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Items: 1 to 20 of 26

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
ArticlePDF–4.8M
2.
A Translational Regulatory Mechanism Mediated by Hypusinated Eukaryotic Initiation Factor 5A Facilitates β-Cell Identity and Function
Craig T. Connors, Catharina B.P. Villaca, Emily K. Anderson-Baucum, Spencer R. Rosario, Caleb D. Rutan, Paul J. Childress, Leah R. Padgett, Morgan A. Robertson, Teresa L. Mastracci
Diabetes. 2024 Mar; 73(3): 461–473. Published online 2023 Dec 6. doi: 10.2337/db23-0148
PMCID:
PMC10882153
ArticlePDF–110M
3.
Deoxyhypusine synthase mutations alter the post-translational modification of eukaryotic initiation factor 5A resulting in impaired human and mouse neural homeostasis
Leah R. Padgett, Mollie R. Shinkle, Spencer Rosario, Tracy Murray Stewart, Jackson R. Foley, Robert A. Casero, Jr., Myung Hee Park, Wendy K. Chung, Teresa L. Mastracci
HGG Adv. 2023 Jul 13; 4(3): 100206. Published online 2023 May 18. doi: 10.1016/j.xhgg.2023.100206
PMCID:
PMC10275725
ArticlePDF–3.6M
4.
Neuron-specific ablation of eIF5A or deoxyhypusine synthase leads to impairments in growth, viability, neurodevelopment, and cognitive functions in mice
Rajesh Kumar Kar, Ashleigh S. Hanner, Matthew F. Starost, Danielle Springer, Teresa L. Mastracci, Raghavendra G. Mirmira, Myung Hee Park
J Biol Chem. 2021 Nov; 297(5): 101333. Published online 2021 Oct 22. doi: 10.1016/j.jbc.2021.101333
PMCID:
PMC8605248
ArticlePDF–3.6M
5.
Deoxyhypusine Synthase Promotes a Pro-Inflammatory Macrophage Phenotype
Emily Anderson-Baucum, Annie R. Piñeros, Abhishek Kulkarni, Bobbie-Jo Webb-Robertson, Bernhard Maier, Ryan M. Anderson, Wenting Wu, Sarah A. Tersey, Teresa L. Mastracci, Isabel Casimiro, Donalyn Scheuner, Thomas O. Metz, Ernesto S. Nakayasu, Carmella Evans-Molina, Raghavendra G. Mirmira
Cell Metab. Author manuscript; available in PMC 2022 Sep 7.
Published in final edited form as: Cell Metab. 2021 Sep 7; 33(9): 1883–1893.e7. doi: 10.1016/j.cmet.2021.08.003
PMCID:
PMC8432737
ArticlePDF–1.0M
6.
Polyamine metabolism is a central determinant of helper T cell lineage fidelity
Daniel J. Puleston, Francesc Baixauli, David E. Sanin, Joy Edwards-Hicks, Matteo Villa, Agnieszka M. Kabat, Marcin M. Kamiński, Michal Stanckzak, Hauke J. Weiss, Katarzyna M. Grzes, Klara Piletic, Cameron S. Field, Mauro Corrado, Fabian Haessler, Chao Wang, Yaarub Musa, Lena Schimmelpfennig, Lea Flachsmann, Gerhard Mittler, Nir Yosef, Vijay K. Kuchroo, Joerg M. Buescher, Stefan Balabanov, Edward J. Pearce, Douglas R. Green, Erika L. Pearce
Cell. 2021 Aug 5; 184(16): 4186–4202.e20. doi: 10.1016/j.cell.2021.06.007
PMCID:
PMC8358979
Article
7.
Deoxyhypusine synthase, an essential enzyme for hypusine biosynthesis, is required for proper exocrine pancreas development
Leah R. Padgett, Morgan A. Robertson, Emily K. Anderson‐Baucum, Craig T. Connors, Wenting Wu, Raghavendra G. Mirmira, Teresa L. Mastracci
FASEB J. 2021 May; 35(5): e21473. Published online 2021 Apr 3. doi: 10.1096/fj.201903177R
PMCID:
PMC8034418
ArticlePDF–1.5M
8.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
ArticlePDF–2.0M
9.
