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Select item 115160521.

Platelet‐Derived Growth Factor C Facilitates Malignant Behavior of Pancreatic Ductal Adenocarcinoma by Regulating SREBP1 Mediated Lipid Metabolism

Yin‐Hao Shi, Zhi‐De Liu, Ming‐Jian Ma, Guang‐Yin Zhao, Ying‐Qin Zhu, Jie‐Qin Wang, Yang‐Yin‐Hui Yu, Xi‐Tai Huang, Jing‐Yuan Ye, Fu‐Xi Li, Xi‐Yu Wang, Qiong‐Cong Xu, Xiao‐Yu Yin

Adv Sci (Weinh) 2024 Oct; 11(40): 2407069. Published online 2024 Sep 3. doi: 10.1002/advs.202407069

PMCID:: PMC11516052

Abstract Article PDF–24M

Select item 114672122.

FUT2 promotes colorectal cancer metastasis by reprogramming fatty acid metabolism via YAP/TAZ signaling and SREBP-1

Chenfei Dong, Yue Zhang, Jiayue Zeng, Suli Chong, Yang Liu, Ziming Bian, Sairong Fan, Xiaoming Chen

Commun Biol. 2024; 7: 1297. Published online 2024 Oct 10. doi: 10.1038/s42003-024-06993-x

PMCID:: PMC11467212

Abstract Article PDF–7.3M

Select item 114110563.

CTBP1 links metabolic syndrome to polycystic ovary syndrome through interruption of aromatase and SREBP1

Yue Kong, Guang Yang, Xu Feng, Zhaodong Ji, Xiaoling Wang, Yang Shao, Jiao Meng, Guidong Yao, Chunxia Ren, Gong Yang

Commun Biol. 2024; 7: 1174. Published online 2024 Sep 18. doi: 10.1038/s42003-024-06857-4

PMCID:: PMC11411056

Abstract Article PDF–6.1M

Select item 113377674.

CLDN6 inhibits breast cancer growth and metastasis through SREBP1-mediated RAS palmitoylation

Qiu Jin, Da Qi, Mingzi Zhang, Huinan Qu, Yuan Dong, Minghao Sun, Chengshi Quan

Cell Mol Biol Lett. 2024; 29: 112. Published online 2024 Aug 21. doi: 10.1186/s11658-024-00629-y

PMCID:: PMC11337767

Abstract Article PDF–9.7M

Select item 112379305.

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein

Xiao Tang, Yang Liu, Jinhui Wang, Teng Long, Bobo Wing Yee Mok, Yan Huang, Ziqing Peng, Qinyu Jia, Chengxi Liu, Pui-Kin So, Sirius Pui-Kam Tse, Cheuk Hei NG, Shiyi Liu, Fei Sun, Shaojun Tang, Zhong-Ping Yao, Honglin Chen, Yusong Guo

J Biol Chem. 2024 Jun; 300(6): 107390. Published online 2024 May 21. doi: 10.1016/j.jbc.2024.107390

PMCID:: PMC11237930

Abstract Article PDF–3.8M

Select item 108159516.

The Role of SCAP/SREBP as Central Regulators of Lipid Metabolism in Hepatic Steatosis

Preethi Chandrasekaran, Ralf Weiskirchen

Int J Mol Sci. 2024 Jan; 25(2): 1109. Published online 2024 Jan 16. doi: 10.3390/ijms25021109

PMCID:: PMC10815951

Abstract Article PDF–6.4M

Select item 108119487.

EXO1/P53/SREBP1 axis-regulated lipid metabolism promotes prostate cancer progression

Zefeng Wang, Zheng Chao, Qi Wang, Fan Zou, Tianbao Song, Lizhe Xu, Jinzhuo Ning, Fan Cheng

J Transl Med. 2024; 22: 104. Published online 2024 Jan 26. doi: 10.1186/s12967-023-04822-z

PMCID:: PMC10811948

Abstract Article PDF–20M

Select item 107514228.

Exogenous H₂S promotes ubiquitin‐mediated degradation of SREBP1 to alleviate diabetic cardiomyopathy via SYVN1 S‐sulfhydration

Shiwu Zhang, Mengyi Wang, Hongxia Li, Qianzhu Li, Ning Liu, Shiyun Dong, Yajun Zhao, Kemiao Pang, Jiayi Huang, Cheng Ren, Yan Wang, Zhen Tian, Fanghao Lu, Weihua Zhang

J Cachexia Sarcopenia Muscle. 2023 Dec; 14(6): 2719–2732. Published online 2023 Oct 30. doi: 10.1002/jcsm.13347

PMCID:: PMC10751422

Abstract Article PDF–3.4M

Select item 105702969.

Palmitoylation-driven PHF2 ubiquitination remodels lipid metabolism through the SREBP1c axis in hepatocellular carcinoma

Do-Won Jeong, Jong-Wan Park, Kyeong Seog Kim, Jiyoung Kim, June Huh, Jieun Seo, Ye Lee Kim, Joo-Youn Cho, Kwang-Woong Lee, Junji Fukuda, Yang-Sook Chun

Nat Commun. 2023; 14: 6370. Published online 2023 Oct 12. doi: 10.1038/s41467-023-42170-0

PMCID:: PMC10570296

Abstract Article PDF–3.7M

Select item 1049478810.

