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Items: 1 to 20 of 165

1.
Metabolic rewiring during bone development underlies tRNA m7G–associated primordial dwarfism
Qiwen Li, Shuang Jiang, Kexin Lei, Hui Han, Yaqian Chen, Weimin Lin, Qiuchan Xiong, Xingying Qi, Xinyan Gan, Rui Sheng, Yuan Wang, Yarong Zhang, Jieyi Ma, Tao Li, Shuibin Lin, Chenchen Zhou, Demeng Chen, Quan Yuan
J Clin Invest. 2024 Oct 15; 134(20): e177220. Published online 2024 Sep 10. doi: 10.1172/JCI177220
PMCID:
PMC11473147
AbstractArticlePDF–17M
2.
Protein phosphatase 4 maintains the survival of primordial follicles by regulating autophagy in oocytes
Ming-Zhe Dong, Ying-Chun Ouyang, Shi-Cai Gao, Lin-Jian Gu, Jia-Ni Guo, Si-Min Sun, Zhen-Bo Wang, Qing-Yuan Sun
Cell Death Dis. 2024 Sep; 15(9): 658. Published online 2024 Sep 8. doi: 10.1038/s41419-024-07051-4
PMCID:
PMC11381532
AbstractArticlePDF–6.1M
3.
TRIM28 secures skeletal stem cell fate during skeletogenesis by silencing neural gene expression and repressing GREM1/AKT/mTOR signaling axis
Huadie Liu, Ye Liu, Seung-Gi Jin, Jennifer Johnson, Hongwen Xuan, Di Lu, Jianshuang Li, Lukai Zhai, Xianfeng Li, Yaguang Zhao, Minmin Liu, Sonya E.L. Craig, Joseph S. Floramo, Vladimir Molchanov, Jie Li, Jia-Da Li, Connie Krawczyk, Xiaobing Shi, Gerd P. Pfeifer, Tao Yang
Cell Rep. Author manuscript; available in PMC 2024 Aug 22.
Published in final edited form as: Cell Rep. 2023 Jan 31; 42(1): 112012. Published online 2023 Jan 20. doi: 10.1016/j.celrep.2023.112012
PMCID:
PMC11339952
AbstractArticlePDF–4.1M
4.
The chromatin regulator Ankrd11 controls cardiac neural crest cell-mediated outflow tract remodeling and heart function
Yana Kibalnyk, Elia Afanasiev, Ronan M. N. Noble, Adrianne E. S. Watson, Irina Poverennaya, Nicole L. Dittmann, Maria Alexiou, Kara Goodkey, Amanda A. Greenwell, John R. Ussher, Igor Adameyko, James Massey, Daniel Graf, Stephane L. Bourque, Jo Anne Stratton, Anastassia Voronova
Nat Commun. 2024; 15: 4632. Published online 2024 Jul 1. doi: 10.1038/s41467-024-48955-1
PMCID:
PMC11217281
AbstractArticlePDF–6.8M
5.
Protein translation rate determines neocortical neuron fate
Ekaterina Borisova, Andrew G. Newman, Marta Couce Iglesias, Rike Dannenberg, Theres Schaub, Bo Qin, Alexandra Rusanova, Marisa Brockmann, Janina Koch, Marieatou Daniels, Paul Turko, Olaf Jahn, David R. Kaplan, Marta Rosário, Takao Iwawaki, Christian M. T. Spahn, Christian Rosenmund, David Meierhofer, Matthew L. Kraushar, Victor Tarabykin, Mateusz C. Ambrozkiewicz
Nat Commun. 2024; 15: 4879. Published online 2024 Jun 7. doi: 10.1038/s41467-024-49198-w
PMCID:
PMC11161512
AbstractArticlePDF–17M
6.
Ring domains are essential for GATOR2-dependent mTORC1 activation
Cong Jiang, Xiaoming Dai, Shaohui He, Hongfei Zhou, Lan Fang, Jianping Guo, Songlei Liu, Tao Zhang, Weijuan Pan, Haihong Yu, Tianmin Fu, Dali Li, Hiroyuki Inuzuka, Ping Wang, Jianru Xiao, Wenyi Wei
Mol Cell. Author manuscript; available in PMC 2024 Apr 19.
