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Select item 111366661.

Hippo–YAP/TAZ signalling coordinates adipose plasticity and energy balance by uncoupling leptin expression from fat mass

Sungwoo Choi, Ju-Gyeong Kang, Yen T. H. Tran, Sun-Hye Jeong, Kun-Young Park, Hyemi Shin, Young Hoon Kim, Myungsun Park, Hahn Nahmgoong, Taejun Seol, Haeyon Jeon, Yeongmin Kim, Sanghee Park, Hee-joo Kim, Min-Seob Kim, Xiaoxu Li, Maroun Bou Sleiman, Eries Lee, Jinhyuk Choi, David Eisenbarth, Sang Heon Lee, Suhyeon Cho, David D. Moore, Johan Auwerx, Il-Young Kim, Jae Bum Kim, Jong-Eun Park, Dae-Sik Lim, Jae Myoung Suh

Nat Metab. 2024; 6(5): 847–860. Published online 2024 May 29. doi: 10.1038/s42255-024-01045-4

PMCID:: PMC11136666

Abstract Article PDF–18M

Select item 110813192.

Exportin 4 DNA promoter methylation in liver fibrosis

Ziyan Pan, Ali Bayoumi, Mayada Metwally, Jacob George, Mohammed Eslam

PLoS One. 2024; 19(5): e0302786. Published online 2024 May 9. doi: 10.1371/journal.pone.0302786

PMCID:: PMC11081319

Abstract Article PDF–1.1M

Select item 109176603.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 106076624.

Proximal Tubular Lats2 Ablation Exacerbates Ischemia/Reperfusion Injury (IRI)-Induced Renal Maladaptive Repair through the Upregulation of P53

Chi Zhang, Zhihuang Zheng, Kexin Xu, Guozhe Cheng, Huijuan Wu, Jun Liu

Int J Mol Sci. 2023 Oct; 24(20): 15258. Published online 2023 Oct 17. doi: 10.3390/ijms242015258

PMCID:: PMC10607662

Abstract Article PDF–22M

Select item 103675685.

Lats2 deficiency protects the heart against myocardial infarction by reducing inflammation and inhibiting mitochondrial fission and STING/p65 signaling

Libao Liu, Shuai Huang, Yingzhen Du, Hao Zhou, Kai Zhang, Jinyuan He

Int J Biol Sci. 2023; 19(11): 3428–3440. Published online 2023 Jul 3. doi: 10.7150/ijbs.84426

PMCID:: PMC10367568

Abstract Article PDF–7.2M

Select item 101144986.

Regenerative reprogramming of the intestinal stem cell state via Hippo signaling suppresses metastatic colorectal cancer

Priscilla Cheung, Jordi Xiol, Michael T. Dill, Wei-Chien Yuan, Riccardo Panero, Jatin Roper, Fernando G. Osorio, Dejan Maglic, Qi Li, Basanta Gurung, Raffaele A. Calogero, Ömer H. Yilmaz, Junhao Mao, Fernando D. Camargo

Cell Stem Cell. Author manuscript; available in PMC 2023 Apr 19.

Published in final edited form as: Cell Stem Cell. 2020 Oct 1; 27(4): 590–604.e9. Published online 2020 Jul 29. doi: 10.1016/j.stem.2020.07.003

PMCID:: PMC10114498

Abstract Article PDF–2.4M

Select item 98169187.

A Stk4 -Foxp3-P65 Transcriptional Complex Promotes Treg Cell Activation and Homeostasis

Ye Cui, Mehdi Benamar, Klaus Schmitz-Abe, Varsha Poondi-Krishnan, Qian Chen, Bat-Erdene Jugder, Benoit Fatou, Jason Fong, Yuelin Zhong, Stuti Mehta, Altantsetseg Buyanbat, Beray Selver Eklioglu, Esra Karabiber, Safa Baris, Ayca Kiykim, Sevgi Keles, Emmanuel Stephen-Victor, Claudia Angelini, Louis-Marie Charbonnier, Talal A. Chatila

Sci Immunol. Author manuscript; available in PMC 2023 Jan 6.

