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Select item 94819331.

ALS-linked loss of Cyclin-F function affects HSP90

Alexander Siebert, Vanessa Gattringer, Jochen H Weishaupt, Christian Behrends

Life Sci Alliance. 2022 Dec; 5(12): e202101359. Published online 2022 Sep 16. doi: 10.26508/lsa.202101359

PMCID:: PMC9481933

Abstract Article PDF–3.5M

Select item 94370392.

Humanized liver TK-NOG mice with functional deletion of hepatic murine cytochrome P450s as a model for studying human drug metabolism

Shotaro Uehara, Yuichi Iida, Miyuki Ida-Tanaka, Motohito Goto, Kenji Kawai, Masafumi Yamamoto, Yuichiro Higuchi, Satoshi Ito, Riichi Takahashi, Hidetaka Kamimura, Mamoru Ito, Hiroshi Yamazaki, Mitsuo Oshimura, Yasuhiro Kazuki, Hiroshi Suemizu

Sci Rep. 2022; 12: 14907. Published online 2022 Sep 1. doi: 10.1038/s41598-022-19242-0

PMCID:: PMC9437039

Abstract Article PDF–2.0M

Select item 79387703.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 74159914.

BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING)

Kou Motani, Hidetaka Kosako

J Biol Chem. 2020 Aug 7; 295(32): 11174–11183. Published online 2020 Jun 17. doi: 10.1074/jbc.RA120.014323

PMCID:: PMC7415991

Abstract Article PDF–2.0M

Select item 69491335.

Application of a novel regulatable Cre recombinase system to define the role of liver and gut metabolism in drug oral bioavailability

Colin J. Henderson, Lesley A. McLaughlin, Maria Osuna-Cabello, Malcolm Taylor, Ian Gilbert, Aileen W. McLaren, C. Roland Wolf

Biochem J. Author manuscript; available in PMC 2020 Jan 8.

Published in final edited form as: Biochem J. 2015 Feb 1; 465(3): 479–488. doi: 10.1042/BJ20140582

PMCID:: PMC6949133

Abstract Article PDF–1.5M

Select item 63824626.

Application of hepatic cytochrome b₅/P450 reductase null (HBRN) mice to study the role of cytochrome b₅ in the cytochrome P450-mediated bioactivation of the anticancer drug ellipticine

Lindsay Reed, Radek Indra, Iveta Mrizova, Michaela Moserova, Heinz H. Schmeiser, C. Roland Wolf, Colin J. Henderson, Marie Stiborova, David H. Phillips, Volker M. Arlt

Toxicol Appl Pharmacol. 2019 Mar 1; 366: 64–74. doi: 10.1016/j.taap.2019.01.020

PMCID:: PMC6382462

Abstract Article

Select item 62980407.

Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors

Hyeonwoo Kim, Christiane D. Wrann, Mark Jedrychowski, Sara Vidoni, Yukiko Kitase, Kenichi Nagano, Chenhe Zhou, Joshua Chou, Virginia-Jeni A. Parkman, Scott J. Novick, Timothy S. Strutzenberg, Bruce D. Pascal, Phuong T. Le, Daniel J. Brooks, Alexander M. Roche, Kaitlyn K. Gerber, Laura Mattheis, Wenjing Chen, Hua Tu, Mary L. Bouxsein, Patrick R. Griffin, Roland Baron, Clifford J. Rosen, Lynda F. Bonewald, Bruce M. Spiegelman

Cell. Author manuscript; available in PMC 2019 Dec 13.

Published in final edited form as: Cell. 2018 Dec 13; 175(7): 1756–1768.e17. doi: 10.1016/j.cell.2018.10.025

Correction in:: Cell. 2019 Jul 11; 178(2): 507–508.

PMCID:: PMC6298040

Abstract Article PDF–1.2M

Select item 54894818.

A novel humanized mouse lacking murine P450 oxidoreductase for studying human drug metabolism

Mercedes Barzi, Francis P. Pankowicz, Barry Zorman, Xing Liu, Xavier Legras, Diane Yang, Malgorzata Borowiak, Beatrice Bissig-Choisat, Pavel Sumazin, Feng Li, Karl-Dimiter Bissig

Nat Commun. 2017; 8: 39. Published online 2017 Jun 28. doi: 10.1038/s41467-017-00049-x

Correction in:: Nat Commun. 2017; 8: 984.

PMCID:: PMC5489481

Abstract Article PDF–2.3M

Select item 47619219.

Oscillating primary transcripts harbor miRNAs with circadian functions

Haifang Wang, Zenghua Fan, Meng Zhao, Juan Li, Minghua Lu, Wei Liu, Hao Ying, Mofang Liu, Jun Yan

Sci Rep. 2016; 6: 21598. Published online 2016 Feb 22. doi: 10.1038/srep21598

PMCID:: PMC4761921

Abstract Article PDF–1.7M

Select item 414390810.

Significance of Neuronal Cytochrome P450 Activity in Opioid-Mediated Stress-Induced Analgesia

Lindsay B. Hough, Julia W. Nalwalk, Weizhu Yang, Xinxin Ding

Brain Res. Author manuscript; available in PMC 2015 Aug 26.

Published in final edited form as: Brain Res. 2014 Aug 26; 1578: 30–37. Published online 2014 Jul 11. doi: 10.1016/j.brainres.2014.07.007

PMCID:: PMC4143908

Abstract Article PDF–320K

Select item 408043111.

