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Select item 81650301.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 73220672.

RIG-I regulates myeloid differentiation by promoting TRIM25-mediated ISGylation

Song-Fang Wu, Li Xia, Xiao-Dong Shi, Yu-Jun Dai, Wei-Na Zhang, Jun-Mei Zhao, Wu Zhang, Xiang-Qin Weng, Jing Lu, Huang-Ying Le, Sheng-ce Tao, Jiang Zhu, Zhu Chen, Yue-Ying Wang, Saijuan Chen

Proc Natl Acad Sci U S A. 2020 Jun 23; 117(25): 14395–14404. Published online 2020 Jun 8. doi: 10.1073/pnas.1918596117

PMCID:: PMC7322067

Abstract Article PDF–2.7M

Select item 71699833.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 65413474.

Epstein-Barr virus (EBV) activates NKL homeobox gene HLX in DLBCL

Stefan Nagel, Cord C. Uphoff, Wilhelm G. Dirks, Claudia Pommerenke, Corinna Meyer, Hans G. Drexler

PLoS One. 2019; 14(5): e0216898. Published online 2019 May 29. doi: 10.1371/journal.pone.0216898

PMCID:: PMC6541347

Abstract Article PDF–2.4M

Select item 64240985.

PRISMA: Protein Interaction Screen on Peptide Matrix Reveals Interaction Footprints and Modifications- Dependent Interactome of Intrinsically Disordered C/EBPβ

Gunnar Dittmar, Daniel Perez Hernandez, Elisabeth Kowenz-Leutz, Marieluise Kirchner, Günther Kahlert, Radoslaw Wesolowski, Katharina Baum, Maria Knoblich, Maria Hofstätter, Arnaud Muller, Jana Wolf, Ulf Reimer, Achim Leutz

iScience. 2019 Mar 29; 13: 351–370. Published online 2019 Mar 1. doi: 10.1016/j.isci.2019.02.026

PMCID:: PMC6424098

Abstract Article PDF–11M

Select item 63685846.

The p300/YY1/miR-500a-5p/HDAC2 signalling axis regulates cell proliferation in human colorectal cancer

Weimei Tang, Weijie Zhou, Li Xiang, Xiaosheng Wu, Pei Zhang, Jing Wang, Guangnan Liu, Wenjing Zhang, Ying Peng, Xiaoting Huang, Jianqun Cai, Yang Bai, Lan Bai, Wei Zhu, Hongxiang Gu, Jing Xiong, Chen Ye, Aimin Li, Side Liu, Jide Wang

Nat Commun. 2019; 10: 663. Published online 2019 Feb 8. doi: 10.1038/s41467-018-08225-3

PMCID:: PMC6368584

Abstract Article PDF–6.8M

Select item 60789637.

A metabolic interplay coordinated by HLX regulates myeloid differentiation and AML through partly overlapping pathways

Indre Piragyte, Thomas Clapes, Aikaterini Polyzou, Ramon I. Klein Geltink, Stylianos Lefkopoulos, Na Yin, Pierre Cauchy, Jonathan D. Curtis, Lhéanna Klaeylé, Xavier Langa, Cora C. A. Beckmann, Marcin W. Wlodarski, Patrick Müller, Dominic Van Essen, Angelika Rambold, Friedrich G. Kapp, Marina Mione, Joerg M. Buescher, Erika L. Pearce, Alexander Polyzos, Eirini Trompouki

Nat Commun. 2018; 9: 3090. Published online 2018 Aug 6. doi: 10.1038/s41467-018-05311-4

PMCID:: PMC6078963

Abstract Article PDF–2.4M

Select item 55316118.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 55079869.

Transcription factor Hlx controls a systematic switch from white to brown fat through Prdm16-mediated co-activation

Lei Huang, Dongning Pan, Qingbo Chen, Lihua J. Zhu, Jianhong Ou, Martin Wabitsch, Yong-Xu Wang

Nat Commun. 2017; 8: 68. Published online 2017 Jul 12. doi: 10.1038/s41467-017-00098-2

PMCID:: PMC5507986

Abstract Article PDF–3.1M

Select item 371794910.

HLX in AML: novel prognostic and therapeutic target

Ashley Pandolfi, Ulrich Steidl

Oncotarget. 2012 Oct; 3(10): 1059–1060. Published online 2012 Oct 11. doi: 10.18632/oncotarget.705

PMCID:: PMC3717949

Article PDF–447K

Select item 361628511.

Interplay between Homeobox proteins and Polycomb repressive complexes in p16^INK4a regulation

Nadine Martin, Nikolay Popov, Francesca Aguilo, Ana O’Loghlen, Selina Raguz, Ambrosius P Snijders, Gopuraja Dharmalingam, SiDe Li, Efstathia Thymiakou, Thomas Carroll, Bernd B Zeisig, Chi Wai Eric So, Gordon Peters, Vasso Episkopou, Martin J Walsh, Jesús Gil

EMBO J. 2013 Apr 3; 32(7): 982–995. Published online 2013 Mar 1. doi: 10.1038/emboj.2013.37

PMCID:: PMC3616285

Abstract Article PDF–2.7M

Select item 352258712.

