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Select item 111648751.

RIPK1 protects naive and regulatory T cells from TNFR1-induced apoptosis

Jelle Huysentruyt, Wolf Steels, Mario Ruiz Perez, Bruno Verstraeten, Mike Vadi, Tatyana Divert, Kayleigh Flies, Nozomi Takahashi, Bart N. Lambrecht, Wim Declercq, Tom Vanden Berghe, Jonathan Maelfait, Peter Vandenabeele, Peter Tougaard

Cell Death Differ. 2024 Jun; 31(6): 820–832. Published online 2024 May 11. doi: 10.1038/s41418-024-01301-w

PMCID:: PMC11164875

Abstract Article PDF–4.2M

Select item 111468882.

The modular nature of apoptotic signaling proteins

K. Hofmann

Cell Mol Life Sci. 1999 Jul; 55(8-9): 1113–1128. doi: 10.1007/s000180050361

PMCID:: PMC11146888

Abstract Article PDF–923K

Select item 110939693.

ZBP1 and TRIF trigger lethal necroptosis in mice lacking caspase-8 and TNFR1

Margaret Solon, Nianfeng Ge, Shannon Hambro, Susan Haller, Jian Jiang, Miriam Baca, Jessica Preston, Allie Maltzman, Katherine E. Wickliffe, Yuxin Liang, Rohit Reja, Dorothee Nickles, Kim Newton, Joshua D. Webster

Cell Death Differ. 2024 May; 31(5): 672–682. Published online 2024 Mar 28. doi: 10.1038/s41418-024-01286-6

PMCID:: PMC11093969

Abstract Article PDF–5.5M

Select item 110456144.

TNF receptor 2 knockout mouse had reduced lung cancer growth and schizophrenia-like behavior through a decrease in TrkB-dependent BDNF level

In Jun Yeo, Ji Eun Yu, Sung-Hyun Kim, Dae Hwan Kim, Miran Jo, Dong Ju Son, Jaesuk Yun, Sang-Bae Han, Jin Tae Hong

Arch Pharm Res. 2024; 47(4): 341–359. Published online 2024 Apr 9. doi: 10.1007/s12272-024-01487-0

PMCID:: PMC11045614

Abstract Article PDF–3.0M

Select item 109176605.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 108842886.

TNFα: TNFR1 signaling inhibits maturation and maintains the pro-inflammatory programming of monocyte-derived macrophages in murine chronic granulomatous disease

Sophie L. Gibbings, Kelsey C. Haist, Elizabeth F. Redente, Peter M. Henson, Donna L. Bratton

Front Immunol. 2024; 15: 1354836. Published online 2024 Feb 9. doi: 10.3389/fimmu.2024.1354836

PMCID:: PMC10884288

Abstract Article PDF–4.2M

Select item 106465517.

cIAPs control RIPK1 kinase activity‐dependent and ‐independent cell death and tissue inflammation

Fabian Schorn, J Paul Werthenbach, Mattes Hoffmann, Mila Daoud, Johanna Stachelscheid, Lars M Schiffmann, Ximena Hildebrandt, Su Ir Lyu, Nieves Peltzer, Alexander Quaas, Domagoj Vucic, John Silke, Manolis Pasparakis, Hamid Kashkar

EMBO J. 2023 Nov; 42(22): e113614. Published online 2023 Oct 4. doi: 10.15252/embj.2023113614

PMCID:: PMC10646551

Abstract Article PDF–3.3M

Select item 106170198.

Prolonged hypoxia alleviates prolyl hydroxylation-mediated suppression of RIPK1 to promote necroptosis and inflammation

Tao Zhang, Daichao Xu, Jianping Liu, Min Wang, Li-Juan Duan, Min Liu, Huyan Meng, Yuan Zhuang, Huibing Wang, Yingnan Wang, Mingming Lv, Zhengyi Zhang, Jia Hu, Linyu Shi, Rui Guo, Xingxing Xie, Hui Liu, Emily Erickson, Yaru Wang, Wenyu Yu, Fabin Dang, Dongxian Guan, Cong Jiang, Xiaoming Dai, Hiroyuki Inuzuka, Peiqiang Yan, Jingchao Wang, Mrigya Babuta, Gewei Lian, Zhenbo Tu, Ji Miao, Gyongyi Szabo, Guo-Hua Fong, Antoine E. Karnoub, Yu-Ru Lee, Lifeng Pan, William G. Kaelin, Jr., Junying Yuan, Wenyi Wei

Nat Cell Biol. Author manuscript; available in PMC 2023 Oct 31.

Published in final edited form as: Nat Cell Biol. 2023 Jul; 25(7): 950–962. Published online 2023 Jul 3. doi: 10.1038/s41556-023-01170-4

PMCID:: PMC10617019

Abstract Article PDF–8.3M

Select item 105473009.

