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Select item 111282131.

Intestinal FGF15 regulates bile acid and cholesterol metabolism but not glucose and energy balance

Nadejda Bozadjieva-Kramer, Jae Hoon Shin, Ziru Li, Alan C. Rupp, Nicole Miller, Stace Kernodle, Nicolas Lanthier, Paulina Henry, Nikhil Seshadri, Andriy Myronovych, Ormond A. MacDougald, Robert W. O’Rourke, Rohit Kohli, Charles F. Burant, Amy E. Rothberg, Randy J. Seeley

JCI Insight. 2024 Apr 8; 9(7): e174164. Published online 2024 Apr 8. doi: 10.1172/jci.insight.174164

PMCID:: PMC11128213

Abstract Article PDF–12M

Select item 109176602.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 106759723.

Gut microbiota-bile acid crosstalk regulates murine lipid metabolism via the intestinal FXR-FGF19 axis in diet-induced humanized dyslipidemia

Hongtao Xu, Fang Fang, Kaizhang Wu, Jiangping Song, Yaqian Li, Xingyu Lu, Juncheng Liu, Liuyang Zhou, Wenqing Yu, Fei Yu, Jie Gao

Microbiome. 2023; 11: 262. Published online 2023 Nov 25. doi: 10.1186/s40168-023-01709-5

PMCID:: PMC10675972

Abstract Article PDF–8.3M

Select item 105485984.

Engineered FGF19^ΔKLB protects against intrahepatic cholestatic liver injury in ANIT-induced and Mdr2-/- mice model

Lu Shi, Tiantian Zhao, Lei Huang, Xiaomin Pan, Tianzhen Wu, Xin Feng, Taoli Chen, Jiamin Wu, Jianlou Niu

BMC Biotechnol. 2023; 23: 43. Published online 2023 Oct 3. doi: 10.1186/s12896-023-00810-9

PMCID:: PMC10548598

Abstract Article PDF–3.0M

Select item 104036405.

Feto-maternal cholesterol transport regulated by β-Klotho–FGF15 axis is essential for fetal growth

Kanako Kobayashi, Kazuko Iwasa, Rika Azuma-Suzuki, Takeshi Kawauchi, Yo-ichi Nabeshima

Life Sci Alliance. 2023 Oct; 6(10): e202301916. Published online 2023 Aug 4. doi: 10.26508/lsa.202301916

PMCID:: PMC10403640

Abstract Article PDF–2.1M

Select item 103596376.

Transgenic mice lacking FGF15/19-SHP phosphorylation display altered bile acids and gut bacteria, promoting nonalcoholic fatty liver disease

Young-Chae Kim, Ming Qi, Xingchen Dong, Sunmi Seok, Hao Sun, Byron Kemper, Ting Fu, Jongsook Kim Kemper

J Biol Chem. 2023 Aug; 299(8): 104946. Published online 2023 Jun 20. doi: 10.1016/j.jbc.2023.104946

PMCID:: PMC10359637

Abstract Article PDF–3.2M

Select item 102536677.

The Midbrain Preisthmus: A Poorly Known Effect of the Isthmic Organizer

Luis Puelles, Matias Hidalgo-Sánchez

Int J Mol Sci. 2023 Jun; 24(11): 9769. Published online 2023 Jun 5. doi: 10.3390/ijms24119769

PMCID:: PMC10253667

Abstract Article PDF–6.8M

Select item 96243748.

TCF7L2 transcriptionally regulates Fgf15 to maintain bile acid and lipid homeostasis through gut-liver crosstalk

Neha Bhat, Fatemehsadat Esteghamat, Bal Krishna Chaube, Kushan Gunawardhana, Mitra Mani, Clay Thames, Dhanpat Jain, Henry N. Ginsberg, Carlos Fernandes-Hernando, Arya Mani

FASEB J. Author manuscript; available in PMC 2023 Mar 1.

Published in final edited form as: FASEB J. 2022 Mar; 36(3): e22185. doi: 10.1096/fj.202101607R

Correction in:: FASEB J. 2022 Mar; 36(3): e22217.

PMCID:: PMC9624374

Abstract Article PDF–4.1M

Select item 91696519.

Single cell enhancer activity distinguishes GABAergic and cholinergic lineages in embryonic mouse basal ganglia

Linda Su-Feher, Anna N. Rubin, Shanni N. Silberberg, Rinaldo Catta-Preta, Kenneth J. Lim, Athena R. Ypsilanti, Iva Zdilar, Christopher S. McGinnis, Gabriel L. McKinsey, Thomas E. Rubino, Jr., Michael J. Hawrylycz, Carol Thompson, Zev J. Gartner, Luis Puelles, Hongkui Zeng, John L. R. Rubenstein, Alex S. Nord

Proc Natl Acad Sci U S A. 2022 Apr 12; 119(15): e2108760119. Published online 2022 Apr 4. doi: 10.1073/pnas.2108760119

PMCID:: PMC9169651

Abstract Article PDF–3.9M

Select item 901940210.

Fibroblast growth factor 19 stimulates water intake

José Ursic-Bedoya, Carine Chavey, Guillaume Desandré, Lucy Meunier, Anne-Marie Dupuy, Iria Gonzalez-Dopeso Reyes, Thierry Tordjmann, Eric Assénat, Urszula Hibner, Damien Gregoire

Mol Metab. 2022 Jun; 60: 101483. Published online 2022 Mar 31. doi: 10.1016/j.molmet.2022.101483

PMCID:: PMC9019402

Abstract Article PDF–1.9M

Select item 870044711.

