu, Abdalla Abdelmaksoud, Michael C. Kelly, Naozumi Ishimaru, Yousuke Takahama
Cell Rep. Author manuscript; available in PMC 2024 May 9.
Published in final edited form as: Cell Rep. 2024 Apr 23; 43(4): 114072. Published online 2024 Apr 5. doi: 10.1016/j.celrep.2024.114072
PMCID:
PMC11079940
AbstractArticlePDF–3.1M
2.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
3.
Klf4 protects thymus integrity during late pregnancy
Lucyle Depoërs, Maude Dumont-Lagacé, Vincent Quoc-Huy Trinh, Chloé Houques, Caroline Côté, Jean-David Larouche, Sylvie Brochu, Claude Perreault
Front Immunol. 2023; 14: 1016378. Published online 2023 Apr 27. doi: 10.3389/fimmu.2023.1016378
PMCID:
PMC10174329
AbstractArticlePDF–9.7M
4.
IL-2 and IL-15 drive intrathymic development of distinct periphery-seeding CD4+Foxp3+ regulatory T lymphocytes
Cécile Apert, Ariel O. Galindo-Albarrán, Sarah Castan, Claire Detraves, Héloise Michaud, Nicola McJannett, Bart Haegeman, Simon Fillatreau, Bernard Malissen, Georg Holländer, Saulius Žuklys, Jérémy C. Santamaria, Olivier P. Joffre, Paola Romagnoli, Joost P. M. van Meerwijk
Front Immunol. 2022; 13: 965303. Published online 2022 Sep 8. doi: 10.3389/fimmu.2022.965303
PMCID:
PMC9495261
AbstractArticlePDF–6.3M
5.
Fine-tuning of β-catenin in mouse thymic epithelial cells is required for postnatal T-cell development
Sayumi Fujimori, Izumi Ohigashi, Hayato Abe, Yosuke Matsushita, Toyomasa Katagiri, Makoto M Taketo, Yousuke Takahama, Shinji Takada
eLife. 2022; 11: e69088. Published online 2022 Jan 19. doi: 10.7554/eLife.69088
PMCID:
PMC8769649
AbstractArticlePDF–18M
6.
Ageing compromises mouse thymus function and remodels epithelial cell differentiation
Jeanette Baran-Gale, Michael D Morgan, Stefano Maio, Fatima Dhalla, Irene Calvo-Asensio, Mary E Deadman, Adam E Handel, Ashley Maynard, Steven Chen, Foad Green, Rene V Sit, Norma F Neff, Spyros Darmanis, Weilun Tan, Andy P May, John C Marioni, Chris P Ponting, Georg A Holländer
eLife. 2020; 9: e56221. Published online 2020 Aug 25. doi: 10.7554/eLife.56221
PMCID:
PMC7490013
AbstractArticlePDF–6.0M
7.
NOTCH1 signaling establishes the medullary thymic epithelial cell progenitor pool during mouse fetal development
Jie Li, Julie Gordon, Edward L. Y. Chen, Shiyun Xiao, Luying Wu, Juan Carlos Zúñiga-Pflücker, Nancy R. Manley
Development. 2020 Jun 15; 147(12): dev178988. Published online 2020 Jun 22. doi: 10.1242/dev.178988
PMCID:
PMC7328004
AbstractArticle
8.
PITHD1 is a proteasome-interacting protein essential for male fertilization
Hiroyuki Kondo, Takafumi Matsumura, Mari Kaneko, Kenichi Inoue, Hidetaka Kosako, Masahito Ikawa, Yousuke Takahama, Izumi Ohigashi
J Biol Chem. 2020 Feb 7; 295(6): 1658–1672. Published online 2020 Jan 8. doi: 10.1074/jbc.RA119.011144
PMCID:
PMC7008373
AbstractArticlePDF–2.9M
9.