Crk and Crkl Are Required in the Endocardial Lineage for Heart Valve Development

Bingruo Wu, Brian Wu, Sonia Benkaci, Lijie Shi, Pengfei Lu, Taeju Park, Bernice E. Morrow, Yidong Wang, Bin Zhou

J Am Heart Assoc. 2023 Sep 19; 12(18): e029683. Published online 2023 Sep 13. doi: 10.1161/JAHA.123.029683

PMCID:: PMC10547300

Abstract Article PDF–41M

Select item 1051006310.

Colitis-induced upregulation of tumor necrosis factor receptor-2 (TNFR2) terminates epithelial regenerative signaling to restore homeostasis

Zohreh Sharifkhodaei, Cambrian Y. Liu, Nandini Girish, Ying Huang, Shivesh Punit, M. Kay Washington, D. Brent Polk

iScience. 2023 Oct 20; 26(10): 107829. Published online 2023 Sep 4. doi: 10.1016/j.isci.2023.107829

PMCID:: PMC10510063

Abstract Article PDF–8.4M

Select item 1044835811.

Tumor-specific CD4 T cells instruct monocyte fate in pancreatic ductal adenocarcinoma

Michael T. Patterson, Adam L. Burrack, Yingzheng Xu, Grant H. Hickok, Zoe C. Schmiechen, Samuel Becker, Eduardo Cruz-Hinojoza, Patricia R. Schrank, Ainsley E. Kennedy, Maria M. Firulyova, Ebony A. Miller, Konstantin Zaitsev, Jesse W. Williams, Ingunn M. Stromnes

Cell Rep. Author manuscript; available in PMC 2023 Aug 24.

Published in final edited form as: Cell Rep. 2023 Jul 25; 42(7): 112732. Published online 2023 Jul 3. doi: 10.1016/j.celrep.2023.112732

PMCID:: PMC10448358

Abstract Article PDF–3.5M

Select item 1044742612.

Bivalent structure of a TNFR2-selective and agonistic TNF-α mutein Fc-fusion protein enhances the expansion activity of regulatory T cells

Masaki Inoue, Yuta Tsuji, Reira Ueno, Daisuke Miyamoto, Keisuke Tanaka, Yuka Moriyasu, Saya Shibata, Mei Okuda, Daisuke Ando, Yasuhiro Abe, Haruhiko Kamada, Shin-ichi Tsunoda

Sci Rep. 2023; 13: 13762. Published online 2023 Aug 23. doi: 10.1038/s41598-023-40925-9

PMCID:: PMC10447426

Abstract Article PDF–5.1M

Select item 1032131813.

A tissue injury sensing and repair pathway distinct from host pathogen defense

Siqi Liu, Yun Ha Hur, Xin Cai, Qian Cong, Yihao Yang, Chiwei Xu, Angelina M. Bilate, Kevin Andrew Uy Gonzales, S. Martina Parigi, Christopher J. Cowley, Brian Hurwitz, Ji-Dung Luo, Tiffany Tseng, Shiri Gur-Cohen, Megan Sribour, Tatiana Omelchenko, John Levorse, Hilda Amalia Pasolli, Craig B. Thompson, Daniel Mucida, Elaine Fuchs

Cell. Author manuscript; available in PMC 2023 Jul 5.

Published in final edited form as: Cell. 2023 May 11; 186(10): 2127–2143.e22. Published online 2023 Apr 24. doi: 10.1016/j.cell.2023.03.031

PMCID:: PMC10321318

Abstract Article PDF–2.7M

Select item 1029835814.

Various Forms of Programmed Cell Death Are Concurrently Activated in the Population of Retinal Ganglion Cells after Ischemia and Reperfusion

Galina Dvoriantchikova, Emily Adis, Karin Lypka, Dmitry Ivanov

Int J Mol Sci. 2023 Jun; 24(12): 9892. Published online 2023 Jun 8. doi: 10.3390/ijms24129892

PMCID:: PMC10298358

Abstract Article PDF–5.6M

Select item 1021313515.

Autoimmune valvular carditis requires endothelial cell TNFR1 expression

Jessica L. Faragher, Jennifer L Auger, Victoria Osinski, Lee A Meier, Brianna J Engelson, Maria M. Firulyova, Mayra I Gonzalez-Torres, Frank Brombacher, Konstantin Zaitsev, Aubyn Marath, Bryce A Binstadt

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2024 Jun 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2023 Jun; 43(6): 943–957. Published online 2023 Apr 6. doi: 10.1161/ATVBAHA.122.319025

PMCID:: PMC10213135

Abstract Article PDF–2.1M

Select item 1015796816.

Sequential treatment with a TNFR2 agonist and a TNFR1 antagonist improves outcomes in a humanized mouse model for MS

Valentina Pegoretti, Jan Bauer, Roman Fischer, Iskra Paro, Wanda Douwenga, Roland E. Kontermann, Klaus Pfizenmaier, Evelien Houben, Bieke Broux, Niels Hellings, Wia Baron, Jon D. Laman, Ulrich L. M. Eisel

J Neuroinflammation. 2023; 20: 106. Published online 2023 May 3. doi: 10.1186/s12974-023-02785-y