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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 106177692.

Dietary potassium stimulates Ppp1Ca-Ppp1r1a dephosphorylation of kidney NaCl cotransporter and reduces blood pressure

P. Richard Grimm, Anamaria Tatomir, Lena L. Rosenbaek, Bo Young Kim, Dimin Li, Eric J. Delpire, Robert A. Fenton, Paul A. Welling

J Clin Invest. 2023 Nov 1; 133(21): e158498. Published online 2023 Nov 1. doi: 10.1172/JCI158498

PMCID:: PMC10617769

Abstract Article PDF–6.3M

Select item 98723283.

B cell–intrinsic requirement for WNK1 kinase in antibody responses in mice

Darryl A. Hayward, Lesley Vanes, Stefanie Wissmann, Sujana Sivapatham, Harald Hartweger, Joshua Biggs O’May, Leonard L. de Boer, Richard Mitter, Robert Köchl, Jens V. Stein, Victor L.J. Tybulewicz

J Exp Med. 2023 Mar 6; 220(3): e20211827. Published online 2023 Jan 20. doi: 10.1084/jem.20211827

PMCID:: PMC9872328

Abstract Article PDF–6.8M

Select item 96649074.

Impaired neurogenesis alters brain biomechanics in a neuroprogenitor-based genetic subtype of congenital hydrocephalus

Phan Q. Duy, Stefan C. Weise, Claudia Marini, Xiao-Jun Li, Dan Liang, Peter J. Dahl, Shaojie Ma, Ana Spajic, Weilai Dong, Jane Juusola, Emre Kiziltug, Adam J. Kundishora, Sunil Koundal, Maysam Z. Pedram, Lucia A. Torres-Fernández, Kristian Händler, Elena De Domenico, Matthias Becker, Thomas Ulas, Stefan A. Juranek, Elisa Cuevas, Le Thi Hao, Bettina Jux, André M. M. Sousa, Fuchen Liu, Suel-Kee Kim, Mingfeng Li, Yiying Yang, Yutaka Takeo, Alvaro Duque, Carol Nelson-Williams, Yonghyun Ha, Kartiga Selvaganesan, Stephanie M. Robert, Amrita K. Singh, Garrett Allington, Charuta G. Furey, Andrew T. Timberlake, Benjamin C. Reeves, Hannah Smith, Ashley Dunbar, Tyrone DeSpenza, Jr., June Goto, Arnaud Marlier, Andres Moreno-De-Luca, Xin Yu, William E. Butler, Bob S. Carter, Evelyn M. R. Lake, R. Todd Constable, Pasko Rakic, Haifan Lin, Engin Deniz, Helene Benveniste, Nikhil S. Malvankar, Juvianee I. Estrada-Veras, Christopher A. Walsh, Seth L. Alper, Joachim L. Schultze, Katrin Paeschke, Angelika Doetzlhofer, F. Gregory Wulczyn, Sheng Chih Jin, Richard P. Lifton, Nenad Sestan, Waldemar Kolanus, Kristopher T. Kahle

Nat Neurosci. Author manuscript; available in PMC 2022 Nov 15.

Published in final edited form as: Nat Neurosci. 2022 Apr; 25(4): 458–473. Published online 2022 Apr 4. doi: 10.1038/s41593-022-01043-3

PMCID:: PMC9664907

Abstract Article PDF–6.3M

Select item 94819335.

ALS-linked loss of Cyclin-F function affects HSP90

Alexander Siebert, Vanessa Gattringer, Jochen H Weishaupt, Christian Behrends

Life Sci Alliance. 2022 Dec; 5(12): e202101359. Published online 2022 Sep 16. doi: 10.26508/lsa.202101359

PMCID:: PMC9481933

Abstract Article PDF–3.5M

Select item 87707446.

Low Salt Delivery Triggers Autocrine Release of Prostaglandin E2 From the Aldosterone-Sensitive Distal Nephron in Familial Hyperkalemic Hypertension Mice

Ava M. Zapf, Paul R. Grimm, Lama Al-Qusairi, Eric Delpire, Paul A. Welling

Front Physiol. 2021; 12: 787323. Published online 2022 Jan 6. doi: 10.3389/fphys.2021.787323

PMCID:: PMC8770744

Abstract Article PDF–1.7M

Select item 81748087.

