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Select item 111552641.

Lineage-specific intolerance to oncogenic drivers restricts histological transformation

Eric E. Gardner, Ethan M. Earlie, Kate Li, Jerin Thomas, Melissa J. Hubisz, Benjamin D. Stein, Chen Zhang, Lewis C. Cantley, Ashley M. Laughney, Harold Varmus

Science. Author manuscript; available in PMC 2024 Jun 6.

Published in final edited form as: Science. 2024 Feb 9; 383(6683): eadj1415. Published online 2024 Feb 9. doi: 10.1126/science.adj1415

PMCID:: PMC11155264

Abstract Article PDF–2.7M

Select item 111419352.

Blocking the angiopoietin-2–dependent integrin β-1 signaling axis abrogates small cell lung cancer invasion and metastasis

Lydia Meder, Charlotte Isabelle Orschel, Christoph Julius Otto, Mirjam Koker, Johannes Brägelmann, Meryem S. Ercanoglu, Sabrina Dähling, Anik Compes, Carolin Selenz, Marieke Nill, Felix Dietlein, Alexandra Florin, Marie-Lisa Eich, Sven Borchmann, Margarete Odenthal, Raquel Blazquez, Frank Hilberg, Florian Klein, Michael Hallek, Reinhard Büttner, H. Christian Reinhardt, Roland T. Ullrich

JCI Insight. 2024 May 22; 9(10): e166402. Published online 2024 May 22. doi: 10.1172/jci.insight.166402

PMCID:: PMC11141935

Abstract Article PDF–6.7M

Select item 111361283.

Retinoblastoma family proteins: insights gained through genetic manipulation of mice

K. A. Wikenheiser-Brokamp

Cell Mol Life Sci. 2006 Apr; 63(7-8): 767–780. Published online 2006 Feb 7. doi: 10.1007/s00018-005-5487-3

PMCID:: PMC11136128

Abstract Article PDF–227K

Select item 108423464.

SKP2 knockout in Rb1/p53 deficient mouse models of osteosarcoma induces immune infiltration and drives a transcriptional program with a favorable prognosis

Alexander Ferrena, Jichuan Wang, Ranxin Zhang, Burcu Karadal-Ferrena, Waleed Al-Hardan, Swapnil Singh, Hasibagan Borjihan, Edward L. Schwartz, Hongling Zhao, Maja H. Oktay, Rui Yang, David S Geller, Bang H Hoang, Deyou Zheng

Mol Cancer Ther. Author manuscript; available in PMC 2024 Aug 1.

Published in final edited form as: Mol Cancer Ther. 2024 Feb 1; 23(2): 223–234. doi: 10.1158/1535-7163.MCT-23-0173

PMCID:: PMC10842346

Abstract Article PDF–1.6M

Select item 107882695.

Epigenetic repression of Cend1 by lysine-specific demethylase 1 is essential for murine heart development

Huahua Liu, Rui Zhou, Shanshan Li, Jinling Dong, Yuan Fang, Yuru Luo, Hongyu Su, Baochang Lai, Lingli Liang, Donghong Zhang, Yanmin Zhang, John Y-J. Shyy, Bin Zhou, Zuyi Yuan, Yidong Wang

iScience. 2024 Jan 19; 27(1): 108722. Published online 2023 Dec 13. doi: 10.1016/j.isci.2023.108722

PMCID:: PMC10788269

Abstract Article PDF–11M

Select item 107743156.

Distinct mesenchymal cell states mediate prostate cancer progression

Hubert Pakula, Mohamed Omar, Ryan Carelli, Filippo Pederzoli, Giuseppe Nicolò Fanelli, Tania Pannellini, Fabio Socciarelli, Lucie Van Emmenis, Silvia Rodrigues, Caroline Fidalgo-Ribeiro, Pier Vitale Nuzzo, Nicholas J. Brady, Wikum Dinalankara, Madhavi Jere, Itzel Valencia, Christopher Saladino, Jason Stone, Caitlin Unkenholz, Richard Garner, Mohammad K. Alexanderani, Francesca Khani, Francisca Nunes de Almeida, Cory Abate-Shen, Matthew B. Greenblatt, David S. Rickman, Christopher E. Barbieri, Brian D. Robinson, Luigi Marchionni, Massimo Loda

Nat Commun. 2024; 15: 363. Published online 2024 Jan 8. doi: 10.1038/s41467-023-44210-1

PMCID:: PMC10774315

Abstract Article PDF–14M

Select item 107665617.

PTEN-regulated PI3K-p110 and AKT isoform plasticity controls metastatic prostate cancer progression

Karina A. Miller, Seamus Degan, Yanqing Wang, Joseph Cohen, Sheng Yu Ku, David W. Goodrich, Irwin H. Gelman

Oncogene. 2024; 43(1): 22–34. Published online 2023 Oct 24. doi: 10.1038/s41388-023-02875-4

Correction in:: Oncogene. 2024; 43(1): 76.

