PMC Links for GEO Profiles (Select 55765745) - PMC

Giovanna De Michele, Daniele Galatolo, Serena Galosi, Andrea Mignarri, Gabriella Silvestri, Carlo Casali, Vincenzo Leuzzi, Ivana Ricca, Melissa Barghigiani, Alessandra Tessa, Ettore Cioffi, Caterina Caputi, Vittorio Riso, Maria Teresa Dotti, Francesco Saccà, Giuseppe De Michele, Sirio Cocozza, Alessandro Filla, Filippo M. Santorelli

J Neurol. 2022; 269(3): 1476–1484. Published online 2021 Jul 22. doi: 10.1007/s00415-021-10712-5

PMCID:: PMC8857164

Abstract Article PDF–805K

Select item 83529645.

Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer

Athea Vichas, Amanda K. Riley, Naomi T. Nkinsi, Shriya Kamlapurkar, Phoebe C. R. Parrish, April Lo, Fujiko Duke, Jennifer Chen, Iris Fung, Jacqueline Watson, Matthew Rees, Austin M. Gabel, James D. Thomas, Robert K. Bradley, John K. Lee, Emily M. Hatch, Marina K. Baine, Natasha Rekhtman, Marc Ladanyi, Federica Piccioni, Alice H. Berger

Nat Commun. 2021; 12: 4789. Published online 2021 Aug 9. doi: 10.1038/s41467-021-24841-y

PMCID:: PMC8352964

Abstract Article PDF–4.5M

Select item 81650306.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 80459427.

Spinocerebellar ataxia type 14: refining clinicogenetic diagnosis in a rare adult‐onset disorder

Tanja Schmitz‐Hübsch, Silke Lux, Peter Bauer, Alexander U. Brandt, Elena Schlapakow, Susanne Greschus, Michael Scheel, Hanna Gärtner, Mehmet E. Kirlangic, Vincent Gras, Dagmar Timmann, Matthis Synofzik, Alejandro Giorgetti, Paolo Carloni, Jon N. Shah, Ludger Schöls, Ute Kopp, Lisa Bußenius, Timm Oberwahrenbrock, Hanna Zimmermann, Caspar Pfueller, Ella‐Maria Kadas, Maria Rönnefarth, Anne‐Sophie Grosch, Matthias Endres, Katrin Amunts, Friedemann Paul, Sarah Doss, Martina Minnerop

Ann Clin Transl Neurol. 2021 Apr; 8(4): 774–789. Published online 2021 Mar 19. doi: 10.1002/acn3.51315

PMCID:: PMC8045942

Abstract Article PDF–846K

Select item 74273278.

Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases

Marija Buljan, Rodolfo Ciuffa, Audrey van Drogen, Anton Vichalkovski, Martin Mehnert, George Rosenberger, Sohyon Lee, Markku Varjosalo, Lucia Espona Pernas, Vincent Spegg, Berend Snijder, Ruedi Aebersold, Matthias Gstaiger

Mol Cell. 2020 Aug 6; 79(3): 504–520.e9. doi: 10.1016/j.molcel.2020.07.001

PMCID:: PMC7427327

Abstract Article

Select item 72137609.

The actin-cytoskeleton linker protein ezrin is regulated during osteosarcoma metastasis by PKC

L Ren, SH Hong, J Cassavaugh, T Osborne, AJ Chou, SY Kim, R Gorlick, SM Hewitt, C Khanna

Oncogene. Author manuscript; available in PMC 2020 May 11.

Published in final edited form as: Oncogene. 2009 Feb 12; 28(6): 792–802. Published online 2008 Dec 8. doi: 10.1038/onc.2008.437

PMCID:: PMC7213760

Abstract Article PDF–2.0M

Select item 698120610.

Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS^G13D

Susan A. Kennedy, Mohamed-Ali Jarboui, Sriganesh Srihari, Cinzia Raso, Kenneth Bryan, Layal Dernayka, Theodosia Charitou, Manuel Bernal-Llinares, Carlos Herrera-Montavez, Aleksandar Krstic, David Matallanas, Max Kotlyar, Igor Jurisica, Jasna Curak, Victoria Wong, Igor Stagljar, Thierry LeBihan, Lisa Imrie, Priyanka Pillai, Miriam A. Lynn, Erik Fasterius, Cristina Al-Khalili Szigyarto, James Breen, Christina Kiel, Luis Serrano, Nora Rauch, Oleksii Rukhlenko, Boris N. Kholodenko, Luis F. Iglesias-Martinez, Colm J. Ryan, Ruth Pilkington, Patrizia Cammareri, Owen Sansom, Steven Shave, Manfred Auer, Nicola Horn, Franziska Klose, Marius Ueffing, Karsten Boldt, David J. Lynn, Walter Kolch

Nat Commun. 2020; 11: 499. Published online 2020 Jan 24. doi: 10.1038/s41467-019-14224-9

PMCID:: PMC6981206

Abstract Article PDF–3.7M

Select item 662157411.

