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Select item 111536111.

The manganese transporter SLC39A8 links alkaline ceramidase 1 to inflammatory bowel disease

Eun-Kyung Choi, Thekkelnaycke M. Rajendiran, Tanu Soni, Jin-Ho Park, Luisa Aring, Chithra K. Muraleedharan, Vicky Garcia-Hernandez, Nobuhiko Kamada, Linda C. Samuelson, Asma Nusrat, Shigeki Iwase, Young Ah Seo

Nat Commun. 2024; 15: 4775. Published online 2024 Jun 5. doi: 10.1038/s41467-024-49049-8

PMCID:: PMC11153611

Abstract Article PDF–7.0M

Select item 109176602.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 105757103.

Critical Role of Zinc Transporter (Zip8) in Myeloid Innate Immune Cell Function and the Host Response against Bacterial Pneumonia

Sannette C. Hall, Deandra R. Smith, Shetty Ravi Dyavar, Todd A. Wyatt, Derrick R. Samuelson, Kristina L. Bailey, Daren L. Knoell

J Immunol. Author manuscript; available in PMC 2023 Oct 13.

Published in final edited form as: J Immunol. 2021 Sep 1; 207(5): 1357–1370. Published online 2021 Aug 11. doi: 10.4049/jimmunol.2001395

PMCID:: PMC10575710

Abstract Article PDF–1.5M

Select item 105574054.

Imbalance in Zinc Homeostasis Enhances Lung Tissue Loss Following Cigarette Smoke Exposure

Daren L. Knoell, Deandra Smith, Shengying Bao, Muna Sapkota, Todd A. Wyatt, Jay L. Zweier, Jennifer Flury, Michael T. Borchers, Mitch Knutson

J Trace Elem Med Biol. Author manuscript; available in PMC 2023 Oct 6.

Published in final edited form as: J Trace Elem Med Biol. 2020 Jul; 60: 126483. Published online 2020 Feb 27. doi: 10.1016/j.jtemb.2020.126483

PMCID:: PMC10557405

Abstract Article PDF–2.2M

Select item 104574515.

Metal-ion transporter SLC39A8 is required for brain manganese uptake and accumulation

Qingli Liu, Supak Jenkitkasemwong, Tamanna Afrin Prami, Shannon Morgan McCabe, Ningning Zhao, Shintaro Hojyo, Toshiyuki Fukada, Mitchell D. Knutson

J Biol Chem. 2023 Aug; 299(8): 105078. Published online 2023 Jul 21. doi: 10.1016/j.jbc.2023.105078

PMCID:: PMC10457451

Abstract Article PDF–1.0M

Select item 101196006.

A mouse model characterizes the roles of ZIP8 in systemic iron recycling and lung inflammation and infection

Vida Zhang, Supak Jenkitkasemwong, Qingli Liu, Tomas Ganz, Elizabeta Nemeth, Mitchell D. Knutson, Airie Kim

Blood Adv. 2023 Apr 11; 7(7): 1336–1349. Published online 2022 Oct 21. doi: 10.1182/bloodadvances.2022007867

PMCID:: PMC10119600

Abstract Article PDF–1.4M

Select item 94401067.

The schizophrenia-associated missense variant rs13107325 regulates dendritic spine density

Shiwu Li, Changguo Ma, Yifan Li, Rui Chen, Yixing Liu, Li Pear Wan, Qiuxia Xiong, Chuang Wang, Yongxia Huo, Xinglun Dang, Yongfeng Yang, Luxian Lv, Xi Chen, Nengyin Sheng, Wenqiang Li, Xiong-Jian Luo

Transl Psychiatry. 2022; 12: 361. Published online 2022 Sep 2. doi: 10.1038/s41398-022-02137-z

PMCID:: PMC9440106

Abstract Article PDF–9.1M

Select item 92407758.

The Allelic Variant A391T of Metal Ion Transporter ZIP8 (SLC39A8) Leads to Hypotension and Enhanced Insulin Resistance

Sophia N. Verouti, Jonai Pujol-Giménez, Paola Bermudez-Lekerika, Laeticia Scherler, Rajesh Bhardwaj, Aurélien Thomas, Sébastien Lenglet, Mark Siegrist, Willy Hofstetter, Daniel G. Fuster, Matthias A. Hediger, Geneviève Escher, Bruno Vogt

Front Physiol. 2022; 13: 912277. Published online 2022 Jun 15. doi: 10.3389/fphys.2022.912277

PMCID:: PMC9240775

Abstract Article PDF–2.2M

Select item 91672849.

Back-translating GWAS findings to animal models reveals a role for Hgfac and Slc39a8 in alcohol and nicotine consumption

F. K. El Banna, J. M. Otto, S. M. Mulloy, W. Tsai, S. M. McElroy, A. L. Wong, G. Cutts, S. I. Vrieze, A. M. Lee

Sci Rep. 2022; 12: 9336. Published online 2022 Jun 4. doi: 10.1038/s41598-022-13283-1

PMCID:: PMC9167284

Abstract Article PDF–3.0M

Select item 915170010.