Roles of WNK4 and SPAK in K⁺-mediated dephosphorylation of the NaCl cotransporter

Anindit Mukherjee, Chao-Ling Yang, James A. McCormick, Kevin Martz, Avika Sharma, David H. Ellison

Am J Physiol Renal Physiol. 2021 May 1; 320(5): F719–F733. Published online 2021 Mar 15. doi: 10.1152/ajprenal.00459.2020

PMCID:: PMC8174808

Abstract Article

Select item 79387708.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 78855629.

SPAK-p38 MAPK signal pathway modulates claudin-18 and barrier function of alveolar epithelium after hyperoxic exposure

Chih-Hao Shen, Jr-Yu Lin, Cheng-Yo Lu, Sung-Sen Yang, Chung-Kan Peng, Kun-Lun Huang

BMC Pulm Med. 2021; 21: 58. Published online 2021 Feb 15. doi: 10.1186/s12890-021-01408-7

PMCID:: PMC7885562

Abstract Article PDF–3.0M

Select item 759126010.

Critical role of WNK1 in MYC-dependent early mouse thymocyte development

Robert Köchl, Lesley Vanes, Miriam Llorian Sopena, Probir Chakravarty, Harald Hartweger, Kathryn Fountain, Andrea White, Jennifer Cowan, Graham Anderson, Victor LJ Tybulewicz

eLife. 2020; 9: e56934. Published online 2020 Oct 14. doi: 10.7554/eLife.56934

PMCID:: PMC7591260

Abstract Article PDF–2.2M

Select item 734391311.

Stimulatory Role of SPAK Signaling in the Regulation of Large Conductance Ca²⁺-Activated Potassium (BK) Channel Protein Expression in Kidney

Ye Bi, Chunmei Li, Yiqian Zhang, Yunman Wang, Shan Chen, Qiang Yue, Robert S. Hoover, Xiaonan H. Wang, Eric Delpire, Douglas C. Eaton, Jieqiu Zhuang, Hui Cai

Front Physiol. 2020; 11: 638. Published online 2020 Jul 2. doi: 10.3389/fphys.2020.00638

PMCID:: PMC7343913

Abstract Article PDF–1.6M

Select item 729503312.

Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant

Meagan A. Quinlan, Matthew J. Robson, Ran Ye, Kristie L. Rose, Kevin L. Schey, Randy D. Blakely

Front Mol Neurosci. 2020; 13: 89. Published online 2020 Jun 8. doi: 10.3389/fnmol.2020.00089

PMCID:: PMC7295033

Abstract Article PDF–2.7M

Select item 721947713.

Developmentally regulated KCC2 phosphorylation is essential for dynamic GABA-mediated inhibition and survival

Miho Wantanabe, Jinwei Zhang, M. Shahid Mansuri, Jingjing Duan, Jason K. Karimy, Eric Delpire, Seth L. Alper, Richard P. Lifton, Atsuo Fukuda, Kristopher T. Kahle

Sci Signal. Author manuscript; available in PMC 2020 May 13.

Published in final edited form as: Sci Signal. 2019 Oct 15; 12(603): eaaw9315. Published online 2019 Oct 15. doi: 10.1126/scisignal.aaw9315

PMCID:: PMC7219477

Abstract Article PDF–2.1M

Select item 698582414.

WNK bodies cluster WNK4 and SPAK/OSR1 to promote NCC activation in hypokalemia

Martin N. Thomson, Catherina A. Cuevas, Tim M. Bewarder, Carsten Dittmayer, Lauren N. Miller, Jinge Si, Ryan J. Cornelius, Xiao-Tong Su, Chao-Ling Yang, James A. McCormick, Juliette Hadchouel, David H. Ellison, Sebastian Bachmann, Kerim Mutig

Am J Physiol Renal Physiol. 2020 Jan 1; 318(1): F216–F228. Published online 2019 Nov 18. doi: 10.1152/ajprenal.00232.2019

PMCID:: PMC6985824

Abstract Article

Select item 645951015.

Mouse screen reveals multiple new genes underlying mouse and human hearing loss

Neil J. Ingham, Selina A. Pearson, Valerie E. Vancollie, Victoria Rook, Morag A. Lewis, Jing Chen, Annalisa Buniello, Elisa Martelletti, Lorenzo Preite, Chi Chung Lam, Felix D. Weiss, Zӧe Powis, Pim Suwannarat, Christopher J. Lelliott, Sally J. Dawson, Jacqueline K. White, Karen P. Steel

PLoS Biol. 2019 Apr; 17(4): e3000194. Published online 2019 Apr 11. doi: 10.1371/journal.pbio.3000194