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Select item 112557611.

Differential Downregulation of β₁‐Adrenergic Receptor Signaling in the Heart

Bing Xu, Sherif Bahriz, Victoria R. Salemme, Ying Wang, Chaoqun Zhu, Meimi Zhao, Yang K. Xiang

J Am Heart Assoc. 2024 Jun 18; 13(12): e033733. Published online 2024 Jun 11. doi: 10.1161/JAHA.123.033733

PMCID:: PMC11255761

Abstract Article PDF–12M

Select item 109331812.

Protective effects of Gα_i3 deficiency in a murine heart-failure model of β₁-adrenoceptor overexpression

Tobias Schröper, Dennis Mehrkens, Veronika Leiss, Frederik Tellkamp, Stefan Engelhardt, Stefan Herzig, Lutz Birnbaumer, Bernd Nürnberg, Jan Matthes

Naunyn Schmiedebergs Arch Pharmacol. 2024; 397(4): 2401–2420. Published online 2023 Oct 16. doi: 10.1007/s00210-023-02751-8

PMCID:: PMC10933181

Abstract Article PDF–5.5M

Select item 108092233.

Epinephrine inhibits PI3Kα via the Hippo kinases

Ting-Yu Lin, Shakti Ramsamooj, Tiffany Perrier, Katarina Liberatore, Louise Lantier, Neil Vasan, Kannan Karukurichi, Seo-Kyoung Hwang, Edward A. Kesicki, Edward R. Kastenhuber, Thorsten Wiederhold, Tomer M. Yaron, Emily M. Huntsman, Mengmeng Zhu, Yilun Ma, Marcia N. Paddock, Guoan Zhang, Benjamin D. Hopkins, Owen McGuinness, Robert E. Schwartz, Baran A. Ersoy, Lewis C. Cantley, Jared L. Johnson, Marcus D. Goncalves

Cell Rep. Author manuscript; available in PMC 2024 Jan 25.

Published in final edited form as: Cell Rep. 2023 Dec 26; 42(12): 113535. Published online 2023 Dec 4. doi: 10.1016/j.celrep.2023.113535

PMCID:: PMC10809223

Abstract Article PDF–2.3M

Select item 106972134.

Identification and characterization of novel candidate compounds targeting 6- and 7-transmembrane μ-opioid receptor isoforms

Arjun Muralidharan, Alexander Samoshkin, Marino Convertino, Marjo Hannele Piltonen, Pavel Gris, Jian Wang, Changyu Jiang, Richard Klares, III, Alexander Linton, Ru-Rong Ji, William Maixner, Nikolay V. Dokholyan, Jeffrey S. Mogil, Luda Diatchenko

Br J Pharmacol. Author manuscript; available in PMC 2023 Dec 5.

Published in final edited form as: Br J Pharmacol. 2021 Jul; 178(13): 2709–2726. Published online 2021 Apr 30. doi: 10.1111/bph.15463

PMCID:: PMC10697213

Abstract Article PDF–2.1M

Select item 103227165.

GDF15 promotes weight loss by enhancing energy expenditure in muscle

Dongdong Wang, Logan K. Townsend, Geneviève J. DesOrmeaux, Sara M. Frangos, Battsetseg Batchuluun, Lauralyne Dumont, Rune Ehrenreich Kuhre, Elham Ahmadi, Sumei Hu, Irena A. Rebalka, Jaya Gautam, Maria Joy Therese Jabile, Chantal A. Pileggi, Sonia Rehal, Eric M. Desjardins, Evangelia E. Tsakiridis, James S. V. Lally, Emma Sara Juracic, A. Russell Tupling, Hertzel C. Gerstein, Guillaume Paré, Theodoros Tsakiridis, Mary-Ellen Harper, Thomas J. Hawke, John R. Speakman, Denis P. Blondin, Graham P. Holloway, Sebastian Beck Jørgensen, Gregory R. Steinberg

Nature. 2023; 619(7968): 143–150. Published online 2023 Jun 28. doi: 10.1038/s41586-023-06249-4

PMCID:: PMC10322716

Abstract Article PDF–26M

Select item 102187306.

Beta1-receptor blockade attenuates atherosclerosis progression following traumatic brain injury in apolipoprotein E deficient mice

Jintao Wang, Jessica Venugopal, Paul Silaghi, Enming J. Su, Chiao Guo, Daniel A. Lawrence, Daniel T. Eitzman

PLoS One. 2023; 18(5): e0285499. Published online 2023 May 26. doi: 10.1371/journal.pone.0285499

PMCID:: PMC10218730

Abstract Article PDF–1.4M

Select item 101045267.

