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Items: 1 to 20 of 56

1.
Reduced DEFA5 Expression and STAT3 Activation Underlie the Submucosal Invasion of Early Gastric Cancers
Sayaka Nagao, Yu Takahashi, Tamami Denda, Yukihisa Tanaka, Yuko Miura, Hiroya Mizutani, Daisuke Ohki, Yoshiki Sakaguchi, Seiichi Yakabi, Yosuke Tsuji, Keiko Niimi, Naomi Kakushima, Nobutake Yamamichi, Yasunori Ota, Kazuhiko Koike, Mitsuhiro Fujishiro
Digestion. 2023 Dec; 104(6): 480–493. Published online 2023 Aug 18. doi: 10.1159/000531790
PMCID:
PMC10711770
AbstractArticle
2.
Lower human defensin 5 in elderly people compared to middle-aged is associated with differences in the intestinal microbiota composition: the DOSANCO Health Study
Yu Shimizu, Kiminori Nakamura, Mani Kikuchi, Shigekazu Ukawa, Koshi Nakamura, Emiko Okada, Akihiro Imae, Takafumi Nakagawa, Ryodai Yamamura, Akiko Tamakoshi, Tokiyoshi Ayabe
GeroScience. 2022 Apr; 44(2): 997–1009. Published online 2021 Jun 8. doi: 10.1007/s11357-021-00398-y
PMCID:
PMC9135951
AbstractArticlePDF–927K
3.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
4.
Linking bacterial enterotoxins and alpha defensin 5 expansion in the Crohn’s colitis: A new insight into the etiopathogenetic and differentiation triggers driving colonic inflammatory bowel disease
Tanu Rana, Olga Y. Korolkova, Girish Rachakonda, Amanda D. Williams, Alexander T. Hawkins, Samuel D. James, Amos M. Sakwe, Nian Hui, Li Wang, Chang Yu, Jeffrey S. Goodwin, Michael G. Izban, Regina S. Offodile, Mary K. Washington, Billy R. Ballard, Duane T. Smoot, Xuan-Zheng Shi, Digna S. Forbes, Anil Shanker, Amosy E. M’Koma
PLoS One. 2021; 16(3): e0246393. Published online 2021 Mar 9. doi: 10.1371/journal.pone.0246393
Correction in:
PLoS One. 2024; 19(5): e0304732.
PMCID:
PMC7942995
AbstractArticlePDF–2.0M
5.
The inhibitory effect of human DEFA5 in growth of gastric cancer by targeting BMI1
Zhongwei Wu, Zhaohui Ding, Bo Cheng, Zongchao Cui
Cancer Sci. 2021 Mar; 112(3): 1075–1083. Published online 2021 Feb 15. doi: 10.1111/cas.14827
PMCID:
PMC7935777
AbstractArticlePDF–1.1M
6.
An alpha-defensin gene single nucleotide polymorphism modulates the gut microbiota and may alter the risk of acute graft-versus-host disease
Armin Rashidi, Adam Herman, Antonio LC Gomes, Jonathan U. Peled, Robert R. Jenq, Daniel G. Brereton, Christopher Staley, Bruce R. Blazar, Daniel J. Weisdorf
Br J Haematol. Author manuscript; available in PMC 2021 Jun 1.
Published in final edited form as: Br J Haematol. 2020 Jun; 189(5): 926–930. Published online 2020 Feb 21. doi: 10.1111/bjh.16458
PMCID:
PMC7536617
AbstractArticlePDF–344K
7.
A reference map of the human binary protein interactome
Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood
Nature. Author manuscript; available in PMC 2020 Oct 8.
Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x
PMCID:
PMC7169983
AbstractArticlePDF–5.4M
8.
Upregulated Expression of Intestinal Antimicrobial Peptide HD5 Associated with Renal Function in IgA Nephropathy
Shaozhen Feng, Zhong Zhong, Jinjin Fan, Xiaoyan Li, Dianchun Shi, Lanping Jiang
Dis Markers. 2020; 2020: 2078279. Published online 2020 Feb 5. doi: 10.1155/2020/2078279
Correction in:
Dis Markers. 2022; 2022: 9797825.
