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Select item 105045651.

SHP-1 phosphatase acts as a coactivator of PCK1 transcription to control gluconeogenesis

Amit Kumar, Michael Schwab, Beisy Laborit Labrada, Maruhen Amir Datsch Silveira, Marilyn Goudreault, Éric Fournier, Kerstin Bellmann, Nicole Beauchemin, Anne-Claude Gingras, Steve Bilodeau, Mathieu Laplante, André Marette

J Biol Chem. 2023 Sep; 299(9): 105164. Published online 2023 Aug 16. doi: 10.1016/j.jbc.2023.105164

PMCID:: PMC10504565

Abstract Article PDF–2.4M

Select item 101149202.

GRB2 promotes thymocyte positive selection by facilitating THEMIS-mediated inactivation of SHP1

Seeyoung Choi, Teri Hatzihristidis, Guillaume Gaud, Avik Dutta, Jan Lee, Awadhesh Arya, Lauren M. Clubb, Daniel B. Stamos, Adrienn Markovics, Katalin Mikecz, Paul Love

J Exp Med. 2023 Jul 3; 220(7): e20221649. Published online 2023 Apr 17. doi: 10.1084/jem.20221649

PMCID:: PMC10114920

Abstract Article PDF–4.4M

Select item 100608473.

Treg-specific deletion of the phosphatase SHP-1 impairs control of inflammation in vivo

QinLei Gu, Kenneth S. Tung, Ulrike M. Lorenz

Front Immunol. 2023; 14: 1139326. Published online 2023 Mar 16. doi: 10.3389/fimmu.2023.1139326

PMCID:: PMC10060847

Abstract Article PDF–6.9M

Select item 100377474.

Repair of Limb Ischemia Is Dependent on Hematopoietic Stem Cell Specific-SHP-1 Regulation of TGF-β1

Chen Wang, Ravi Nistala, Min Cao, De-Pei Li, Yi Pan, Mojgan Golzy, Yuqi Cui, Zhenguo Liu, XunLei Kang

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2023 Mar 24.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2023 Jan; 43(1): 92–108. Published online 2022 Nov 22. doi: 10.1161/ATVBAHA.122.318205

PMCID:: PMC10037747

Abstract Article PDF–2.7M

Select item 98218605.

CD47 halts Ptpn6-deficient neutrophils from provoking lethal inflammation

Lalita Mazgaeen, Matthew Yorek, Saurabh Saini, Peter Vogel, David K. Meyerholz, Thirumala-Devi Kanneganti, Prajwal Gurung

Sci Adv. 2023 Jan; 9(1): eade3942. Published online 2023 Jan 6. doi: 10.1126/sciadv.ade3942

PMCID:: PMC9821860

Abstract Article PDF–2.3M

Select item 96388556.

Concomitant deletion of Ptpn6 and Ptpn11 in T cells fails to improve anticancer responses

Pedro M O Ventura, Milica Gakovic, Berenice A Fischer, Laura Spinelli, Giorgia Rota, Shalini Pathak, Hanif J Khameneh, Alessandro Zenobi, Sarah Thomson, Walter Birchmeier, Doreen A Cantrell, Greta Guarda

EMBO Rep. 2022 Nov; 23(11): e55399. Published online 2022 Oct 4. doi: 10.15252/embr.202255399

PMCID:: PMC9638855

Abstract Article PDF–963K

Select item 83429877.

TRIM31 facilitates K27-linked polyubiquitination of SYK to regulate antifungal immunity

Xueer Wang, Honghai Zhang, Zhugui Shao, Wanxin Zhuang, Chao Sui, Feng Liu, Xiaorong Chen, Jinxiu Hou, Lingli Kong, Hansen Liu, Yi Zheng, Bingyu Liu, Tian Chen, Lei Zhang, Xinming Jia, Chengjiang Gao

Signal Transduct Target Ther. 2021; 6: 298. Published online 2021 Aug 6. doi: 10.1038/s41392-021-00711-3

PMCID:: PMC8342987

Abstract Article PDF–6.2M

Select item 83132398.

Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development

Francesco Bedogni, Robert F. Hevner

Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034

PMCID:: PMC8313239

Abstract Article PDF–1.6M

Select item 82456329.

Ets-2 deletion in myeloid cells attenuates IL-1α-mediated inflammatory disease caused by a Ptpn6 point mutation

Sarang Tartey, Prajwal Gurung, Rajendra Karki, Amanda Burton, Paul Hertzog, Thirumala-Devi Kanneganti

Cell Mol Immunol. 2021 Jul; 18(7): 1798–1808. Published online 2020 Mar 19. doi: 10.1038/s41423-020-0398-7

PMCID:: PMC8245632

Abstract Article PDF–3.1M

Select item 793877010.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 782294111.

Enhanced BCR signaling inflicts early plasmablast and germinal center B cell death

Juan Carlos Yam-Puc, Lingling Zhang, Raul A Maqueda-Alfaro, Laura Garcia-Ibanez, Yang Zhang, Jessica Davies, Yotis A Senis, Michael Snaith, Kai-Michael Toellner

iScience. 2021 Feb 19; 24(2): 102038. Published online 2021 Jan 7. doi: 10.1016/j.isci.2021.102038

PMCID:: PMC7822941

Abstract Article PDF–5.2M

Select item 760553112.