Glutamate Receptor δ2 Associates with Metabotropic Glutamate Receptor 1 (mGluR1), Protein Kinase Cγ, and Canonical Transient Receptor Potential 3 and Regulates mGluR1-Mediated Synaptic Transmission in Cerebellar Purkinje Neurons

Akihiko S. Kato, Michael D. Knierman, Edward R. Siuda, John T. R. Isaac, Eric S. Nisenbaum, David S. Bredt

J Neurosci. 2012 Oct 31; 32(44): 15296–15308. doi: 10.1523/JNEUROSCI.0705-12.2012

PMCID:: PMC6621574

Abstract Article PDF–2.9M

Select item 659610612.

The Role of Cysteine String Protein α Phosphorylation at Serine 10 and 34 by Protein Kinase Cγ for Presynaptic Maintenance

Toshihiko Shirafuji, Takehiko Ueyama, Naoko Adachi, Ken-Ichi Yoshino, Yusuke Sotomaru, Junsuke Uwada, Azumi Kaneoka, Taro Ueda, Shigeru Tanaka, Izumi Hide, Naoaki Saito, Norio Sakai

J Neurosci. 2018 Jan 10; 38(2): 278–290. doi: 10.1523/JNEUROSCI.1649-17.2017

PMCID:: PMC6596106

Abstract Article PDF–2.2M

Select item 617513613.

Genotype‐phenotype correlations, dystonia and disease progression in spinocerebellar ataxia type 14

Viorica Chelban, Sarah Wiethoff, Bjørn K. Fabian‐Jessing, Nourelhoda A. Haridy, Alaa Khan, Stephanie Efthymiou, Esther B. E. Becker, Emer O'Connor, Joshua Hersheson, Katrina Newland, Allan Thomas Hojland, Pernille A. Gregersen, Suzanne G. Lindquist, Michael B. Petersen, Jørgen E. Nielsen, Michael Nielsen, Nicholas W. Wood, Paola Giunti, Henry Houlden

Mov Disord. 2018 Jul; 33(7): 1119–1129. Published online 2018 Mar 30. doi: 10.1002/mds.27334

PMCID:: PMC6175136

Abstract Article PDF–3.1M

Select item 615193114.

Neurodegeneration in SCA14 is associated with increased PKCγ kinase activity, mislocalization and aggregation

Maggie M. K. Wong, Stephanie D. Hoekstra, Jane Vowles, Lauren M. Watson, Geraint Fuller, Andrea H. Németh, Sally A. Cowley, Olaf Ansorge, Kevin Talbot, Esther B. E. Becker

Acta Neuropathol Commun. 2018; 6: 99. Published online 2018 Sep 24. doi: 10.1186/s40478-018-0600-7

PMCID:: PMC6151931

Abstract Article PDF–7.6M

Select item 588337715.

Calcium Signaling, PKC Gamma, IP₃R1 and CAR8 Link Spinocerebellar Ataxias and Purkinje Cell Dendritic Development

Etsuko Shimobayashi, Josef P. Kapfhammer

Curr Neuropharmacol. 2018 Feb; 16(2): 151–159. Published online 2018 Feb. doi: 10.2174/1570159X15666170529104000

PMCID:: PMC5883377

Abstract Article PDF–499K

Select item 553161116.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 552533817.

Increased biological activity of protein Kinase C gamma is not required in Spinocerebellar ataxia 14

Etsuko Shimobayashi, Josef P. Kapfhammer

Mol Brain. 2017; 10: 34. Published online 2017 Jul 24. doi: 10.1186/s13041-017-0313-z

PMCID:: PMC5525338

Abstract Article PDF–2.4M

Select item 531939518.

S. pombe Uba1-Ubc15 structure reveals a novel regulatory mechanism of ubiquitin E2 activity

Zongyang Lv, Kimberly A. Rickman, Lingmin Yuan, Katelyn Williams, Shanmugam Panneer Selvam, Alec N. Woosley, Philip H. Howe, Besim Ogretmen, Agata Smogorzewska, Shaun K. Olsen

Mol Cell. Author manuscript; available in PMC 2018 Feb 16.

Published in final edited form as: Mol Cell. 2017 Feb 16; 65(4): 699–714.e6. Published online 2017 Feb 2. doi: 10.1016/j.molcel.2017.01.008

PMCID:: PMC5319395

Abstract Article PDF–4.3M

Select item 526093919.

Gsk3β and Tomm20 are substrates of the SCFFbxo7/PARK15 ubiquitin ligase associated with Parkinson's disease

Felipe Roberti Teixeira, Suzanne J. Randle, Shachi P. Patel, Tycho E.T. Mevissen, Grasilda Zenkeviciute, Tie Koide, David Komander, Heike Laman

Biochem J. 2016 Oct 15; 473(20): 3563–3580. Prepublished online 2016 Aug 8. Published online 2016 Oct 11. doi: 10.1042/BCJ20160387

PMCID:: PMC5260939

Abstract Article PDF–1.1M

Select item 516644020.

LysoPCs induce Hck- and PKCδ-mediated activation of PKCγ causing p47^phox phosphorylation and membrane translocation in neutrophils

Marguerite R. Kelher, Nathan J. D. McLaughlin, Anirban Banerjee, David J. Elzi, Fabia Gamboni, Samina Y. Khan, Xianzhong Meng, Sanchayita Mitra, Christopher C. Silliman

J Leukoc Biol. 2017 Jan; 101(1): 261–273. Published online 2016 Aug 16. doi: 10.1189/jlb.3A0813-420RRR

PMCID:: PMC5166440

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