PMCID:: PMC10766561

Abstract Article PDF–3.9M

Select item 107212638.

Mutant RB1 enhances therapeutic efficacy of PARPis in lung adenocarcinoma by triggering the cGAS/STING pathway

Qi Dong, Tong Yu, Bo Chen, Mingyue Liu, Xiang Sun, Huiying Cao, Kaidong Liu, Huanhuan Xu, Yuquan Wang, Shuping Zhuang, Zixin Jin, Haihai Liang, Yang Hui, Yunyan Gu

JCI Insight. 2023 Nov 8; 8(21): e165268. Published online 2023 Nov 8. doi: 10.1172/jci.insight.165268

PMCID:: PMC10721263

Abstract Article PDF–4.4M

Select item 106562859.

Ligand-dependent hedgehog signaling maintains an undifferentiated, malignant osteosarcoma phenotype

Vijesh G. Vaghjiani, Catherine R. Cochrane, W. Samantha N. Jayasekara, Wai Chin Chong, Anette Szczepny, Beena Kumar, Luciano G. Martelotto, Andrew McCaw, Kirstyn Carey, Maya Kansara, David M. Thomas, Carl Walkley, Stuart Mudge, Daniel J. Gough, Peter A. Downie, Craig D. Peacock, William Matsui, D. Neil Watkins, Jason E. Cain

Oncogene. 2023; 42(47): 3529–3541. Published online 2023 Oct 16. doi: 10.1038/s41388-023-02864-7

PMCID:: PMC10656285

Abstract Article PDF–4.5M

Select item 1060034110.

STRA8–RB interaction is required for timely entry of meiosis in mouse female germ cells

Ryuki Shimada, Yuzuru Kato, Naoki Takeda, Sayoko Fujimura, Kei-ichiro Yasunaga, Shingo Usuki, Hitoshi Niwa, Kimi Araki, Kei-ichiro Ishiguro

Nat Commun. 2023; 14: 6443. Published online 2023 Oct 25. doi: 10.1038/s41467-023-42259-6

PMCID:: PMC10600341

Abstract Article PDF–12M

Select item 1051699711.

YAP silencing by RB1 mutation is essential for small-cell lung cancer metastasis

Zhengming Wu, Junhui Su, Fu-long Li, Tao Chen, Jaimie Mayner, Adam Engler, Shenghong Ma, Qingquan Li, Kun-Liang Guan

Nat Commun. 2023; 14: 5916. Published online 2023 Sep 22. doi: 10.1038/s41467-023-41585-z

PMCID:: PMC10516997

Abstract Article PDF–1.7M

Select item 1015223412.

Comprehensive Metabolic Tracing Reveals the Origin and Catabolism of Cysteine in Mammalian Tissues and Tumors

Sang Jun Yoon, Joseph A. Combs, Aimee Falzone, Nicolas Prieto-Farigua, Samantha Caldwell, Hayley D. Ackerman, Elsa R. Flores, Gina M. DeNicola

Cancer Res. 2023 May 2; 83(9): 1426–1442. Published online 2023 Mar 2. doi: 10.1158/0008-5472.CAN-22-3000

Correction in:: Cancer Res. 2024 Apr 15; 84(8): 1372.

PMCID:: PMC10152234

Abstract Article PDF–16M

Select item 1007046013.

NEMO- and RelA-dependent NF-κB signaling promotes small cell lung cancer

Lioba Koerner, Marcel Schmiel, Tsun-Po Yang, Martin Peifer, Reinhard Buettner, Manolis Pasparakis

Cell Death Differ. 2023 Apr; 30(4): 938–951. Published online 2023 Jan 18. doi: 10.1038/s41418-023-01112-5

PMCID:: PMC10070460

Abstract Article PDF–7.1M

Select item 997290114.

A multiplexed in vivo approach to identify driver genes in small cell lung cancer

Myung Chang Lee, Hongchen Cai, Christopher W. Murray, Chuan Li, Yan Ting Shue, Laura Andrejka, Andy L. He, Alessandra M.E. Holzem, Alexandros P. Drainas, Julie H. Ko, Garry L. Coles, Christina Kong, Shirley Zhu, ChunFang Zhu, Jason Wang, Matt van de Rijn, Dmitri A. Petrov, Monte M. Winslow, Julien Sage

Cell Rep. Author manuscript; available in PMC 2023 Feb 28.

