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Select item 114530471.

Advanced paternal age exacerbates neuroinflammation in offspring via m6A modification-mediated intergenerational inheritance

Yiting Mao, Yicong Meng, Kexin Zou, Ningxin Qin, Yinyu Wang, Jing Yan, PinJia Chen, Yi Cheng, Weihui Shi, Chengliang Zhou, Huixi Chen, Jianzhong Sheng, Xinmei Liu, Jiexue Pan, Hefeng Huang

J Neuroinflammation. 2024; 21: 249. Published online 2024 Oct 4. doi: 10.1186/s12974-024-03248-8

PMCID:: PMC11453047

Abstract Article PDF–8.9M

Select item 112675632.

METTL14‐mediated upregulation of lncRNA HOTAIR represses PP1α expression by promoting H3K4me1 demethylation in oxycodone‐treated mice

Tian‐Cong Liu, Hong‐Xi Li, Yu‐Xiao Wan, Guang Shi, Yun‐Peng Zhao, Yi‐Fei Liu, Xin‐Yu Fan

CNS Neurosci Ther. 2024 Jul; 30(7): e14830. Published online 2024 Jul 24. doi: 10.1111/cns.14830

PMCID:: PMC11267563

Abstract Article PDF–4.2M

Select item 110888933.

Silencing METTL14 alleviates liver injury in non-alcoholic fatty liver disease by regulating mitochondrial homeostasis

Wei Wang, Jun Yan, Long Han, Zi-Lin Zou, Ai-Lei Xu

Biomol Biomed. 2024 Jun 1; 24(3): 505–519. Published online 2024 Jun 1. doi: 10.17305/bb.2023.9698

PMCID:: PMC11088893

Abstract Article PDF–4.6M

Select item 110838484.

METTL14 regulates CD8⁺T-cell activation and immune responses to anti‐PD‐1 therapy in lung cancer

Chongqi Sun, Jian Wang, Huixing Li, Luyao Liu, Yu Lin, Ling Zhang, Xianglong Zu, Yizhi Zhu, Yongqian Shu, Dong Shen, Qiong Wang, Yiqian Liu

World J Surg Oncol. 2024; 22: 128. Published online 2024 May 10. doi: 10.1186/s12957-024-03402-9

PMCID:: PMC11083848

Abstract Article PDF–5.6M

Select item 110443135.

METTL14-mediated N6-methyladenosine modification induces the ferroptosis of hypoxia/reoxygenation-induced cardiomyocytes

Chunyu Zhao, Jianing Li

J Cardiothorac Surg. 2024; 19: 265. Published online 2024 Apr 25. doi: 10.1186/s13019-024-02711-0

PMCID:: PMC11044313

Abstract Article PDF–2.1M

Select item 110215056.

METTL14 downregulation drives S100A4⁺ monocyte-derived macrophages via MyD88/NF-κB pathway to promote MAFLD progression

Yue-fan Wang, Wen-li Zhang, Zhi-xuan Li, Yue Liu, Jian Tan, Hao-zan Yin, Zhi-chao Zhang, Xian-jie Piao, Min-hao Ruan, Zhi-hui Dai, Si-jie Wang, Chen-yang Mu, Ji-hang Yuan, Shu-han Sun, Hui Liu, Fu Yang

Signal Transduct Target Ther. 2024; 9: 91. Published online 2024 Apr 17. doi: 10.1038/s41392-024-01797-1

PMCID:: PMC11021505

Abstract Article PDF–13M

Select item 109176607.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 108447168.

METTL14 promotes IL‐6‐induced viability, glycolysis and inflammation in HaCaT cells via the m6A modification of TRIM27

Yiran Chen, Yanwei Xiang, Xiao Miao, Le Kuai, Xiaojie Ding, Tian Ma, Bin Li, Bin Fan

J Cell Mol Med. 2024 Feb; 28(3): e18085. Published online 2023 Dec 25. doi: 10.1111/jcmm.18085

PMCID:: PMC10844716

Abstract Article PDF–6.0M

Select item 107878379.

