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Items: 1 to 20 of 23

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
2.
Epithelial Dual Oxidase 2 Shapes the Mucosal Microbiome and Contributes to Inflammatory Susceptibility
Juan Camilo Castrillón-Betancur, Víctor Alonso López-Agudelo, Nina Sommer, Sven Cleeves, Joana Pimenta Bernardes, Saskia Weber-Stiehl, Philip Rosenstiel, Felix Sommer
Antioxidants (Basel) 2023 Oct; 12(10): 1889. Published online 2023 Oct 21. doi: 10.3390/antiox12101889
PMCID:
PMC10603924
AbstractArticlePDF–2.9M
3.
Intestinal Epithelial Inactivity of Dual Oxidase 2 Results in Microbiome-Mediated Metabolic Syndrome
Hajar Hazime, G. Michelle Ducasa, Ana M. Santander, Nivis Brito, Eddy E. González, Yuguang Ban, Jonathan Kaunitz, Yasutada Akiba, Irina Fernández, Juan F. Burgueño, Maria T. Abreu
Cell Mol Gastroenterol Hepatol. 2023; 16(4): 557–572. Published online 2023 Jun 25. doi: 10.1016/j.jcmgh.2023.06.009
PMCID:
PMC10468370
AbstractArticlePDF–5.1M
4.
Endoplasmic reticulum stress in the intestinal epithelium initiates purine metabolite synthesis and promotes Th17 cell differentiation in the gut
Jinzhi Duan, Juan D. Matute, Lukas W. Unger, Thomas Hanley, Alexandra Schnell, Xi Lin, Niklas Krupka, Paul Griebel, Conner Lambden, Brandon Sit, Joep Grootjans, Michal Pyzik, Felix Sommer, Sina Kaiser, Maren Falk-Paulsen, Helmut Grasberger, John Y. Kao, Tobias Fuhrer, Hai Li, Donggi Paik, Yunjin Lee, Samuel Refetoff, Jonathan N. Glickman, Adrienne W. Paton, Lynn Bry, James C. Paton, Uwe Sauer, Andrew J. Macpherson, Philip Rosenstiel, Vijay K. Kuchroo, Matthew K. Waldor, Jun R. Huh, Arthur Kaser, Richard S. Blumberg
Immunity. Author manuscript; available in PMC 2024 May 9.
Published in final edited form as: Immunity. 2023 May 9; 56(5): 1115–1131.e9. Published online 2023 Mar 13. doi: 10.1016/j.immuni.2023.02.018
PMCID:
PMC10175221
AbstractArticlePDF–3.8M
5.
Telocytes reduce oxidative stress by downregulating DUOX2 expression in inflamed lungs of mice: Telocytes reduce oxidative stress in inflamed lungs of mice
Haihong Tang, Tao Liang, Yile Zhou, Huihui Ju, Dongli Song, Hao Fang
Acta Biochim Biophys Sin (Shanghai) 2022 Apr; 54(4): 574–582. Published online 2022 Feb 16. doi: 10.3724/abbs.2022017
PMCID:
PMC9828416
AbstractArticlePDF–5.3M
6.
Germline saturation mutagenesis induces skeletal phenotypes in mice
Jonathan J Rios, Kristin Denton, Jamie Russell, Julia Kozlitina, Carlos R Ferreira, Amy F Lewanda, Joshua E Mayfield, Eva Moresco, Sara Ludwig, Miao Tang, Xiaohong Li, Stephen Lyon, Anas Khanshour, Nandina Paria, Aysha Khalid, Yang Li, Xudong Xie, Jian Q Feng, Qian Xu, Yongbo Lu, Robert E Hammer, Carol A Wise, Bruce Beutler
J Bone Miner Res. Author manuscript; available in PMC 2022 Aug 1.
Published in final edited form as: J Bone Miner Res. 2021 Aug; 36(8): 1548–1565. Published online 2021 May 10. doi: 10.1002/jbmr.4323
PMCID:
PMC8862308
AbstractArticlePDF–2.5M
7.