PMCID:
PMC7025039
AbstractArticlePDF–806K
9.
Human Enteric Defensin 5 Promotes Shigella Infection of Macrophages
Dan Xu, Chongbing Liao, Jiu Xiao, Kun Fang, Wei Zhang, Weirong Yuan, Wuyuan Lu
Infect Immun. 2020 Jan; 88(1): e00769-19. Prepublished online 2019 Oct 14. Published online 2019 Dec 17. doi: 10.1128/IAI.00769-19
PMCID:
PMC6921650
AbstractArticlePDF–2.0M
10.
Paneth cell α-defensins HD-5 and HD-6 display differential degradation into active antimicrobial fragments
D. Ehmann, J. Wendler, L. Koeninger, I. S. Larsen, T. Klag, J. Berger, A. Marette, M. Schaller, E. F. Stange, N. P. Malek, B. A. H. Jensen, J. Wehkamp
Proc Natl Acad Sci U S A. 2019 Feb 26; 116(9): 3746–3751. Published online 2019 Feb 11. doi: 10.1073/pnas.1817376116
PMCID:
PMC6397583
AbstractArticlePDF–1.1M
11.
Age-of-Diagnosis Dependent Ileal Immune Intensification and Reduced Alpha-Defensin in Older versus Younger Pediatric Crohn Disease Patients despite Already Established Dysbiosis
Yael Haberman, Melanie Schirmer, Phillip J. Dexheimer, Rebekah Karns, Tzipi Braun, Mi-Ok Kim, Thomas D. Walters, Robert N. Baldassano, Joshua D Noe, Joel Rosh, James Markowitz, Wallace V. Crandall, David R. Mack, Anne M. Griffiths, Melvin B. Heyman, Susan S. Baker, Richard Kellermayer, Dedrick Moulton, Ashish S. Patel, Ajay S. Gulati, Steven J Steiner, Neal LeLeiko, Anthony Otley, Maria Oliva-Hemker, David Ziring, Barbara S Kirschner, David J Keljo, Stephen L. Guthery, Stanley A Cohen, Scott Snapper, Jonathan Evans, Marla Dubinsky, Bruce Aronow, Jeffrey S. Hyams, Subra Kugathasan, Curtis Huttenhower, Ramnik J. Xavier, Lee A. Denson
Mucosal Immunol. Author manuscript; available in PMC 2019 Jun 12.
Published in final edited form as: Mucosal Immunol. 2019 Mar; 12(2): 491–502. Published online 2018 Dec 12. doi: 10.1038/s41385-018-0114-4
PMCID:
PMC6375755
AbstractArticlePDF–2.0M
12.
Recipient single nucleotide polymorphisms in Paneth cell antimicrobial peptide genes and acute graft-versus-host disease: Analysis of BMT CTN-0201 and -0901 samples
Armin Rashidi, Ryan Shanley, Sophia L. Yohe, Bharat Thyagarajan, Julie Curtsinger, Claudio Anasetti, Edmund K. Waller, Bart L. Scott, Bruce R. Blazar, Daniel J. Weisdorf
Br J Haematol. Author manuscript; available in PMC 2019 Sep 1.
Published in final edited form as: Br J Haematol. 2018 Sep; 182(6): 887–894. Published online 2018 Jul 13. doi: 10.1111/bjh.15492
PMCID:
PMC6128755
AbstractArticlePDF–465K
13.
Alpha‐defensins (α‐Defs) in Crohn's disease: decrease of ileal α‐Def 5 via permanent methylation and increase in plasma α‐Def 1‐3 concentrations offering biomarker utility
E. Cerrillo, I. Moret, M. Iborra, D. Ramos, E. Busó, L. Tortosa, E. Sáez‐González, P. Nos, B. Beltrán
Clin Exp Immunol. 2018 Apr; 192(1): 120–128. Published online 2018 Jan 10. doi: 10.1111/cei.13085
PMCID:
PMC5842403
AbstractArticlePDF–511K
14.
