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Items: 1 to 20 of 1644

1.
Inhibition of lung tumorigenesis by transient reprogramming in cancer cells
Pablo Pedrosa, Zhenguang Zhang, Victor Nuñez-Quintela, David Macias, Jianfeng Ge, Mary Denholm, Anna Dyas, Valentin Estevez-Souto, Patricia Lado-Fernandez, Patricia Gonzalez, Maria Gomez, Jose Ezequiel Martin, Sabela Da Silva-Alvarez, Manuel Collado, Daniel Muñoz-Espín
Cell Death Dis. 2024 Nov; 15(11): 857. Published online 2024 Nov 25. doi: 10.1038/s41419-024-07207-2
PMCID:
PMC11589828
AbstractArticlePDF–5.7M
2.
Stress granules are not present in Kras mutant cancers and do not control tumor growth
Maxime Libert, Sophie Quiquempoix, Jean S Fain, Sébastien Pyr dit Ruys, Malak Haidar, Margaux Wulleman, Gaëtan Herinckx, Didier Vertommen, Christelle Bouchart, Tatjana Arsenijevic, Jean-Luc Van Laethem, Patrick Jacquemin
EMBO Rep. 2024 Nov; 25(11): 4693–4707. Published online 2024 Oct 10. doi: 10.1038/s44319-024-00284-6
PMCID:
PMC11549491
AbstractArticlePDF–3.3M
3.
High mitochondrial DNA levels accelerate lung adenocarcinoma progression
Mara Mennuni, Stephen E. Wilkie, Pauline Michon, David Alsina, Roberta Filograna, Markus Lindberg, David E. Sanin, Florian Rosenberger, Alina Schaaf, Erik Larsson, Erika L. Pearce, Nils-Göran Larsson
Sci Adv. 2024 Nov 1; 10(44): eadp3481. Published online 2024 Nov 1. doi: 10.1126/sciadv.adp3481
PMCID:
PMC11529711
AbstractArticlePDF–2.2M
4.
Self-sustaining long-term 3D epithelioid cultures reveal drivers of clonal expansion in esophageal epithelium
Albert Herms, David Fernandez-Antoran, Maria P. Alcolea, Argyro Kalogeropoulou, Ujjwal Banerjee, Gabriel Piedrafita, Emilie Abby, Jose Antonio Valverde-Lopez, Inês S. Ferreira, Irene Caseda, Maria T. Bejar, Stefan C. Dentro, Sara Vidal-Notari, Swee Hoe Ong, Bartomeu Colom, Kasumi Murai, Charlotte King, Krishnaa Mahbubani, Kourosh Saeb-Parsy, Alan R. Lowe, Moritz Gerstung, Philip H. Jones
Nat Genet. 2024; 56(10): 2158–2173. Published online 2024 Sep 23. doi: 10.1038/s41588-024-01875-8
PMCID:
PMC11525200
AbstractArticlePDF–57M
5.
Inactivation of HIPK2 attenuates KRASG12D activity and prevents pancreatic tumorigenesis
Silvia Sozzi, Isabella Manni, Cristiana Ercolani, Maria Grazia Diodoro, Armando Bartolazzi, Francesco Spallotta, Giulia Piaggio, Laura Monteonofrio, Silvia Soddu, Cinzia Rinaldo, Davide Valente
J Exp Clin Cancer Res. 2024; 43: 265. Published online 2024 Sep 28. doi: 10.1186/s13046-024-03189-3
PMCID:
PMC11437985
AbstractArticlePDF–3.3M
6.
Mutant TP53 switches therapeutic vulnerability during gastric cancer progression within interleukin-6 family cytokines
Anne Huber, Amr H. Allam, Christine Dijkstra, Stefan Thiem, Jennifer Huynh, Ashleigh R. Poh, Joshua Konecnik, Saumya P. Jacob, Rita Busuttil, Yang Liao, David Chisanga, Wei Shi, Mariah G. Alorro, Stephen Forrow, Daniele V.F. Tauriello, Eduard Batlle, Alex Boussioutas, David S. Williams, Michael Buchert, Matthias Ernst, Moritz F. Eissmann
Cell Rep. 2024 Aug 27; 43(8): 114616. Published online 2024 Aug 9. doi: 10.1016/j.celrep.2024.114616
PMCID:
PMC11372443
AbstractArticle
7.
