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Select item 82795871.

Sex-dependent compensatory mechanisms preserve blood pressure homeostasis in prostacyclin receptor–deficient mice

Soon Y. Tang, Hu Meng, Seán T. Anderson, Dimitra Sarantopoulou, Soumita Ghosh, Nicholas F. Lahens, Katherine N. Theken, Emanuela Ricciotti, Elizabeth J. Hennessy, Vincent Tu, Kyle Bittinger, Aalim M. Weiljie, Gregory R. Grant, Garret A. FitzGerald

J Clin Invest. 2021 Jul 15; 131(14): e136310. Published online 2021 Jul 15. doi: 10.1172/JCI136310

PMCID:: PMC8279587

Abstract Article PDF–2.9M

Select item 80118972.

Prostaglandin I₂ signaling licenses Treg suppressive function and prevents pathogenic reprogramming

Allison E. Norlander, Melissa H. Bloodworth, Shinji Toki, Jian Zhang, Weisong Zhou, Kelli Boyd, Vasiliy V. Polosukhin, Jacqueline-Yvonne Cephus, Zachary J. Ceneviva, Vivek D. Gandhi, Nowrin U. Chowdhury, Louis-Marie Charbonnier, Lisa M. Rogers, Janey Wang, David M. Aronoff, Lisa Bastarache, Dawn C. Newcomb, Talal A. Chatila, R. Stokes Peebles, Jr.

J Clin Invest. 2021 Apr 1; 131(7): e140690. Published online 2021 Apr 1. doi: 10.1172/JCI140690

PMCID:: PMC8011897

Abstract Article PDF–5.8M

Select item 76850743.

Prostacyclin receptor in tumor endothelial cells promotes angiogenesis in an autocrine manner

Takahiro Osawa, Noritaka Ohga, Yasuhiro Hida, Kazuko Kitayama, Kosuke Akiyama, Yuichiro Onodera, Manabu Fujie, Nobuo Shinohara, Masanobu Shindoh, Katsuya Nonomura, Kyoko Hida

Cancer Sci. 2012 Jun; 103(6): 1038–1044. Published online 2012 Apr 17. doi: 10.1111/j.1349-7006.2012.02261.x

PMCID:: PMC7685074

Abstract Article PDF–510K

Select item 75198874.

Mechanistic definition of the cardiovascular mPGES-1/COX-2/ADMA axis

Nicholas S Kirkby, Joan Raouf, Blerina Ahmetaj-Shala, Bin Liu, Sarah I Mazi, Matthew L Edin, Mark Geoffrey Chambers, Marina Korotkova, Xiaomeng Wang, Walter Wahli, Darryl C Zeldin, Rolf Nüsing, Yingbi Zhou, Per-Johan Jakobsson, Jane A Mitchell

Cardiovasc Res. 2020 Oct 1; 116(12): 1972–1980. Published online 2019 Nov 5. doi: 10.1093/cvr/cvz290

PMCID:: PMC7519887

Abstract Article PDF–928K

Select item 61620945.

The PGI₂ analog cicaprost inhibits IL-33-induced Th2 responses, IL-2 production, and CD25 expression in mouse CD4⁺ T cells

Weisong Zhou, Jian Zhang, Shinji Toki, Kasia Goleniewska, Marc O. Johnson, Melissa H. Bloodworth, Dawn C. Newcomb, R. Stokes Peebles, Jr.

J Immunol. Author manuscript; available in PMC 2019 Oct 1.

Published in final edited form as: J Immunol. 2018 Oct 1; 201(7): 1936–1945. Published online 2018 Aug 20. doi: 10.4049/jimmunol.1700605

PMCID:: PMC6162094

Abstract Article PDF–2.2M

Select item 60101856.

NEUROPROTECTIVE PROPERTIES OF PROSTAGLANDIN I₂ IP RECEPTOR IN FOCAL CEREBRAL ISCHEMIA

S. SALEEM, Z. A. SHAH, T. MARUYAMA, S. NARUMIYA, S. DORÉ

Neuroscience. Author manuscript; available in PMC 2018 Jun 20.

Published in final edited form as: Neuroscience. 2010 Sep 29; 170(1): 317–323. Published online 2010 Jul 14. doi: 10.1016/j.neuroscience.2010.06.060

PMCID:: PMC6010185

Abstract Article PDF–773K

Select item 60101737.