NPC1L1 Deficiency Suppresses Ileal Fibroblast Growth Factor 15 Expression and Increases Bile Acid Pool Size in High-Fat-Diet-Fed Mice

Lin Jia, Yinyan Ma, Jamie Haywood, Long Jiang, Bingzhong Xue, Hang Shi, Paul A. Dawson, Liqing Yu

Cells. 2021 Dec; 10(12): 3468. Published online 2021 Dec 9. doi: 10.3390/cells10123468

PMCID:: PMC8700447

Abstract Article PDF–1.5M

Select item 865015412.

Wnt1 Lineage Specific Deletion of Gpr161 Results in Embryonic Midbrain Malformation and Failure of Craniofacial Skeletal Development

Sung-Eun Kim, Karla Robles-Lopez, Xuanye Cao, Kristyn Liu, Pooja J. Chothani, Nikitha Bhavani, Lauren Rahman, Saikat Mukhopadhyay, Bogdan J. Wlodarczyk, Richard H. Finnell

Front Genet. 2021; 12: 761418. Published online 2021 Nov 23. doi: 10.3389/fgene.2021.761418

PMCID:: PMC8650154

Abstract Article PDF–2.4M

Select item 837486113.

Hepatic FGF21 preserves thermoregulation and cardiovascular function during bacterial inflammation

Sarah C. Huen, Andrew Wang, Kyle Feola, Reina Desrouleaux, Harding H. Luan, Richard Hogg, Cuiling Zhang, Qing-Jun Zhang, Zhi-Ping Liu, Ruslan Medzhitov

J Exp Med. 2021 Oct 4; 218(10): e20202151. Published online 2021 Aug 18. doi: 10.1084/jem.20202151

PMCID:: PMC8374861

Abstract Article PDF–4.3M

Select item 834648314.

Intestinal-derived FGF15 protects against deleterious effects of vertical sleeve gastrectomy in mice

Nadejda Bozadjieva-Kramer, Jae Hoon Shin, Yikai Shao, Ruth Gutierrez-Aguilar, Ziru Li, Kristy M. Heppner, Samuel Chiang, Sara G. Vargo, Katrina Granger, Darleen A. Sandoval, Ormond A. MacDougald, Randy J. Seeley

Nat Commun. 2021; 12: 4768. Published online 2021 Aug 6. doi: 10.1038/s41467-021-24914-y

PMCID:: PMC8346483

Abstract Article PDF–6.8M

Select item 833600315.

Fgf15 Neurons of the Dorsomedial Hypothalamus Control Glucagon Secretion and Hepatic Gluconeogenesis

Alexandre Picard, Salima Metref, David Tarussio, Wanda Dolci, Xavier Berney, Sophie Croizier, Gwenaël Labouebe, Bernard Thorens

Diabetes. 2021 Jul; 70(7): 1443–1457. Published online 2021 Apr 21. doi: 10.2337/db20-1121

PMCID:: PMC8336003

Abstract Article PDF–4.7M

Select item 831323916.

Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development

Francesco Bedogni, Robert F. Hevner

Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034

PMCID:: PMC8313239

Abstract Article PDF–1.6M

Select item 825156217.

Insights into the etiology and physiopathology of MODY5/HNF1B pancreatic phenotype with a mouse model of the human disease

Evans Quilichini, Mélanie Fabre, Christoffer Nord, Thassadite Dirami, Axelle Le Marec, Silvia Cereghini, Raymond C Pasek, Maureen Gannon, Ulf Ahlgren, Cécile Haumaitre

J Pathol. 2021 May; 254(1): 31–45. Published online 2021 Mar 18. doi: 10.1002/path.5629

PMCID:: PMC8251562

Abstract Article PDF–46M

Select item 803445618.

FGF19 protects skeletal muscle against obesity‐induced muscle atrophy, metabolic derangement and abnormal irisin levels via the AMPK/SIRT‐1/PGC‐α pathway

Ai Guo, Kai Li, Hong‐Chuan Tian, Zhen Fan, Qiu‐Nan Chen, Yun‐Fei Yang, Jing Yu, Yong‐Xin Wu, Qian Xiao

J Cell Mol Med. 2021 Apr; 25(7): 3585–3600. Published online 2021 Mar 10. doi: 10.1111/jcmm.16448

PMCID:: PMC8034456

Abstract Article PDF–3.4M

Select item 795726519.

FGF8 and BMP2 mediated dynamic regulation of dental mesenchyme proliferation and differentiation via Lhx8/Suv39h1 complex

Chen Zhou, Danying Chen, Jianhan Ren, Delan Huang, Runze Li, Haotian Luo, Chenyu Guan, Yang Cao, Weicai Wang

J Cell Mol Med. 2021 Mar; 25(6): 3051–3062. Published online 2021 Feb 13. doi: 10.1111/jcmm.16351

PMCID:: PMC7957265

Abstract Article PDF–2.4M

Select item 790644920.

FGF19 in the Hindbrain Lowers Blood Glucose and Alters Excitability of Vagal Motor Neurons in Hyperglycemic Mice

Jordan B Wean, Bret N Smith

Endocrinology. 2021 Apr; 162(4): bqab021. Published online 2021 Feb 3. doi: 10.1210/endocr/bqab021

PMCID:: PMC7906449

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