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Select item 114765311.

Knock-Out of IKKepsilon Ameliorates Atherosclerosis and Fatty Liver Disease by Alterations of Lipid Metabolism in the PCSK9 Model in Mice

Ulrike Weiss, Eleonora Mungo, Michelle Haß, Denis Benning, Robert Gurke, Lisa Hahnefeld, Erika Dorochow, Jessica Schlaudraff, Tobias Schmid, Silvia Kuntschar, Sofie Meyer, Rebekka Medert, Marc Freichel, Gerd Geisslinger, Ellen Niederberger

Int J Mol Sci. 2024 Oct; 25(19): 10721. Published online 2024 Oct 5. doi: 10.3390/ijms251910721

PMCID:: PMC11476531

Abstract Article PDF–2.6M

Select item 114469122.

IKKε-deficient macrophages impede cardiac repair after myocardial infarction by enhancing the macrophage–myofibroblast transition

Hyang Hee Cho, Siyeon Rhee, Dong Im Cho, Ju Hee Jun, HyoJung Heo, Su Han Cho, Dohyup Kim, Mingqiang Wang, Bo Gyeong Kang, Soo Ji Yoo, Meeyoung Cho, Soo yeon Lim, Jae Yeong Cho, In Seok Jeong, Yong Sook Kim, Youngkeun Ahn

Exp Mol Med. 2024 Sep; 56(9): 2052–2064. Published online 2024 Sep 12. doi: 10.1038/s12276-024-01304-0

PMCID:: PMC11446912

Abstract Article PDF–5.9M

Select item 108495993.

Atypical inflammatory kinase IKBKE phosphorylates and inactivates FoxA1 to promote liver tumorigenesis

Bing Gao, Xueji Wu, Lang Bu, Qiwei Jiang, Lei Wang, Haining Liu, Xiaomei Zhang, Yuanzhong Wu, Xiaoxing Li, Jingting Li, Ying Liang, Lixia Xu, Wei Xie, Jianping Guo

Sci Adv. 2024 Feb 9; 10(6): eadk2285. Published online 2024 Feb 7. doi: 10.1126/sciadv.adk2285

PMCID:: PMC10849599

Abstract Article PDF–5.3M

Select item 107619004.

IKKε and TBK1 prevent RIPK1 dependent and independent inflammation

Remzi Onur Eren, Göksu Gökberk Kaya, Robin Schwarzer, Manolis Pasparakis

Nat Commun. 2024; 15: 130. Published online 2024 Jan 2. doi: 10.1038/s41467-023-44372-y

PMCID:: PMC10761900

Abstract Article PDF–6.9M

Select item 106660355.

Mitochondria-associated membrane collapse impairs TBK1-mediated proteostatic stress response in ALS

Seiji Watanabe, Yuri Murata, Yasuyoshi Oka, Kotaro Oiwa, Mai Horiuchi, Yohei Iguchi, Okiru Komine, Akira Sobue, Masahisa Katsuno, Tomoo Ogi, Koji Yamanaka

Proc Natl Acad Sci U S A. 2023 Nov 21; 120(47): e2315347120. Published online 2023 Nov 15. doi: 10.1073/pnas.2315347120

PMCID:: PMC10666035

Abstract Article PDF–8.9M

Select item 101914416.

USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities

Chao Liu, Lingang Sun, Yijun Tan, Qi Wang, Tao Luo, Chenlu Li, Nan Yao, Yuting Xie, Xiao Yi, Yi Zhu, Tiannan Guo, Junfeng Ji

Sci Adv. 2023 May; 9(20): eade3888. Published online 2023 May 17. doi: 10.1126/sciadv.ade3888

PMCID:: PMC10191441

Abstract Article PDF–2.4M

Select item 89031957.

The RNA helicase DHX16 recognizes specific viral RNA to trigger RIG-I-dependent innate antiviral immunity

Adam Hage, Preeti Bharaj, Sarah van Tol, Maria I. Giraldo, Maria Gonzalez-Orozco, Karl M. Valerdi, Abbey N. Warren, Leopoldo Aguilera-Aguirre, Xuping Xie, Steven G. Widen, Hong M. Moulton, Benhur Lee, Jeffrey R. Johnson, Nevan J. Krogan, Adolfo García-Sastre, Pei-Yong Shi, Alexander N. Freiberg, Ricardo Rajsbaum

Cell Rep. 2022 Mar 8; 38(10): 110434. Published online 2022 Mar 8. doi: 10.1016/j.celrep.2022.110434

PMCID:: PMC8903195

Abstract Article PDF–5.7M

Select item 84638958.