Mice Deficient in Intestinal Epithelium Cytochrome P450 Reductase are Prone to Acute Toxin-induced Mucosal Damage

Sarita Ahlawat, Fang Xie, Yi Zhu, Rebecca D'Hondt, Xinxin Ding, Qing-Yu Zhang, Nicholas J. Mantis

Sci Rep. 2014; 4: 5551. Published online 2014 Jul 3. doi: 10.1038/srep05551

PMCID:: PMC4080431

Abstract Article PDF–1.2M

Select item 385677612.

Pyrethroid activity-based probes for profiling cytochrome P450 activities associated with insecticide interactions

Hanafy M. Ismail, Paul M. O’Neill, David W. Hong, Robert D. Finn, Colin J. Henderson, Aaron T. Wright, Benjamin F. Cravatt, Janet Hemingway, Mark J. I. Paine

Proc Natl Acad Sci U S A. 2013 Dec 3; 110(49): 19766–19771. Published online 2013 Nov 18. doi: 10.1073/pnas.1320185110

PMCID:: PMC3856776

Abstract Article PDF–841K

Select item 378349713.

Conditional Deletion of Cytochrome P450 Reductase in Osteoprogenitor Cells Affects Long Bone and Skull Development in Mice Recapitulating Antley-Bixler Syndrome: Role of a Redox Enzyme in Development

Satya P. Panda, Anyonya R. Guntur, Srikanth R. Polusani, Roberto J. Fajardo, Peter T. Gakunga, Linda J. Roman, Bettie Sue Masters

PLoS One. 2013; 8(9): e75638. Published online 2013 Sep 25. doi: 10.1371/journal.pone.0075638

PMCID:: PMC3783497

Abstract Article PDF–3.4M

Select item 377588214.

The role of renal proximal tubule P450 enzymes in chloroform-induced nephrotoxicity: utility of renal specific P450 reductase knockout mouse models

Senyan Liu, Yunyi Yao, Shijun Lu, Kenneth Aldous, Xinxin Ding, Changlin Mei, Jun Gu

Toxicol Appl Pharmacol. Author manuscript; available in PMC 2014 Oct 1.

Published in final edited form as: Toxicol Appl Pharmacol. 2013 Oct 1; 272(1): 230–237. Published online 2013 Jun 1. doi: 10.1016/j.taap.2013.05.022

PMCID:: PMC3775882

Abstract Article PDF–2.7M

Select item 373104215.

Suppression of cytochrome P450 reductase expression promotes astrocytosis in subventricular zone of adult mice

Yunyi Yao, Senyan Liu, Yue Wang, Weiping Yuan, Xinxin Ding, Tao Cheng, Qin Shen, Jun Gu

Neurosci Lett. Author manuscript; available in PMC 2014 Aug 26.

Published in final edited form as: Neurosci Lett. 2013 Aug 26; 548: 84–89. Published online 2013 May 30. doi: 10.1016/j.neulet.2013.05.043

PMCID:: PMC3731042

Abstract Article PDF–2.1M

Select item 372478016.

Suppression of Cytochrome P450 Reductase Enhances Long-Term Hematopoietic Stem Cell Repopulation Efficiency in Mice

Yan Zhang, Fang Dong, Na Zhang, Hui Cheng, Yakun Pang, Xiaomin Wang, Jing Xu, Xinxin Ding, Tao Cheng, Jun Gu, Weiping Yuan

PLoS One. 2013; 8(7): e69913. Published online 2013 Jul 26. doi: 10.1371/journal.pone.0069913

PMCID:: PMC3724780

Abstract Article PDF–2.5M

Select item 357241017.

A conditional knockout resource for the genome–wide study of mouse gene function

William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley

Nature. Author manuscript; available in PMC 2013 Feb 14.

Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163

PMCID:: PMC3572410

Abstract Article PDF–1.1M

Select item 349426018.

Disruption of P450-mediated vitamin E hydroxylase activities alters vitamin E status in tocopherol supplemented mice and reveals extra-hepatic vitamin E metabolism

Sabrina A. Bardowell, Xinxin Ding, Robert S. Parker

J Lipid Res. 2012 Dec; 53(12): 2667–2676. doi: 10.1194/jlr.M030734

PMCID:: PMC3494260

Abstract Article PDF–1.0M

Select item 343226419.

Network Organization of the Huntingtin Proteomic Interactome in Mammalian Brain

Dyna I. Shirasaki, Erin R. Greiner, Ismael Al-Ramahi, Michelle Gray, Pinmanee Boontheung, Daniel H. Geschwind, Juan Botas, Giovanni Coppola, Steve Horvath, Joseph A. Loo, X. William Yang

Neuron. Author manuscript; available in PMC 2013 Jul 12.

Published in final edited form as: Neuron. 2012 Jul 12; 75(1): 41–57. doi: 10.1016/j.neuron.2012.05.024

PMCID:: PMC3432264

Abstract Article PDF–4.9M

Select item 339383820.

Neurobehavioral abnormalities in a brain-specific NADPH-cytochrome P450 reductase knockout mouse model

Cheng Fang, Valerie J. Bolivar, Jun Gu, Weizhu Yang, Scott O. Zeitlin, Xinxin Ding

Neuroscience. Author manuscript; available in PMC 2013 Aug 30.

Published in final edited form as: Neuroscience. 2012 Aug 30; 218: 170–180. Published online 2012 May 22. doi: 10.1016/j.neuroscience.2012.05.027

PMCID:: PMC3393838

Abstract Article PDF–1.0M

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