METTL14 contributes to acute lung injury by stabilizing NLRP3 expression in an IGF2BP2-dependent manner

Fei Cao, Guojun Chen, Yixin Xu, Xintong Wang, Xiaole Tang, Wenyu Zhang, Xiong Song, Xiaohua Yang, Weian Zeng, Jingdun Xie

Cell Death Dis. 2024 Jan; 15(1): 43. Published online 2024 Jan 13. doi: 10.1038/s41419-023-06407-6

PMCID:: PMC10787837

Abstract Article PDF–8.2M

Select item 1055869910.

Adipose METTL14‐Elicited N⁶‐Methyladenosine Promotes Obesity, Insulin Resistance, and NAFLD Through Suppressing β Adrenergic Signaling and Lipolysis

Qianqian Kang, Xiaorong Zhu, Decheng Ren, Alexander Ky, Ormond A. MacDougald, Robert W. O'Rourke, Liangyou Rui

Adv Sci (Weinh) 2023 Oct; 10(28): 2301645. Published online 2023 Aug 1. doi: 10.1002/advs.202301645

PMCID:: PMC10558699

Abstract Article PDF–4.1M

Select item 1054364311.

Mettl14-mediated m⁶A modification ensures the cell-cycle progression of late-born retinal progenitor cells

Liang Li, Yue Sun, Alexander E. Davis, Sahil H. Shah, Lobna K. Hamed, Man-Ru Wu, Cheng-Hui Lin, Jun B. Ding, Sui Wang

Cell Rep. Author manuscript; available in PMC 2023 Oct 2.

Published in final edited form as: Cell Rep. 2023 Jun 27; 42(6): 112596. Published online 2023 Jun 1. doi: 10.1016/j.celrep.2023.112596

PMCID:: PMC10543643

Abstract Article PDF–3.9M

Select item 1050118612.

METTL14 is a chromatin regulator independent of its RNA N⁶-methyladenosine methyltransferase activity

Xiaoyang Dou, Lulu Huang, Yu Xiao, Chang Liu, Yini Li, Xinning Zhang, Lishan Yu, Ran Zhao, Lei Yang, Chuan Chen, Xianbin Yu, Boyang Gao, Meijie Qi, Yawei Gao, Bin Shen, Shuying Sun, Chuan He, Jun Liu

Protein Cell. 2023 Sep; 14(9): 683–697. Published online 2023 Feb 23. doi: 10.1093/procel/pwad009

PMCID:: PMC10501186

Abstract Article PDF–4.4M

Select item 1007407713.

METTL14 modulates glycolysis to inhibit colorectal tumorigenesis in p53‐wild‐type cells

Yichao Hou, Xintian Zhang, Han Yao, Lidan Hou, Qingwei Zhang, Enwei Tao, Xiaoqiang Zhu, Shanshan Jiang, Yimeng Ren, Xialu Hong, Shiyuan Lu, Xiaoxu Leng, Yile Xie, Yaqi Gao, Yu Liang, Ting Zhong, Bohan Long, Jing‐Yuan Fang, Xiangjun Meng

EMBO Rep. 2023 Apr; 24(4): e56325. Published online 2023 Feb 16. doi: 10.15252/embr.202256325

PMCID:: PMC10074077

Abstract Article PDF–4.6M

Select item 981342914.

Mettl14 mutation restrains liver regeneration by attenuating mitogens derived from non-parenchymal liver cells

Insook Yang, Seung Yeon Oh, Suin Jang, Il Yong Kim, You Me Sung, Je Kyung Seong

BMB Rep. 2022 Dec 31; 55(12): 633–638. Published online 2022 Dec 31. doi: 10.5483/BMBRep.2022.55.12.140

PMCID:: PMC9813429

Abstract Article PDF–1.2M

Select item 980718715.