TBK1 and IKKε act like an OFF switch to limit NLRP3 inflammasome pathway activation

Fabian A. Fischer, Linda F. M. Mies, Sohaib Nizami, Eirini Pantazi, Sara Danielli, Benjamin Demarco, Michael Ohlmeyer, Michelle Sue Jann Lee, Cevayir Coban, Jonathan C. Kagan, Elena Di Daniel, Jelena S. Bezbradica

Proc Natl Acad Sci U S A. 2021 Sep 21; 118(38): e2009309118. Published online 2021 Sep 13. doi: 10.1073/pnas.2009309118

PMCID:: PMC8463895

Abstract Article PDF–1.5M

Select item 81215079.

FGF21 is required for the metabolic benefits of IKKε/TBK1 inhibition

Shannon M. Reilly, Mohammad Abu-Odeh, Magdalene Ameka, Julia H. DeLuca, Meghan C. Naber, Benyamin Dadpey, Nima Ebadat, Andrew V. Gomez, Xiaoling Peng, BreAnne Poirier, Elyse Walk, Matthew J. Potthoff, Alan R. Saltiel

J Clin Invest. 2021 May 17; 131(10): e145546. Published online 2021 May 17. doi: 10.1172/JCI145546

PMCID:: PMC8121507

Abstract Article PDF–2.6M

Select item 788651410.

I-κB Kinase-ε Deficiency Attenuates the Development of Angiotensin II-Induced Myocardial Hypertrophy in Mice

Yide Cao, Liangpeng Li, Yafeng Liu, Ganyi Chen, Zhonghao Tao, Rui Wang, Wen Chen

Oxid Med Cell Longev. 2021; 2021: 6429197. Published online 2021 Feb 8. doi: 10.1155/2021/6429197

PMCID:: PMC7886514

Abstract Article PDF–2.1M

Select item 753346911.

IKKε deficiency inhibits acute lung injury following renal ischemia reperfusion injury

Chao Meng, Yi Qian, Cui Zhang, Han Liu, Xinwei Mu, Aiping Zhang

Mol Med Rep. 2020 Nov; 22(5): 4213–4220. Published online 2020 Sep 22. doi: 10.3892/mmr.2020.11532

PMCID:: PMC7533469

Abstract Article PDF–770K

Select item 738274812.

A Novel Molecular Mechanism of IKKε-Mediated Akt/mTOR Inhibition in the Cardiomyocyte Autophagy after Myocardial Infarction

Shuai He, Jian Shen, Liangpeng Li, Yueyue Xu, Yide Cao, Li Yin, Zhonghao Tao, Zhibing Qiu, Wen Chen, Xin Chen

Oxid Med Cell Longev. 2020; 2020: 7046923. Published online 2020 Jul 16. doi: 10.1155/2020/7046923

PMCID:: PMC7382748

Abstract Article PDF–3.4M

Select item 699875113.

IKK Epsilon Deficiency Attenuates Angiotensin II-Induced Abdominal Aortic Aneurysm Formation in Mice by Inhibiting Inflammation, Oxidative Stress, and Apoptosis

Hao Chai, ZhongHao Tao, YongChao Qi, HaoYu Qi, Wen Chen, YueYue Xu, LeiYang Zhang, HongWei Chen, Xin Chen

Oxid Med Cell Longev. 2020; 2020: 3602824. Published online 2020 Jan 22. doi: 10.1155/2020/3602824

PMCID:: PMC6998751

Abstract Article PDF–2.8M

Select item 698579014.

Hepatic IKKε expression is dispensable for high-fat feeding-induced increases in liver lipid content and alterations in glucose tolerance

J. Jason Collier, Heidi M. Batdorf, Tamra M. Mendoza, David H. Burk, Thomas M. Martin, Jingying Zhang, Randall L. Mynatt, Susan J. Burke

Am J Physiol Endocrinol Metab. 2020 Jan 1; 318(1): E11–E21. Published online 2019 Oct 29. doi: 10.1152/ajpendo.00309.2019

PMCID:: PMC6985790

Abstract Article

Select item 671062915.