Inhibition of ULK1/2 and KRASG12C controls tumor growth in preclinical models of lung cancer
Phaedra C Ghazi, Kayla T O'Toole, Sanjana Srinivas Boggaram, Michael T Scherzer, Mark R Silvis, Yun Zhang, Madhumita Bogdan, Bryan D Smith, Guillermina Lozano, Daniel L Flynn, Eric L Snyder, Conan G Kinsey, Martin McMahon
eLife. 2024; 13: RP96992. Published online 2024 Aug 30. doi: 10.7554/eLife.96992
PMCID:
PMC11364435
AbstractArticlePDF–5.1M
8.
Activation of STING in pancreatic cancer-associated fibroblasts exerts an antitumor effect by enhancing tumor immunity
Yoshimasa Suzuki, Takeshi Sato, Makoto Sugimori, Yushi Kanemaru, Sho Onodera, Hiromi Tsuchiya, Yoshinori Nakamori, Sho Tsuyuki, Aya Ikeda, Ryosuke Ikeda, Yoshihiro Goda, Hiroaki Kaneko, Kuniyasu Irie, Soichiro Sue, Shin Maeda
Sci Rep. 2024; 14: 17071. Published online 2024 Jul 24. doi: 10.1038/s41598-024-68061-y
PMCID:
PMC11269671
AbstractArticlePDF–12M
9.
Early-stage lung cancer is driven by a transitional cell state dependent on a KRAS-ITGA3-SRC axis
Aaron L Moye, Antonella FM Dost, Robert Ietswaart, Shreoshi Sengupta, VanNashlee Ya, Chrystal Aluya, Caroline G Fahey, Sharon M Louie, Margherita Paschini, Carla F Kim
EMBO J. 2024 Jul; 43(14): 2843–2861. Published online 2024 May 16. doi: 10.1038/s44318-024-00113-5
PMCID:
PMC11251082
AbstractArticlePDF–4.3M
10.
Glucose-6-phosphate dehydrogenase maintains redox homeostasis and biosynthesis in LKB1-deficient KRAS-driven lung cancer
Taijin Lan, Sara Arastu, Jarrick Lam, Hyungsin Kim, Wenping Wang, Samuel Wang, Vrushank Bhatt, Eduardo Cararo Lopes, Zhixian Hu, Michael Sun, Xuefei Luo, Jonathan M. Ghergurovich, Xiaoyang Su, Joshua D. Rabinowitz, Eileen White, Jessie Yanxiang Guo
Nat Commun. 2024; 15: 5857. Published online 2024 Jul 12. doi: 10.1038/s41467-024-50157-8
PMCID:
PMC11245543
AbstractArticlePDF–3.3M
11.
Distinct origin and region-dependent contribution of stromal fibroblasts to fibrosis following traumatic injury in mice
Daniel Holl, Wing Fung Hau, Anais Julien, Shervin Banitalebi, Jannis Kalkitsas, Soniya Savant, Enric Llorens-Bobadilla, Yann Herault, Guillaume Pavlovic, Mahmood Amiry-Moghaddam, David Oliveira Dias, Christian Göritz
Nat Neurosci. 2024; 27(7): 1285–1298. Published online 2024 Jun 7. doi: 10.1038/s41593-024-01678-4
PMCID:
PMC11239523
AbstractArticlePDF–13M
12.
CRACD Loss Induces Neuroendocrine Cell Plasticity of Lung Adenocarcinoma
Bongjun Kim, Shengzhe Zhang, Yuanjian Huang, Kyung-Pil Ko, Youn-Sang Jung, Jinho Jang, Gengyi Zou, Jie Zhang, Sohee Jun, Kee-Beom Kim, Kwon-Sik Park, Jae-Il Park
Cell Rep. Author manuscript; available in PMC 2024 Jul 2.
Published in final edited form as: Cell Rep. 2024 Jun 25; 43(6): 114286. Published online 2024 May 25. doi: 10.1016/j.celrep.2024.114286
PMCID:
PMC11216895
AbstractArticlePDF–2.9M
13.
FAK loss reduces BRAFV600E-induced ERK phosphorylation to promote intestinal stemness and cecal tumor formation
Chenxi Gao, Huaibin Ge, Shih-Fan Kuan, Chunhui Cai, Xinghua Lu, Farzad Esni, Robert E Schoen, Jing H Wang, Edward Chu, Jing Hu
eLife. 2024; 13: RP94605. Published online 2024 Jun 26. doi: 10.7554/eLife.94605
PMCID:
PMC11208045
AbstractArticlePDF–5.3M
14.
