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Items: 1 to 20 of 70

1.
Conditional hepatocyte ablation of PDIA1 uncovers indispensable roles in both APOB and MTTP folding to support VLDL secretion
Zhouji Chen, Shiyu Wang, Anita Pottekat, Alec Duffey, Insook Jang, Benny H. Chang, Jaehyung Cho, Brian N. Finck, Nicholas O. Davidson, Randal J. Kaufman
Mol Metab. 2024 Feb; 80: 101874. Published online 2024 Jan 9. doi: 10.1016/j.molmet.2024.101874
PMCID:
PMC10832468
AbstractArticlePDF–4.8M
2.
Loss of hepatic SMLR1 causes hepatosteatosis and protects against atherosclerosis due to decreased hepatic VLDL secretion
Willemien van Zwol, Antoine Rimbert, Justina C. Wolters, Marieke Smit, Vincent W. Bloks, Niels J. Kloosterhuis, Nicolette C. A. Huijkman, Mirjam H. Koster, Umesh Tharehalli, Simon M. de Neck, Colin Bournez, Marceline M. Fuh, Jeroen Kuipers, Sujith Rajan, Alain de Bruin, Henry N. Ginsberg, Gerard J. P. van Westen, M. Mahmood Hussain, Ludger Scheja, Joerg Heeren, Philip Zimmerman, Bart van de Sluis, Jan Albert Kuivenhoven
Hepatology. 2023 Nov; 78(5): 1418–1432. Published online 2022 Oct 12. doi: 10.1002/hep.32709
PMCID:
PMC10581432
AbstractArticlePDF–1.9M
3.
Feto-maternal cholesterol transport regulated by β-Klotho–FGF15 axis is essential for fetal growth
Kanako Kobayashi, Kazuko Iwasa, Rika Azuma-Suzuki, Takeshi Kawauchi, Yo-ichi Nabeshima
Life Sci Alliance. 2023 Oct; 6(10): e202301916. Published online 2023 Aug 4. doi: 10.26508/lsa.202301916
PMCID:
PMC10403640
AbstractArticlePDF–2.1M
4.
Liver specific deletion of mouse Tm6sf2 promotes steatosis, fibrosis and hepatocellular cancer
Elizabeth P. Newberry, Zoe Hall, Yan Xie, Elizabeth A. Molitor, Peter O. Bayguinov, Gregory W. Strout, James A.J. Fitzpatrick, Elizabeth M. Brunt, Julian L. Griffin, Nicholas O. Davidson
Hepatology. Author manuscript; available in PMC 2022 Sep 1.
Published in final edited form as: Hepatology. 2021 Sep; 74(3): 1203–1219. Published online 2021 May 22. doi: 10.1002/hep.31771
PMCID:
PMC8390580
AbstractArticlePDF–3.5M
5.
PRAP1 is a novel lipid-binding protein that promotes lipid absorption by facilitating MTTP-mediated lipid transport
Hubert Peng, Tzu-Yuan Chiu, Yu-Jen Liang, Chia-Jen Lee, Chih-Syuan Liu, Ching-Shu Suen, Jeffrey J.-Y. Yen, Hung-Ta Chen, Ming-Jing Hwang, M. Mahmood Hussain, Hsin-Chou Yang, Hsin-Fang Yang-Yen
J Biol Chem. 2021 Jan-Jun; 296: 100052. Published online 2020 Nov 24. doi: 10.1074/jbc.RA120.015002
PMCID:
PMC7949078
AbstractArticlePDF–6.1M
6.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
7.
Identification of antisense transcripts of the microsomal triglyceride transfer protein genes in humans and mice
Shuai Zhang, M. Mahmood Hussain
Biochem Biophys Res Commun. Author manuscript; available in PMC 2020 Sep 17.
Published in final edited form as: Biochem Biophys Res Commun. 2019 Sep 17; 517(2): 317–323. Published online 2019 Jul 25. doi: 10.1016/j.bbrc.2019.07.069
PMCID:
PMC6689254
AbstractArticlePDF–1.5M
8.
