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Select item 111418681.

Lack of SPNS1 results in accumulation of lysolipids and lysosomal storage disease in mouse models

Hoa T.T. Ha, SiYi Liu, Xuan T.A. Nguyen, Linh K. Vo, Nancy C.P. Leong, Dat T. Nguyen, Shivaranjani Balamurugan, Pei Yen Lim, YaJun Wu, Eunju Seong, Toan Q. Nguyen, Jeongah Oh, Markus R. Wenk, Amaury Cazenave-Gassiot, Zuhal Yapici, Wei-Yi Ong, Margit Burmeister, Long N. Nguyen

JCI Insight. 2024 Apr 22; 9(8): e175462. Published online 2024 Mar 7. doi: 10.1172/jci.insight.175462

PMCID:: PMC11141868

Abstract Article PDF–2.8M

Select item 110740232.

Initiation of acute pancreatitis in mice is independent of fusion between lysosomes and zymogen granules

Lukas Zierke, Daniel John, Marcel Gischke, Quang Trung Tran, Matthias Sendler, Frank Ulrich Weiss, Uwe T. Bornscheuer, Christoph Ritter, Markus M. Lerch, Ali A. Aghdassi

Cell Mol Life Sci. 2024 Dec; 81(1): 207. Published online 2024 May 6. doi: 10.1007/s00018-024-05247-7

PMCID:: PMC11074023

Abstract Article PDF–6.5M

Select item 107607223.

Cathepsin B aggravates atherosclerosis in ApoE-deficient mice by modulating vascular smooth muscle cell pyroptosis through NF-κB / NLRP3 signaling pathway

Hui Li, Quanwei Zhao, Danan Liu, Bo Zhou, Fujun Liao, Long Chen

PLoS One. 2024; 19(1): e0294514. Published online 2024 Jan 2. doi: 10.1371/journal.pone.0294514

PMCID:: PMC10760722

Abstract Article PDF–2.8M

Select item 104416114.

Trypsin activity in secretagogue-induced murine pancreatitis is solely elicited by cathepsin B and does not mediate key pathologic responses

Andrea Geisz, Thanh Tran, Anna Orekhova, Miklós Sahin-Tóth

Gastroenterology. Author manuscript; available in PMC 2024 Apr 1.

Published in final edited form as: Gastroenterology. 2023 Apr; 164(4): 684–687.e4. Published online 2023 Jan 11. doi: 10.1053/j.gastro.2023.01.004

PMCID:: PMC10441611

Article PDF–411K

Select item 101854325.

Cathepsin B Deficiency Improves Memory Deficits and Reduces Amyloid-β in hAβPP Mouse Models Representing the Major Sporadic Alzheimer’s Disease Condition

Gregory Hook, Mark Kindy, Vivian Hook

J Alzheimers Dis. 2023; 93(1): 33–46. Prepublished online 2023 Mar 21. Published online 2023 May 2. doi: 10.3233/JAD-221005

PMCID:: PMC10185432

Abstract Article PDF–467K

Select item 101200856.

B cell peripheral tolerance is promoted by cathepsin B protease

Marissa Y. Chou, Dan Liu, Jinping An, Ying Xu, Jason G. Cyster

Proc Natl Acad Sci U S A. 2023 Apr 18; 120(16): e2300099120. Published online 2023 Apr 11. doi: 10.1073/pnas.2300099120

PMCID:: PMC10120085

Abstract Article PDF–1.6M

Select item 97441627.

Cathepsin B plays a role in spermatogenesis and sperm maturation through regulating autophagy and apoptosis in mice

Zongzhuang Wen, Haixia Zhu, Bin Wu, Aizhen Zhang, Hongxiang Wang, Yin Cheng, Hui Zhao, Jianyuan Li, Min Liu, Jiangang Gao

PeerJ. 2022; 10: e14472. Published online 2022 Dec 2. doi: 10.7717/peerj.14472

PMCID:: PMC9744162

Abstract Article PDF–31M

Select item 96137568.

S-Nitrosylation of cathepsin B affects autophagic flux and accumulation of protein aggregates in neurodegenerative disorders

Ki-Ryeong Kim, Eun-Jung Cho, Jae-Won Eom, Sang-Seok Oh, Tomohiro Nakamura, Chang-ki Oh, Stuart A. Lipton, Yang-Hee Kim

Cell Death Differ. 2022 Nov; 29(11): 2137–2150. Published online 2022 Apr 24. doi: 10.1038/s41418-022-01004-0

PMCID:: PMC9613756

Abstract Article PDF–4.7M

Select item 95531149.

Cathepsin B Gene Knockout Improves Behavioral Deficits and Reduces Pathology in Models of Neurologic Disorders

Gregory Hook, Thomas Reinheckel, Junjun Ni, Zhou Wu, Mark Kindy, Christoph Peters, Vivian Hook

Pharmacol Rev. 2022 Jul; 74(3): 600–629. Published online 2022 Jul. doi: 10.1124/pharmrev.121.000527

PMCID:: PMC9553114

Abstract Article PDF–1.8M

Select item 930513910.

Kakonein restores hyperglycemia‐induced macrophage digestion dysfunction through regulation of cathepsin B‐dependent NLRP3 inflammasome activation

Dawei Lian, Li Zhu, Yunhong Yu, Xiaojuan Zhang, Yike Lin, Jiaying Liu, Ruifang Han, Yitong Guo, Dongpeng Cai, Wenjing Xiao, Yulin Chen, Hong He, Danping Xu, Chaoyang Zheng, Xiao Wang, Yi Huang, Yang Chen

J Leukoc Biol. 2022 Jul; 112(1): 143–155. Published online 2022 Feb 27. doi: 10.1002/JLB.3MA0821-418R

PMCID:: PMC9305139

Abstract Article PDF–5.8M

Select item 909784011.

