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Select item 112995061.

Inhibition of HCK in myeloid cells restricts pancreatic tumor growth and metastasis

Ashleigh R. Poh, Megan O’Brien, David Chisanga, Hong He, David Baloyan, Jasmin Traichel, Christine Dijkstra, Michaël Chopin, Stephen Nutt, Lachlan Whitehead, Louis Boon, Ashleigh Parkin, Clifford Lowell, Marina Pajic, Wei Shi, Mehrdad Nikfarjam, Matthias Ernst

Cell Rep. Author manuscript; available in PMC 2024 Aug 5.

Published in final edited form as: Cell Rep. 2022 Oct 11; 41(2): 111479. doi: 10.1016/j.celrep.2022.111479

PMCID:: PMC11299506

Abstract Article PDF–1.4M

Select item 103540752.

HCK induces macrophage activation to promote renal inflammation and fibrosis via suppression of autophagy

Man Chen, Madhav C. Menon, Wenlin Wang, Jia Fu, Zhengzi Yi, Zeguo Sun, Jessica Liu, Zhengzhe Li, Lingyun Mou, Khadija Banu, Sui-Wan Lee, Ying Dai, Nanditha Anandakrishnan, Evren U. Azeloglu, Kyung Lee, Weijia Zhang, Bhaskar Das, John Cijiang He, Chengguo Wei

Nat Commun. 2023; 14: 4297. Published online 2023 Jul 18. doi: 10.1038/s41467-023-40086-3

PMCID:: PMC10354075

Abstract Article PDF–8.1M

Select item 103078523.

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility

Juan Gu, Pingyang Ke, Haokun Guo, Jing Liu, Yan Liu, Xin Tian, Zhuo Huang, Xin Xu, Demei Xu, Yuanlin Ma, Xuefeng Wang, Fei Xiao

Cell Death Differ. 2023 Jul; 30(7): 1726–1741. Published online 2023 May 4. doi: 10.1038/s41418-023-01174-5

PMCID:: PMC10307852

Abstract Article PDF–8.8M

Select item 101176564.

Analysis of intracellular tyrosine phosphorylation in circulating neutrophils as a rapid assay for the in vivo effect of oral tyrosine kinase inhibitors

Krisztina Futosi, Boglárka Bajza, Dorottya Deli, András Erdélyi, Simon Tusnády, Attila Mócsai

Front Pharmacol. 2023; 14: 1056154. Published online 2023 Apr 6. doi: 10.3389/fphar.2023.1056154

PMCID:: PMC10117656

Abstract Article PDF–3.0M

Select item 84354565.

Hematopoietic cell kinase enhances osteosarcoma development via the MEK/ERK pathway

Weibo Liu, Teng Li, Wenhao Hu, Quanbo Ji, Fanqi Hu, Qi Wang, Xiaoqing Yang, Dengbin Qi, Hui Chen, Xuesong Zhang

J Cell Mol Med. 2021 Sep; 25(18): 8789–8795. Published online 2021 Aug 7. doi: 10.1111/jcmm.16836

PMCID:: PMC8435456

Abstract Article PDF–896K

Select item 80645886.

Inhibition of the SRC Kinase HCK Impairs STAT3-Dependent Gastric Tumor Growth in Mice

Ashleigh R. Poh, Amy R. Dwyer, Moritz F. Eissmann, Ashwini L. Chand, David Baloyan, Louis Boon, Michael W. Murrey, Lachlan Whitehead, Megan O'Brien, Clifford A. Lowell, Tracy L. Putoczki, Fiona J. Pixley, Robert J.J. O'Donoghue, Matthias Ernst

Cancer Immunol Res. Author manuscript; available in PMC 2021 Apr 23.

Published in final edited form as: Cancer Immunol Res. 2020 Apr; 8(4): 428–435. Published online 2020 Jan 28. doi: 10.1158/2326-6066.CIR-19-0623

PMCID:: PMC8064588

Abstract Article PDF–1.1M

Select item 79387707.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 75461158.

