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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 108232782.

SCD1 inhibition enhances the effector functions of CD8⁺ T cells via ACAT1‐dependent reduction of esterified cholesterol

Toshihiro Sugi, Yuki Katoh, Toshikatsu Ikeda, Daichi Seta, Takashi Iwata, Hiroshi Nishio, Masaki Sugawara, Daiki Kato, Kanoko Katoh, Kei Kawana, Tomonori Yaguchi, Yutaka Kawakami, Shuichi Hirai

Cancer Sci. 2024 Jan; 115(1): 48–58. Published online 2023 Oct 25. doi: 10.1111/cas.15999

PMCID:: PMC10823278

Abstract Article PDF–1.4M

Select item 96038603.

The Deubiquitinating Enzyme USP48 Interacts with the Retinal Degeneration-Associated Proteins UNC119a and ARL3

Laura Sánchez-Bellver, Andrea Férriz-Gordillo, Marc Carrillo-Pz, Laura Rabanal, Francesc R. Garcia-Gonzalo, Gemma Marfany

Int J Mol Sci. 2022 Oct; 23(20): 12527. Published online 2022 Oct 19. doi: 10.3390/ijms232012527

PMCID:: PMC9603860

Abstract Article PDF–3.4M

Select item 91701414.

Acat1/Soat1 knockout extends the mutant Npc1 mouse lifespan and ameliorates functional deficiencies in multiple organelles of mutant cells

Maximillian A. Rogers, Catherine C. Y. Chang, Robert A. Maue, Elaina M. Melton, Andrew A. Peden, William S. Garver, Junghoon Lee, Peter Schroen, Mitchell Huang, Ta-Yuan Chang

Proc Natl Acad Sci U S A. 2022 May 3; 119(18): e2201646119. Published online 2022 May 4. doi: 10.1073/pnas.2201646119

PMCID:: PMC9170141

Abstract Article PDF–2.7M

Select item 73698235.

A Dipeptidyl Peptidase-4 Inhibitor Inhibits Foam Cell Formation of Macrophages in Type 1 Diabetes via Suppression of CD36 and ACAT-1 Expression

Michishige Terasaki, Hironori Yashima, Yusaku Mori, Tomomi Saito, Takanori Matsui, Munenori Hiromura, Hideki Kushima, Naoya Osaka, Makoto Ohara, Tomoyasu Fukui, Tsutomu Hirano, Sho-ichi Yamagishi

Int J Mol Sci. 2020 Jul; 21(13): 4811. Published online 2020 Jul 7. doi: 10.3390/ijms21134811

PMCID:: PMC7369823

Abstract Article PDF–991K

Select item 72163716.

Involvement of ABC-transporters and acyltransferase 1 in intracellular cholesterol-mediated autophagy in bovine alveolar macrophages in response to the Bacillus Calmette-Guerin (BCG) infection

Jinrui Xu, Yanbing Zhou, Yi Yang, Cuiping Lv, Xiaoming Liu, Yujiong Wang

BMC Immunol. 2020; 21: 26. Published online 2020 May 12. doi: 10.1186/s12865-020-00356-x

PMCID:: PMC7216371

Abstract Article PDF–1.8M

Select item 69165007.

Enhanced acyl-CoA:cholesterol acyltransferase activity increases cholesterol levels on the lipid droplet surface and impairs adipocyte function

Yanqing Xu, Ximing Du, Nigel Turner, Andrew J. Brown, Hongyuan Yang

J Biol Chem. 2019 Dec 13; 294(50): 19306–19321. Published online 2019 Nov 14. doi: 10.1074/jbc.RA119.011160

PMCID:: PMC6916500

Abstract Article PDF–5.8M

Select item 64028848.

Loss of ACAT1 Attenuates Atherosclerosis Aggravated by Loss of NCEH1 in Bone Marrow-Derived Cells

Hisataka Yamazaki, Manabu Takahashi, Tetsuji Wakabayashi, Kent Sakai, Daisuke Yamamuro, Akihito Takei, Shoko Takei, Shuichi Nagashima, Hiroaki Yagyu, Motohiro Sekiya, Ken Ebihara, Shun Ishibashi

J Atheroscler Thromb. 2019 Mar 1; 26(3): 246–259. doi: 10.5551/jat.44040

PMCID:: PMC6402884

Abstract Article PDF–1.4M

Select item 63466859.

Plasticity in the Glucagon Interactome Reveals Novel Proteins That Regulate Glucagon Secretion in α-TC1-6 Cells

Farzad Asadi, Savita Dhanvantari

Front Endocrinol (Lausanne) 2018; 9: 792. Published online 2019 Jan 18. doi: 10.3389/fendo.2018.00792

PMCID:: PMC6346685

Abstract Article PDF–3.6M

Select item 633346010.

ATG5 is required for B cell polarization and presentation of particulate antigens

Florent Arbogast, Johan Arnold, Philippe Hammann, Lauriane Kuhn, Johana Chicher, Diane Murera, Justine Weishaar, Sylviane Muller, Jean-Daniel Fauny, Frédéric Gros

Autophagy. 2019; 15(2): 280–294. Published online 2018 Sep 22. doi: 10.1080/15548627.2018.1516327

PMCID:: PMC6333460

Abstract Article PDF–2.7M

Select item 631390011.

Proteomic Analysis of the Spinophilin Interactome in Rodent Striatum Following Psychostimulant Sensitization

Darryl S. Watkins, Jason D. True, Amber L. Mosley, Anthony J. Baucum, II

Proteomes. 2018 Dec; 6(4): 53. Published online 2018 Dec 17. doi: 10.3390/proteomes6040053

Correction in:: Proteomes. 2019 Mar; 7(1): 7.

