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Select item 110731601.

Competitive blocking of LRP4–sclerostin binding interface strongly promotes bone anabolic functions

Svetlana Katchkovsky, Biplab Chatterjee, Chen-Viki Abramovitch-Dahan, Niv Papo, Noam Levaot

Cell Mol Life Sci. 2022 Feb; 79(2): 113. Published online 2022 Jan 31. doi: 10.1007/s00018-022-04127-2

PMCID:: PMC11073160

Abstract Article PDF–1.1M

Select item 108301272.

Sostdc1 suppression in the absence of sclerostin potentiates anabolic action of cortical bone in mice

Roy B. Choi, April M. Hoggatt, Daniel J. Horan, Emily Z. Rogers, Gabriela G. Loots, Alexander G. Robling

J Bone Miner Res. Author manuscript; available in PMC 2024 Jan 31.

Published in final edited form as: J Bone Miner Res. 2023 May; 38(5): 765–774. Published online 2023 Mar 22. doi: 10.1002/jbmr.4798

PMCID:: PMC10830127

Abstract Article PDF–1.9M

Select item 108093893.

Profiles of Wnt pathway gene expression during tooth morphogenesis

Resmi Raju, Jeremie Oliver Piña, Daniela M. Roth, Parna Chattaraj, Fahad K. Kidwai, Fabio R. Faucz, James Iben, Gus Fridell, Ryan K. Dale, Rena N. D’Souza

Front Physiol. 2023; 14: 1316635. Published online 2024 Jan 10. doi: 10.3389/fphys.2023.1316635

PMCID:: PMC10809389

Abstract Article PDF–5.3M

Select item 105021524.

Multimodal spatiotemporal transcriptomic resolution of embryonic palate osteogenesis

Jeremie Oliver Piña, Resmi Raju, Daniela M. Roth, Emma Wentworth Winchester, Parna Chattaraj, Fahad Kidwai, Fabio R. Faucz, James Iben, Apratim Mitra, Kiersten Campbell, Gus Fridell, Caroline Esnault, Justin L. Cotney, Ryan K. Dale, Rena N. D’Souza

Nat Commun. 2023; 14: 5687. Published online 2023 Sep 14. doi: 10.1038/s41467-023-41349-9

PMCID:: PMC10502152

Abstract Article PDF–11M

Select item 103916705.

Peroxisome proliferator activated receptor-γ in osteoblasts controls bone formation and fat mass by regulating sclerostin expression

Soohyun P. Kim, Avery H. Seward, Jean Garcia-Diaz, Nathalie Alekos, Nicole R. Gould, Susan Aja, Joseph P. Stains, Michael J. Wolfgang, Ryan C. Riddle

iScience. 2023 Jul 21; 26(7): 106999. Published online 2023 May 29. doi: 10.1016/j.isci.2023.106999

PMCID:: PMC10391670

Abstract Article PDF–6.4M

Select item 102366256.

Sclerostin blockade promotes bone metastases of Wnt‐responsive breast cancer cells

Toru Hiraga, Kanji Horibe, Masanori Koide, Teruhito Yamashita, Yasuhiro Kobayashi

Cancer Sci. 2023 Jun; 114(6): 2460–2470. Published online 2023 Mar 9. doi: 10.1111/cas.15765

PMCID:: PMC10236625

Abstract Article PDF–5.0M

Select item 101631437.

SOST gene suppression stimulates osteocyte Wnt/β-catenin signaling to prevent bone resorption and attenuates particle-induced osteolysis

Zixue Jiao, Hao Chai, Shendong Wang, Chunguang Sun, Qun Huang, Wei Xu

J Mol Med (Berl) 2023; 101(5): 607–620. Published online 2023 May 1. doi: 10.1007/s00109-023-02319-2

PMCID:: PMC10163143

Abstract Article PDF–9.4M

Select item 100430138.

Effect of sclerostin inactivation in a mouse model of severe dominant osteogenesis imperfecta

Juliana Marulanda, Josephine T. Tauer, Iris Boraschi-Diaz, Ghalib Bardai, Frank Rauch

Sci Rep. 2023; 13: 5010. Published online 2023 Mar 27. doi: 10.1038/s41598-023-32221-3

PMCID:: PMC10043013

Abstract Article PDF–2.3M

Select item 96627989.

Sclerostin ablation prevents aortic valve stenosis in mice

J. Ethan Joll, II, Lance A. Riley, Matthew R. Bersi, Jeffry S. Nyman, W. David Merryman

Am J Physiol Heart Circ Physiol. 2022 Nov 1; 323(5): H1037–H1047. Published online 2022 Oct 14. doi: 10.1152/ajpheart.00355.2022

PMCID:: PMC9662798

Abstract Article

Select item 934588210.

Regulation of sclerostin by the SIRT1 stabilization pathway in osteocytes

Jung-Min Kim, Yeon-Suk Yang, Jun Xie, Oksun Lee, JiHea Kim, Jaehyoung Hong, Brigitte Boldyreff, Odile Filhol, Hyonho Chun, Matthew B. Greenblatt, Guangping Gao, Jae-Hyuck Shim

Cell Death Differ. 2022 Aug; 29(8): 1625–1638. Published online 2022 Feb 15. doi: 10.1038/s41418-022-00952-x

PMCID:: PMC9345882

Abstract Article PDF–4.4M

Select item 932084511.

Suppression of Sost/Sclerostin and Dickkopf‐1 Augment Intervertebral Disc Structure in Mice

Tori Kroon, Neharika Bhadouria, Paul Niziolek, Daniel Edwards, III, Roy Choi, Erica L Clinkenbeard, Alexander Robling, Nilsson Holguin

J Bone Miner Res. 2022 Jun; 37(6): 1156–1169. Published online 2022 Apr 20. doi: 10.1002/jbmr.4546

PMCID:: PMC9320845

Abstract Article PDF–22M

Select item 863975312.

