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Items: 1 to 20 of 118

1.
Biased binding of class IA phosphatidyl inositol 3-kinase subunits to inducible costimulator (CD278)
Yenny Y. Acosta, Maria Paz Zafra, Gloria Ojeda, Ilaria Seren Bernardone, Umberto Dianzani, Pilar Portolés, Jose M. Rojo
Cell Mol Life Sci. 2011 Sep; 68(18): 3065–3079. Published online 2010 Dec 28. doi: 10.1007/s00018-010-0606-1
PMCID:
PMC11115116
AbstractArticlePDF–743K
2.
A combined opposite targeting of p110δ PI3K and RhoA abrogates skin cancer
Niki Tzenaki, Lydia Xenou, Evangelia Goulielmaki, Anna Tsapara, Irene Voudouri, Angelika Antoniou, George Valianatos, Maria Tzardi, Eelco De Bree, Aikaterini Berdiaki, Antonios Makrigiannakis, Evangelia A. Papakonstanti
Commun Biol. 2024; 7: 26. Published online 2024 Jan 5. doi: 10.1038/s42003-023-05639-8
PMCID:
PMC10770346
AbstractArticlePDF–3.2M
3.
Human PIK3R1 mutations disrupt lymphocyte differentiation to cause activated PI3Kδ syndrome 2
Tina Nguyen, Anthony Lau, Julia Bier, Kristen C. Cooke, Helen Lenthall, Stephanie Ruiz-Diaz, Danielle T. Avery, Henry Brigden, David Zahra, William A Sewell, Luke Droney, Satoshi Okada, Takaki Asano, Hassan Abolhassani, Zahra Chavoshzadeh, Roshini S. Abraham, Nipunie Rajapakse, Eric W. Klee, Joseph A. Church, Andrew Williams, Melanie Wong, Christoph Burkhart, Gulbu Uzel, David R. Croucher, David E. James, Cindy S. Ma, Robert Brink, Stuart G. Tangye, Elissa K. Deenick
J Exp Med. 2023 Jun 5; 220(6): e20221020. Published online 2023 Mar 21. doi: 10.1084/jem.20221020
PMCID:
PMC10037341
AbstractArticlePDF–6.2M
4.
PI3-kinase deletion promotes myelodysplasia by dysregulating autophagy in hematopoietic stem cells
Kristina Ames, Imit Kaur, Yang Shi, Meng M. Tong, Taneisha Sinclair, Shayda Hemmati, Shira G. Glushakow-Smith, Ellen Tein, Lindsay Gurska, Ulrich Steidl, Robert Dubin, Jidong Shan, Cristina Montagna, Kith Pradhan, Amit Verma, Kira Gritsman
Sci Adv. 2023 Feb; 9(8): eade8222. Published online 2023 Feb 22. doi: 10.1126/sciadv.ade8222
PMCID:
PMC9946350
AbstractArticlePDF–2.4M
5.
A CRISPR screen targeting PI3K effectors identifies RASA3 as a negative regulator of LFA-1–mediated adhesion in T cells
Kristoffer H. Johansen, Dominic P. Golec, Bonnie Huang, Chung Park, Julie H. Thomsen, Silvia Preite, Jennifer L. Cannons, Fabien Garçon, Edward C. Schrom, Christina Courreges, Tibor Z. Veres, James Harrison, Meritxell Nus, James D. Phelan, Wolfgang Bergmeier, John Kehrl, Klaus Okkenhaug, Pamela L. Schwartzberg
Sci Signal. Author manuscript; available in PMC 2023 Jan 19.
Published in final edited form as: Sci Signal. 2022 Jul 19; 15(743): eabl9169. Published online 2022 Jul 19. doi: 10.1126/scisignal.abl9169
PMCID:
PMC9637254
AbstractArticlePDF–3.2M
6.
DOCK2 and phosphoinositide-3 kinase δ mediate two complementary signaling pathways for CXCR5-dependent B cell migration
Stefanie Wissmann, Bettina Stolp, Ana Marcos Jímenez, Jens V. Stein
Front Immunol. 2022; 13: 982383. Published online 2022 Oct 19. doi: 10.3389/fimmu.2022.982383
PMCID:
PMC9627044
AbstractArticlePDF–4.0M
7.
