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Items: 1 to 20 of 125

1.
The IFIH1-A946T risk variant promotes diabetes in a sex-dependent manner
Amanda J. Stock, Pierina Gonzalez Paredes, Luciana Previato de Almeida, Stanley D. Kosanke, Srinivaas Chetlur, Hannah Budde, Paul Wakenight, Theresa A. Zwingman, Aaron B.I. Rosen, Eric J. Allenspach, Kathleen J. Millen, Jane H. Buckner, David J. Rawlings, Jacquelyn A. Gorman
Front Immunol. 2024; 15: 1349601. Published online 2024 Feb 29. doi: 10.3389/fimmu.2024.1349601
PMCID:
PMC10937421
AbstractArticlePDF–7.8M
2.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
3.
Aberrant RNA sensing in regulatory T cells causes systemic autoimmunity
Domnica Luca, Sumin Lee, Keiji Hirota, Yasutaka Okabe, Junji Uehori, Kazushi Izawa, Anna-Lisa Lanz, Verena Schütte, Burcu Sivri, Yuta Tsukamoto, Fabian Hauck, Rayk Behrendt, Axel Roers, Takashi Fujita, Ryuta Nishikomori, Min Ae Lee-Kirsch, Hiroki Kato
Sci Adv. 2024 Mar 1; 10(9): eadk0820. Published online 2024 Mar 1. doi: 10.1126/sciadv.adk0820
PMCID:
PMC10906915
AbstractArticlePDF–4.5M
4.
MDA5 RNA-sensing pathway activation by Mycobacterium tuberculosis promotes innate immune subversion and pathogen survival
C. Korin Bullen, Alok K. Singh, Stefanie Krug, Shichun Lun, Preeti Thakur, Geetha Srikrishna, William R. Bishai
JCI Insight. 2023 Oct 23; 8(20): e166242. Published online 2023 Oct 23. doi: 10.1172/jci.insight.166242
PMCID:
PMC10619499
AbstractArticlePDF–1.4M
5.
Long noncoding RNA 1392 regulates MDA5 by interaction with ELAVL1 to inhibit coxsackievirus B5 infection
Jing Li, Jinwei Li, Peiying Teng, Fan Yang, Jihong Zhang, Bo Sun, Wei Chen
Virol Sin. 2023 Oct; 38(5): 699–708. Published online 2023 Aug 3. doi: 10.1016/j.virs.2023.08.001
PMCID:
PMC10590689
AbstractArticlePDF–1.8M
6.
The phenotype of the most common human ADAR1p150 Zα mutation P193A in mice is partially penetrant
Zhen Liang, Alistair M Chalk, Scott Taylor, Ankita Goradia, Jacki E Heraud‐Farlow, Carl R Walkley
EMBO Rep. 2023 May; 24(5): e55835. Published online 2023 Mar 28. doi: 10.15252/embr.202255835
PMCID:
PMC10157378
AbstractArticlePDF–5.6M
7.
MDA5-dependent responses contribute to autoimmune diabetes progression and hindrance
Samuel I. Blum, Jared P. Taylor, Jessie M. Barra, Ashley R. Burg, Qiao Shang, Shihong Qiu, Oren Shechter, Aleah R. Hayes, Todd J. Green, Aron M. Geurts, Yi-Guang Chen, Hubert M. Tse
JCI Insight. 2023 Jan 24; 8(2): e157929. Published online 2023 Jan 24. doi: 10.1172/jci.insight.157929
PMCID:
PMC9977297
AbstractArticlePDF–2.2M
8.
A Study on MDA5 Signaling in Splenic B Cells from an Imiquimod-Induced Lupus Mouse Model with Proteomics
Yu-Jih Su, Fu-An Li, Jim Jinn-Chyuan Sheu, Sung-Chou Li, Shao-Wen Weng, Feng-Chih Shen, Yen-Hsiang Chang, Huan-Yuan Chen, Chia-Wei Liou, Tsu-Kung Lin, Jiin-Haur Chuang, Pei-Wen Wang
Cells. 2022 Nov; 11(21): 3350. Published online 2022 Oct 24. doi: 10.3390/cells11213350
PMCID:
PMC9657434
AbstractArticlePDF–2.4M
9.
ADAR1 mutation causes ZBP1-dependent immunopathology
Nicholas W. Hubbard, Joshua M. Ames, Megan Maurano, Lan H. Chu, Kim Y. Somfleth, Nandan S Gokhale, Margo Werner, Jessica M. Snyder, Katrina Lichauco, Ram Savan, Daniel B. Stetson, Andrew Oberst
Nature. Author manuscript; available in PMC 2023 Jan 20.
Published in final edited form as: Nature. 2022 Jul; 607(7920): 769–775. Published online 2022 Jul 20. doi: 10.1038/s41586-022-04896-7
PMCID:
PMC9339495
AbstractArticlePDF–5.3M
10.
Lung type II alveolar epithelial cells collaborate with CCR2+ inflammatory monocytes in host defense against poxvirus infection
Ning Yang, Joseph M. Luna, Peihong Dai, Yi Wang, Charles M. Rice, Liang Deng
Nat Commun. 2022; 13: 1671. Published online 2022 Mar 29. doi: 10.1038/s41467-022-29308-2
PMCID:
PMC8964745
AbstractArticlePDF–3.8M
11.
TLR2 senses the SARS-CoV-2 envelope protein to produce inflammatory cytokines
Min Zheng, Rajendra Karki, Evan Peter Williams, Dong Yang, Elizabeth Fitzpatrick, Peter Vogel, Colleen Beth Jonsson, Thirumala-Devi Kanneganti
Nat Immunol. Author manuscript; available in PMC 2022 Feb 27.