Innate Immune Signaling Organelles Display Natural and Programmable Signaling Flexibility

Yunhao Tan, Jonathan C. Kagan

Cell. Author manuscript; available in PMC 2020 Apr 4.

Published in final edited form as: Cell. 2019 Apr 4; 177(2): 384–398.e11. Published online 2019 Mar 7. doi: 10.1016/j.cell.2019.01.039

PMCID:: PMC6710629

Abstract Article PDF–1.2M

Select item 643083116.

Microbial recognition by GEF-H1 controls IKKε mediated activation of IRF5

Yun Zhao, Rachid Zagani, Sung-Moo Park, Naohiro Yoshida, Pankaj Shah, Hans-Christian Reinecker

Nat Commun. 2019; 10: 1349. Published online 2019 Mar 22. doi: 10.1038/s41467-019-09283-x

PMCID:: PMC6430831

Abstract Article PDF–3.4M

Select item 634848717.

Reciprocal regulation of STING and TCR signaling by mTORC1 for T-cell activation and function

Takayuki Imanishi, Midori Unno, Wakana Kobayashi, Natsumi Yoneda, Satoshi Matsuda, Kazutaka Ikeda, Takayuki Hoshii, Atsushi Hirao, Kensuke Miyake, Glen N Barber, Makoto Arita, Ken J Ishii, Shizuo Akira, Takashi Saito

Life Sci Alliance. 2019 Feb; 2(1): e201800282. Published online 2019 Jan 25. doi: 10.26508/lsa.201800282

PMCID:: PMC6348487

Abstract Article PDF–2.2M

Select item 626810018.

TBK1 and IKKε prevent TNF-induced cell death by RIPK1 phosphorylation

Elodie Lafont, Peter Draber, Eva Rieser, Matthias Reichert, Sebastian Kupka, Diego de Miguel, Helena Draberova, Anne von Mässenhausen, Amandeep Bhamra, Stephen Henderson, Katarzyna Wojdyla, Avigayil Chalk, Silvia Surinova, Andreas Linkermann, Henning Walczak

Nat Cell Biol. Author manuscript; available in PMC 2019 May 12.

Published in final edited form as: Nat Cell Biol. 2018 Dec; 20(12): 1389–1399. Published online 2018 Nov 12. doi: 10.1038/s41556-018-0229-6

PMCID:: PMC6268100

Abstract Article PDF–2.8M

Select item 609412519.

Eda-activated RelB recruits an SWI/SNF (BAF) chromatin-remodeling complex and initiates gene transcription in skin appendage formation

Jian Sima, Zhijiang Yan, Yaohui Chen, Elin Lehrmann, Yongqing Zhang, Ramaiah Nagaraja, Weidong Wang, Zhong Wang, David Schlessinger

Proc Natl Acad Sci U S A. 2018 Aug 7; 115(32): 8173–8178. Published online 2018 Jul 23. doi: 10.1073/pnas.1800930115

PMCID:: PMC6094125

Abstract Article PDF–1.5M

Select item 608262820.

IL-17 receptor-associated adaptor Act1 directly stabilizes mRNAs to mediate IL-17 inflammatory signaling

Tomasz Herjan, Lingzi Hong, Jodi Bubenik, Katarzyna Bulek, Wen Qian, Caini Liu, Xiao Li, Xing Chen, Hui Yang, Suidong Ouyang, Hao Zhou, Junjie Zhao, Vasu Komireddy, Eric Cockman, Mark Aronica, Kewal Asosingh, Donny D. Licatalosi, Jun Qin, Paul L. Fox, Thomas A. Hamilton, Donna Driscoll, Xiaoxia Li

Nat Immunol. Author manuscript; available in PMC 2018 Sep 21.

Published in final edited form as: Nat Immunol. 2018 Apr; 19(4): 354–365. Published online 2018 Mar 21. doi: 10.1038/s41590-018-0071-9

PMCID:: PMC6082628

Abstract Article PDF–1.5M

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