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Items: 1 to 20 of 29

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
2.
GPR68 limits the severity of chemical-induced oral epithelial dysplasia
David Shore, Nosakhere Griggs, Vincent Graffeo, A. R. M. Ruhul Amin, Xiang-ming Zha, Yan Xu, Jeremy P. McAleer
Sci Rep. 2023; 13: 353. Published online 2023 Jan 7. doi: 10.1038/s41598-023-27546-y
PMCID:
PMC9825365
AbstractArticlePDF–4.4M
3.
OGR1-dependent regulation of the allergen-induced asthma phenotype
Ajay P. Nayak, Deepak A. Deshpande, Sushrut D. Shah, Dominic R. Villalba, Roslyn Yi, Nadan Wang, Raymond B. Penn
Am J Physiol Lung Cell Mol Physiol. 2021 Dec 1; 321(6): L1044–L1054. Published online 2021 Oct 20. doi: 10.1152/ajplung.00200.2021
PMCID:
PMC8715030
AbstractArticle
4.
GPR68 Contributes to Persistent Acidosis-Induced Activation of AGC Kinases and Tyrosine Phosphorylation in Organotypic Hippocampal Slices
Guokun Zhou, Xiang-ming Zha
Front Neurosci. 2021; 15: 692217. Published online 2021 May 25. doi: 10.3389/fnins.2021.692217
PMCID:
PMC8185064
AbstractArticlePDF–2.1M
5.
RNA-Seq analysis of knocking out the neuroprotective proton-sensitive GPR68 on basal and acute ischemia-induced transcriptome changes and signaling in mouse brain.
Guokun Zhou, Tao Wang, Xiang-ming Zha
FASEB J. Author manuscript; available in PMC 2022 Apr 1.
Published in final edited form as: FASEB J. 2021 Apr; 35(4): e21461. doi: 10.1096/fj.202002511R
PMCID:
PMC7970445
AbstractArticlePDF–2.9M
6.
GPR68 Is a Neuroprotective Proton Receptor in Brain Ischemia
Tao Wang, Guokun Zhou, Mindi He, Yuanyuan Xu, W.G. Rusyniak, Yan Xu, Yonghua Ji, Roger P. Simon, Zhi-Gang Xiong, Xiang-ming Zha
Stroke. 2020 Dec; 51(12): 3690–3700. Published online 2020 Oct 16. doi: 10.1161/STROKEAHA.120.031479
PMCID:
PMC7678672
AbstractArticlePDF–8.9M
7.
The protective role of proton-sensing TDAG8 in the brain injury in a mouse ischemia reperfusion model
Koichi Sato, Ayaka Tobo, Chihiro Mogi, Masayuki Tobo, Nobuhiro Yamane, Masahiko Tosaka, Hideaki Tomura, Dong-Soon Im, Fumikazu Okajima
Sci Rep. 2020; 10: 17193. Published online 2020 Oct 14. doi: 10.1038/s41598-020-74372-7
PMCID:
PMC7566628
AbstractArticlePDF–4.2M
8.
GPR68 deletion impairs hippocampal long-term potentiation and passive avoidance behavior
Yuanyuan Xu, Mike T. Lin, Xiang-ming Zha
Mol Brain. 2020; 13: 132. Published online 2020 Sep 29. doi: 10.1186/s13041-020-00672-8
Correction in:
Mol Brain. 2021; 14: 40.
PMCID:
PMC7526169
AbstractArticlePDF–2.8M
9.
Impaired endothelium-mediated cerebrovascular reactivity promotes anxiety and respiration disorders in mice
Jan Wenzel, Cathrin E. Hansen, Carla Bettoni, Miriam A. Vogt, Beate Lembrich, Rentsenkhand Natsagdorj, Gianna Huber, Josefine Brands, Kjestine Schmidt, Julian C. Assmann, Ines Stölting, Kathrin Saar, Jan Sedlacik, Jens Fiehler, Peter Ludewig, Michael Wegmann, Nina Feller, Marius Richter, Helge Müller-Fielitz, Thomas Walther, Gabriele M. König, Evi Kostenis, Walter Raasch, Norbert Hübner, Peter Gass, Stefan Offermanns, Cor de Wit, Carsten A. Wagner, Markus Schwaninger
Proc Natl Acad Sci U S A. 2020 Jan 21; 117(3): 1753–1761. Published online 2020 Jan 2. doi: 10.1073/pnas.1907467117
PMCID:
PMC6983400
AbstractArticlePDF–3.6M
10.