TWIST1 interacts with β/δ-catenins during neural tube development and regulates fate transition in cranial neural crest cells
Jessica W. Bertol, Shelby Johnston, Rabia Ahmed, Victoria K. Xie, Kelsea M. Hubka, Lissette Cruz, Larissa Nitschke, Marta Stetsiv, Jeremy P. Goering, Paul Nistor, Sally Lowell, Hanne Hoskens, Peter Claes, Seth M. Weinberg, Irfan Saadi, Mary C. Farach-Carson, Walid D. Fakhouri
Development. 2022 Aug 1; 149(15): dev200068. Published online 2022 Aug 8. doi: 10.1242/dev.200068
PMCID:
PMC9440756
AbstractArticle
8.
Lack of Functional P110δ Affects Expression of Activation Marker CD80 but Does Not Influence Functions of Neutrophils
Aneta Manda-Handzlik, Agnieszka Mroczek, Weronika Kuźmicka, Adrianna Cieloch, Zuzanna Homoncik, Angelika Muchowicz, Urszula Demkow, Małgorzata Wachowska
Int J Mol Sci. 2022 Jun; 23(12): 6361. Published online 2022 Jun 7. doi: 10.3390/ijms23126361
PMCID:
PMC9223848
AbstractArticlePDF–2.2M
9.
PI3K regulates the activation of NLRP3 inflammasome in atherosclerosis through part-dependent AKT signaling pathway
Zhenzhu Liu, Jing Li, Shu Lin, Yuhang Wu, Dan He, Peng Qu
Exp Anim. 2021; 70(4): 488–497. Published online 2021 Jun 22. doi: 10.1538/expanim.21-0002
PMCID:
PMC8614019
AbstractArticlePDF–2.9M
10.
PI3Kδ coordinates transcriptional, chromatin, and metabolic changes to promote effector CD8+ T cells at the expense of central memory
Jennifer L. Cannons, Alejandro V. Villarino, Senta M. Kapnick, Silvia Preite, Han-Yu Shih, Julio Gomez-Rodriguez, Zenia Kaul, Hirofumi Shibata, Julie M. Reilley, Bonnie Huang, Robin Handon, Ian T. McBain, Selamawit Gossa, Tuoqi Wu, Helen C. Su, Dorian B. McGavern, John J. O’Shea, Peter J. McGuire, Gulbu Uzel, Pamela L. Schwartzberg
Cell Rep. Author manuscript; available in PMC 2021 Nov 11.
Published in final edited form as: Cell Rep. 2021 Oct 12; 37(2): 109804. doi: 10.1016/j.celrep.2021.109804
PMCID:
PMC8582080
AbstractArticlePDF–3.2M
11.
Activated PI3Kδ signals compromise plasma cell survival via limiting autophagy and increasing ER stress
Fahd Al Qureshah, Sara Sagadiev, Christopher D. Thouvenel, Shuozhi Liu, Zhaolin Hua, Baidong Hou, Mridu Acharya, Richard G. James, David J. Rawlings
J Exp Med. 2021 Dec 6; 218(12): e20211035. Published online 2021 Sep 29. doi: 10.1084/jem.20211035
PMCID:
PMC8485856
AbstractArticlePDF–5.5M
12.
Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development
Francesco Bedogni, Robert F. Hevner
Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034
PMCID:
PMC8313239
AbstractArticlePDF–1.6M
13.
Phosphoinositide 3-Kinase p110 Delta Differentially Restrains and Directs Naïve Versus Effector CD8+ T Cell Transcriptional Programs
Laura Spinelli, Julia M. Marchingo, Aneela Nomura, Marcos P. Damasio, Doreen A. Cantrell
Front Immunol. 2021; 12: 691997. Published online 2021 Jun 18. doi: 10.3389/fimmu.2021.691997
PMCID:
PMC8250422
AbstractArticlePDF–5.8M
14.
