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Items: 1 to 20 of 347

1.
Circulating senescent myeloid cells infiltrate the brain and cause neurodegeneration in histiocytic disorders
C. Matthias Wilk, Flurin Cathomas, Orsolya Török, Jessica Le Berichel, Matthew D. Park, Camille Bigenwald, George R. Heaton, Pauline Hamon, Leanna Troncoso, Brooks P. Scull, Diana Dangoor, Aymeric Silvin, Ryan Fleischmann, Meriem Belabed, Howard Lin, Elias Merad Taouli, Steffen Boettcher, Long Li, Antonio Aubry, Markus G. Manz, Julia K. Kofler, Zhenyu Yue, Sergio A. Lira, Florent Ginhoux, John F. Crary, Kenneth L. McClain, Jennifer L. Picarsic, Scott J. Russo, Carl E. Allen, Miriam Merad
Immunity. Author manuscript; available in PMC 2024 Dec 12.
Published in final edited form as: Immunity. 2023 Dec 12; 56(12): 2790–2802.e6. doi: 10.1016/j.immuni.2023.11.011
PMCID:
PMC11587932
AbstractArticlePDF–2.8M
2.
Tumour-intrinsic endomembrane trafficking by ARF6 shapes an immunosuppressive microenvironment that drives melanomagenesis and response to checkpoint blockade therapy
Yinshen Wee, Junhua Wang, Emily C. Wilson, Coulson P. Rich, Aaron Rogers, Zongzhong Tong, Evelyn DeGroot, Y. N. Vashisht Gopal, Michael A. Davies, H. Atakan Ekiz, Joshua K. H. Tay, Chris Stubben, Kenneth M. Boucher, Juan M. Oviedo, Keke C. Fairfax, Matthew A. Williams, Sheri L. Holmen, Roger K. Wolff, Allie H. Grossmann
Nat Commun. 2024; 15: 6613. Published online 2024 Aug 4. doi: 10.1038/s41467-024-50881-1
PMCID:
PMC11298541
AbstractArticlePDF–5.5M
3.
FAK loss reduces BRAFV600E-induced ERK phosphorylation to promote intestinal stemness and cecal tumor formation
Chenxi Gao, Huaibin Ge, Shih-Fan Kuan, Chunhui Cai, Xinghua Lu, Farzad Esni, Robert E Schoen, Jing H Wang, Edward Chu, Jing Hu
eLife. 2024; 13: RP94605. Published online 2024 Jun 26. doi: 10.7554/eLife.94605
PMCID:
PMC11208045
AbstractArticlePDF–5.3M
4.
Single-Cell Profiling Reveals the Impact of Genetic Alterations on the Differentiation of Inflammation-Induced Murine Colon Tumors
Ahmed H. Ghobashi, Rosie Lanzloth, Christopher A. Ladaika, Ashiq Masood, Heather M. O’Hagan
Cancers (Basel) 2024 Jun; 16(11): 2040. Published online 2024 May 28. doi: 10.3390/cancers16112040
PMCID:
PMC11171101
AbstractArticlePDF–9.3M
5.
Targeting miR‐31 represses tumourigenesis and dedifferentiation of BRAFV600E‐associated thyroid carcinoma
Peitao Zhang, Lizhao Guan, Wei Sun, Yu Zhang, Yaying Du, Shukai Yuan, Xiaolong Cao, Zhengquan Yu, Qiang Jia, Xiangqian Zheng, Zhaowei Meng, Xingrui Li, Li Zhao
Clin Transl Med. 2024 May; 14(5): e1694. Published online 2024 May 26. doi: 10.1002/ctm2.1694
PMCID:
PMC11128713
AbstractArticlePDF–8.1M
6.
Proteostatic reactivation of the developmental transcription factor TBX3 drives BRAF/MAPK-mediated tumorigenesis
Zhenlei Zhang, Yufan Wu, Jinrong Fu, Xiujie Yu, Yang Su, Shikai Jia, Huili Cheng, Yan Shen, Xianghui He, Kai Ren, Xiangqian Zheng, Haixia Guan, Feng Rao, Li Zhao
Nat Commun. 2024; 15: 4108. Published online 2024 May 15. doi: 10.1038/s41467-024-48173-9
Correction in:
Nat Commun. 2024; 15: 4936.
PMCID:
PMC11096176
AbstractArticlePDF–5.7M
7.
Noncovalently particle-anchored cytokines with prolonged tumor retention safely elicit potent antitumor immunity
Liqian Niu, Eungyo Jang, Ai Lin Chin, Ziyu Huo, Wenbo Wang, Wenjun Cai, Rong Tong
Sci Adv. 2024 Apr 19; 10(16): eadk7695. Published online 2024 Apr 19. doi: 10.1126/sciadv.adk7695
PMCID:
PMC11029804
AbstractArticlePDF–6.9M
8.