PROSTACYCLIN RECEPTOR DELETION AGGRAVATES HIPPOCAMPAL NEURONAL LOSS AFTER BILATERAL COMMON CAROTID ARTERY OCCLUSION IN MOUSE

G. WEI, K. K. KIBLER, R. C. KOEHLER, T. MARUYAMA, S. NARUMIYA, S. DORÉ

Neuroscience. Author manuscript; available in PMC 2018 Jun 20.

Published in final edited form as: Neuroscience. 2008 Oct 28; 156(4): 1111–1117. Published online 2008 Aug 20. doi: 10.1016/j.neuroscience.2008.07.073

PMCID:: PMC6010173

Abstract Article PDF–529K

Select item 59207018.

A Protective Role of Microsomal Prostaglandin E Synthase-1 Derived PGE₂ and the Endothelial EP4 Receptor in Vascular Responses to Injury

Huifeng Hao, Sheng Hu, Qing Wan, Chuansheng Xu, Hong Chen, Liyuan Zhu, Zhenyu Xu, Jian Meng, Richard M. Breyer, Nailin Li, De-Pei Liu, Garret A. FitzGerald, Miao Wang

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2019 May 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2018 May; 38(5): 1115–1124. Published online 2018 Mar 29. doi: 10.1161/ATVBAHA.118.310713

PMCID:: PMC5920701

Abstract Article PDF–1.3M

Select item 49926709.

PGI₂ suppresses proinflammatory chemokine expression, CD4 T cell activation, and STAT6-independent allergic lung inflammation

Weisong Zhou, Jian Zhang, Kasia Goleniewska, Daniel E. Dulek, Shinji Toki, Dawn C. Newcomb, Jacqueline Y. Cephus, Robert D. Collins, Pingsheng Wu, Mark R. Boothby, R. Stokes Peebles, Jr.

J Immunol. Author manuscript; available in PMC 2017 Sep 1.

Published in final edited form as: J Immunol. 2016 Sep 1; 197(5): 1577–1586. Published online 2016 Jul 25. doi: 10.4049/jimmunol.1501063

PMCID:: PMC4992670

Abstract Article PDF–1.5M

Select item 496327910.

Cardiovascular Consequences of Prostanoid I Receptor Deletion in Microsomal Prostaglandin E Synthase-1 Deficient Hyperlipidemic Mice

Soon Yew Tang, James Monslow, Gregory R. Grant, Leslie Todd, Sven-Christian Pawelzik, Lihong Chen, John Lawson, Ellen Puré, Garret A. FitzGerald

Circulation. Author manuscript; available in PMC 2017 Jul 26.

Published in final edited form as: Circulation. 2016 Jul 26; 134(4): 328–338. doi: 10.1161/CIRCULATIONAHA.116.022308

PMCID:: PMC4963279

Abstract Article PDF–1.1M

Select item 476863411.

Evidence That Links Loss of Cyclooxygenase-2 With Increased Asymmetric Dimethylarginine: Novel Explanation of Cardiovascular Side Effects Associated With Anti-Inflammatory Drugs

Blerina Ahmetaj-Shala, Nicholas S. Kirkby, Rebecca Knowles, Malak Al’Yamani, Sarah Mazi, Zhen Wang, Arthur T. Tucker, Louise Mackenzie, Paul C. J. Armstrong, Rolf M. Nüsing, James A. P. Tomlinson, Timothy D. Warner, James Leiper, Jane A. Mitchell

Circulation. 2015 Feb 17; 131(7): 633–642. Published online 2015 Feb 16. doi: 10.1161/CIRCULATIONAHA.114.011591

PMCID:: PMC4768634

Abstract Article PDF–644K

Select item 458830812.

Mucosally transplanted mesenchymal stem cells stimulate intestinal healing by promoting angiogenesis

Nicholas A. Manieri, Madison R. Mack, Molly D. Himmelrich, Daniel L. Worthley, Elaine M. Hanson, Lars Eckmann, Timothy C. Wang, Thaddeus S. Stappenbeck

J Clin Invest. 2015 Sep 1; 125(9): 3606–3618. Published online 2015 Aug 17. doi: 10.1172/JCI81423

PMCID:: PMC4588308

Abstract Article PDF–9.0M

Select item 409668613.

Pulmonary Arterial Hypertension: The Clinical Syndrome

Yen-Chun Lai, Karin C. Potoka, Hunter C. Champion, Ana L. Mora, Mark T. Gladwin

Circ Res. Author manuscript; available in PMC 2015 Jun 20.