CARD9 mediates dendritic cell-induced development of Lyn-deficiency–associated autoimmune and inflammatory diseases

Jun Ma, Clare L. Abram, Yongmei Hu, Clifford A. Lowell

Sci Signal. Author manuscript; available in PMC 2020 Oct 9.

Published in final edited form as: Sci Signal. 2019 Oct 8; 12(602): eaao3829. Published online 2019 Oct 8. doi: 10.1126/scisignal.aao3829

PMCID:: PMC7546115

Abstract Article PDF–1.5M

Select item 74159919.

BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING)

Kou Motani, Hidetaka Kosako

J Biol Chem. 2020 Aug 7; 295(32): 11174–11183. Published online 2020 Jun 17. doi: 10.1074/jbc.RA120.014323

PMCID:: PMC7415991

Abstract Article PDF–2.0M

Select item 721564710.

Expression of a Constitutively Active Form of Hck in Chondrocytes Activates Wnt and Hedgehog Signaling Pathways, and Induces Chondrocyte Proliferation in Mice

Viviane K. S. Kawata Matsuura, Carolina Andrea Yoshida, Hisato Komori, Chiharu Sakane, Kei Yamana, Qing Jiang, Toshihisa Komori

Int J Mol Sci. 2020 Apr; 21(8): 2682. Published online 2020 Apr 12. doi: 10.3390/ijms21082682

PMCID:: PMC7215647

Abstract Article PDF–63M

Select item 718790711.

Genetic ablation of hematopoietic cell kinase accelerates Alzheimer’s disease-like neuropathology in Tg2576 mice

Siok Lam Lim, Diana Nguyen Tran, Zanett Kieu, Christine Chen, Emmanuel Villanueva, Sagar Ghiaar, Victoria Gallup, Joannee Zumkehr, David H. Cribbs, Carlos J. Rodriguez-Ortiz, Masashi Kitazawa

Mol Neurobiol. Author manuscript; available in PMC 2021 May 1.

Published in final edited form as: Mol Neurobiol. 2020 May; 57(5): 2447–2460. Published online 2020 Mar 7. doi: 10.1007/s12035-020-01894-6

PMCID:: PMC7187907

Abstract Article PDF–1.9M

Select item 664569012.

Inhibition of hematopoietic cell kinase dysregulates microglial function and accelerates early stage Alzheimer’s disease-like neuropathology

Siok Lam Lim, Diana Nguyen Tran, Joannee Zumkehr, Christine Chen, Sagar Ghiaar, Zanett Kieu, Emmanuel Villanueva, Victoria Gallup, Carlos J. Rodriguez-Ortiz, Masashi Kitazawa

Glia. Author manuscript; available in PMC 2019 Jul 22.

Published in final edited form as: Glia. 2018 Dec; 66(12): 2700–2718. Published online 2018 Sep 12. doi: 10.1002/glia.23522

PMCID:: PMC6645690

Abstract Article PDF–3.5M

Select item 650553513.

Hemopoietic Cell Kinase amplification with Protein Tyrosine Phosphatase Receptor T depletion leads to polycythemia, aberrant marrow erythoid maturation, and splenomegaly

Matthew Ku, Ruth N. MacKinnon, Meaghan Wall, Nisha Narayan, Carl Walkley, Heung-Chin Cheng, Lynda J. Campbell, Louise E. Purton, Harshal Nandurkar

Sci Rep. 2019; 9: 7050. Published online 2019 May 7. doi: 10.1038/s41598-019-43373-6

PMCID:: PMC6505535

Abstract Article PDF–2.8M

Select item 610366114.

