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Select item 112200261.

DOK1 and DOK2 regulate CD8 T cell signaling and memory formation without affecting tumor cell killing

Vladimir Laletin, Pierre-Louis Bernard, Camille Montersino, Yuji Yamanashi, Daniel Olive, Rémy Castellano, Geoffrey Guittard, Jacques A. Nunès

Sci Rep. 2024; 14: 15053. Published online 2024 Jul 1. doi: 10.1038/s41598-024-66075-0

PMCID:: PMC11220026

Abstract Article PDF–1.8M

Select item 88205212.

Introduction to DOK2 and its Potential Role in Cancer

Pei SUN, Rumeng LI, Yingying MENG, Shijun XI, Qinqi WANG, Xiulan YANG, Xiaochun PENG, Jun CAI

Physiol Res. 2021 Oct; 70(5): 671–685. Published online 2021 Sep 10. doi: 10.33549/physiolres.934710

PMCID:: PMC8820521

Abstract Article PDF–1.0M

Select item 79387703.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 63079554.

Compound haploinsufficiency of Dok2 and Dusp4 promotes lung tumorigenesis

Ming Chen, Jiangwen Zhang, Alice H. Berger, Moussa S. Diolombi, Christopher Ng, Jacqueline Fung, Roderick T. Bronson, Mireia Castillo-Martin, Tin Htwe Thin, Carlos Cordon-Cardo, Robin Plevin, Pier Paolo Pandolfi

J Clin Invest. 2019 Jan 2; 129(1): 215–222. Published online 2018 Nov 26. doi: 10.1172/JCI99699

PMCID:: PMC6307955

Abstract Article PDF–9.3M

Select item 55122525.

Dok-1 and Dok-2 Are Required To Maintain Herpes Simplex Virus 1-Specific CD8⁺ T Cells in a Murine Model of Ocular Infection

Soumia Lahmidi, Mitra Yousefi, Slimane Dridi, Pascale Duplay, Angela Pearson

J Virol. 2017 Aug 1; 91(15): e02297-16. Prepublished online 2017 May 10. Published online 2017 Jul 12. doi: 10.1128/JVI.02297-16

PMCID:: PMC5512252

Abstract Article PDF–2.6M

Select item 53082186.

The Proximal Signaling Network of the BCR-ABL1 Oncogene Shows a Modular Organization

Björn Titz, Tracey Low, Evangelia Komisopoulou, Sharon S Chen, Liudmilla Rubbi, Thomas G Graeber

Oncogene. Author manuscript; available in PMC 2017 Feb 14.

Published in final edited form as: Oncogene. 2010 Nov 4; 29(44): 5895–5910. Published online 2010 Aug 9. doi: 10.1038/onc.2010.331

PMCID:: PMC5308218

Abstract Article PDF–3.8M

Select item 49702137.

Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA

Xiaoyun Liu, Yan Jiao, Yanhong Cao, Nan Deng, Yonghui Ma, Karen A. Hasty, Andrew Kang, Hong Chen, John M. Stuart, Weikuan Gu

BMC Immunol. 2016; 17: 25. Published online 2016 Aug 2. doi: 10.1186/s12865-016-0163-y

PMCID:: PMC4970213

Abstract Article PDF–2.5M

Select item 46180868.

The Interleukin-2-mTORc1 Axis Defines the Reciprocal Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells

John P. Ray, Matthew M. Staron, Justin A. Shyer, Ping-Chih Ho, Heather D. Marshall, Simon M. Gray, Brian J. Laidlaw, Koichi Araki, Rafi Ahmed, Susan M. Kaech, Joe Craft

Immunity. Author manuscript; available in PMC 2016 Oct 20.

Published in final edited form as: Immunity. 2015 Oct 20; 43(4): 690–702. Published online 2015 Sep 22. doi: 10.1016/j.immuni.2015.08.017

PMCID:: PMC4618086

Abstract Article PDF–2.2M

Select item 41957879.

Dok1 and Dok2 proteins regulate natural killer cell development and function

Javier Celis-Gutierrez, Marilyn Boyron, Thierry Walzer, Pier Paolo Pandolfi, Stipan Jonjić, Daniel Olive, Marc Dalod, Eric Vivier, Jacques A Nunès

EMBO J. 2014 Sep 1; 33(17): 1928–1940. Published online 2014 Jun 24. doi: 10.15252/embj.201387404

PMCID:: PMC4195787

Abstract Article PDF–1.8M

Select item 393106410.

Dok-2 Adaptor Protein Regulates the Shear-dependent Adhesive Function of Platelet Integrin α_IIbβ₃ in Mice

Sascha C. Hughan, Christopher M. Spring, Simone M. Schoenwaelder, Sharelle Sturgeon, Imala Alwis, Yuping Yuan, James D. McFadyen, Erik Westein, Duncan Goddard, Akiko Ono, Yuji Yamanashi, Warwick S. Nesbitt, Shaun P. Jackson

J Biol Chem. 2014 Feb 21; 289(8): 5051–5060. Published online 2014 Jan 2. doi: 10.1074/jbc.M113.520148

PMCID:: PMC3931064

Abstract Article PDF–1.3M

Select item 382185711.