Deletion of Fibroblast growth factor 9 globally and in skeletal muscle results in enlarged tuberosities at sites of deltoid tendon attachments

Connor C. Leek, Jaclyn M. Soulas, Iman Bhattacharya, Elahe Ganji, Ryan C. Locke, Megan C. Smith, Jaysheel D. Bhavsar, Shawn W. Polson, David M. Ornitz, Megan L. Killian

Dev Dyn. Author manuscript; available in PMC 2021 Dec 3.

Published in final edited form as: Dev Dyn. 2021 Dec; 250(12): 1778–1795. Published online 2021 Jun 16. doi: 10.1002/dvdy.383

PMCID:: PMC8639753

Abstract Article PDF–3.1M

Select item 849903213.

Protection From Glucocorticoid-Induced Osteoporosis by Anti-Catabolic Signaling in the Absence of Sost/Sclerostin

Amy Y Sato, Meloney Cregor, Jesus Delgado-Calle, Keith W Condon, Matthew R Allen, Munro Peacock, Lilian I Plotkin, Teresita Bellido

J Bone Miner Res. Author manuscript; available in PMC 2021 Oct 8.

Published in final edited form as: J Bone Miner Res. 2016 Oct; 31(10): 1791–1802. Published online 2016 Jun 5. doi: 10.1002/jbmr.2869

PMCID:: PMC8499032

Abstract Article PDF–1.9M

Select item 849691514.

Bone‐derived sclerostin and Wnt/β‐catenin signaling regulate PDGFRα⁺ adipoprogenitor cell differentiation

Soohyun P. Kim, Hao Da, Lei Wang, Makoto M. Taketo, Mei Wan, Ryan C. Riddle

FASEB J. 2021 Nov; 35(11): e21957. Published online 2021 Oct 4. doi: 10.1096/fj.202100691R

PMCID:: PMC8496915

Abstract Article PDF–1.6M

Select item 843151615.

Sclerostin Depletion Induces Inflammation in the Bone Marrow of Mice

Cristine Donham, Betsabel Chicana, Alexander G. Robling, Asmaa Mohamed, Sonny Elizaldi, Michael Chi, Brian Freeman, Alberto Millan, Deepa K. Murugesh, Nicholas R. Hum, Aimy Sebastian, Gabriela G. Loots, Jennifer O. Manilay

Int J Mol Sci. 2021 Sep; 22(17): 9111. Published online 2021 Aug 24. doi: 10.3390/ijms22179111

PMCID:: PMC8431516

Abstract Article PDF–4.5M

Select item 837414716.

Decreased Sclerostin Secretion in Humans and Mice With Nonalcoholic Fatty Liver Disease

Fangli Zhou, Yan Wang, Yujue Li, Mengjia Tang, Shan Wan, Haoming Tian, Xiang Chen

Front Endocrinol (Lausanne) 2021; 12: 707505. Published online 2021 Aug 5. doi: 10.3389/fendo.2021.707505

PMCID:: PMC8374147

Abstract Article PDF–3.3M

Select item 835533717.

The developing mouse coronal suture at single-cell resolution

D’Juan T. Farmer, Hana Mlcochova, Yan Zhou, Nils Koelling, Guanlin Wang, Neil Ashley, Helena Bugacov, Hung-Jhen Chen, Riana Parvez, Kuo-Chang Tseng, Amy E. Merrill, Robert E. Maxson, Jr., Andrew O. M. Wilkie, J. Gage Crump, Stephen R. F. Twigg

Nat Commun. 2021; 12: 4797. Published online 2021 Aug 10. doi: 10.1038/s41467-021-24917-9

PMCID:: PMC8355337

Abstract Article PDF–9.6M

Select item 825603618.

Stat3 loss in mesenchymal progenitors causes Job syndrome–like skeletal defects by reducing Wnt/β-catenin signaling

Prem Swaroop Yadav, Shuhao Feng, Qian Cong, Hanjun Kim, Yuchen Liu, Yingzi Yang

Proc Natl Acad Sci U S A. 2021 Jun 29; 118(26): e2020100118. Published online 2021 Jun 25. doi: 10.1073/pnas.2020100118

PMCID:: PMC8256036

Abstract Article PDF–3.8M

Select item 811735219.

The Chromatin Regulator Ankrd11 Controls Palate and Cranial Bone Development

Daniela Marta Roth, Pranidhi Baddam, Haiming Lin, Marta Vidal-García, Jose David Aponte, Sarah-Thea De Souza, Devyn Godziuk, Adrianne Eve Scovil Watson, Tim Footz, Nathan F. Schachter, Sean E. Egan, Benedikt Hallgrímsson, Daniel Graf, Anastassia Voronova

Front Cell Dev Biol. 2021; 9: 645386. Published online 2021 Apr 29. doi: 10.3389/fcell.2021.645386

PMCID:: PMC8117352

Abstract Article PDF–1.5M

Select item 799467120.

Kindlin-2 mediates mechanotransduction in bone by regulating expression of Sclerostin in osteocytes

Lei Qin, Xuekun Fu, Jing Ma, Manxia Lin, Peijun Zhang, Yishu Wang, Qinnan Yan, Chu Tao, Wen Liu, Bin Tang, Di Chen, Xiaochun Bai, Huiling Cao, Guozhi Xiao

Commun Biol. 2021; 4: 402. Published online 2021 Mar 25. doi: 10.1038/s42003-021-01950-4