The Janus kinase 1 is critical for pancreatic cancer initiation and progression
Hridaya Shrestha, Patrick D. Rädler, Rayane Dennaoui, Madison N. Wicker, Nirakar Rajbhandari, Yunguang Sun, Amy R. Peck, Kerry Vistisen, Aleata A. Triplett, Rafic Beydoun, Esta Sterneck, Dieter Saur, Hallgeir Rui, Kay-Uwe Wagner
Cell Rep. Author manuscript; available in PMC 2024 Jun 23.
Published in final edited form as: Cell Rep. 2024 May 28; 43(5): 114202. Published online 2024 May 10. doi: 10.1016/j.celrep.2024.114202
PMCID:
PMC11194014
AbstractArticlePDF–3.3M
15.
Developmental effect of RASopathy mutations on neuronal network activity on a chip
Eva-Maria Weiss, Debarpan Guhathakurta, Aneta Petrušková, Verena Hundrup, Martin Zenker, Anna Fejtová
Front Cell Neurosci. 2024; 18: 1388409. Published online 2024 Jun 7. doi: 10.3389/fncel.2024.1388409
PMCID:
PMC11190344
AbstractArticlePDF–2.2M
16.
In vivo CRISPR screens reveal SCAF1 and USP15 as drivers of pancreatic cancer
Sebastien Martinez, Shifei Wu, Michael Geuenich, Ahmad Malik, Ramona Weber, Tristan Woo, Amy Zhang, Gun Ho Jang, Dzana Dervovic, Khalid N. Al-Zahrani, Ricky Tsai, Nassima Fodil, Philippe Gros, Steven Gallinger, G. Gregory Neely, Faiyaz Notta, Ataman Sendoel, Kieran Campbell, Ulrich Elling, Daniel Schramek
Nat Commun. 2024; 15: 5266. Published online 2024 Jun 20. doi: 10.1038/s41467-024-49450-3
PMCID:
PMC11189927
AbstractArticlePDF–2.3M
17.
Differential extracellular vesicle concentration and their biomarker expression of integrin αv/β5, EpCAM, and glypican-1 in pancreatic cancer models
Reed Jacobson, Sangdeuk Ha, Sakurako Tani, Shrinwanti Ghosh, Yagna P. R. Jarajapu, Randall E. Brand, Jiha Kim, Yongki Choi
Sci Rep. 2024; 14: 14273. Published online 2024 Jun 20. doi: 10.1038/s41598-024-65209-8
PMCID:
PMC11189911
AbstractArticlePDF–1.2M
18.
Trefoil factor 1 suppresses stemness and enhances chemosensitivity of pancreatic cancer
Junpei Yamaguchi, Toshio Kokuryo, Yukihiro Yokoyama, Shunsuke Oishi, Masaki Sunagawa, Takashi Mizuno, Shunsuke Onoe, Nobuyuki Watanabe, Atsushi Ogura, Tomoki Ebata
Cancer Med. 2024 Jun; 13(11): e7395. Published online 2024 Jun 13. doi: 10.1002/cam4.7395
PMCID:
PMC11176577
AbstractArticlePDF–17M
19.
K‐ras oncogene silencing strategy reduces tumor growth and enhances gemcitabine chemotherapy efficacy for pancreatic cancer treatment
Soukaina Réjiba, Séverine Wack, Marc Aprahamian, Amor Hajri
Cancer Sci. 2007 Jul; 98(7): 1128–1136. Published online 2007 May 8. doi: 10.1111/j.1349-7006.2007.00506.x
PMCID:
PMC11159785
AbstractArticlePDF–371K
20.
Statin prevents cancer development in chronic inflammation by blocking interleukin 33 expression
Jong Ho Park, Mahsa Mortaja, Heehwa G. Son, Xutu Zhao, Lauren M. Sloat, Marjan Azin, Jun Wang, Michael R. Collier, Krishna S. Tummala, Anna Mandinova, Nabeel Bardeesy, Yevgeniy R. Semenov, Mari Mino-Kenudson, Shadmehr Demehri
Nat Commun. 2024; 15: 4099. Published online 2024 May 30. doi: 10.1038/s41467-024-48441-8
PMCID:
PMC11139893
AbstractArticlePDF–2.6M

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