Suppression of autophagy and HCK signaling promotes PTGS2^high FCGR3⁻ NK cell differentiation triggered by ectopic endometrial stromal cells

Jie Mei, Wen-Jie Zhou, Xiao-Yong Zhu, Han Lu, Ke Wu, Hui-Li Yang, Qiang Fu, Chun-Yan Wei, Kai-Kai Chang, Li-Ping Jin, Jian Wang, Yong-Ming Wang, Da-Jin Li, Ming-Qing Li

Autophagy. 2018; 14(8): 1376–1397. Published online 2018 Jul 20. doi: 10.1080/15548627.2018.1476809

PMCID:: PMC6103661

Abstract Article PDF–5.2M

Select item 562486515.

The Syk Tyrosine Kinase Is Required for Skin Inflammation in an In Vivo Mouse Model of Epidermolysis Bullosa Acquisita

Tamás Németh, Oana Virtic, Cassian Sitaru, Attila Mócsai

J Invest Dermatol. 2017 Oct; 137(10): 2131–2139. doi: 10.1016/j.jid.2017.05.017

PMCID:: PMC5624865

Abstract Article PDF–2.7M

Select item 547932916.

Inhibition of Hematopoietic Cell Kinase Activity Suppresses Myeloid Cell-Mediated Colon Cancer Progression

Ashleigh R. Poh, Christopher G. Love, Frederick Masson, Adele Preaudet, Cary Tsui, Lachlan Whitehead, Simon Monard, Yelena Khakham, Lotta Burstroem, Guillaume Lessene, Oliver Sieber, Clifford Lowell, Tracy L. Putoczki, Robert J.J. O’Donoghue, Matthias Ernst

Cancer Cell. Author manuscript; available in PMC 2017 Jun 21.

Published in final edited form as: Cancer Cell. 2017 Apr 10; 31(4): 563–575.e5. doi: 10.1016/j.ccell.2017.03.006

PMCID:: PMC5479329

Abstract Article PDF–1.1M

Select item 540771617.

Genomic Analysis of Kidney Allograft Injury Identifies Hematopoietic Cell Kinase as a Key Driver of Renal Fibrosis

Chengguo Wei, Li Li, Madhav C. Menon, Weijia Zhang, Jia Fu, Brian Kidd, Karen L. Keung, Christopher Woytovich, Ilana Greene, Wenzhen Xiao, Fadi Salem, Zhengzi Yi, John Cijiang He, Joel T. Dudley, Barbara Murphy

J Am Soc Nephrol. 2017 May; 28(5): 1385–1393. Published online 2016 Dec 7. doi: 10.1681/ASN.2016020238

PMCID:: PMC5407716

Abstract Article

Select item 538122618.

Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function

Tingting Zhang, Wei Du, Andrew F. Wilson, Satoshi H. Namekawa, Paul R. Andreassen, Amom Ruhikanta Meetei, Qishen Pang

Sci Rep. 2017; 7: 45626. Published online 2017 Apr 5. doi: 10.1038/srep45626

PMCID:: PMC5381226

Abstract Article PDF–1.4M

Select item 507071419.

Three-dimensional migration of macrophages requires Hck for podosome organization and extracellular matrix proteolysis

Céline Cougoule, Véronique Le Cabec, Renaud Poincloux, Talal Al Saati, Jean-Louis Mège, Guillaume Tabouret, Clifford A. Lowell, Nathalie Laviolette-Malirat, Isabelle Maridonneau-Parini

Blood. 2010 Feb 18; 115(7): 1444–1452. Prepublished online 2009 Sep 6. doi: 10.1182/blood-2009-04-218735

Correction in:: Blood. 2010 Sep 23; 116(12): 2195.

PMCID:: PMC5070714

Abstract Article

Select item 503007820.

The Neutrophil Btk Signalosome Regulates Integrin Activation during Sterile Inflammation

Stephanie Volmering, Helena Block, Mark Boras, Clifford A. Lowell, Alexander Zarbock

Immunity. Author manuscript; available in PMC 2016 Sep 20.

Published in final edited form as: Immunity. 2016 Jan 19; 44(1): 73–87. Published online 2016 Jan 5. doi: 10.1016/j.immuni.2015.11.011

PMCID:: PMC5030078

Abstract Article PDF–1.1M

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