DUOX2 variants associate with preclinical disturbances in microbiota-immune homeostasis and increased inflammatory bowel disease risk
Helmut Grasberger, Andrew T. Magis, Elisa Sheng, Matthew P. Conomos, Min Zhang, Lea S. Garzotto, Guoqing Hou, Shrinivas Bishu, Hiroko Nagao-Kitamoto, Mohamad El-Zaatari, Sho Kitamoto, Nobuhiko Kamada, Ryan W. Stidham, Yasutada Akiba, Jonathan Kaunitz, Yael Haberman, Subra Kugathasan, Lee A. Denson, Gilbert S. Omenn, John Y. Kao
J Clin Invest. 2021 May 3; 131(9): e141676. Published online 2021 May 3. doi: 10.1172/JCI141676
PMCID:
PMC8087203
AbstractArticlePDF–4.6M
8.
Epithelial TLR4 signaling activates DUOX2 to induce microbiota-driven tumorigenesis
Juan F Burgueño, Julia Fritsch, Eddy E Gonzalez, Kevin S Landau, Ana M Santander, Irina Fernández, Hajar Hazime, Julie M Davies, Rebeca Santaolalla, Matthew C Phillips, Sophia Diaz, Rishu Dheer, Nivis Brito, Judith Pignac-Kobinger, Ester Fernández, Gregory E Conner, Maria T Abreu
Gastroenterology. Author manuscript; available in PMC 2022 Feb 1.
Published in final edited form as: Gastroenterology. 2021 Feb; 160(3): 797–808.e6. Published online 2020 Oct 24. doi: 10.1053/j.gastro.2020.10.031
PMCID:
PMC7879481
AbstractArticlePDF–1.3M
9.
Neurotoxic Activation of Microglia Is Promoted by a Nox1-Dependent NADPH Oxidase
Cyril Chéret, Annie Gervais, Aurélia Lelli, Catherine Colin, Lahouari Amar, Philippe Ravassard, Jacques Mallet, Ana Cumano, Karl-Heinz Krause, Michel Mallat
J Neurosci. 2008 Nov 12; 28(46): 12039–12051. doi: 10.1523/JNEUROSCI.3568-08.2008
PMCID:
PMC6671643
AbstractArticlePDF–668K
10.
Necroptosis of Intestinal Epithelial Cells Induces Type 3 Innate Lymphoid Cell-Dependent Lethal Ileitis
Ryodai Shindo, Masaki Ohmuraya, Sachiko Komazawa-Sakon, Sanae Miyake, Yutaka Deguchi, Soh Yamazaki, Takashi Nishina, Takayuki Yoshimoto, Soichiro Kakuta, Masato Koike, Yasuo Uchiyama, Hiroyuki Konishi, Hiroshi Kiyama, Tetuo Mikami, Kenta Moriwaki, Kimi Araki, Hiroyasu Nakano
iScience. 2019 May 31; 15: 536–551. Published online 2019 May 14. doi: 10.1016/j.isci.2019.05.011
PMCID:
PMC6538961
AbstractArticlePDF–19M
11.
Chemiluminescence imaging of Duox2-derived hydrogen peroxide for longitudinal visualization of biological response to viral infection in nasal mucosa
Hyun Jik Kim, Young Hun Seo, Sujin An, Ara Jo, Ick Chan Kwon, Sehoon Kim
Theranostics. 2018; 8(7): 1798–1807. Published online 2018 Feb 12. doi: 10.7150/thno.22481
PMCID:
PMC5858501
AbstractArticlePDF–1.1M
12.
Deficiency in Duox2 activity alleviates ileitis in GPx1- and GPx2-knockout mice without affecting apoptosis incidence in the crypt epithelium
Fong-Fong Chu, R. Steven Esworthy, James H. Doroshow, Helmut Grasberger, Agnes Donko, Thomas L. Leto, Qiang Gao, Binghui Shen
Redox Biol. 2017 Apr; 11: 144–156. Published online 2016 Nov 22. doi: 10.1016/j.redox.2016.11.001
PMCID:
PMC5148781
AbstractArticlePDF–2.4M
13.
Increased Expression of DUOX2 is an Epithelial Response to Mucosal Dysbiosis Required for Immune Homeostasis in Mouse Intestine
Helmut Grasberger, Jun Gao, Hiroko Nagao-Kitamoto, Sho Kitamoto, Min Zhang, Nobuhiko Kamada, Kathryn A. Eaton, Mohamad El-Zaatari, Andrew B. Shreiner, Juanita L. Merchant, Chung Owyang, John Y. Kao
Gastroenterology. Author manuscript; available in PMC 2016 Dec 1.