Mutant β₁-adrenergic receptor improves REM sleep and ameliorates tau accumulation in a mouse model of tauopathy

Qing Dong, Louis J. Ptáček, Ying-Hui Fu

Proc Natl Acad Sci U S A. 2023 Apr 11; 120(15): e2221686120. Published online 2023 Apr 4. doi: 10.1073/pnas.2221686120

PMCID:: PMC10104526

Abstract Article PDF–5.0M

Select item 98982378.

Catecholamine induces Kupffer cell apoptosis via growth differentiation factor 15 in alcohol-associated liver disease

Hee-Hoon Kim, Young-Ri Shim, Sung Eun Choi, Myung-Ho Kim, Giljae Lee, Hyun Ju You, Won-Mook Choi, Keungmo Yang, Tom Ryu, Kyurae Kim, Min Jeong Kim, Chaerin Woo, Katherine Po Sin Chung, Song Hwa Hong, Hyuk Soo Eun, Seok-Hwan Kim, GwangPyo Ko, Jong-Eun Park, Bin Gao, Won Kim, Won-Il Jeong

Exp Mol Med. 2023 Jan; 55(1): 158–170. Published online 2023 Jan 11. doi: 10.1038/s12276-022-00921-x

PMCID:: PMC9898237

Abstract Article PDF–8.9M

Select item 97988859.

Brain motor and fear circuits regulate leukocytes during acute stress

Wolfram C. Poller, Jeffrey Downey, Agnes A. Mooslechner, Nargis Khan, Long Li, Christopher T. Chan, Cameron S. McAlpine, Chunliang Xu, Florian Kahles, Shun He, Henrike Janssen, John E. Mindur, Sumnima Singh, Máté G. Kiss, Laura Alonso-Herranz, Yoshiko Iwamoto, Rainer H. Kohler, Lai Ping Wong, Kashish Chetal, Scott J. Russo, Ruslan I. Sadreyev, Ralph Weissleder, Matthias Nahrendorf, Paul S. Frenette, Maziar Divangahi, Filip K. Swirski

Nature. Author manuscript; available in PMC 2022 Dec 29.

Published in final edited form as: Nature. 2022 Jul; 607(7919): 578–584. Published online 2022 May 30. doi: 10.1038/s41586-022-04890-z

PMCID:: PMC9798885

Abstract Article PDF–4.5M

Select item 973409810.

Noradrenergic signaling mediates cortical early tagging and storage of remote memory

Xiaocen Fan, Jiachen Song, Chaonan Ma, Yanbo Lv, Feifei Wang, Lan Ma, Xing Liu

Nat Commun. 2022; 13: 7623. Published online 2022 Dec 9. doi: 10.1038/s41467-022-35342-x

PMCID:: PMC9734098

Abstract Article PDF–6.2M

Select item 946258311.

Pharmacological activation of the C5a receptor leads to stimulation of the β-adrenergic receptor and alleviates cognitive impairment in a murine model of familial Alzheimer’s disease

Eleni Fella, Revekka Papacharalambous, Demos Kynigopoulos, Maria Ioannou, Rita Derua, Christiana Christodoulou, Myrto Stylianou, Christos Karaiskos, Alexia Kagiava, Gerasimou Petroula, Chryso Pierides, Maria Kyriakou, Laura Koumas, Paul Costeas, Elena Panayiotou

Front Immunol. 2022; 13: 947071. Published online 2022 Aug 26. doi: 10.3389/fimmu.2022.947071

PMCID:: PMC9462583

Abstract Article PDF–2.1M

Select item 934885112.

Deconstructing cold-induced brown adipocyte neogenesis in mice

Rayanne B Burl, Elizabeth Ann Rondini, Hongguang Wei, Roger Pique-Regi, James G Granneman

eLife. 2022; 11: e80167. Published online 2022 Jul 18. doi: 10.7554/eLife.80167

PMCID:: PMC9348851

Abstract Article PDF–20M

Select item 930850513.

A functional circuit formed by the autonomic nerves and myofibroblasts controls mammalian alveolar formation for gas exchange

Kuan Zhang, Erica Yao, Shao-An Wang, Ethan Chuang, Julia Wong, Liliana Minichiello, Andrew Schroeder, Walter Eckalbar, Paul J. Wolters, Pao-Tien Chuang

Dev Cell. Author manuscript; available in PMC 2023 Jul 11.

