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Select item 109910671.

Inhibition of CK2 Diminishes Fibrotic Scar Formation and Improves Outcomes After Ischemic Stroke via Reducing BRD4 Phosphorylation

Xuemei Li, Qinghuan Yang, Peiran Jiang, Jun Wen, Yue Chen, Jiagui Huang, Mingfen Tian, Jiangxia Ren, Qin Yang

Neurochem Res. 2024; 49(5): 1254–1267. Published online 2024 Feb 21. doi: 10.1007/s11064-024-04112-0

PMCID:: PMC10991067

Abstract Article PDF–6.6M

Select item 74126902.

Salvianic acid A alleviates chronic alcoholic liver disease by inhibiting HMGB1 translocation via down‐regulating BRD4

Yanwen Lan, Ran Yan, Wen Shan, Junyi Chu, Ruimin Sun, Ruiwen Wang, Yan Zhao, Zhanyu Wang, Ning Zhang, Jihong Yao

J Cell Mol Med. 2020 Aug; 24(15): 8518–8531. Published online 2020 Jun 29. doi: 10.1111/jcmm.15473

PMCID:: PMC7412690

Abstract Article PDF–2.2M

Select item 72916713.

MiR-101-containing extracellular vesicles bind to BRD4 and enhance proliferation and migration of trophoblasts in preeclampsia

Jinhui Cui, Xinjuan Chen, Shuo Lin, Ling Li, Jianhui Fan, Hongying Hou, Ping Li

Stem Cell Res Ther. 2020; 11: 231. Published online 2020 Jun 11. doi: 10.1186/s13287-020-01720-9

PMCID:: PMC7291671

Abstract Article PDF–3.4M

Select item 65618024.

The BD2 domain of BRD4 is a determinant in EndoMT and vein graft neointima formation

Mengxue Zhang, Bowen Wang, Go Urabe, Yitao Huang, Jorge Plutzky, K. Craig Kent, Lian-Wang Guo

Cell Signal. Author manuscript; available in PMC 2020 Sep 1.

Published in final edited form as: Cell Signal. 2019 Sep; 61: 20–29. Published online 2019 May 7. doi: 10.1016/j.cellsig.2019.05.005

PMCID:: PMC6561802

Abstract Article PDF–1.8M

Select item 64843355.

BRD4 inhibition attenuates inflammatory response in microglia and facilitates recovery after spinal cord injury in rats

Jianle Wang, Jiaoxiang Chen, Haiming Jin, Dongdong Lin, Yu Chen, Ximiao Chen, Ben Wang, Sunli Hu, Yan Wu, Yaosen Wu, Yifei Zhou, Naifeng Tian, Weiyang Gao, Xiangyang Wang, Xiaolei Zhang

J Cell Mol Med. 2019 May; 23(5): 3214–3223. Published online 2019 Feb 26. doi: 10.1111/jcmm.14196

PMCID:: PMC6484335

Abstract Article PDF–1.2M

Select item 62977446.

Function of BRD4 in the pathogenesis of high glucose-induced cardiac hypertrophy

Qian Wang, Yuxin Sun, Tianshu Li, Lianqin Liu, Yunxia Zhao, Liyuan Li, Ling Zhang, Yan Meng

Mol Med Rep. 2019 Jan; 19(1): 499–507. Published online 2018 Nov 21. doi: 10.3892/mmr.2018.9681

PMCID:: PMC6297744

Abstract Article PDF–1.7M

Select item 57011337.

Structural Mechanism of the Oxygenase JMJD6 Recognition by the Extraterminal (ET) Domain of BRD4

Tsuyoshi Konuma, Di Yu, Chengcheng Zhao, Ying Ju, Rajal Sharma, Chunyan Ren, Qiang Zhang, Ming-Ming Zhou, Lei Zeng

Sci Rep. 2017; 7: 16272. Published online 2017 Nov 24. doi: 10.1038/s41598-017-16588-8

PMCID:: PMC5701133

Abstract Article PDF–2.2M

Select item 52196048.