PMCID:: PMC6313900

Abstract Article PDF–2.5M

Select item 624418312.

Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells

Sunyuan Zhang, Nicholas A. Williamson, Marie A. Bogoyevitch

Sci Data. 2018; 5: 180262. Published online 2018 Nov 20. doi: 10.1038/sdata.2018.262

PMCID:: PMC6244183

Abstract Article PDF–753K

Select item 617100813.

Myeloid-specific Acat1 ablation attenuates inflammatory responses in macrophages, improves insulin sensitivity, and suppresses diet-induced obesity

Li-Hao Huang, Elaina M. Melton, Haibo Li, Paul Sohn, DaeYoung Jung, Ching-Yi Tsai, Tian Ma, Hiroyuki Sano, HyeKyung Ha, Randall H. Friedline, Jason K. Kim, Edward Usherwood, Catherine C. Y. Chang, Ta-Yuan Chang

Am J Physiol Endocrinol Metab. 2018 Sep 1; 315(3): E340–E356. Published online 2018 Mar 13. doi: 10.1152/ajpendo.00174.2017

PMCID:: PMC6171008

Abstract Article

Select item 592842514.

In vitro exploration of ACAT contributions to lipid droplet formation during adipogenesis

Yuyan Zhu, Chih-Yu Chen, Junjie Li, Ji-Xin Cheng, Miran Jang, Kee-Hong Kim

J Lipid Res. 2018 May; 59(5): 820–829. Published online 2018 Mar 16. doi: 10.1194/jlr.M081745

PMCID:: PMC5928425

Abstract Article PDF–1.1M

Select item 574647515.

QTL Mapping of Macrophage Cholesterol Metabolism and CRISPR/Cas9 Editing Implicate an ACAT1 Truncation as a Causal Modifier Variant

Qimin Hai, Brian Ritchey, Peggy Robinet, Alexander M. Alzayed, Greg Brubaker, Jinying Zhang, Jonathan D. Smith

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2019 Jan 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2018 Jan; 38(1): 83–91. Published online 2017 Nov 2. doi: 10.1161/ATVBAHA.117.310173

PMCID:: PMC5746475

Abstract Article PDF–1002K

Select item 538122616.

Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function

Tingting Zhang, Wei Du, Andrew F. Wilson, Satoshi H. Namekawa, Paul R. Andreassen, Amom Ruhikanta Meetei, Qishen Pang

Sci Rep. 2017; 7: 45626. Published online 2017 Apr 5. doi: 10.1038/srep45626

PMCID:: PMC5381226

Abstract Article PDF–1.4M

Select item 532570217.

Interaction of tau with the RNA-Binding Protein TIA1 Regulates tau Pathophysiology and Toxicity

Tara Vanderweyde, Daniel J. Apicco, Katherine Youmans-Kidder, Peter E.A. Ash, Casey Cook, Edroaldo Lummertz da Rocha, Karen Jansen-West, Alissa A. Frame, Allison Citro, John D. Leszyk, Pavel Ivanov, Jose F. Abisambra, Martin Steffen, Hu Li, Leonard Petrucelli, Benjamin Wolozin

Cell Rep. Author manuscript; available in PMC 2017 Feb 24.

Published in final edited form as: Cell Rep. 2016 May 17; 15(7): 1455–1466. Published online 2016 May 6. doi: 10.1016/j.celrep.2016.04.045

PMCID:: PMC5325702

Abstract Article PDF–2.1M

Select item 481354918.

Myeloid Acyl-CoA:Cholesterol Acyltransferase 1 Deficiency Reduces Lesion Macrophage Content and Suppresses Atherosclerosis Progression

Li-Hao Huang, Elaina M. Melton, Haibo Li, Paul Sohn, Maximillian A. Rogers, Mary Jo Mulligan-Kehoe, Steven N. Fiering, William F. Hickey, Catherine C. Y. Chang, Ta-Yuan Chang

J Biol Chem. 2016 Mar 18; 291(12): 6232–6244. Published online 2016 Jan 21. doi: 10.1074/jbc.M116.713818

PMCID:: PMC4813549

Abstract Article PDF–2.9M

Select item 452104819.

Integration-independent Transgenic Huntington Disease Fragment Mouse Models Reveal Distinct Phenotypes and Life Span in Vivo

Robert O'Brien, Francesco DeGiacomo, Jennifer Holcomb, Akilah Bonner, Karen L. Ring, Ningzhe Zhang, Khan Zafar, Andreas Weiss, Brenda Lager, Birgit Schilling, Bradford W. Gibson, Sylvia Chen, Seung Kwak, Lisa M. Ellerby

J Biol Chem. 2015 Jul 31; 290(31): 19287–19306. Published online 2015 May 29. doi: 10.1074/jbc.M114.623561

PMCID:: PMC4521048

Abstract Article PDF–3.5M

Select item 451399620.

A compendium of expression patterns of cholesterol biosynthetic enzymes in the mouse embryo

Melda Şişecioğlu, Harun Budak, Lars Geffers, Murat Çankaya, Mehmet Çiftci, Christina Thaller, Gregor Eichele, Ömer İrfan Küfrevioğlu, Hasan Özdemir

J Lipid Res. 2015 Aug; 56(8): 1551–1559. doi: 10.1194/jlr.M059634

PMCID:: PMC4513996

Abstract Article PDF–3.4M

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