The Mettl3 epitranscriptomic writer amplifies p53 stress responses

Nitin Raj, Mengxiong Wang, Jose A. Seoane, Richard L. Zhao, Alyssa M. Kaiser, Nancie A. Moonie, Janos Demeter, Anthony M. Boutelle, Craig H. Kerr, Abigail S. Mulligan, Clare Moffatt, Shelya X. Zeng, Hua Lu, Maria Barna, Christina Curtis, Howard Y. Chang, Peter K. Jackson, Laura D. Attardi

Mol Cell. Author manuscript; available in PMC 2023 Jul 7.

Published in final edited form as: Mol Cell. 2022 Jul 7; 82(13): 2370–2384.e10. Published online 2022 May 4. doi: 10.1016/j.molcel.2022.04.010

PMCID:: PMC9807187

Abstract Article PDF–2.7M

Select item 979224316.

METTL14 Regulates Intestine Cellular Senescence through m⁶A Modification of Lamin B Receptor

Zizhen Zhang, Meng Xue, Jingyu Chen, Zhuo Wang, Fangyu Ju, Jiaojiao Ni, Jiawei Sun, Haoyue Wu, Huimei Zheng, Ziwei Lou, Yawen Zhang, Xiaohang Yang, Shujie Chen, Yongmei Xi, Liangjing Wang

Oxid Med Cell Longev. 2022; 2022: 9096436. Published online 2022 Dec 19. doi: 10.1155/2022/9096436

PMCID:: PMC9792243

Abstract Article PDF–2.7M

Select item 962969417.

Mettl14-mediated m6A modification enhances the function of Foxp3⁺ regulatory T cells and promotes allograft acceptance

Yanzhuo Liu, Yinglin Yuan, Zili Zhou, Yuanyuan Cui, Yan Teng, Hao Huang, Hao Yuan, Yanling Zhang, Lu Yang, Gaoping Zhao

Front Immunol. 2022; 13: 1022015. Published online 2022 Oct 19. doi: 10.3389/fimmu.2022.1022015

Correction in:: Front Immunol. 2022; 13: 1112027.

PMCID:: PMC9629694

Abstract Article PDF–13M

Select item 962648318.

Downregulation of METTL14 improves postmenopausal osteoporosis via IGF2BP1 dependent posttranscriptional silencing of SMAD1

Chaoqing Huang, Yuan Wang

Cell Death Dis. 2022 Nov; 13(11): 919. Published online 2022 Nov 1. doi: 10.1038/s41419-022-05362-y

PMCID:: PMC9626483

Abstract Article PDF–6.4M

Select item 949571619.

METTL14-dependent m⁶A modification controls iNKT cell development and function

Liang Cao, Eva Morgun, Samantha Genardi, Lavanya Visvabharathy, Yongyong Cui, Haochu Huang, Chyung-Ru Wang

Cell Rep. Author manuscript; available in PMC 2022 Sep 22.

Published in final edited form as: Cell Rep. 2022 Aug 2; 40(5): 111156. doi: 10.1016/j.celrep.2022.111156

PMCID:: PMC9495716

Abstract Article PDF–2.3M

Select item 949228320.

METTL14 Regulates Osteogenesis of Bone Marrow Mesenchymal Stem Cells via Inducing Autophagy Through m⁶A/IGF2BPs/Beclin-1 Signal Axis

Mingyu He, Hong Lei, Xiaoqi He, Ying Liu, Ao Wang, Zijing Ren, Xiaoyan Liu, Gege Yan, Wenbo Wang, Yang Wang, Guanghui Li, Tong Wang, Jiaying Pu, Zhihua Shen, Yanquan Wang, Jiajie Xie, Weijie Du, Ye Yuan, Lei Yang

Stem Cells Transl Med. 2022 Sep; 11(9): 987–1001. Published online 2022 Aug 18. doi: 10.1093/stcltm/szac049

PMCID:: PMC9492283

Abstract Article PDF–68M

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