Published in final edited form as: Nat Immunol. 2021 Jul; 22(7): 829–838. Published online 2021 May 7. doi: 10.1038/s41590-021-00937-x
PMCID:
PMC8882317
AbstractArticlePDF–3.7M
12.
ADAR1 RNA editing regulates endothelial cell functions via the MDA-5 RNA sensing signaling pathway
Xinfeng Guo, Silvia Liu, Rose Yan, Vy Nguyen, Mazen Zenati, Timothy R Billiar, Qingde Wang
Life Sci Alliance. 2022 Mar; 5(3): e202101191. Published online 2021 Dec 30. doi: 10.26508/lsa.202101191
PMCID:
PMC8739526
AbstractArticlePDF–4.2M
13.
Chemotherapy-induced transposable elements activate MDA5 to enhance haematopoietic regeneration
Thomas Clapes, Aikaterini Polyzou, Pia Prater, Sagar, Antonio Morales-Hernández, Mariana Galvao Ferrarini, Natalie Kehrer, Stylianos Lefkopoulos, Veronica Bergo, Barbara Hummel, Nadine Obier, Daniel Maticzka, Anne Bridgeman, Josip S. Herman, Ibrahim Ilik, Lhéanna Klaeylé, Jan Rehwinkel, Shannon McKinney-Freeman, Rolf Backofen, Asifa Akhtar, Nina Cabezas-Wallscheid, Ritwick Sawarkar, Rita Rebollo, Dominic Grün, Eirini Trompouki
Nat Cell Biol. 2021; 23(7): 704–717. Published online 2021 Jul 12. doi: 10.1038/s41556-021-00707-9
Correction in:
Nat Cell Biol. 2021; 23(12): 1338.
PMCID:
PMC8492473
AbstractArticlePDF–6.1M
14.
Antimicrobial immunity impedes CNS vascular repair following brain injury
Panagiotis Mastorakos, Mathew V. Russo, Tianzan Zhou, Kory Johnson, Dorian B. McGavern
Nat Immunol. Author manuscript; available in PMC 2022 Mar 23.
Published in final edited form as: Nat Immunol. 2021 Oct; 22(10): 1280–1293. Published online 2021 Sep 23. doi: 10.1038/s41590-021-01012-1
PMCID:
PMC8488012
AbstractArticlePDF–9.7M
15.
Protein Kinase R and the Integrated Stress Response drive immunopathology caused by mutations in the RNA deaminase ADAR1
Megan Maurano, Jessica M. Snyder, Caitlin Connelly, Jorge Henao-Mejia, Carmela Sidrauski, Daniel B. Stetson
Immunity. Author manuscript; available in PMC 2022 Sep 14.
Published in final edited form as: Immunity. 2021 Sep 14; 54(9): 1948–1960.e5. Published online 2021 Aug 2. doi: 10.1016/j.immuni.2021.07.001
PMCID:
PMC8446335
AbstractArticlePDF–3.6M
16.
Riok3 inhibits the antiviral immune response by facilitating TRIM40-mediated RIG-I and MDA5 degradation
Yong Shen, Kejun Tang, Dongdong Chen, Mengying Hong, Fangfang Sun, SaiSai Wang, Yuehai Ke, Tingting Wu, Ren Sun, Jing Qian, Yushen Du
Cell Rep. Author manuscript; available in PMC 2021 Aug 14.
Published in final edited form as: Cell Rep. 2021 Jun 22; 35(12): 109272. doi: 10.1016/j.celrep.2021.109272
PMCID:
PMC8363743
AbstractArticlePDF–3.2M
17.
RNA editing at a limited number of sites is sufficient to prevent MDA5 activation in the mouse brain
Jung In Kim, Taisuke Nakahama, Ryuichiro Yamasaki, Pedro Henrique Costa Cruz, Tuangtong Vongpipatana, Maal Inoue, Nao Kanou, Yanfang Xing, Hiroyuki Todo, Toshiharu Shibuya, Yuki Kato, Yukio Kawahara
PLoS Genet. 2021 May; 17(5): e1009516. Published online 2021 May 13. doi: 10.1371/journal.pgen.1009516
PMCID:
PMC8118328
AbstractArticlePDF–4.3M
18.
Viral infection of cells within the tumor microenvironment mediates antitumor immunotherapy via selective TBK1-IRF3 signaling
Michael C. Brown, Mubeen M. Mosaheb, Malte Mohme, Zachary P. McKay, Eda K. Holl, Jonathan P. Kastan, Yuanfan Yang, Georgia M. Beasley, E. Shelley Hwang, David M. Ashley, Darell D. Bigner, Smita K. Nair, Matthias Gromeier
Nat Commun. 2021; 12: 1858. Published online 2021 Mar 25. doi: 10.1038/s41467-021-22088-1
PMCID:
PMC7994570
AbstractArticlePDF–5.0M
19.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
20.
MDA5 is an essential vita-PAMP sensor necessary for host resistance against Aspergillus fumigatus
Xi Wang, Alayna K. Caffrey-Carr, Ko-wei Liu, Vanessa Espinosa, Walburga Croteau, Sourabh Dhingra, Amariliz Rivera, Robert A. Cramer, Joshua J. Obar
J Immunol. Author manuscript; available in PMC 2021 Dec 1.
Published in final edited form as: J Immunol. 2020 Dec 1; 205(11): 3058–3070. Published online 2020 Oct 21. doi: 10.4049/jimmunol.2000802
PMCID:
PMC7785165
AbstractArticlePDF–1.9M

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