Brd4 inhibition attenuates unilateral ureteral obstruction-induced fibrosis by blocking TGF-β-mediated Nox4 expression

Baoshang Zhou, Jiao Mu, Yi Gong, Caibao Lu, Youguang Zhao, Ting He, Zhexue Qin

Redox Biol. 2017 Apr; 11: 390–402. Published online 2016 Dec 30. doi: 10.1016/j.redox.2016.12.031

PMCID:: PMC5219604

Abstract Article PDF–1.5M

Select item 42547779.

BRD4 Sustains Melanoma Proliferation and Represents a New Target for Epigenetic Therapy

Miguel F. Segura, Bárbara Fontanals-Cirera, Avital Gaziel-Sovran, María V. Guijarro, Doug Hanniford, Guangtao Zhang, Pilar González-Gomez, Marta Morante, Luz Jubierre, Weijia Zhang, Farbod Darvishian, Michael Ohlmeyer, Iman Osman, Ming-Ming Zhou, Eva Hernando

Cancer Res. Author manuscript; available in PMC 2014 Dec 3.

Published in final edited form as: Cancer Res. 2013 Oct 15; 73(20): 6264–6276. Published online 2013 Aug 15. doi: 10.1158/0008-5472.CAN-13-0122-T

PMCID:: PMC4254777

Abstract Article PDF–987K

Select item 412903810.

Bromodomain 4 protein is a predictor of survival for urothelial carcinoma of bladder

Yang Yan, Feng-Qiang Yang, Hai-Min Zhang, Jun Li, Wei Li, Guang-Chun Wang, Jian-Ping Che, Jun-Hua Zheng, Min Liu

Int J Clin Exp Pathol. 2014; 7(7): 4231–4238. Published online 2014 Jun 15.

PMCID:: PMC4129038

Abstract Article PDF–600K

Select item 409928911.

The Bromodomain: From Epigenome Reader to Druggable Target

Roberto Sanchez, Jamel Meslamani, Ming-Ming Zhou

Biochim Biophys Acta. Author manuscript; available in PMC 2015 Aug 1.

Published in final edited form as: Biochim Biophys Acta. 2014 Aug; 1839(8): 676–685. Published online 2014 Mar 28. doi: 10.1016/j.bbagrm.2014.03.011

PMCID:: PMC4099289

Abstract Article PDF–968K

Select item 408999512.

BET Acetyl-Lysine Binding Proteins Control Pathological Cardiac Hypertrophy

Jessica I. Spiltoir, Matthew S. Stratton, Maria A. Cavasin, Kim Demos-Davies, Brian G. Reid, Jun Qi, James E. Bradner, Timothy A. McKinsey

J Mol Cell Cardiol. Author manuscript; available in PMC 2014 Jul 9.

Published in final edited form as: J Mol Cell Cardiol. 2013 Oct; 63: 175–179. Published online 2013 Aug 9. doi: 10.1016/j.yjmcc.2013.07.017

PMCID:: PMC4089995

Abstract Article PDF–911K

Select item 388691813.

Brd4 and JMJD6-associated Anti-pause Enhancers in Regulation of Transcriptional Pause Release

Wen Liu, Qi Ma, Kaki Wong, Wenbo Li, Kenny Ohgi, Jie Zhang, Aneel Aggarwal, Michael G. Rosenfeld

Cell. Author manuscript; available in PMC 2014 Dec 19.

Published in final edited form as: Cell. 2013 Dec 19; 155(7): 1581–1595. doi: 10.1016/j.cell.2013.10.056

PMCID:: PMC3886918

Abstract Article PDF–2.7M

Select item 369040214.

The methyltransferase SMYD3 mediates the recruitment of transcriptional cofactors at the myostatin and c-Met genes and regulates skeletal muscle atrophy

Valentina Proserpio, Raffaella Fittipaldi, James G. Ryall, Vittorio Sartorelli, Giuseppina Caretti

Genes Dev. 2013 Jun 1; 27(11): 1299–1312. doi: 10.1101/gad.217240.113

PMCID:: PMC3690402

Abstract Article PDF–2.4M

Select item 368335815.