Published in final edited form as: Cell Rep. 2023 Jan 31; 42(1): 111990. Published online 2023 Jan 13. doi: 10.1016/j.celrep.2023.111990

PMCID:: PMC9972901

Abstract Article PDF–2.5M

Select item 992517415.

Tissue- and cell-specific properties of enterochromaffin cells affect the fate of tumorigenesis toward nonendocrine adenocarcinoma of the small intestine

Yoshitatsu Sei, Jianying Feng, Xilin Zhao, Pradeep Dagur, J. Philip McCoy, Juanita L. Merchant, Stephen A. Wank

Am J Physiol Gastrointest Liver Physiol. 2023 Mar 1; 324(3): G177–G189. Published online 2022 Dec 20. doi: 10.1152/ajpgi.00205.2022

PMCID:: PMC9925174

Abstract Article

Select item 987086516.

The NFIB/CARM1 partnership is a driver in preclinical models of small cell lung cancer

Guozhen Gao, Simone Hausmann, Natasha M. Flores, Ana Morales Benitez, Jianjun Shen, Xiaojie Yang, Maria D. Person, Sitaram Gayatri, Donghang Cheng, Yue Lu, Bin Liu, Pawel K. Mazur, Mark T. Bedford

Nat Commun. 2023; 14: 363. Published online 2023 Jan 23. doi: 10.1038/s41467-023-35864-y

PMCID:: PMC9870865

Abstract Article PDF–6.7M

Select item 986996917.

ATR represents a therapeutic vulnerability in clear cell renal cell carcinoma

Philipp Seidel, Anne Rubarth, Kyra Zodel, Asin Peighambari, Felix Neumann, Yannick Federkiel, Hsin Huang, Rouven Hoefflin, Mojca Adlesic, Christian Witt, David J. Hoffmann, Patrick Metzger, Ralph K. Lindemann, Frank T. Zenke, Christoph Schell, Melanie Boerries, Dominik von Elverfeldt, Wilfried Reichardt, Marie Follo, Joachim Albers, Ian J. Frew

JCI Insight. 2022 Dec 22; 7(24): e156087. Published online 2022 Dec 22. doi: 10.1172/jci.insight.156087

PMCID:: PMC9869969

Abstract Article PDF–3.4M

Select item 981240018.

Loss of epigenetic regulation disrupts lineage integrity, induces aberrant alveogenesis and promotes breast cancer

Ellen Langille, Khalid N. Al-Zahrani, Zhibo Ma, Minggao Liang, Liis Uuskula-Reimand, Roderic Espin, Katie Teng, Ahmad Malik, Helga Bergholtz, Samah El Ghamrasni, Somaieh Afiuni-Zadeh, Ricky Tsai, Sana Alvi, Andrew Elia, YiQing Lü, Robin H. Oh, Katelyn J. Kozma, Daniel Trcka, Masahiro Narimatsu, Jeff C. Liu, Thomas Nguyen, Seda Barutcu, Sampath K. Loganathan, Rod Bremner, Gary D. Bader, Sean E. Egan, David W. Cescon, Therese Sørlie, Jeffrey L. Wrana, Hartland W. Jackson, Michael D. Wilson, Agnieszka K. Witkiewicz, Erik S. Knudsen, Miguel Angel Pujana, Geoffrey M. Wahl, Daniel Schramek

Cancer Discov. Author manuscript; available in PMC 2023 Jun 2.

Published in final edited form as: Cancer Discov. 2022 Dec 2; 12(12): 2930–2953. doi: 10.1158/2159-8290.CD-21-0865

PMCID:: PMC9812400

Abstract Article PDF–4.5M

Select item 967236119.

Rb1 negatively regulates bone formation and remodeling through inhibiting transcriptional regulation of YAP in Glut1 and OPG expression and glucose metabolism in male mice

Yang Li, Shuting Yang, Shuying Yang

Mol Metab. 2022 Dec; 66: 101630. Published online 2022 Nov 4. doi: 10.1016/j.molmet.2022.101630

PMCID:: PMC9672361

Abstract Article PDF–4.5M

Select item 953628020.

Loss of ATRX promotes aggressive features of osteosarcoma with increased NF-κB signaling and integrin binding

Suzanne Bartholf DeWitt, Sarah Hoskinson Plumlee, Hailey E. Brighton, Dharshan Sivaraj, E.J. Martz, Maryam Zand, Vardhman Kumar, Maya U. Sheth, Warren Floyd, Jacob V. Spruance, Nathan Hawkey, Shyni Varghese, Jianhua Ruan, David G. Kirsch, Jason A. Somarelli, Ben Alman, William C. Eward

JCI Insight. 2022 Sep 8; 7(17): e151583. Published online 2022 Sep 8. doi: 10.1172/jci.insight.151583

PMCID:: PMC9536280

Abstract Article PDF–3.8M

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