Trans-omics Impact of Thymoproteasome in Cortical Thymic Epithelial Cells
Izumi Ohigashi, Yu Tanaka, Kenta Kondo, Sayumi Fujimori, Hiroyuki Kondo, Amy C. Palin, Victoria Hoffmann, Mina Kozai, Yosuke Matsushita, Shinsuke Uda, Ryo Motosugi, Jun Hamazaki, Hiroyuki Kubota, Shigeo Murata, Keiji Tanaka, Toyomasa Katagiri, Hidetaka Kosako, Yousuke Takahama
Cell Rep. Author manuscript; available in PMC 2019 Dec 6.
Published in final edited form as: Cell Rep. 2019 Nov 26; 29(9): 2901–2916.e6. doi: 10.1016/j.celrep.2019.10.079
PMCID:
PMC6897492
AbstractArticlePDF–2.7M
10.
Modulation of autoimmune pathogenesis by T cell-triggered inflammatory cell death
Katsuhiro Sasaki, Ai Himeno, Tomoko Nakagawa, Yoshiteru Sasaki, Hiroshi Kiyonari, Kazuhiro Iwai
Nat Commun. 2019; 10: 3878. Published online 2019 Aug 28. doi: 10.1038/s41467-019-11858-7
PMCID:
PMC6713751
AbstractArticlePDF–4.4M
11.
Identification of an intronic regulatory element necessary for tissue-specific expression of Foxn1 in thymic epithelial cells
Brian M. Larsen, Jennifer E. Cowan, Yueqiang Wang, Yu Tanaka, Yongge Zhao, Benjamin Voisin, Michael G. Constantinides, Keisuke Nagao, Yasmine Belkaid, Parirokh Awasthi, Yousuke Takahama, Avinash Bhandoola
J Immunol. Author manuscript; available in PMC 2020 Aug 1.
Published in final edited form as: J Immunol. 2019 Aug 1; 203(3): 686–695. Published online 2019 Jun 26. doi: 10.4049/jimmunol.1801540
PMCID:
PMC6650349
AbstractArticlePDF–1.9M
12.
A human PSMB11 variant affects thymoproteasome processing and CD8+ T cell production
Izumi Ohigashi, Yuki Ohte, Kazuya Setoh, Hiroshi Nakase, Akiko Maekawa, Hiroshi Kiyonari, Yoko Hamazaki, Miho Sekai, Tetsuo Sudo, Yasuharu Tabara, Hiromi Sawai, Yosuke Omae, Rika Yuliwulandari, Yasuhito Tanaka, Masashi Mizokami, Hiroshi Inoue, Masanori Kasahara, Nagahiro Minato, Katsushi Tokunaga, Keiji Tanaka, Fumihiko Matsuda, Shigeo Murata, Yousuke Takahama
JCI Insight. 2017 May 18; 2(10): e93664. Published online 2017 May 18. doi: 10.1172/jci.insight.93664
PMCID:
PMC5436549
AbstractArticlePDF–1.1M
13.
Fgf21 regulates T-cell development in the neonatal and juvenile thymus
Yoshiaki Nakayama, Yuki Masuda, Hiroya Ohta, Tomohiro Tanaka, Miwa Washida, Yo-ichi Nabeshima, Ayumi Miyake, Nobuyuki Itoh, Morichika Konishi
Sci Rep. 2017; 7: 330. Published online 2017 Mar 23. doi: 10.1038/s41598-017-00349-8
PMCID:
PMC5428243
AbstractArticlePDF–4.6M
14.
Foxn1-β5t transcriptional axis controls CD8+ T-cell production in the thymus
Muhammad Myn Uddin, Izumi Ohigashi, Ryo Motosugi, Tomomi Nakayama, Mie Sakata, Jun Hamazaki, Yasumasa Nishito, Immanuel Rode, Keiji Tanaka, Tatsuya Takemoto, Shigeo Murata, Yousuke Takahama
Nat Commun. 2017; 8: 14419. Published online 2017 Feb 8. doi: 10.1038/ncomms14419
PMCID:
PMC5309848
AbstractArticlePDF–1.8M
15.
