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Select item 112476761.

In vivo validation of late‐onset Alzheimer's disease genetic risk factors

Michael Sasner, Christoph Preuss, Ravi S. Pandey, Asli Uyar, Dylan Garceau, Kevin P. Kotredes, Harriet Williams, Adrian L. Oblak, Peter Bor‐Chian Lin, Bridget Perkins, Disha Soni, Cindy Ingraham, Audrey Lee‐Gosselin, Bruce T. Lamb, Gareth R. Howell, Gregory W. Carter

Alzheimers Dement. 2024 Jul; 20(7): 4970–4984. Published online 2024 Apr 30. doi: 10.1002/alz.13840

PMCID:: PMC11247676

Abstract Article PDF–3.3M

Select item 109297482.

Cystin is required for maintaining fibrocystin (FPC) levels and safeguarding proteome integrity in mouse renal epithelial cells: A mechanistic connection between the kidney defects in cpk mice and human ARPKD

Yiming J. Zhang, Chaozhe Yang, Wei Wang, Naoe Harafuji, Piotr Stasiak, P. Darwin Bell, Ljubica Caldovic, Elizabeth Sztul, Lisa M. Guay‐Woodford, Zsuzsanna Bebok

FASEB J. 2023 Jul; 37(7): e23008. Published online 2023 Jun 15. doi: 10.1096/fj.202300100R

PMCID:: PMC10929748

Abstract Article PDF–5.9M

Select item 108218743.

Single-cell multiomics decodes regulatory programs for mouse secondary palate development

Fangfang Yan, Akiko Suzuki, Chihiro Iwaya, Guangsheng Pei, Xian Chen, Hiroki Yoshioka, Meifang Yu, Lukas M. Simon, Junichi Iwata, Zhongming Zhao

Nat Commun. 2024; 15: 821. Published online 2024 Jan 27. doi: 10.1038/s41467-024-45199-x

PMCID:: PMC10821874

Abstract Article PDF–6.4M

Select item 107626504.

Replication stress and defective checkpoints make fallopian tube epithelial cells putative drivers of high-grade serous ovarian cancer

Pamoda Galhenage, Yunlan Zhou, Erica Perry, Brenda Loc, Kelly Fietz, Sonia Iyer, Ferenc Reinhardt, Tiego Da Silva, Vladimir Botchkarev, Jie Chen, Christopher P. Crum, Robert A. Weinberg, Shailja Pathania

Cell Rep. Author manuscript; available in PMC 2024 Jan 3.

Published in final edited form as: Cell Rep. 2023 Oct 31; 42(10): 113144. Published online 2023 Sep 19. doi: 10.1016/j.celrep.2023.113144

PMCID:: PMC10762650

Abstract Article PDF–2.5M

Select item 105793735.

Fibrocystin/Polyductin releases a C-terminal fragment that translocates into mitochondria and suppresses cystogenesis

Rebecca V Walker, Qin Yao, Hangxue Xu, Anthony Maranto, Kristen F Swaney, Sreekumar Ramachandran, Rong Li, Laura Cassina, Brian M Polster, Patricia Outeda, Alessandra Boletta, Terry Watnick, Feng Qian

Nat Commun. 2023; 14: 6513. Published online 2023 Oct 16. doi: 10.1038/s41467-023-42196-4

PMCID:: PMC10579373

Abstract Article PDF–12M

Select item 103908776.

Enhancers of the PAIR4 regulatory module promote distal V_H gene recombination at the Igh locus

Louisa Hill, Markus Jaritz, Hiromi Tagoh, Karina Schindler, Daniela Kostanova‐Poliakova, Qiong Sun, Tanja A Schwickert, Martin Leeb, Meinrad Busslinger

EMBO J. 2023 Aug; 42(15): e112741. Published online 2023 Jun 20. doi: 10.15252/embj.2022112741

PMCID:: PMC10390877

Abstract Article PDF–1.5M

Select item 97188237.