HSPA8 Activates Wnt/β‐Catenin Signaling to Facilitate BRAF V600E Colorectal Cancer Progression by CMA‐Mediated CAV1 Degradation
Bowen Li, Hui Ming, Siyuan Qin, Li Zhou, Zhao Huang, Ping Jin, Liyuan Peng, Maochao Luo, Tingting Zhang, Kui Wang, Rui Liu, Yih‐Cherng Liou, Edouard C. Nice, Jingwen Jiang, Canhua Huang
Adv Sci (Weinh) 2024 Jan; 11(3): 2306535. Published online 2023 Nov 16. doi: 10.1002/advs.202306535
PMCID:
PMC10797426
AbstractArticlePDF–6.3M
9.
Dual targeting of MAPK and PI3K pathways unlocks redifferentiation of Braf-mutated thyroid cancer organoids
Hélène Lasolle, Andrea Schiavo, Adrien Tourneur, Pierre Gillotay, Bárbara de Faria da Fonseca, Lucieli Ceolin, Olivier Monestier, Benilda Aganahi, Laura Chomette, Marina Malta Letro Kizys, Lieven Haenebalcke, Tim Pieters, Steven Goossens, Jody Haigh, Vincent Detours, Ana Luiza Silva Maia, Sabine Costagliola, Mírian Romitti
Oncogene. 2024; 43(3): 155–170. Published online 2023 Nov 20. doi: 10.1038/s41388-023-02889-y
PMCID:
PMC10786723
AbstractArticlePDF–14M
10.
BRAFV600E mutation and DSS treatment synergize to induce cecal tumor formation in mice
Chenxi Gao, Farzad Esni, Edward Chu, Jing Hu
Biochem Biophys Rep. 2024 Mar; 37: 101634. Published online 2024 Jan 1. doi: 10.1016/j.bbrep.2023.101634
PMCID:
PMC10771891
AbstractArticlePDF–6.0M
11.
Apolipoprotein E2 Stimulates Protein Synthesis and Promotes Melanoma Progression and Metastasis
Nneoma Adaku, Benjamin N. Ostendorf, Wenbin Mei, Sohail F. Tavazoie
Cancer Res. Author manuscript; available in PMC 2023 Dec 22.
Published in final edited form as: Cancer Res. 2023 Sep 15; 83(18): 3013–3025. doi: 10.1158/0008-5472.CAN-23-1252
PMCID:
PMC10740391
AbstractArticlePDF–1.7M
12.
BRAF D594A mutation defines a unique biological and immuno-modulatory subgroup associated with functional CD8+ T cell infiltration in colorectal cancer
Wenjing Li, Chenyi Zhao, Wenhui Li, Yang Gong, Kaili Ma, Yujie Lu, Xiaowei Liu, Lianjun Zhang, Feng Guo
J Transl Med. 2023; 21: 737. Published online 2023 Oct 18. doi: 10.1186/s12967-023-04606-5
PMCID:
PMC10585750
AbstractArticlePDF–16M
13.
GREB1 isoform 4 is specifically transcribed by MITF and required for melanoma proliferation
Koei Shinzawa, Shinji Matsumoto, Ryota Sada, Akikazu Harada, Kaori Saitoh, Keiko Kato, Satsuki Ikeda, Akiyoshi Hirayama, Kazunori Yokoi, Atsushi Tanemura, Keisuke Nimura, Masahito Ikawa, Tomoyoshi Soga, Akira Kikuchi
Oncogene. 2023; 42(42): 3142–3156. Published online 2023 Sep 1. doi: 10.1038/s41388-023-02803-6
PMCID:
PMC10575781
AbstractArticlePDF–5.0M
14.
Oncogenic context shapes the fitness landscape of tumor suppression
Lily M. Blair, Joseph M. Juan, Lafia Sebastian, Vy B. Tran, Wensheng Nie, Gregory D. Wall, Mehmet Gerceker, Ian K. Lai, Edwin A. Apilado, Gabriel Grenot, David Amar, Giorgia Foggetti, Mariana Do Carmo, Zeynep Ugur, Debbie Deng, Alex Chenchik, Maria Paz Zafra, Lukas E. Dow, Katerina Politi, Jonathan J. MacQuitty, Dmitri A. Petrov, Monte M. Winslow, Michael J. Rosen, Ian P. Winters
Nat Commun. 2023; 14: 6422. Published online 2023 Oct 12. doi: 10.1038/s41467-023-42156-y
PMCID:
PMC10570323
AbstractArticlePDF–6.1M
15.
Multiplexed screens identify RAS paralogs HRAS and NRAS as suppressors of KRAS-driven lung cancer growth
Rui Tang, Emily G. Shuldiner, Marcus Kelly, Christopher W. Murray, Jess D. Hebert, Laura Andrejka, Min K. Tsai, Nicholas W. Hughes, Mitchell I Parker, Hongchen Cai, Yao-Cheng Li, Geoffrey M. Wahl, Roland L Dunbrack, Peter K. Jackson, Dmitri A. Petrov, Monte M. Winslow
Nat Cell Biol. Author manuscript; available in PMC 2023 Sep 26.