The ZIP8/SIRT1 axis regulates alveolar progenitor cell renewal in aging and idiopathic pulmonary fibrosis

Jiurong Liang, Guanling Huang, Xue Liu, Forough Taghavifar, Ningshan Liu, Yizhou Wang, Nan Deng, Changfu Yao, Ting Xie, Vrishika Kulur, Kristy Dai, Ankita Burman, Simon C. Rowan, S. Samuel Weigt, John Belperio, Barry Stripp, William C. Parks, Dianhua Jiang, Paul W. Noble

J Clin Invest. 2022 Jun 1; 132(11): e157338. Published online 2022 Jun 1. doi: 10.1172/JCI157338

PMCID:: PMC9151700

Abstract Article PDF–1.9M

Select item 910689011.

The schizophrenia-associated variant in SLC39A8 alters protein glycosylation in the mouse brain

Robert G. Mealer, Sarah E. Williams, Maxence Noel, Bo Yang, Alexandria K. D’Souza, Toru Nakata, Daniel B. Graham, Elizabeth A. Creasey, Murat Cetinbas, Ruslan I. Sadreyev, Edward M. Scolnick, Christina M. Woo, Jordan W. Smoller, Ramnik J. Xavier, Richard D. Cummings

Mol Psychiatry. Author manuscript; available in PMC 2022 Sep 8.

Published in final edited form as: Mol Psychiatry. 2022 Mar; 27(3): 1405–1415. Published online 2022 Mar 8. doi: 10.1038/s41380-022-01490-1

PMCID:: PMC9106890

Abstract Article PDF–1.0M

Select item 883470912.

ZIP8-Mediated Intestinal Dysbiosis Impairs Pulmonary Host Defense against Bacterial Pneumonia

Derrick R. Samuelson, Deandra R. Smith, Kelly C. Cunningham, Todd A. Wyatt, Sannette C. Hall, Daryl J. Murry, Yashpal S. Chhonker, Daren L. Knoell

Int J Mol Sci. 2022 Feb; 23(3): 1022. Published online 2022 Jan 18. doi: 10.3390/ijms23031022

PMCID:: PMC8834709

Abstract Article PDF–4.5M

Select item 810255813.

ZIP8 exacerbates collagen-induced arthritis by increasing pathogenic T cell responses

Jung-Ah Kang, Ji-Sun Kwak, Sang-Heon Park, Kyu-Young Sim, Seul Ki Kim, Youngnim Shin, In Jung Jung, Jeong-In Yang, Jang-Soo Chun, Sung-Gyoo Park

Exp Mol Med. 2021 Apr; 53(4): 560–571. Published online 2021 Apr 1. doi: 10.1038/s12276-021-00591-1

PMCID:: PMC8102558

Abstract Article PDF–3.0M

Select item 789594814.

Schizophrenia-associated SLC39A8 polymorphism is a loss-of-function allele altering glutamate receptor and innate immune signaling

Wei Chou Tseng, Veronica Reinhart, Thomas A. Lanz, Mark L. Weber, Jincheng Pang, Kevin Xuong Vinh Le, Robert D. Bell, Patricio O’Donnell, Derek L. Buhl

Transl Psychiatry. 2021; 11: 136. Published online 2021 Feb 19. doi: 10.1038/s41398-021-01262-5

PMCID:: PMC7895948

Abstract Article PDF–2.5M

Select item 768232715.

A missense variant in SLC39A8 confers risk for Crohn’s disease by disrupting manganese homeostasis and intestinal barrier integrity

Toru Nakata, Elizabeth A. Creasey, Motohiko Kadoki, Helen Lin, Martin K. Selig, Junmei Yao, Ariel Lefkovith, Mark J. Daly, Daniel B. Graham, Ramnik J. Xavier

Proc Natl Acad Sci U S A. 2020 Nov 17; 117(46): 28930–28938. Published online 2020 Nov 2. doi: 10.1073/pnas.2014742117

PMCID:: PMC7682327

Abstract Article PDF–1.2M

Select item 760552316.

Pleiotropic ZIP8 A391T implicates abnormal manganese homeostasis in complex human disease

Laxmi Sunuwar, Azra Frkatović, Sodbo Sharapov, Qinchuan Wang, Heather M. Neu, Xinqun Wu, Talin Haritunians, Fengyi Wan, Sarah Michel, Shaoguang Wu, Mark Donowitz, Dermot McGovern, Gordan Lauc, Cynthia Sears, Joanna Melia

JCI Insight. 2020 Oct 15; 5(20): e140978. Published online 2020 Oct 15. doi: 10.1172/jci.insight.140978

PMCID:: PMC7605523

Abstract Article PDF–10M

Select item 676517917.

Genomic architecture of Shh-dependent cochlear morphogenesis

Victor Muthu, Alex M. Rohacek, Yao Yao, Staci M. Rakowiecki, Alexander S. Brown, Ying-Tao Zhao, James Meyers, Kyoung-Jae Won, Shweta Ramdas, Christopher D. Brown, Kevin A. Peterson, Douglas J. Epstein

Development. 2019 Sep 15; 146(18): dev181339. Published online 2019 Sep 19. doi: 10.1242/dev.181339