Inhibition of TRPV1 by SHP-1 in nociceptive primary sensory neurons is critical in PD-L1 analgesia

Ben-Long Liu, Qi-Lai Cao, Xin Zhao, Hui-Zhu Liu, Yu-Qiu Zhang

JCI Insight. 2020 Oct 15; 5(20): e137386. Published online 2020 Oct 15. doi: 10.1172/jci.insight.137386

PMCID:: PMC7605531

Abstract Article PDF–24M

Select item 755071813.

Shp1 Loss Enhances Macrophage Effector Function and Promotes Anti-Tumor Immunity

Darienne R. Myers, Clare L. Abram, David Wildes, Amira Belwafa, Alia M. N. Welsh, Christopher J. Schulze, Tiffany J. Choy, Tram Nguyen, Neil Omaque, Yongmei Hu, Mallika Singh, Rich Hansen, Mark A. Goldsmith, Elsa Quintana, Jacqueline A. M. Smith, Clifford A. Lowell

Front Immunol. 2020; 11: 576310. Published online 2020 Sep 29. doi: 10.3389/fimmu.2020.576310

PMCID:: PMC7550718

Abstract Article PDF–2.4M

Select item 741599114.

BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING)

Kou Motani, Hidetaka Kosako

J Biol Chem. 2020 Aug 7; 295(32): 11174–11183. Published online 2020 Jun 17. doi: 10.1074/jbc.RA120.014323

PMCID:: PMC7415991

Abstract Article PDF–2.0M

Select item 740483815.

SHP‐1 suppresses the antiviral innate immune response by targeting TRAF3

Doudou Hao, Yu Wang, Liuyan Li, Gui Qian, Jing Liu, Manman Li, Yihua Zhang, Ruixue Zhou, Dapeng Yan

FASEB J. 2020 Sep; 34(9): 12392–12405. Published online 2020 Jul 23. doi: 10.1096/fj.202000600RR

PMCID:: PMC7404838

Abstract Article PDF–1.5M

Select item 739756916.

THEMIS-SHP1 Recruitment by 4–1BB Tunes LCK-Mediated Priming of Chimeric Antigen Receptor-Redirected T Cells

Chuang Sun, Peishun Shou, Hongwei Du, Koichi Hirabayashi, Yuhui Chen, Laura E. Herring, Sarah Ahn, Yang Xu, Kyogo Suzuki, Guangming Li, Ourania Tsahouridis, Lishan Su, Barbara Savoldo, Gianpietro Dotti

Cancer Cell. Author manuscript; available in PMC 2021 Feb 10.

Published in final edited form as: Cancer Cell. 2020 Feb 10; 37(2): 216–225.e6. Published online 2020 Jan 30. doi: 10.1016/j.ccell.2019.12.014

PMCID:: PMC7397569

Abstract Article PDF–2.6M

Select item 731874017.

Regulation of autoimmune arthritis by the SHP-1 tyrosine phosphatase

Adrienn Markovics, Daniel M. Toth, Tibor T. Glant, Katalin Mikecz

Arthritis Res Ther. 2020; 22: 160. Published online 2020 Jun 26. doi: 10.1186/s13075-020-02250-8

PMCID:: PMC7318740

Abstract Article PDF–1.7M

Select item 726532418.

PD-1 and BTLA regulate T cell signaling differentially and only partially through SHP1 and SHP2

Xiaozheng Xu, Bowen Hou, Amitkumar Fulzele, Takeya Masubuchi, Yunlong Zhao, Zijun Wu, Yanyan Hu, Yong Jiang, Yanzhe Ma, Haopeng Wang, Eric J. Bennett, Guo Fu, Enfu Hui

J Cell Biol. 2020 Jun 1; 219(6): e201905085. Published online 2020 May 21. doi: 10.1083/jcb.201905085

PMCID:: PMC7265324

Abstract Article PDF–5.9M

Select item 722702819.

Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss

Gayle B. Collin, Navdeep Gogna, Bo Chang, Nattaya Damkham, Jai Pinkney, Lillian F. Hyde, Lisa Stone, Jürgen K. Naggert, Patsy M. Nishina, Mark P. Krebs

Cells. 2020 Apr; 9(4): 931. Published online 2020 Apr 10. doi: 10.3390/cells9040931

PMCID:: PMC7227028

Abstract Article PDF–5.4M

Select item 712503820.

Inhibition of SHP-1 expands the repertoire of antitumor T cells available to respond to immune checkpoint blockade.

Jeremy P. Snook, Ashleigh J. Soedel, H. Atakan Ekiz, Ryan M. O’Connell, Matthew A. Williams

Cancer Immunol Res. Author manuscript; available in PMC 2020 Oct 1.

Published in final edited form as: Cancer Immunol Res. 2020 Apr; 8(4): 506–517. Published online 2020 Feb 19. doi: 10.1158/2326-6066.CIR-19-0690

PMCID:: PMC7125038

Abstract Article PDF–1.7M

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