Published in final edited form as: Dev Cell. 2022 Jul 11; 57(13): 1566–1581.e7. Published online 2022 Jun 16. doi: 10.1016/j.devcel.2022.05.021

PMCID:: PMC9308505

Abstract Article PDF–5.9M

Select item 920741314.

The Effects of Maternal Intake of EPA and DHA Enriched Diet During Pregnancy and Lactation on Offspring’s Muscle Development and Energy Homeostasis

Saeed Ghnaimawi, Shilei Zhang, Jamie I. Baum, Yan Huang

Front Physiol. 2022; 13: 881624. Published online 2022 Jun 6. doi: 10.3389/fphys.2022.881624

PMCID:: PMC9207413

Abstract Article PDF–6.0M

Select item 920252315.

Brown adipocyte ATF4 activation improves thermoregulation and systemic metabolism

Esther Paulo, Yun Zhang, Ruchi Masand, Tony L. Huynh, Youngho Seo, Danielle L. Swaney, Margaret Soucheray, Erica Stevenson, David Jimenez-Morales, Nevan J. Krogan, Biao Wang

Cell Rep. Author manuscript; available in PMC 2022 Jun 16.

Published in final edited form as: Cell Rep. 2021 Sep 21; 36(12): 109742. doi: 10.1016/j.celrep.2021.109742

PMCID:: PMC9202523

Abstract Article PDF–4.2M

Select item 861815516.

Quantitative Analysis of the Cardiac Phosphoproteome in Response to Acute β-Adrenergic Receptor Stimulation In Vivo

Alican Güran, Yanlong Ji, Pan Fang, Kuan-Ting Pan, Henning Urlaub, Metin Avkiran, Christof Lenz

Int J Mol Sci. 2021 Nov; 22(22): 12584. Published online 2021 Nov 22. doi: 10.3390/ijms222212584

PMCID:: PMC8618155

Abstract Article PDF–3.3M

Select item 841489917.

Activation of the Thiazide-Sensitive Sodium-Chloride Cotransporter by Beta3-Adrenoreceptor in the Distal Convoluted Tubule

Serena Milano, Monica Carmosino, Andrea Gerbino, Ilenia Saponara, Dominga Lapi, Massimo Dal Monte, Paola Bagnoli, Maria Svelto, Giuseppe Procino

Front Physiol. 2021; 12: 695824. Published online 2021 Aug 13. doi: 10.3389/fphys.2021.695824

PMCID:: PMC8414899

Abstract Article PDF–21M

Select item 785610418.

Intracellular β1-Adrenergic Receptors and Organic Cation Transporter 3 Mediate Phospholamban Phosphorylation to Enhance Cardiac Contractility

Ying Wang, Qian Shi, Minghui Li, Meimi Zhao, Raghavender Reddy Gopireddy, Jian-Peng Teoh, Bing Xu, Chaoqun Zhu, Kyle E. Ireton, Sanghavi Srinivasan, Shaoliang Chen, Paul J. Gasser, Julie Bossuyt, Johannes W. Hell, Donald M. Bers, Yang K. Xiang

Circ Res. Author manuscript; available in PMC 2022 Jan 22.

Published in final edited form as: Circ Res. 2021 Jan 22; 128(2): 246–261. Published online 2020 Nov 13. doi: 10.1161/CIRCRESAHA.120.317452

PMCID:: PMC7856104

Abstract Article PDF–2.6M

Select item 778280519.

Early-life-trauma triggers interferon-β resistance and neurodegeneration in a multiple sclerosis model via downregulated β1-adrenergic signaling

Yee Ming Khaw, Danish Majid, Sungjong Oh, Eunjoo Kang, Makoto Inoue

Nat Commun. 2021; 12: 105. Published online 2021 Jan 4. doi: 10.1038/s41467-020-20302-0

PMCID:: PMC7782805

Abstract Article PDF–2.4M

Select item 738497420.

Origin and function of stress-induced IL6 in murine models

Hua Qing, Reina Desrouleaux, Kavita Israni-Winger, Nia Fogelman, Cuiling Zhang, Saleh Rashad, Noah W. Palm, Rajita Sinha, Marina R. Picciotto, Rachel J. Perry, Andrew Wang

Cell. Author manuscript; available in PMC 2021 Jul 23.

Published in final edited form as: Cell. 2020 Jul 23; 182(2): 372–387.e14. Published online 2020 Jun 30. doi: 10.1016/j.cell.2020.05.054

PMCID:: PMC7384974

Abstract Article PDF–1.2M

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