Published in final edited form as: Nat Cell Biol. 2023 Jan; 25(1): 159–169. Published online 2023 Jan 12. doi: 10.1038/s41556-022-01049-w
PMCID:
PMC10521195
AbstractArticlePDF–6.8M
16.
BRAFV600E-mutated serrated colorectal neoplasia drives transcriptional activation of cholesterol metabolism
Paulina Rzasa, Sarah Whelan, Pooyeh Farahmand, Hong Cai, Inna Guterman, Raquel Palacios-Gallego, Shanthi S. Undru, Lauren Sandford, Caleb Green, Catherine Andreadi, Maria Mintseva, Emma Parrott, Hong Jin, Fiona Hey, Susan Giblett, Nicolas B. Sylvius, Natalie S. Allcock, Anna Straatman-Iwanowska, Roberto Feuda, Cristina Tufarelli, Karen Brown, Catrin Pritchard, Alessandro Rufini
Commun Biol. 2023; 6: 962. Published online 2023 Sep 21. doi: 10.1038/s42003-023-05331-x
PMCID:
PMC10514332
AbstractArticlePDF–4.5M
17.
Microenvironmental Snail1-induced immunosuppression promotes melanoma growth
Marta Arumi-Planas, Francisco Javier Rodriguez-Baena, Francisco Cabello-Torres, Francisco Gracia, Cristina Lopez-Blau, M. Angela Nieto, Berta Sanchez-Laorden
Oncogene. 2023; 42(36): 2659–2672. Published online 2023 Jul 29. doi: 10.1038/s41388-023-02793-5
PMCID:
PMC10473961
AbstractArticlePDF–3.9M
18.
TERT accelerates BRAF mutant–induced thyroid cancer dedifferentiation and progression by regulating ribosome biogenesis
Pengcheng Yu, Ning Qu, Rui Zhu, Jiaqian Hu, Peizhen Han, Jiahao Wu, Licheng Tan, Hualei Gan, Cong He, Chuantao Fang, Yubin Lei, Jian Li, Chenxi He, Fei Lan, Xiao Shi, Wenjun Wei, Yu Wang, Qinghai Ji, Fa-Xing Yu, Yu-Long Wang
Sci Adv. 2023 Sep; 9(35): eadg7125. Published online 2023 Aug 30. doi: 10.1126/sciadv.adg7125
PMCID:
PMC10468137
AbstractArticlePDF–3.1M
19.
UTX inactivation in germinal center B cells promotes the development of multiple myeloma with extramedullary disease
Ola Rizq, Naoya Mimura, Motohiko Oshima, Shuji Momose, Naoya Takayama, Naoki Itokawa, Shuhei Koide, Asuka Shibamiya, Yurie Miyamoto-Nagai, Mohamed Rizk, Yaeko Nakajima-Takagi, Kazumasa Aoyama, Changshan Wang, Atsunori Saraya, Ryoji Ito, Masanori Seimiya, Mariko Watanabe, Satoshi Yamasaki, Tatsuhiro Shibata, Kiyoshi Yamaguchi, Yoichi Furukawa, Tetsuhiro Chiba, Emiko Sakaida, Chiaki Nakaseko, Jun-ichi Tamaru, Yu-Tzu Tai, Kenneth C. Anderson, Hiroaki Honda, Atsushi Iwama
Leukemia. 2023; 37(9): 1895–1907. Published online 2023 May 17. doi: 10.1038/s41375-023-01928-7
Correction in:
Leukemia. 2023; 37(9): 1952.
PMCID:
PMC10457198
AbstractArticlePDF–4.0M
20.
A cellular hierarchy in melanoma uncouples growth and metastasis
Panagiotis Karras, Ignacio Bordeu, Joanna Pozniak, Ada Nowosad, Cecilia Pazzi, Nina Van Raemdonck, Ewout Landeloos, Yannick van Herck, Dennis Pedri, Greet Bervoets, Samira Makhzami, Jia Hui Khoo, Benjamin Pavie, Jochen Lamote, Oskar Marin-Bejar, Michael Dewaele, Han Liang, Xingju Zhang, Yichao Hua, Jasper Wouters, Robin Browaeys, Gabriele Bergers, Yvan Saeys, Francesca Bosisio, Joost van den Oord, Diether Lambrechts, Anil K. Rustgi, Oliver Bechter, Cedric Blanpain, Benjamin D. Simons, Florian Rambow, Jean-Christophe Marine
Nature. Author manuscript; available in PMC 2023 Aug 19.
Published in final edited form as: Nature. 2022 Oct; 610(7930): 190–198. Published online 2022 Sep 21. doi: 10.1038/s41586-022-05242-7
Correction in:
Nature. 2022 Oct 19
PMCID:
PMC10439739
AbstractArticlePDF–9.1M

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