Regulation of ovarian cancer G protein-coupled receptor-1 expression and signaling
Ajay P. Nayak, Tonio Pera, Deepak A. Deshpande, James V. Michael, Jennifer R. Liberato, Shi Pan, Eric Tompkins, Henry P. Morelli, Roslyn Yi, Nadan Wang, Raymond B. Penn
Am J Physiol Lung Cell Mol Physiol. 2019 May 1; 316(5): L894–L902. Published online 2019 Feb 6. doi: 10.1152/ajplung.00426.2018
PMCID:
PMC6589584
AbstractArticle
11.
GPR68 senses flow and is essential for vascular physiology
Jie Xu, Jayanti Mathur, Emilie Vessières, Scott Hammack, Keiko Nonomura, Julie Favre, Linda Grimaud, Matt Petrus, Allain Francisco, Jingyuan Li, Van Lee, Fu-li Xiang, James K. Mainquist, Stuart M. Cahalan, Anthony P. Orth, John R. Walker, Shang Ma, Viktor Lukacs, Laura Bordone, Michael Bandell, Bryan Laffitte, Yan Xu, Shu Chien, Daniel Henrion, Ardem Patapoutian
Cell. Author manuscript; available in PMC 2019 Apr 19.
Published in final edited form as: Cell. 2018 Apr 19; 173(3): 762–775.e16. doi: 10.1016/j.cell.2018.03.076
PMCID:
PMC5951615
AbstractArticlePDF–1.4M
12.
Functional profiling of microtumors to identify cancer associated fibroblast-derived drug targets
Shane R. Horman, Jeremy To, John Lamb, Jocelyn H. Zoll, Nicole Leonetti, Buu Tu, Rita Moran, Robbin Newlin, John R. Walker, Anthony P. Orth
Oncotarget. 2017 Nov 21; 8(59): 99913–99930. Published online 2017 Oct 20. doi: 10.18632/oncotarget.21915
PMCID:
PMC5725140
AbstractArticlePDF–6.6M
13.
Regulation of breathing by CO2 requires the proton-activated receptor GPR4 in retrotrapezoid nucleus neurons
Natasha N. Kumar, Ana Velic, Jorge Soliz, Yingtang Shi, Keyong Li, Sheng Wang, Janelle L. Weaver, Josh Sen, Stephen B.G. Abbott, Roman M. Lazarenko, Marie-Gabrielle Ludwig, Edward Perez-Reyes, Nilufar Mohebbi, Carla Bettoni, Max Gassmann, Thomas Suply, Klaus Seuwen, Patrice G. Guyenet, Carsten A. Wagner, Douglas A. Bayliss
Science. Author manuscript; available in PMC 2016 Dec 20.
Published in final edited form as: Science. 2015 Jun 12; 348(6240): 1255–1260. Published online 2015 Jun 11. doi: 10.1126/science.aaa0922
PMCID:
PMC5171229
AbstractArticlePDF–1.1M
14.
Mutations in the pH-Sensing G-protein-Coupled Receptor GPR68 Cause Amelogenesis Imperfecta
David A. Parry, Claire E.L. Smith, Walid El-Sayed, James A. Poulter, Roger C. Shore, Clare V. Logan, Chihiro Mogi, Koichi Sato, Fumikazu Okajima, Akihiro Harada, Hong Zhang, Mine Koruyucu, Figen Seymen, Jan C.-C. Hu, James P. Simmer, Mushtaq Ahmed, Hussain Jafri, Colin A. Johnson, Chris F. Inglehearn, Alan J. Mighell
Am J Hum Genet. 2016 Oct 6; 99(4): 984–990. Published online 2016 Sep 29. doi: 10.1016/j.ajhg.2016.08.020
PMCID:
PMC5065684
AbstractArticlePDF–1.1M
15.
Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65
Xi-Ping Huang, Joel Karpiak, Wesley K. Kroeze, Hu Zhu, Xin Chen, Sheryl S. Moy, Kara A. Saddoris, Viktoriya Nikolova, Martilias S. Farrell, Sheng Wang, Thomas J. Mangano, Deepak A. Deshpande, Alice Jiang, Raymond B. Penn, Jian Jin, Beverly H. Koller, Terry Kenakin, Brian K. Shoichet, Bryan L. Roth
Nature. Author manuscript; available in PMC 2016 Nov 26.
Published in final edited form as: Nature. 2015 Nov 26; 527(7579): 477–483. Published online 2015 Nov 9. doi: 10.1038/nature15699
PMCID:
PMC4796946
AbstractArticlePDF–2.2M
16.
Increased bone density in mice lacking the proton receptor, OGR1
Nancy S. Krieger, Zhenqiang Yao, Kelly Kyker-Snowman, Min Ho Kim, Brendan F. Boyce, David A. Bushinsky
Kidney Int. Author manuscript; available in PMC 2017 Mar 1.
Published in final edited form as: Kidney Int. 2016 Mar; 89(3): 565–573. Published online 2016 Jan 6. doi: 10.1016/j.kint.2015.12.020
PMCID:
PMC4757816
AbstractArticlePDF–1.9M
17.
OGR1/GPR68 Modulates the Severity of Experimental Autoimmune Encephalomyelitis and Regulates Nitric Oxide Production by Macrophages
Cheryl A. D’Souza, Fei Linda Zhao, Xujian Li, Yan Xu, Shannon E. Dunn, Li Zhang
PLoS One. 2016; 11(2): e0148439. Published online 2016 Feb 1. doi: 10.1371/journal.pone.0148439
PMCID:
PMC4735495
AbstractArticlePDF–1.6M
18.
Reciprocal regulation of two G protein-coupled receptors sensing extracellular concentrations of Ca2+ and H+
Wei-Chun Wei, Benjamin Jacobs, Esther B. E. Becker, Maike D. Glitsch
Proc Natl Acad Sci U S A. 2015 Aug 25; 112(34): 10738–10743. Published online 2015 Aug 10. doi: 10.1073/pnas.1506085112
PMCID:
PMC4553783
AbstractArticlePDF–1.2M
19.
Regulator of G-protein signaling 2 (RGS2) suppresses premature calcium release in mouse eggs
Miranda L. Bernhardt, Katie M. Lowther, Elizabeth Padilla-Banks, Caitlin E. McDonough, Katherine N. Lee, Alexei V. Evsikov, Tracy F. Uliasz, Peter Chidiac, Carmen J. Williams, Lisa M. Mehlmann
Development. 2015 Aug 1; 142(15): 2633–2640. doi: 10.1242/dev.121707
PMCID:
PMC4529029
AbstractArticle
20.
Proton-Sensing Ovarian Cancer G Protein-Coupled Receptor 1 on Dendritic Cells Is Required for Airway Responses in a Murine Asthma Model
Haruka Aoki, Chihiro Mogi, Takeshi Hisada, Takashi Nakakura, Yosuke Kamide, Isao Ichimonji, Hideaki Tomura, Masayuki Tobo, Koichi Sato, Hiroaki Tsurumaki, Kunio Dobashi, Tetsuya Mori, Akihiro Harada, Masanobu Yamada, Masatomo Mori, Tamotsu Ishizuka, Fumikazu Okajima
PLoS One. 2013; 8(11): e79985. Published online 2013 Nov 11. doi: 10.1371/journal.pone.0079985
PMCID:
PMC3823589
AbstractArticlePDF–2.3M

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