Published in final edited form as: Sci Immunol. 2022 Sep 23; 7(75): eabl8357. Published online 2022 Sep 23. doi: 10.1126/sciimmunol.abl8357

PMCID:: PMC9816918

Abstract Article PDF–3.0M

Select item 97054398.

Inactivation of LATS1/2 drives luminal-basal plasticity to initiate basal-like mammary carcinomas

Joseph G. Kern, Andrew M. Tilston-Lunel, Anthony Federico, Boting Ning, Amy Mueller, Grace B. Peppler, Eleni Stampouloglou, Nan Cheng, Randy L. Johnson, Marc E. Lenburg, Jennifer E. Beane, Stefano Monti, Xaralabos Varelas

Nat Commun. 2022; 13: 7198. Published online 2022 Nov 28. doi: 10.1038/s41467-022-34864-8

PMCID:: PMC9705439

Abstract Article PDF–6.2M

Select item 96553139.

Targeted Disruption of Lats1 and Lats2 in Mice Impairs Testis Development and Alters Somatic Cell Fate

Nour Abou Nader, Amélie Ménard, Adrien Levasseur, Guillaume St-Jean, Derek Boerboom, Gustavo Zamberlam, Alexandre Boyer

Int J Mol Sci. 2022 Nov; 23(21): 13585. Published online 2022 Nov 5. doi: 10.3390/ijms232113585

PMCID:: PMC9655313

Abstract Article PDF–4.1M

Select item 962974510.

Single-cell multiomics identifies clinically relevant mesenchymal stem-like cells and key regulators for MPNST malignancy

Lai Man Natalie Wu, Feng Zhang, Rohit Rao, Mike Adam, Kai Pollard, Sara Szabo, Xuezhao Liu, Katie A. Belcher, Zaili Luo, Sean Ogurek, Colleen Reilly, Xin Zhou, Li Zhang, Joshua Rubin, Long-sheng Chang, Mei Xin, Jiyang Yu, Mario Suva, Christine A. Pratilas, Steven Potter, Q. Richard Lu

Sci Adv. 2022 Nov; 8(44): eabo5442. Published online 2022 Nov 2. doi: 10.1126/sciadv.abo5442

PMCID:: PMC9629745

Abstract Article PDF–16M

Select item 958780511.

LATS1/2 control TGFB-directed epithelial-to-mesenchymal transition in the murine dorsal cranial neuroepithelium through YAP regulation

Idaliz M. Martínez Traverso, Jeffrey D. Steimle, Xiaolei Zhao, Jun Wang, James F. Martin

Development. 2022 Sep 15; 149(18): dev200860. Published online 2022 Sep 20. doi: 10.1242/dev.200860

PMCID:: PMC9587805

Abstract Article

Select item 956230112.

The Hippo pathway links adipocyte plasticity to adipose tissue fibrosis

Hongyu Shen, Xun Huang, Yiheng Zhao, Dongmei Wu, Kaili Xue, Jingfei Yao, Yushuang Wang, Nan Tang, Yifu Qiu

Nat Commun. 2022; 13: 6030. Published online 2022 Oct 13. doi: 10.1038/s41467-022-33800-0

PMCID:: PMC9562301

Abstract Article PDF–6.0M

Select item 952918813.

Transcription Factors YAP/TAZ and SRF Cooperate To Specify Renal Myofibroblasts in the Developing Mouse Kidney

Keri A. Drake, Christopher Chaney, Mohita Patel, Amrita Das, Julia Bittencourt, Martin Cohn, Thomas J. Carroll

J Am Soc Nephrol. 2022 Sep; 33(9): 1694–1707. Published online 2022 Sep. doi: 10.1681/ASN.2021121559

Correction in:: J Am Soc Nephrol. 2023 Mar; 34(3): 515–516.

PMCID:: PMC9529188

Abstract Article

Select item 952674914.

Exportin 4 depletion leads to nuclear accumulation of a subset of circular RNAs

Liang Chen, Yucong Wang, Jiamei Lin, Zhenxing Song, Qinwei Wang, Wenfang Zhao, Yan Wang, Xiaoyu Xiu, Yuqi Deng, Xiuzhi Li, Qiqi Li, Xiaolin Wang, Jingxin Li, Xu Liu, Kunpeng Liu, Jincong Zhou, Kuan Li, Yuchan Liu, Shanhui Liao, Qin Deng, Chao Xu, Qianwen Sun, Shengzhou Wu, Kaiming Zhang, Min-Xin Guan, Tianhua Zhou, Fei Sun, Xiujun Cai, Chuan Huang, Ge Shan

Nat Commun. 2022; 13: 5769. Published online 2022 Oct 1. doi: 10.1038/s41467-022-33356-z

PMCID:: PMC9526749

Abstract Article PDF–6.9M

Select item 924310715.