Published in final edited form as: Mol Cell. 2023 Jan 5; 83(1): 74–89.e9. Published online 2022 Dec 16. doi: 10.1016/j.molcel.2022.11.021
PMCID:
PMC11027793
AbstractArticlePDF–3.0M
7.
A BMP-controlled metabolic/epigenetic signaling cascade directs midfacial morphogenesis
Jingwen Yang, Lingxin Zhu, Haichun Pan, Hiroki Ueharu, Masako Toda, Qian Yang, Shawn A. Hallett, Lorin E. Olson, Yuji Mishina
J Clin Invest. 2024 Apr 15; 134(8): e165787. Published online 2024 Mar 11. doi: 10.1172/JCI165787
PMCID:
PMC11014657
AbstractArticlePDF–16M
8.
GLIS3 expression in the thyroid gland in relation to TSH signaling and regulation of gene expression
Hong Soon Kang, Sara A. Grimm, Xiao-Hui Liao, Anton M. Jetten
Cell Mol Life Sci. 2024 Dec; 81(1): 65. Published online 2024 Jan 28. doi: 10.1007/s00018-024-05113-6
PMCID:
PMC10822819
AbstractArticlePDF–5.8M
9.
The translational oscillation in oocyte and early embryo development
Rajan Iyyappan, Daria Aleshkina, Hao Ming, Michal Dvoran, Kianoush Kakavand, Denisa Jansova, Edgar del Llano, Lenka Gahurova, Alexander W Bruce, Tomas Masek, Martin Pospisek, Filip Horvat, Michal Kubelka, Zongliang Jiang, Andrej Susor
Nucleic Acids Res. 2023 Dec 11; 51(22): 12076–12091. Published online 2023 Nov 10. doi: 10.1093/nar/gkad996
PMCID:
PMC10711566
AbstractArticlePDF–2.3M
10.
Impairment of serine transport across the blood–brain barrier by deletion of Slc38a5 causes developmental delay and motor dysfunction
Inna Radzishevsky, Maali Odeh, Oded Bodner, Salman Zubedat, Lihi Shaulov, Maxim Litvak, Kayoko Esaki, Takeo Yoshikawa, Bella Agranovich, Wen-Hong Li, Alex Radzishevsky, Eyal Gottlieb, Avi Avital, Herman Wolosker
Proc Natl Acad Sci U S A. 2023 Oct 17; 120(42): e2302780120. Published online 2023 Oct 9. doi: 10.1073/pnas.2302780120
PMCID:
PMC10589673
AbstractArticlePDF–6.8M
11.
Uncovering a mammalian neural-specific poly(A) binding protein with unique properties
Sahil Sharma, Sam Kajjo, Zineb Harra, Benedeta Hasaj, Victoria Delisle, Debashish Ray, Rodrigo L. Gutierrez, Isabelle Carrier, Claudia Kleinman, Quaid Morris, Timothy R. Hughes, Roderick McInnes, Marc R. Fabian
Genes Dev. 2023 Aug 1; 37(15-16): 760–777. doi: 10.1101/gad.350597.123
PMCID:
PMC10546976
AbstractArticlePDF–5.4M
12.
KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility
Juan Gu, Pingyang Ke, Haokun Guo, Jing Liu, Yan Liu, Xin Tian, Zhuo Huang, Xin Xu, Demei Xu, Yuanlin Ma, Xuefeng Wang, Fei Xiao
Cell Death Differ. 2023 Jul; 30(7): 1726–1741. Published online 2023 May 4. doi: 10.1038/s41418-023-01174-5
PMCID:
PMC10307852
AbstractArticlePDF–8.8M
13.
The RSK2-RPS6 axis promotes axonal regeneration in the peripheral and central nervous systems
Charlotte Decourt, Julia Schaeffer, Beatrice Blot, Antoine Paccard, Blandine Excoffier, Mario Pende, Homaira Nawabi, Stephane Belin
PLoS Biol. 2023 Apr; 21(4): e3002044. Published online 2023 Apr 17. doi: 10.1371/journal.pbio.3002044
PMCID:
PMC10109519
AbstractArticlePDF–5.3M
14.