FAM120A couples SREBP-dependent transcription and splicing of lipogenesis enzymes downstream of mTORC1

Sungyun Cho, Yujin Chun, Long He, Cuauhtemoc B. Ramirez, Kripa S. Ganesh, Kyungjo Jeong, Junho Song, Jin Gyu Cheong, Zhongchi Li, Jungmin Choi, Joohwan Kim, Nikos Koundouros, Fangyuan Ding, Noah Dephoure, Cholsoon Jang, John Blenis, Gina Lee

Mol Cell. Author manuscript; available in PMC 2024 Aug 17.

Published in final edited form as: Mol Cell. 2023 Aug 17; 83(16): 3010–3026.e8. doi: 10.1016/j.molcel.2023.07.017

PMCID:: PMC10494788

Abstract Article PDF–2.8M

Select item 987545711.

TRIM21 attenuates renal carcinoma lipogenesis and malignancy by regulating SREBF1 protein stability

Xintian Chen, Hongmei Yong, Miaolei Chen, Chuyin Deng, Pengfei Wang, Sufang Chu, Minle Li, Pingfu Hou, Junnian Zheng, Zhongwei Li, Jin Bai

J Exp Clin Cancer Res. 2023; 42: 34. Published online 2023 Jan 25. doi: 10.1186/s13046-022-02583-z

PMCID:: PMC9875457

Abstract Article PDF–13M

Select item 963328512.

Apelin‐mediated deamidation of HMGA1 promotes tumorigenesis by enhancing SREBP1 activity and lipid synthesis

Yihan Zhu, Ying Yang, Hong Bu, Hong Huang, Hongyu Chen, Jingjing Ran, Liwen Qin, Yinyun Ni, Menglin Yao, Tingting Song, Mufeng Li, Yongfeng Yang, Tingting Guo, Ningning Chao, Zhiqing Liu, Weimin Li, Li Zhang

Cancer Sci. 2022 Nov; 113(11): 3722–3734. Published online 2022 Sep 10. doi: 10.1111/cas.15515

PMCID:: PMC9633285

Abstract Article PDF–12M

Select item 933831313.

HSF1 phosphorylation establishes an active chromatin state via the TRRAP–TIP60 complex and promotes tumorigenesis

Mitsuaki Fujimoto, Ryosuke Takii, Masaki Matsumoto, Mariko Okada, Keiich I. Nakayama, Ryuichiro Nakato, Katsunori Fujiki, Katsuhiko Shirahige, Akira Nakai

Nat Commun. 2022; 13: 4355. Published online 2022 Jul 29. doi: 10.1038/s41467-022-32034-4

PMCID:: PMC9338313

Abstract Article PDF–2.8M

Select item 926261414.

A dual-activity topoisomerase complex regulates mRNA translation and turnover

Shuaikun Su, Yutong Xue, Alexei Sharov, Yongqing Zhang, Seung Kyu Lee, Jennifer L Martindale, Wen Li, Wai Lim Ku, Keji Zhao, Supriyo De, Weiping Shen, Payel Sen, Myriam Gorospe, Dongyi Xu, Weidong Wang

Nucleic Acids Res. 2022 Jul 8; 50(12): 7013–7033. Published online 2022 Jun 24. doi: 10.1093/nar/gkac538

PMCID:: PMC9262614

Abstract Article PDF–3.6M

Select item 923162315.

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1

Boris Simonetti, James L. Daly, Lorena Simón-Gracia, Katja Klein, Saroja Weeratunga, Carlos Antón-Plágaro, Allan Tobi, Lorna Hodgson, Philip A. Lewis, Kate J. Heesom, Deborah K. Shoemark, Andrew D. Davidson, Brett M. Collins, Tambet Teesalu, Yohei Yamauchi, Peter J. Cullen

Proc Natl Acad Sci U S A. 2022 Jun 21; 119(25): e2201980119. Published online 2022 Jun 13. doi: 10.1073/pnas.2201980119

PMCID:: PMC9231623

Abstract Article PDF–6.0M

Select item 914616216.

Leptin Silencing Attenuates Lipid Accumulation through Sterol Regulatory Element-Binding Protein 1 Inhibition in Nasopharyngeal Carcinoma

Sheng-Dean Luo, Hsin-Ting Tsai, Tai-Jan Chiu, Shau-Hsuan Li, Ya-Ling Hsu, Li-Jen Su, Meng-Hsiu Tsai, Ching-Yi Lee, Chang-Chun Hsiao, Chang-Han Chen

Int J Mol Sci. 2022 May; 23(10): 5700. Published online 2022 May 20. doi: 10.3390/ijms23105700

PMCID:: PMC9146162

Abstract Article PDF–2.1M

Select item 889702217.

Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mitophagy

Xin Sun, Yuhan Shu, Guiqin Ye, Caixia Wu, Mengting Xu, Ruilan Gao, Dongsheng Huang, Jianbin Zhang

Acta Pharm Sin B. 2022 Feb; 12(2): 838–852. Published online 2021 Jul 21. doi: 10.1016/j.apsb.2021.07.003

PMCID:: PMC8897022

Abstract Article PDF–3.0M

Select item 880664718.

Long intergenic non-protein coding RNA 02570 promotes nasopharyngeal carcinoma progression by adsorbing microRNA miR-4649-3p thereby upregulating both sterol regulatory element binding protein 1, and fatty acid synthase

Fei Liu, Jiazhang Wei, Yanrong Hao, Jiao Lan, Wei Li, Jingjin Weng, Min Li, Cheng Su, Bing Li, Mingzheng Mo, Fengzhu Tang, Yongli Wang, Yong Yang, Wei Jiao, Shenhong Qu

Bioengineered. 2021; 12(1): 7108–7119. Published online 2021 Sep 21. doi: 10.1080/21655979.2021.1979317