DOK2 Inhibits EGFR-Mutated Lung Adenocarcinoma

Alice H. Berger, Ming Chen, Alessandro Morotti, Justyna A. Janas, Masaru Niki, Roderick T. Bronson, Barry S. Taylor, Marc Ladanyi, Linda Van Aelst, Katerina Politi, Harold E. Varmus, Pier Paolo Pandolfi

PLoS One. 2013; 8(11): e79526. Published online 2013 Nov 8. doi: 10.1371/journal.pone.0079526

PMCID:: PMC3821857

Abstract Article PDF–1.5M

Select item 357241012.

A conditional knockout resource for the genome–wide study of mouse gene function

William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley

Nature. Author manuscript; available in PMC 2013 Feb 14.

Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163

PMCID:: PMC3572410

Abstract Article PDF–1.1M

Select item 351434113.

Dok2 mediates the CD200Fc attenuation of Aβ-induced changes in glia

Anthony Lyons, Eric J Downer, Derek A Costello, Niamh Murphy, Marina A Lynch

J Neuroinflammation. 2012; 9: 107. Published online 2012 May 29. doi: 10.1186/1742-2094-9-107

PMCID:: PMC3514341

Abstract Article PDF–14M

Select item 331415014.

The inositol 5-phosphatase SHIP-1 and adaptors Dok-1 and 2 play central roles in CD4-mediated inhibitory signaling

Paul M. Waterman, Susanne Marschner, Erin Brandl, John C. Cambier

Immunol Lett. Author manuscript; available in PMC 2013 Mar 30.

Published in final edited form as: Immunol Lett. 2012 Mar 30; 143(1): 122–130. Published online 2012 Feb 24. doi: 10.1016/j.imlet.2012.02.009

PMCID:: PMC3314150

Abstract Article PDF–2.1M

Select item 317805915.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 295644316.

Identification of DOK family genes as lung tumor suppressors

Alice H. Berger, Masaru Niki, Alessandro Morotti, Barry S. Taylor, Nicholas D. Socci, Agnes Viale, Cameron Brennan, Janos Szoke, Noriko Motoi, Paul B. Rothman, Julie Teruya-Feldstein, William L. Gerald, Marc Ladanyi, Pier Paolo Pandolfi

Nat Genet. Author manuscript; available in PMC 2010 Oct 18.

Published in final edited form as: Nat Genet. 2010 Mar; 42(3): 216–223. Published online 2010 Feb 7. doi: 10.1038/ng.527

PMCID:: PMC2956443

Abstract Article PDF–3.5M

Select item 255627017.

Large-scale gene trapping in C57BL/6N mouse embryonic stem cells

Gwenn M. Hansen, Diane C. Markesich, Michael B. Burnett, Qichao Zhu, Karen M. Dionne, Lizabeth J. Richter, Richard H. Finnell, Arthur T. Sands, Brian P. Zambrowicz, Alejandro Abuin

Genome Res. 2008 Oct; 18(10): 1670–1679. doi: 10.1101/gr.078352.108

PMCID:: PMC2556270

Abstract Article PDF–493K

Select item 221302018.

Dok-1 and Dok-2 are negative regulators of lipopolysaccharide-induced signaling

Hisaaki Shinohara, Akane Inoue, Noriko Toyama-Sorimachi, Yoshinori Nagai, Tomoharu Yasuda, Hiromi Suzuki, Reiko Horai, Yoichiro Iwakura, Tadashi Yamamoto, Hajime Karasuyama, Kensuke Miyake, Yuji Yamanashi

J Exp Med. 2005 Feb 7; 201(3): 333–339. doi: 10.1084/jem.20041817

PMCID:: PMC2213020

Abstract Article PDF–1.1M

Select item 221199819.

Role of Dok-1 and Dok-2 in Leukemia Suppression

Masaru Niki, Antonio Di Cristofano, Mingming Zhao, Hiroaki Honda, Hisamaru Hirai, Linda Van Aelst, Carlos Cordon-Cardo, Pier Paolo Pandolfi

J Exp Med. 2004 Dec 20; 200(12): 1689–1695. doi: 10.1084/jem.20041306

PMCID:: PMC2211998

Abstract Article PDF–2.2M

Select item 221199720.

Role of Dok-1 and Dok-2 in Myeloid Homeostasis and Suppression of Leukemia

Tomoharu Yasuda, Masaki Shirakata, Atsushi Iwama, Asuka Ishii, Yasuhiro Ebihara, Mitsujiro Osawa, Kazuho Honda, Hisaaki Shinohara, Katsuko Sudo, Kohichiro Tsuji, Hiromitsu Nakauchi, Yoichiro Iwakura, Hisamaru Hirai, Hideaki Oda, Tadashi Yamamoto, Yuji Yamanashi

J Exp Med. 2004 Dec 20; 200(12): 1681–1687. doi: 10.1084/jem.20041247

PMCID:: PMC2211997

Abstract Article PDF–3.0M

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