The Bromodomain Protein Brd4 Insulates Chromatin from DNA Damage Signaling

Scott R. Floyd, Michael E. Pacold, Qiuying Huang, Scott M. Clarke, Fred C. Lam, Ian G. Cannell, Bryan D. Bryson, Jonathan Rameseder, Michael J. Lee, Emily J. Blake, Anna Fydrych, Richard Ho, Benjamin A. Greenberger, Grace C. Chen, Amanda Maffa, Amanda M. Del Rosario, David E. Root, Anne E. Carpenter, William C. Hahn, David M. Sabatini, Clark C. Chen, Forest M. White, James E. Bradner, Michael B. Yaffe

Nature. Author manuscript; available in PMC 2013 Dec 13.

Published in final edited form as: Nature. 2013 Jun 13; 498(7453): 246–250. Published online 2013 Jun 2. doi: 10.1038/nature12147

PMCID:: PMC3683358

Article PDF–1.4M

Select item 359539616.

Phospho Switch Triggers Brd4 Chromatin Binding and Activator Recruitment for Gene-Specific Targeting

Shwu-Yuan Wu, A-Young Lee, Hsien-Tsung Lai, Hong Zhang, Cheng-Ming Chiang

Mol Cell. Author manuscript; available in PMC 2014 Mar 7.

Published in final edited form as: Mol Cell. 2013 Mar 7; 49(5): 843–857. Published online 2013 Jan 11. doi: 10.1016/j.molcel.2012.12.006

PMCID:: PMC3595396

Abstract Article PDF–5.5M

Select item 352230817.

Bromodomain-containing Protein 4 (BRD4) Regulates RNA Polymerase II Serine 2 Phosphorylation in Human CD4+ T Cells

Weishi Zhang, Celine Prakash, Calvin Sum, Yue Gong, Yinghui Li, Jeffrey J. T. Kwok, Nina Thiessen, Sven Pettersson, Steven J. M. Jones, Stefan Knapp, Henry Yang, Keh-Chuang Chin

J Biol Chem. 2012 Dec 14; 287(51): 43137–43155. Published online 2012 Oct 19. doi: 10.1074/jbc.M112.413047

PMCID:: PMC3522308

Abstract Article PDF–5.2M

Select item 350581818.

Cell cycle gene-specific control of transcription has a critical role in proliferation of primordial germ cells

Daiji Okamura, Ikuma Maeda, Hirofumi Taniguchi, Yuko Tokitake, Makiko Ikeda, Keiko Ozato, Nathan Mise, Kuniya Abe, Toshiaki Noce, Juan Carlos Izpisua Belmonte, Yasuhisa Matsui

Genes Dev. 2012 Nov 15; 26(22): 2477–2482. doi: 10.1101/gad.202242.112

PMCID:: PMC3505818

Abstract Article PDF–663K

Select item 334500919.

BRD4 is an atypical kinase that phosphorylates Serine2 of the RNA Polymerase II carboxy-terminal domain

Ballachanda N. Devaiah, Brian A. Lewis, Natasha Cherman, Michael C. Hewitt, Brian K. Albrecht, Pamela G. Robey, Keiko Ozato, Robert J. Sims, III, Dinah S. Singer

Proc Natl Acad Sci U S A. 2012 May 1; 109(18): 6927–6932. Published online 2012 Apr 16. doi: 10.1073/pnas.1120422109

PMCID:: PMC3345009

Abstract Article PDF–719K

Select item 332830020.

RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

Johannes Zuber, Junwei Shi, Eric Wang, Amy R. Rappaport, Harald Herrmann, Edward A. Sison, Daniel Magoon, Jun Qi, Katharina Blatt, Mark Wunderlich, Meredith J. Taylor, Christopher Johns, Agustin Chicas, James C. Mulloy, Scott C. Kogan, Patrick Brown, Peter Valent, James E. Bradner, Scott W. Lowe, Christopher R. Vakoc

Nature. Author manuscript; available in PMC 2012 Apr 17.

Published in final edited form as: Nature. 2011 Aug 3; 478(7370): 524–528. Published online 2011 Aug 3. doi: 10.1038/nature10334

PMCID:: PMC3328300

Abstract Article PDF–2.0M

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