Novel Genetic Loci Identified for the Pathophysiology of Childhood Obesity in the Hispanic Population

Anthony G. Comuzzie, Shelley A. Cole, Sandra L. Laston, V. Saroja Voruganti, Karin Haack, Richard A. Gibbs, Nancy F. Butte

PLoS One. 2012; 7(12): e51954. Published online 2012 Dec 14. doi: 10.1371/journal.pone.0051954

PMCID:: PMC3522587

Abstract Article PDF–130K

Select item 351400413.

Downregulation of Hlx Closely Related to the Decreased Expressions of T-bet and Runx3 in Patients with Gastric Cancer May Be Associated with a Pathological Event Leading to the Imbalance of Th1/Th2

Yan Xu, Jingjing Gao, Zhaoliang Su, Xiaoli Dai, Yazhen Li, Yingzhao Liu, Jianguo Chen, Jia Tong, Yun Zhang, Chaoyang Wu, Dong Zheng, Shengjun Wang, Huaxi Xu

Clin Dev Immunol. 2012; 2012: 949821. Published online 2012 Nov 19. doi: 10.1155/2012/949821

PMCID:: PMC3514004

Abstract Article PDF–1.7M

Select item 350886214.

Hepatocyte growth factor regulates HLX1 gene expression to modulate HTR-8/SVneo trophoblast cells

Hai-Ying Liu, Xue-Qin Jia, Ling-Xue Gao, Yu-Yan Ma

Reprod Biol Endocrinol. 2012; 10: 83. Published online 2012 Sep 18. doi: 10.1186/1477-7827-10-83

PMCID:: PMC3508862

Abstract Article PDF–758K

Select item 342269115.

H2.0-like homeobox (HLX) regulates early hematopoiesis and promotes acute myeloid leukemia

Masahiro Kawahara, Ashley Pandolfi, Boris Bartholdy, Laura Barreyro, Britta Will, Michael Roth, Ujunwa C. Okoye-Okafor, Tihomira I. Todorova, Maria E. Figueroa, Ari Melnick, Constantine S. Mitsiades, Ulrich Steidl

Cancer Cell. Author manuscript; available in PMC 2013 Aug 14.

Published in final edited form as: Cancer Cell. 2012 Aug 14; 22(2): 194–208. doi: 10.1016/j.ccr.2012.06.027

PMCID:: PMC3422691

Abstract Article PDF–5.4M

Select item 326876716.

TBX21 and HLX1 Polymorphisms Influence Cytokine Secretion at Birth

Vera Isabel Casaca, Sabina Illi, Kathrin Suttner, Isolde Schleich, Nikolaus Ballenberger, Elizabeth Klucker, Elif Turan, Erika von Mutius, Michael Kabesch, Bianca Schaub

PLoS One. 2012; 7(1): e31069. Published online 2012 Jan 30. doi: 10.1371/journal.pone.0031069

PMCID:: PMC3268767

Abstract Article PDF–348K

Select item 318838817.

Leveraging the power of next-generation sequencing to generate interactome datasets

Haiyuan Yu, Leah Tardivo, Stanley Tam, Evan Weiner, Fana Gebreab, Changyu Fan, Nenad Svrzikapa, Tomoko Hirozane-Kishikawa, Edward Rietman, Xinping Yang, Julie Sahalie, Kourosh Salehi-Ashtiani, Tong Hao, Michael E. Cusick, David E. Hill, Frederick P. Roth, Pascal Braun, Marc Vidal

Nat Methods. Author manuscript; available in PMC 2011 Dec 1.

Published in final edited form as: Nat Methods. 2011 Jun; 8(6): 478–480. Published online 2011 Apr 24. doi: 10.1038/nmeth.1597

PMCID:: PMC3188388

Abstract Article PDF–932K

Select item 317805918.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 309676119.

The VEGF-regulated transcription factor HLX controls the expression of guidance cues and negatively regulates sprouting of endothelial cells

Julia Testori, Bernhard Schweighofer, Iris Helfrich, Caterina Sturtzel, Karoline Lipnik, Sabine Gesierich, Patrick Nasarre, Renate Hofer-Warbinek, Martin Bilban, Hellmut G. Augustin, Erhard Hofer

Blood. Author manuscript; available in PMC 2011 May 18.

Published in final edited form as: Blood. 2011 Mar 3; 117(9): 2735–2744. Published online 2011 Jan 11. doi: 10.1182/blood-2010-07-293209

PMCID:: PMC3096761

Abstract Article PDF–1.1M

Select item 287483220.

Sequence variants in the HLX gene at chromosome 1q41-1q42 in patients with diaphragmatic hernia

AM Slavotinek, A Moshrefi, N LopezJimenez, R Chao, A Mendell, GM Shaw, LA Pennacchio, MD Bates

Clin Genet. Author manuscript; available in PMC 2010 May 24.

Published in final edited form as: Clin Genet. 2009 May; 75(5): 429–439. doi: 10.1111/j.1399-0004.2009.01182.x

PMCID:: PMC2874832

Abstract Article PDF–1.3M

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