PI3Kδ Forms Distinct Multiprotein Complexes at the TCR Signalosome in Naïve and Differentiated CD4+ T Cells
Daisy H. Luff, Katarzyna Wojdyla, David Oxley, Tamara Chessa, Kevin Hudson, Phillip T. Hawkins, Len R. Stephens, Simon T. Barry, Klaus Okkenhaug
Front Immunol. 2021; 12: 631271. Published online 2021 Mar 8. doi: 10.3389/fimmu.2021.631271
PMCID:
PMC7982423
AbstractArticlePDF–2.6M
15.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
16.
Class IA PI3Ks regulate subcellular and functional dynamics of IDO1
Alberta Iacono, Andrea Pompa, Francesca De Marchis, Eleonora Panfili, Francesco A Greco, Alice Coletti, Ciriana Orabona, Claudia Volpi, Maria L Belladonna, Giada Mondanelli, Elisa Albini, Carmine Vacca, Marco Gargaro, Francesca Fallarino, Roberta Bianchi, Carine De Marcos Lousa, Emilia MC Mazza, Silvio Bicciato, Elisa Proietti, Francesca Milano, Maria P Martelli, Ioana M Iamandii, Mariona Graupera Garcia‐Mila, Judith Llena Sopena, Phillip Hawkins, Sabine Suire, Klaus Okkenhaug, Anne‐Katrien Stark, Fabio Grassi, Michele Bellucci, Paolo Puccetti, Laura Santambrogio, Antonio Macchiarulo, Ursula Grohmann, Maria T Pallotta
EMBO Rep. 2020 Dec 3; 21(12): e49756. Published online 2020 Nov 7. doi: 10.15252/embr.201949756
PMCID:
PMC7726814
AbstractArticlePDF–5.6M
17.
Deletion of P110δ promotes the development of myocarditis in ApoE-deficient mice by increasing mononuclear cell peritoneal infiltration
Qi-Zhi Zhang, Ai-Ying Xue, Wei Wei, Ai-Min Pang, Li-Na Cao, Fang Liu
Mol Med Rep. 2020 Nov; 22(5): 3629–3634. Published online 2020 Aug 21. doi: 10.3892/mmr.2020.11451
PMCID:
PMC7533459
AbstractArticlePDF–443K
18.
Cholesterol metabolism drives regulatory B cell IL-10 through provision of geranylgeranyl pyrophosphate
Jack A. Bibby, Harriet A. Purvis, Thomas Hayday, Anita Chandra, Klaus Okkenhaug, Sofia Rosenzweig, Ivona Aksentijevich, Michael Wood, Helen J. Lachmann, Claudia Kemper, Andrew P. Cope, Esperanza Perucha
Nat Commun. 2020; 11: 3412. Published online 2020 Jul 8. doi: 10.1038/s41467-020-17179-4
PMCID:
PMC7343868
AbstractArticlePDF–2.6M
19.
Loss of Phosphatidylinositol 3-Kinase Activity in Regulatory T Cells Leads to Neuronal Inflammation
Anne-Katrien Stark, Elizabeth C. M. Davenport, Daniel T. Patton, Cheryl L. Scudamore, Bart Vanhaesebroeck, Marc Veldhoen, Oliver A. Garden, Klaus Okkenhaug
J Immunol. 2020 Jul 1; 205(1): 78–89. Published online 2020 May 15. doi: 10.4049/jimmunol.2000043
PMCID:
PMC7311201
AbstractArticlePDF–1.8M
20.
PI3Kδ as a Novel Therapeutic Target in Pathological Angiogenesis
Wenyi Wu, Guohong Zhou, Haote Han, Xionggao Huang, Heng Jiang, Shizuo Mukai, Andrius Kazlauskas, Jing Cui, Joanne Aiko Matsubara, Bart Vanhaesebroeck, Xiaobo Xia, Jiantao Wang, Hetian Lei
Diabetes. 2020 Apr; 69(4): 736–748. Published online 2020 Jan 8. doi: 10.2337/db19-0713
PMCID:
PMC7085248
AbstractArticlePDF–2.4M

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