Hypusination Orchestrates the Antimicrobial Response of Macrophages
Alain P. Gobert, Jordan L. Finley, Yvonne L. Latour, Mohammad Asim, Thaddeus M. Smith, Thomas G. Verriere, Daniel P. Barry, Margaret M. Allaman, Alberto G. Delagado, Kristie L. Rose, M. Wade Calcutt, Kevin L. Schey, Johanna C. Sierra, M. Blanca Piazuelo, Raghavendra G. Mirmira, Keith T. Wilson
Cell Rep. Author manuscript; available in PMC 2021 Jan 18.
Published in final edited form as: Cell Rep. 2020 Dec 15; 33(11): 108510. doi: 10.1016/j.celrep.2020.108510
PMCID:
PMC7812972
ArticlePDF–3.8M
10.
Hypusine biosynthesis in β cells links polyamine metabolism to facultative cellular proliferation to maintain glucose homeostasis
Esther M. Levasseur, Kentaro Yamada, Annie R. Piñeros, Wenting Wu, Farooq Syed, Kara S. Orr, Emily Anderson-Baucum, Teresa L. Mastracci, Bernhard Maier, Amber L. Mosley, Yunlong Liu, Ernesto Bernal-Mizrachi, Laura C. Alonso, Donald Scott, Adolfo Garcia-Ocaña, Sarah A. Tersey, Raghavendra G. Mirmira
Sci Signal. Author manuscript; available in PMC 2020 Jun 3.
Published in final edited form as: Sci Signal. 2019 Dec 3; 12(610): eaax0715. Published online 2019 Dec 3. doi: 10.1126/scisignal.aax0715
PMCID:
PMC7202401
ArticlePDF–3.8M
11.
Polyamines Control eIF5A Hypusination, TFEB Translation, and Autophagy to Reverse B Cell Senescence
Hanlin Zhang, Ghada Alsaleh, Jack Feltham, Yizhe Sun, Gennaro Napolitano, Thomas Riffelmacher, Philip Charles, Lisa Frau, Philip Hublitz, Zhanru Yu, Shabaz Mohammed, Andrea Ballabio, Stefan Balabanov, Jane Mellor, Anna Katharina Simon
Mol Cell. 2019 Oct 3; 76(1): 110–125.e9. doi: 10.1016/j.molcel.2019.08.005
PMCID:
PMC6863385
Article
12.
Mouse screen reveals multiple new genes underlying mouse and human hearing loss
Neil J. Ingham, Selina A. Pearson, Valerie E. Vancollie, Victoria Rook, Morag A. Lewis, Jing Chen, Annalisa Buniello, Elisa Martelletti, Lorenzo Preite, Chi Chung Lam, Felix D. Weiss, Zӧe Powis, Pim Suwannarat, Christopher J. Lelliott, Sally J. Dawson, Jacqueline K. White, Karen P. Steel
PLoS Biol. 2019 Apr; 17(4): e3000194. Published online 2019 Apr 11. doi: 10.1371/journal.pbio.3000194
PMCID:
PMC6459510
ArticlePDF–5.1M
13.
Biological Relevance and Therapeutic Potential of the Hypusine Modification System
Nora Pällmann, Melanie Braig, Henning Sievert, Michael Preukschas, Irm Hermans-Borgmeyer, Michaela Schweizer, Claus Henning Nagel, Melanie Neumann, Peter Wild, Eugenia Haralambieva, Christian Hagel, Carsten Bokemeyer, Joachim Hauber, Stefan Balabanov
J Biol Chem. 2015 Jul 24; 290(30): 18343–18360. Published online 2015 Jun 2. doi: 10.1074/jbc.M115.664490
PMCID:
PMC4513096
ArticlePDF–4.7M
14.
Deoxyhypusine Synthase Promotes Differentiation and Proliferation of T Helper Type 1 (Th1) Cells in Autoimmune Diabetes
Stephanie C. Colvin, Bernhard Maier, David L. Morris, Sarah A. Tersey, Raghavendra G. Mirmira
J Biol Chem. 2013 Dec 20; 288(51): 36226–36235. Published online 2013 Nov 6. doi: 10.1074/jbc.M113.473942
PMCID:
PMC3868737
ArticlePDF–3.1M
15.