Crosstalk between dihydroceramides produced by Porphyromonas gingivalis and host lysosomal cathepsin B in the promotion of osteoclastogenesis

Carolina Duarte, Chiaki Yamada, Christopher Garcia, Juliet Akkaoui, Anny Ho, Frank Nichols, Alexandru Movila

J Cell Mol Med. 2022 May; 26(10): 2841–2851. Published online 2022 Apr 16. doi: 10.1111/jcmm.17299

PMCID:: PMC9097840

Abstract Article PDF–5.0M

Select item 881011512.

MicroRNA-140-5p represses chondrocyte pyroptosis and relieves cartilage injury in osteoarthritis by inhibiting cathepsin B/Nod-like receptor protein 3

Lei Zhang, Jianjun Qiu, Jixiang Shi, Shaoyang Liu, Hanlin Zou

Bioengineered. 2021; 12(2): 9933–9948. Published online 2021 Nov 29. doi: 10.1080/21655979.2021.1985342

PMCID:: PMC8810115

Abstract Article PDF–3.9M

Select item 873850413.

Evaluation of novel cathepsin-X inhibitors in vitro and in vivo and their ability to improve cathepsin-B-directed antitumor therapy

Ana Mitrović, Janja Završnik, Georgy Mikhaylov, Damijan Knez, Urša Pečar Fonović, Petra Matjan Štefin, Miha Butinar, Stanislav Gobec, Boris Turk, Janko Kos

Cell Mol Life Sci. 2022 Jan; 79(1): 34. Published online 2022 Jan 6. doi: 10.1007/s00018-021-04117-w

PMCID:: PMC8738504

Abstract Article PDF–8.2M

Select item 858439414.

Cathepsin B Regulates Mice Granulosa Cells’ Apoptosis and Proliferation In Vitro

Chao Chen, Muhammad Jamil Ahmad, Tingzhu Ye, Chao Du, Xinxin Zhang, Aixin Liang, Liguo Yang

Int J Mol Sci. 2021 Nov; 22(21): 11827. Published online 2021 Oct 31. doi: 10.3390/ijms222111827

PMCID:: PMC8584394

Abstract Article PDF–2.2M

Select item 803899615.

The Ncoa7 locus regulates V-ATPase formation and function, neurodevelopment and behaviour

Enrico Castroflorio, Joery den Hoed, Daria Svistunova, Mattéa J. Finelli, Alberto Cebrian-Serrano, Silvia Corrochano, Andrew R. Bassett, Benjamin Davies, Peter L. Oliver

Cell Mol Life Sci. 2021 Apr; 78(7): 3503–3524. Published online 2020 Dec 19. doi: 10.1007/s00018-020-03721-6

PMCID:: PMC8038996

Abstract Article PDF–6.4M

Select item 798803816.

Cathepsin B and D deficiency in the mouse pancreas induces impaired autophagy and chronic pancreatitis

Hideaki Iwama, Sally Mehanna, Mai Imasaka, Shinsuke Hashidume, Hiroshi Nishiura, Ken-ichi Yamamura, Chigure Suzuki, Yasuo Uchiyama, Etsuro Hatano, Masaki Ohmuraya

Sci Rep. 2021; 11: 6596. Published online 2021 Mar 23. doi: 10.1038/s41598-021-85898-9

PMCID:: PMC7988038

Abstract Article PDF–2.6M

Select item 793877017.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 787312818.

The secreted inhibitor of invasive cell growth CREG1 is negatively regulated by cathepsin proteases

Alejandro Gomez-Auli, Larissa Elisabeth Hillebrand, Daniel Christen, Sira Carolin Günther, Martin Lothar Biniossek, Christoph Peters, Oliver Schilling, Thomas Reinheckel

Cell Mol Life Sci. 2021 Jan; 78(2): 733–755. Published online 2020 May 8. doi: 10.1007/s00018-020-03528-5

PMCID:: PMC7873128

Abstract Article PDF–3.8M

Select item 758162619.

Cathepsin B inhibition blocks neurite outgrowth in cultured neurons by regulating lysosomal trafficking and remodeling

Muzhou Jiang, Jie Meng, Fan Zeng, Hong Qing, Gregory Hook, Vivian Hook, Zhou Wu, Junjun Ni

J Neurochem. Author manuscript; available in PMC 2021 Jan 1.

Published in final edited form as: J Neurochem. 2020 Nov; 155(3): 300–312. Published online 2020 Jun 15. doi: 10.1111/jnc.15032

PMCID:: PMC7581626

Abstract Article PDF–2.4M

Select item 737606220.

B cell zone reticular cell microenvironments shape CXCL13 gradient formation

Jason Cosgrove, Mario Novkovic, Stefan Albrecht, Natalia B. Pikor, Zhaoukun Zhou, Lucas Onder, Urs Mörbe, Jovana Cupovic, Helen Miller, Kieran Alden, Anne Thuery, Peter O’Toole, Rita Pinter, Simon Jarrett, Emily Taylor, Daniel Venetz, Manfred Heller, Mariagrazia Uguccioni, Daniel F. Legler, Charles J. Lacey, Andrew Coatesworth, Wojciech G. Polak, Tom Cupedo, Bénedicte Manoury, Marcus Thelen, Jens V. Stein, Marlene Wolf, Mark C. Leake, Jon Timmis, Burkhard Ludewig, Mark C. Coles

Nat Commun. 2020; 11: 3677. Published online 2020 Jul 22. doi: 10.1038/s41467-020-17135-2

PMCID:: PMC7376062

Abstract Article PDF–9.2M

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