Published in final edited form as: Gastroenterology. 2015 Dec; 149(7): 1849–1859. Published online 2015 Aug 7. doi: 10.1053/j.gastro.2015.07.062
Correction in:
Gastroenterology. 2023 Mar 21
PMCID:
PMC4663159
AbstractArticlePDF–1.8M
14.
Proteinase activated receptor-2-mediated dual oxidase-2 up-regulation is involved in enhanced airway reactivity and inflammation in a mouse model of allergic asthma
Ahmed Nadeem, Naif O Alharbi, Harissios Vliagoftis, Manoj Tyagi, Sheikh F Ahmad, Mohamed M Sayed-Ahmed
Immunology. 2015 Jul; 145(3): 391–403. Published online 2015 Jun 12. doi: 10.1111/imm.12453
PMCID:
PMC4479538
AbstractArticlePDF–992K
15.
Dual Oxidase 2 in Lung Epithelia Is Essential for Hyperoxia-Induced Acute Lung Injury in Mice
Min-Ji Kim, Jae-Chan Ryu, Younghee Kwon, Suhee Lee, Yun Soo Bae, Joo-Heon Yoon, Ji-Hwan Ryu
Antioxid Redox Signal. 2014 Nov 1; 21(13): 1803–1818. doi: 10.1089/ars.2013.5677
PMCID:
PMC4203470
AbstractArticlePDF–1.7M
16.
Hypothyroidism-associated missense mutation impairs NADPH oxidase activity and intracellular trafficking of Duox2
Ágnes Donkó, Stanislas Morand, Agnieszka Korzeniowska, Howard E. Boudreau, Melinda Zana, László Hunyady, Miklós Geiszt, Thomas L. Leto
Free Radic Biol Med. Author manuscript; available in PMC 2015 Aug 1.
Published in final edited form as: Free Radic Biol Med. 2014 Aug; 0: 190–200. Published online 2014 May 20. doi: 10.1016/j.freeradbiomed.2014.05.006
PMCID:
PMC4111973
AbstractArticlePDF–781K
17.
A conditional knockout resource for the genome–wide study of mouse gene function
William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley
Nature. Author manuscript; available in PMC 2013 Feb 14.
Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163
PMCID:
PMC3572410
AbstractArticlePDF–1.1M
18.
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas
Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042
PMCID:
PMC3178059
AbstractArticlePDF–1.0M
19.
RIKEN Integrated Sequence Analysis (RISA) System—384-Format Sequencing Pipeline with 384 Multicapillary Sequencer
Kazuhiro Shibata, Masayoshi Itoh, Katsunori Aizawa, Sumiharu Nagaoka, Nobuya Sasaki, Piero Carninci, Hideaki Konno, Junichi Akiyama, Katsuo Nishi, Tokuji Kitsunai, Hideo Tashiro, Mari Itoh, Noriko Sumi, Yoshiyuki Ishii, Shin Nakamura, Makoto Hazama, Tsutomu Nishine, Akira Harada, Rintaro Yamamoto, Hiroyuki Matsumoto, Sumito Sakaguchi, Takashi Ikegami, Katsuya Kashiwagi, Syuji Fujiwake, Kouji Inoue, Yoshiyuki Togawa, Masaki Izawa, Eiji Ohara, Masanori Watahiki, Yuko Yoneda, Tomokazu Ishikawa, Kaori Ozawa, Takumi Tanaka, Shuji Matsuura, Jun Kawai, Yasushi Okazaki, Masami Muramatsu, Yorinao Inoue, Akira Kira, Yoshihide Hayashizaki
Genome Res. 2000 Nov; 10(11): 1757–1771. doi: 10.1101/gr.152600
PMCID:
PMC310992
AbstractArticlePDF–3.4M
20.
Normalization and Subtraction of Cap-Trapper-Selected cDNAs to Prepare Full-Length cDNA Libraries for Rapid Discovery of New Genes
Piero Carninci, Yuko Shibata, Norihito Hayatsu, Yuichi Sugahara, Kazuhiro Shibata, Masayoshi Itoh, Hideaki Konno, Yasushi Okazaki, Masami Muramatsu, Yoshihide Hayashizaki
Genome Res. 2000 Oct; 10(10): 1617–1630. doi: 10.1101/gr.145100
PMCID:
PMC310980
AbstractArticlePDF–1.4M

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