DOT1L regulates chamber-specific transcriptional networks during cardiogenesis and mediates postnatal cell cycle withdrawal

Paola Cattaneo, Michael G. B. Hayes, Nina Baumgarten, Dennis Hecker, Sofia Peruzzo, Galip S. Aslan, Paolo Kunderfranco, Veronica Larcher, Lunfeng Zhang, Riccardo Contu, Gregory Fonseca, Simone Spinozzi, Ju Chen, Gianluigi Condorelli, Stefanie Dimmeler, Marcel H. Schulz, Sven Heinz, Nuno Guimarães-Camboa, Sylvia M. Evans

Nat Commun. 2022; 13: 7444. Published online 2022 Dec 2. doi: 10.1038/s41467-022-35070-2

PMCID:: PMC9718823

Abstract Article PDF–9.4M

Select item 96748538.

Biasing the conformation of ELMO2 reveals that myoblast fusion can be exploited to improve muscle regeneration

Viviane Tran, Sarah Nahlé, Amélie Robert, Inès Desanlis, Ryan Killoran, Sophie Ehresmann, Marie-Pier Thibault, David Barford, Kodi S. Ravichandran, Martin Sauvageau, Matthew J. Smith, Marie Kmita, Jean-François Côté

Nat Commun. 2022; 13: 7077. Published online 2022 Nov 18. doi: 10.1038/s41467-022-34806-4

PMCID:: PMC9674853

Abstract Article PDF–3.6M

Select item 93067809.

Transcription factor mesenchyme homeobox protein 2 (MEOX2) modulates nociceptor function

Tomislav Kokotović, Ewelina M. Lenartowicz, Michiel Langeslag, Cosmin I. Ciotu, Christopher W. Fell, Angelica Scaramuzza, Michael J. M. Fischer, Michaela Kress, Josef M. Penninger, Vanja Nagy

FEBS J. 2022 Jun; 289(12): 3457–3476. Published online 2022 Feb 16. doi: 10.1111/febs.16347

PMCID:: PMC9306780

Abstract Article PDF–1.8M

Select item 880618310.

Differential regulation of cranial and cardiac neural crest by serum response factor and its cofactors

Colin J Dinsmore, Philippe Soriano

eLife. 2022; 11: e75106. Published online 2022 Jan 19. doi: 10.7554/eLife.75106

PMCID:: PMC8806183

Abstract Article PDF–9.5M

Select item 875164011.

The imprinted Igf2-Igf2r axis is critical for matching placental microvasculature expansion to fetal growth

Ionel Sandovici, Aikaterini Georgopoulou, Vicente Pérez-García, Antonia Hufnagel, Jorge López-Tello, Brian Y.H. Lam, Samira N. Schiefer, Chelsea Gaudreau, Fátima Santos, Katharina Hoelle, Giles S.H. Yeo, Keith Burling, Moritz Reiterer, Abigail L. Fowden, Graham J. Burton, Cristina M. Branco, Amanda N. Sferruzzi-Perri, Miguel Constância

Dev Cell. 2022 Jan 10; 57(1): 63–79.e8. doi: 10.1016/j.devcel.2021.12.005

PMCID:: PMC8751640

Abstract Article

Select item 854796312.

NHE6 depletion corrects ApoE4-mediated synaptic impairments and reduces amyloid plaque load

Theresa Pohlkamp, Xunde Xian, Connie H Wong, Murat S Durakoglugil, Gordon Chandler Werthmann, Takaomi C Saido, Bret M Evers, Charles L White, III, Jade Connor, Robert E Hammer, Joachim Herz

eLife. 2021; 10: e72034. Published online 2021 Oct 7. doi: 10.7554/eLife.72034

PMCID:: PMC8547963

Abstract Article PDF–12M

Select item 852828513.

The glucose-sensing transcription factor MLX balances metabolism and stress to suppress apoptosis and maintain spermatogenesis

Patrick A. Carroll, Brian W. Freie, Pei Feng Cheng, Sivakanthan Kasinathan, Haiwei Gu, Theresa Hedrich, James A. Dowdle, Vivek Venkataramani, Vijay Ramani, Xiaoying Wu, Daniel Raftery, Jay Shendure, Donald E. Ayer, Charles H. Muller, Robert N. Eisenman

PLoS Biol. 2021 Oct; 19(10): e3001085. Published online 2021 Oct 20. doi: 10.1371/journal.pbio.3001085

PMCID:: PMC8528285

Abstract Article PDF–7.1M

Select item 844633514.