Foxn1 regulates key target genes essential for T cell development in postnatal thymic epithelial cells
Saulius Žuklys, Adam Handel, Saule Zhanybekova, Fatima Govani, Marcel Keller, Stefano Maio, Carlos E. Mayer, Hong Ying Teh, Katrin Hafen, Giuseppe Gallone, Thomas Barthlott, Chris P. Ponting, Georg A. Holländer
Nat Immunol. Author manuscript; available in PMC 2017 Feb 22.
Published in final edited form as: Nat Immunol. 2016 Oct; 17(10): 1206–1215. Published online 2016 Aug 22. doi: 10.1038/ni.3537
PMCID:
PMC5033077
AbstractArticlePDF–2.4M
16.
Specialized proteasome subunits play an essential role in thymic selection of CD8+ T cells
Eleanor Z. Kincaid, Shigeo Murata, Keiji Tanaka, Kenneth L. Rock
Nat Immunol. Author manuscript; available in PMC 2016 Dec 13.
Published in final edited form as: Nat Immunol. 2016 Aug; 17(8): 938–945. Published online 2016 Jun 13. doi: 10.1038/ni.3480
PMCID:
PMC4955723
AbstractArticlePDF–3.7M
17.
Dynamic spatio‐temporal contribution of single β5t+ cortical epithelial precursors to the thymus medulla
Carlos E. Mayer, Saulius Žuklys, Saule Zhanybekova, Izumi Ohigashi, Hong‐Ying Teh, Stephen N. Sansom, Noriko Shikama‐Dorn, Katrin Hafen, Iain C. Macaulay, Mary E. Deadman, Chris P. Ponting, Yousuke Takahama, Georg A. Holländer
Eur J Immunol. 2016 Apr; 46(4): 846–856. Published online 2016 Jan 18. doi: 10.1002/eji.201545995
PMCID:
PMC4832341
AbstractArticlePDF–2.0M
18.
TCR affinity for thymoproteasome-dependent positively selecting peptides conditions antigen responsiveness in CD8+ T cells
Kensuke Takada, Francois Van Laethem, Yan Xing, Kazuyuki Akane, Haruhiko Suzuki, Shigeo Murata, Keiji Tanaka, Stephen C. Jameson, Alfred Singer, Yousuke Takahama
Nat Immunol. Author manuscript; available in PMC 2016 Mar 29.
Published in final edited form as: Nat Immunol. 2015 Oct; 16(10): 1069–1076. Published online 2015 Aug 24. doi: 10.1038/ni.3237
PMCID:
PMC4810782
AbstractArticlePDF–1.7M
19.
Thymoproteasomes produce unique peptide motifs for positive selection of CD8+ T cells
Katsuhiro Sasaki, Kensuke Takada, Yuki Ohte, Hiroyuki Kondo, Hiroyuki Sorimachi, Keiji Tanaka, Yousuke Takahama, Shigeo Murata
Nat Commun. 2015; 6: 7484. Published online 2015 Jun 23. doi: 10.1038/ncomms8484
PMCID:
PMC4557289
AbstractArticlePDF–802K
20.
The thymic cortical epithelium determines the TCR repertoire of IL-17-producing γδT cells
Takeshi Nitta, Ryunosuke Muro, Yukiko Shimizu, Sachiko Nitta, Hiroyo Oda, Yuki Ohte, Motohito Goto, Rieko Yanobu-Takanashi, Tomoya Narita, Hiroshi Takayanagi, Hisataka Yasuda, Tadashi Okamura, Shigeo Murata, Harumi Suzuki
EMBO Rep. 2015 May; 16(5): 638–653. Published online 2015 Mar 13. doi: 10.15252/embr.201540096
PMCID:
PMC4428049
AbstractArticlePDF–3.2M

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