Inactivation of the Hippo tumor suppressor pathway promotes melanoma

Marc A. Vittoria, Nathan Kingston, Kristyna Kotynkova, Eric Xia, Rui Hong, Lee Huang, Shayna McDonald, Andrew Tilston-Lunel, Revati Darp, Joshua D. Campbell, Deborah Lang, Xiaowei Xu, Craig J. Ceol, Xaralabos Varelas, Neil J. Ganem

Nat Commun. 2022; 13: 3732. Published online 2022 Jun 29. doi: 10.1038/s41467-022-31399-w

PMCID:: PMC9243107

Abstract Article PDF–7.2M

Select item 921355216.

NANOG initiates epiblast fate through the coordination of pluripotency genes expression

Nicolas Allègre, Sabine Chauveau, Cynthia Dennis, Yoan Renaud, Dimitri Meistermann, Lorena Valverde Estrella, Pierre Pouchin, Michel Cohen-Tannoudji, Laurent David, Claire Chazaud

Nat Commun. 2022; 13: 3550. Published online 2022 Jun 21. doi: 10.1038/s41467-022-30858-8

PMCID:: PMC9213552

Abstract Article PDF–4.4M

Select item 887642717.

Myofibroblast YAP/TAZ activation is a key step in organ fibrogenesis

Xiaolin He, Monica F. Tolosa, Tianzhou Zhang, Santosh Kumar Goru, Luisa Ulloa Severino, Paraish S. Misra, Caitríona M. McEvoy, Lauren Caldwell, Stephen G. Szeto, Feng Gao, Xiaolan Chen, Cassandra Atin, Victoria Ki, Noah Vukosa, Catherine Hu, Johnny Zhang, Christopher Yip, Adriana Krizova, Jeffrey L. Wrana, Darren A. Yuen

JCI Insight. 2022 Feb 22; 7(4): e146243. Published online 2022 Feb 22. doi: 10.1172/jci.insight.146243

PMCID:: PMC8876427

Abstract Article PDF–28M

Select item 864878118.

Lats2 promotes heart failure by stimulating p53-mediated apoptosis during pressure overload

Dan Shao, Peiyong Zhai, Chengchen Hu, Risa Mukai, Sebastiano Sciarretta, Dominic Del Re, Junichi Sadoshima

Sci Rep. 2021; 11: 23469. Published online 2021 Dec 6. doi: 10.1038/s41598-021-02846-3

PMCID:: PMC8648781

Abstract Article PDF–7.1M

Select item 845253219.

The aryl hydrocarbon receptor promotes differentiation during mouse preimplantational embryo development

Ana Nacarino-Palma, Francisco J. González-Rico, Claudia M. Rejano-Gordillo, Ana Ordiales-Talavero, Jaime M. Merino, Pedro M. Fernández-Salguero

Stem Cell Reports. 2021 Sep 14; 16(9): 2351–2363. Published online 2021 Sep 2. doi: 10.1016/j.stemcr.2021.08.002

PMCID:: PMC8452532

Abstract Article PDF–3.1M

Select item 836361520.

The Hippo kinase LATS2 impairs pancreatic β-cell survival in diabetes through the mTORC1-autophagy axis

Ting Yuan, Karthika Annamalai, Shruti Naik, Blaz Lupse, Shirin Geravandi, Anasua Pal, Aleksandra Dobrowolski, Jaee Ghawali, Marina Ruhlandt, Kanaka Durga Devi Gorrepati, Zahra Azizi, Dae-Sik Lim, Kathrin Maedler, Amin Ardestani

Nat Commun. 2021; 12: 4928. Published online 2021 Aug 13. doi: 10.1038/s41467-021-25145-x

PMCID:: PMC8363615

Abstract Article PDF–7.0M

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