Protein Kinase R and the Integrated Stress Response drive immunopathology caused by mutations in the RNA deaminase ADAR1

Megan Maurano, Jessica M. Snyder, Caitlin Connelly, Jorge Henao-Mejia, Carmela Sidrauski, Daniel B. Stetson

Immunity. Author manuscript; available in PMC 2022 Sep 14.

Published in final edited form as: Immunity. 2021 Sep 14; 54(9): 1948–1960.e5. Published online 2021 Aug 2. doi: 10.1016/j.immuni.2021.07.001

PMCID:: PMC8446335

Abstract Article PDF–3.6M

Select item 835323615.

Mek1 and Mek2 Functional Redundancy in Erythropoiesis

Laurent Beuret, Simon-Pierre Fortier-Beaulieu, Vincent Rondeau, Sophie Roy, Nicolas Houde, Karl Balabanian, Marion Espéli, Jean Charron

Front Cell Dev Biol. 2021; 9: 639022. Published online 2021 Jul 27. doi: 10.3389/fcell.2021.639022

PMCID:: PMC8353236

Abstract Article PDF–4.3M

Select item 803996816.

The versican-hyaluronan complex provides an essential extracellular matrix niche for Flk1⁺ hematoendothelial progenitors

Sumeda Nandadasa, Anna O’Donnell, Ayako Murao, Yu Yamaguchi, Ronald J. Midura, Lorin Olson, Suneel S. Apte

Matrix Biol. Author manuscript; available in PMC 2022 Mar 1.

Published in final edited form as: Matrix Biol. 2021 Mar; 97: 40–57. Published online 2021 Jan 14. doi: 10.1016/j.matbio.2021.01.002

PMCID:: PMC8039968

Abstract Article PDF–4.4M

Select item 792839117.

Embryonic Expression of Nras^{G 12 D} Leads to Embryonic Lethality and Cardiac Defects

Xiaona You, Myung-Jeom Ryu, Eunjin Cho, Yanzhi Sang, Alisa Damnernsawad, Yun Zhou, Yangang Liu, Jing Zhang, Youngsook Lee

Front Cell Dev Biol. 2021; 9: 633661. Published online 2021 Feb 11. doi: 10.3389/fcell.2021.633661

PMCID:: PMC7928391

Abstract Article PDF–5.2M

Select item 789404718.

The actin-regulatory protein Hem-1 is essential for alveolar macrophage development

Nutthakarn Suwankitwat, Stephen Libby, H. Denny Liggitt, Alan Avalos, Alanna Ruddell, Jason W. Rosch, Heon Park, Brian M. Iritani

J Exp Med. 2021 Apr 5; 218(4): e20200472. Published online 2021 Feb 17. doi: 10.1084/jem.20200472

PMCID:: PMC7894047

Abstract Article PDF–5.4M

Select item 770670819.

FGF signaling regulates development by processes beyond canonical pathways

Ayan T. Ray, Pierre Mazot, J. Richard Brewer, Catarina Catela, Colin J. Dinsmore, Philippe Soriano

Genes Dev. 2020 Dec 1; 34(23-24): 1735–1752. doi: 10.1101/gad.342956.120

Correction in:: Genes Dev. 2021 May 1; 35(9-10): 783.

PMCID:: PMC7706708

Abstract Article PDF–18M

Select item 769888920.

Facilitation of Bone Healing Processes Based on the Developmental Function of Meox2 in Tooth Loss Lesion

Tae-Young Kim, Jae-Kyung Park, Yam Prasad Aryal, Eui-Seon Lee, Sanjiv Neupane, Shijin Sung, Elina Pokharel, Chang-Yeol Yeon, Ji-Youn Kim, Jae-Kwang Jung, Hitoshi Yamamoto, Chang-Hyeon An, Youngkyun Lee, Wern-Joo Sohn, Il-Ho Jang, Seo-Young An, Jae-Young Kim

Int J Mol Sci. 2020 Nov; 21(22): 8701. Published online 2020 Nov 18. doi: 10.3390/ijms21228701