Human alpha defensin 5 is a candidate biomarker to delineate inflammatory bowel disease
Amanda D. Williams, Olga Y. Korolkova, Amos M. Sakwe, Timothy M. Geiger, Samuel D. James, Roberta L. Muldoon, Alan J. Herline, J. Shawn Goodwin, Michael G. Izban, Mary K. Washington, Duane T. Smoot, Billy R. Ballard, Maria Gazouli, Amosy E. M'Koma
PLoS One. 2017; 12(8): e0179710. Published online 2017 Aug 17. doi: 10.1371/journal.pone.0179710
Correction in:
PLoS One. 2017; 12(12): e0189551.
PMCID:
PMC5560519
AbstractArticlePDF–24M
15.
Architecture of the human interactome defines protein communities and disease networks
Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper
Nature. Author manuscript; available in PMC 2017 Nov 17.
Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366
PMCID:
PMC5531611
AbstractArticlePDF–2.7M
16.
Functional intersection of Human Defensin 5 with the TNF receptor pathway
Wuyuan Lu, Erik de Leeuw
FEBS Lett. Author manuscript; available in PMC 2017 Mar 31.
Published in final edited form as: FEBS Lett. 2014 May 21; 588(10): 1906–1912. Published online 2014 Mar 26. doi: 10.1016/j.febslet.2014.03.028
PMCID:
PMC5374975
AbstractArticlePDF–796K
17.
Studies on the Interaction of Tumor-Derived HD5 Alpha Defensins with Adenoviruses and Implications for Oncolytic Adenovirus Therapy
Charles Vragniau, Jens-Martin Hübner, Peter Beidler, Sucheol Gil, Kamola Saydaminova, Zhuo-Zhuang Lu, Roma Yumul, Hongjie Wang, Maximilian Richter, Pavel Sova, Charles Drescher, Pascal Fender, André Lieber
J Virol. 2017 Mar 15; 91(6): e02030-16. Prepublished online 2017 Jan 11. Published online 2017 Feb 28. doi: 10.1128/JVI.02030-16
PMCID:
PMC5331826
AbstractArticlePDF–2.9M
18.
Visualizing Attack of Escherichia coli by the Antimicrobial Peptide Human Defensin 5
Haritha R. Chileveru, Shion A. Lim, Phoom Chairatana, Andrew J. Wommack, I-Ling Chiang, Elizabeth M. Nolan
Biochemistry. Author manuscript; available in PMC 2017 Jan 27.
Published in final edited form as: Biochemistry. 2015 Mar 10; 54(9): 1767–1777. Published online 2015 Mar 2. doi: 10.1021/bi501483q
PMCID:
PMC5270551
AbstractArticlePDF–1.7M
19.
α-Defensin HD5 Inhibits Human Papillomavirus 16 Infection via Capsid Stabilization and Redirection to the Lysosome
Mayim E. Wiens, Jason G. Smith
mBio. 2017 Jan-Feb; 8(1): e02304-16. Published online 2017 Jan 24. doi: 10.1128/mBio.02304-16
PMCID:
PMC5263252
AbstractArticlePDF–2.6M
20.
hORFeome v3.1: A resource of human open reading frames representing over 10,000 human genes
Philippe Lamesch, Ning Li, Stuart Milstein, Changyu Fan, Tong Hao, Gabor Szabo, Zhenjun Hu, Kavitha Venkatesan, Graeme Bethel, Paul Martin, Jane Rogers, Stephanie Lawlor, Stuart McLaren, Amélie Dricot, Heather Borick, Michael E. Cusick, Jean Vandenhaute, Ian Dunham, David E. Hill, Marc Vidal
Genomics. 2007 Mar; 89(3): 307–315. doi: 10.1016/j.ygeno.2006.11.012
PMCID:
PMC4647941
AbstractArticle

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