A conditional knockout resource for the genome–wide study of mouse gene function
William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley
Nature. Author manuscript; available in PMC 2013 Feb 14.
Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163
PMCID:
PMC3572410
ArticlePDF–1.1M
16.
Essential role of eIF5A-1 and deoxyhypusine synthase in mouse embryonic development
Kazuhiro Nishimura, Seung Bum Lee, Jong Hwan Park, Myung Hee Park
Amino Acids. Author manuscript; available in PMC 2012 Feb 1.
Published in final edited form as: Amino Acids. 2012 Feb; 42(2-3): 703–710. Published online 2011 Aug 18. doi: 10.1007/s00726-011-0986-z
PMCID:
PMC3220921
ArticlePDF–1.4M
17.
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas
Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042
PMCID:
PMC3178059
ArticlePDF–1.0M
18.
Deoxyhypusine synthase haploinsufficiency attenuates acute cytokine signaling
Andrew T Templin, Bernhard Maier, Yurika Nishiki, Sarah A Tersey, Raghavendra G Mirmira
Cell Cycle. 2011 Apr 1; 10(7): 1043–1049. Published online 2011 Apr 1. doi: 10.4161/cc.10.7.15206
PMCID:
PMC3100881
ArticlePDF–1.7M
19.
A High-Resolution Anatomical Atlas of the Transcriptome in the Mouse Embryo
Graciana Diez-Roux, Sandro Banfi, Marc Sultan, Lars Geffers, Santosh Anand, David Rozado, Alon Magen, Elena Canidio, Massimiliano Pagani, Ivana Peluso, Nathalie Lin-Marq, Muriel Koch, Marchesa Bilio, Immacolata Cantiello, Roberta Verde, Cristian De Masi, Salvatore A. Bianchi, Juliette Cicchini, Elodie Perroud, Shprese Mehmeti, Emilie Dagand, Sabine Schrinner, Asja Nürnberger, Katja Schmidt, Katja Metz, Christina Zwingmann, Norbert Brieske, Cindy Springer, Ana Martinez Hernandez, Sarah Herzog, Frauke Grabbe, Cornelia Sieverding, Barbara Fischer, Kathrin Schrader, Maren Brockmeyer, Sarah Dettmer, Christin Helbig, Violaine Alunni, Marie-Annick Battaini, Carole Mura, Charlotte N. Henrichsen, Raquel Garcia-Lopez, Diego Echevarria, Eduardo Puelles, Elena Garcia-Calero, Stefan Kruse, Markus Uhr, Christine Kauck, Guangjie Feng, Nestor Milyaev, Chuang Kee Ong, Lalit Kumar, MeiSze Lam, Colin A. Semple, Attila Gyenesei, Stefan Mundlos, Uwe Radelof, Hans Lehrach, Paolo Sarmientos, Alexandre Reymond, Duncan R. Davidson, Pascal Dollé, Stylianos E. Antonarakis, Marie-Laure Yaspo, Salvador Martinez, Richard A. Baldock, Gregor Eichele, Andrea Ballabio
PLoS Biol. 2011 Jan; 9(1): e1000582. Published online 2011 Jan 18. doi: 10.1371/journal.pbio.1000582
PMCID:
PMC3022534
ArticlePDF–3.8M
20.
Inhibition of Deoxyhypusine Synthase Enhances Islet β Cell Function and Survival in the Setting of Endoplasmic Reticulum Stress and Type 2 Diabetes
Reiesha D. Robbins, Sarah A. Tersey, Takeshi Ogihara, Dhananjay Gupta, Thomas B. Farb, James Ficorilli, Krister Bokvist, Bernhard Maier, Raghavendra G. Mirmira
J Biol Chem. 2010 Dec 17; 285(51): 39943–39952. Published online 2010 Oct 18. doi: 10.1074/jbc.M110.170142
PMCID:
PMC3000976
ArticlePDF–2.6M

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