Published in final edited form as: Circ Res. 2014 Jun 20; 115(1): 115–130. doi: 10.1161/CIRCRESAHA.115.301146

PMCID:: PMC4096686

Abstract Article PDF–2.3M

Select item 406530714.

Mast cell maturation is driven via a group III phospholipase A₂-prostaglandin D₂–DP1 receptor paracrine axis

Yoshitaka Taketomi, Noriko Ueno, Takumi Kojima, Hiroyasu Sato, Remi Murase, Kei Yamamoto, Satoshi Tanaka, Mariko Sakanaka, Masanori Nakamura, Yasumasa Nishito, Momoko Kawana, Naotomo Kambe, Kazutaka Ikeda, Ryo Taguchi, Satoshi Nakamizo, Kenji Kabashima, Michael H. Gelb, Makoto Arita, Takehiko Yokomizo, Motonao Nakamura, Kikuko Watanabe, Hiroyuki Hirai, Masataka Nakamura, Yoshimichi Okayama, Chisei Ra, Kosuke Aritake, Yoshihiro Urade, Kazushi Morimoto, Yukihiko Sugimoto, Takao Shimizu, Shuh Narumiya, Shuntaro Hara, Makoto Murakami

Nat Immunol. Author manuscript; available in PMC 2014 Jun 21.

Published in final edited form as: Nat Immunol. 2013 Jun; 14(6): 554–563. Published online 2013 Apr 28. doi: 10.1038/ni.2586

PMCID:: PMC4065307

Abstract Article PDF–1.0M

Select item 368502115.

PGI₂ signaling inhibits antigen uptake and increases migration of immature dendritic cells

Shinji Toki, Kasia Goleniewska, Matthew M. Huckabee, Weisong Zhou, Dawn C. Newcomb, Garret A. FitzGerald, William E. Lawson, R. Stokes Peebles, Jr.

J Leukoc Biol. 2013 Jul; 94(1): 77–88. doi: 10.1189/jlb.1112559

PMCID:: PMC3685021

Abstract Article

Select item 356613316.

Molecular Analysis of the Prostacyclin Receptor’s Interaction with the PDZ1 Domain of Its Adaptor Protein PDZK1

Gabriel Birrane, Eamon P. Mulvaney, Rinku Pal, B. Therese Kinsella, Olivier Kocher

PLoS One. 2013; 8(2): e53819. Published online 2013 Feb 6. doi: 10.1371/journal.pone.0053819

PMCID:: PMC3566133

Abstract Article PDF–1.0M

Select item 340252817.

The COX-2/PGI2 Receptor Axis Plays an Obligatory Role in Mediating the Cardioprotection Conferred by the Late Phase of Ischemic Preconditioning

Yiru Guo, Deepali Nivas Tukaye, Wen-Jian Wu, Xiaoping Zhu, Michael Book, Wei Tan, Steven P. Jones, Gregg Rokosh, Shuh Narumiya, Qianhong Li, Roberto Bolli

PLoS One. 2012; 7(7): e41178. Published online 2012 Jul 23. doi: 10.1371/journal.pone.0041178

PMCID:: PMC3402528

Abstract Article PDF–933K

Select item 334967418.

Prostaglandin I₂ Signaling Drives Th17 Differentiation and Exacerbates Experimental Autoimmune Encephalomyelitis

Weisong Zhou, Dustin R. Dowell, Matthew M. Huckabee, Dawn C. Newcomb, Madison G. Boswell, Kasia Goleniewska, Matthew T. Lotz, Shinji Toki, Huiyong Yin, Songyi Yao, Chandramohan Natarajan, Pingsheng Wu, Subramaniam Sriram, Richard M. Breyer, Garret A. FitzGerald, R. Stokes Peebles, Jr

PLoS One. 2012; 7(5): e33518. Published online 2012 May 10. doi: 10.1371/journal.pone.0033518

PMCID:: PMC3349674

Abstract Article PDF–646K

Select item 321390719.

A major role for the EP4 receptor in regulation of renin

Carie S. Facemire, Mytrang Nguyen, Leigh Jania, William H. Beierwaltes, Hyung-Suk Kim, Beverly H. Koller, Thomas M. Coffman

Am J Physiol Renal Physiol. 2011 Nov; 301(5): F1035–F1041. Published online 2011 Aug 10. doi: 10.1152/ajprenal.00054.2011

PMCID:: PMC3213907

Abstract Article

Select item 317805920.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

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