Mechanosensitive mTORC1 signaling maintains lymphatic valves
Cansaran Saygili Demir, Amélie Sabine, Muyun Gong, Olivier Dormond, Tatiana V. Petrova
J Cell Biol. 2023 Jun 5; 222(6): e202207049. Published online 2023 Apr 10. doi: 10.1083/jcb.202207049
PMCID:
PMC10097975
AbstractArticlePDF–9.6M
15.
Activation of the PI3K/AKT/mTOR Pathway in Cajal–Retzius Cells Leads to Their Survival and Increases Susceptibility to Kainate-Induced Seizures
Nasim Ramezanidoraki, Driss El Ouardi, Margaux Le, Stéphanie Moriceau, Mahboubeh Ahmadi, Dossi Elena, Danae Rolland, Philippe Bun, Gwenaëlle Le Pen, Guillaume Canaud, Nadia Bahi-Buisson, Nathalie Rouach, Rebecca Piskorowski, Alessandra Pierani, Pierre Billuart
Int J Mol Sci. 2023 Mar; 24(6): 5376. Published online 2023 Mar 11. doi: 10.3390/ijms24065376
PMCID:
PMC10048971
AbstractArticlePDF–3.2M
16.
Hepatic ribosomal protein S6 (Rps6) insufficiency results in failed bile duct development and loss of hepatocyte viability; a ribosomopathy-like phenotype that is partially p53-dependent
Sarah A. Comerford, Elizabeth A. Hinnant, Yidong Chen, Robert E. Hammer
PLoS Genet. 2023 Jan; 19(1): e1010595. Published online 2023 Jan 19. doi: 10.1371/journal.pgen.1010595
PMCID:
PMC9888725
AbstractArticlePDF–6.9M
17.
Phosphorylation of the novel mTOR substrate Unkempt regulates cellular morphogenesis
Pranetha Baskaran, Simeon R. Mihaylov, Elin Vinsland, Kriti Shah, Lucy Granat, Sila K. Ultanir, Andrew R. Tee, Jernej Murn, Joseph M. Bateman
J Biol Chem. 2023 Jan; 299(1): 102788. Published online 2022 Dec 9. doi: 10.1016/j.jbc.2022.102788
PMCID:
PMC9852543
AbstractArticlePDF–2.8M
18.
Fine-tuning of mTOR signaling by the UBE4B-KLHL22 E3 ubiquitin ligase cascade in brain development
Xiangxing Kong, Xin Shu, Jiachuan Wang, Dandan Liu, Yingchun Ni, Weiqi Zhao, Lebo Wang, Zhihua Gao, Jiadong Chen, Bing Yang, Xing Guo, Zhiping Wang
Development. 2022 Dec 15; 149(24): dev201286. Published online 2022 Dec 20. doi: 10.1242/dev.201286
PMCID:
PMC9845739
AbstractArticle
19.
Mechanism of cystogenesis by Cd79a-driven, conditional mTOR activation in developing mouse nephrons
Linh Tran Nguyen Truc, Satoshi Matsuda, Akiko Takenouchi, Quynh Tran Thuy Huong, Yui Kotani, Tatsuhiko Miyazaki, Hiroaki Kanda, Katsuhiko Yoshizawa, Hiroyasu Tsukaguchi
Sci Rep. 2023; 13: 508. Published online 2023 Jan 10. doi: 10.1038/s41598-023-27766-2
PMCID:
PMC9832032
AbstractArticlePDF–17M
20.
mTORC1 signaling facilitates differential stem cell differentiation to shape the developing murine lung and is associated with mitochondrial capacity
Kuan Zhang, Erica Yao, Ethan Chuang, Biao Chen, Evelyn Y. Chuang, Pao-Tien Chuang
Nat Commun. 2022; 13: 7252. Published online 2022 Nov 25. doi: 10.1038/s41467-022-34763-y
PMCID:
PMC9700781
AbstractArticlePDF–11M

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