ATP binding cassette family A protein 1 determines hexosylceramide and sphingomyelin levels in human and mouse plasma
Jahangir Iqbal, Meghan T. Walsh, Samar M. Hammad, Marina Cuchel, Daniel J. Rader, M. Mahmood Hussain
J Lipid Res. 2018 Nov; 59(11): 2084–2097. Published online 2018 Oct 2. doi: 10.1194/jlr.M087502
PMCID:
PMC6210916
AbstractArticlePDF–1.8M
9.
TFAM is required for maturation of the fetal and adult intestinal epithelium
Manasa Srivillibhuthur, Bailey N. Warder, Natalie H. Toke, Pooja P. Shah, Qiang Feng, Nan Gao, Edward M. Bonder, Michael P. Verzi
Dev Biol. Author manuscript; available in PMC 2019 Jul 15.
Published in final edited form as: Dev Biol. 2018 Jul 15; 439(2): 92–101. Published online 2018 Apr 22. doi: 10.1016/j.ydbio.2018.04.015
PMCID:
PMC5978755
AbstractArticlePDF–2.6M
10.
PCYT1A Regulates Phosphatidylcholine Homeostasis from the Inner Nuclear Membrane in Response to Membrane Stored Curvature Elastic Stress
Afreen Haider, Yu-Chen Wei, Koini Lim, Antonio D. Barbosa, Che-Hsiung Liu, Ursula Weber, Marek Mlodzik, Kadri Oras, Simon Collier, M. Mahmood Hussain, Liang Dong, Satish Patel, Anna Alvarez-Guaita, Vladimir Saudek, Benjamin J. Jenkins, Albert Koulman, Marcus K. Dymond, Roger C. Hardie, Symeon Siniossoglou, David B. Savage
Dev Cell. 2018 May 21; 45(4): 481–495.e8. doi: 10.1016/j.devcel.2018.04.012
PMCID:
PMC5971203
AbstractArticlePDF–5.3M
11.
CD1d-Restricted pathways in hepatocytes control local natural killer T cell homeostasis and hepatic inflammation
Sebastian Zeissig, Kenneth Peuker, Shankar Iyer, Thomas Gensollen, Stephanie K. Dougan, Torsten Olszak, Arthur Kaser, Richard S. Blumberg
Proc Natl Acad Sci U S A. 2017 Sep 26; 114(39): 10449–10454. Published online 2017 Sep 11. doi: 10.1073/pnas.1701428114
PMCID:
PMC5625893
AbstractArticlePDF–1004K
12.
Microsomal triglyceride transfer protein contributes to lipid droplet maturation in adipocytes
Larry L. Swift, Joseph D. Love, Carla M. Harris, Benny H. Chang, W. Gray Jerome
PLoS One. 2017; 12(8): e0181046. Published online 2017 Aug 9. doi: 10.1371/journal.pone.0181046
PMCID:
PMC5549975
AbstractArticlePDF–14M
13.
The constitutive lipid droplet protein PLIN2 regulates autophagy in liver
Tsung-Huang Tsai, Elaine Chen, Lan Li, Pradip Saha, Hsiao-Ju Lee, Li-Shin Huang, Gregory S. Shelness, Lawrence Chan, Benny Hung-Junn Chang
Autophagy. 2017; 13(7): 1130–1144. Published online 2017 May 26. doi: 10.1080/15548627.2017.1319544
PMCID:
PMC5529083
AbstractArticlePDF–1.3M
14.
Kidney triglyceride accumulation in the fasted mouse is dependent upon serum free fatty acids
Diego Scerbo, Ni-Huiping Son, Alaa Sirwi, Lixia Zeng, Kelli M. Sas, Vincenza Cifarelli, Gabriele Schoiswohl, Lesley-Ann Huggins, Namrata Gumaste, Yunying Hu, Subramaniam Pennathur, Nada A. Abumrad, Erin E. Kershaw, M. Mahmood Hussain, Katalin Susztak, Ira J. Goldberg
J Lipid Res. 2017 Jun; 58(6): 1132–1142. Published online 2017 Apr 12. doi: 10.1194/jlr.M074427
Correction in:
J Lipid Res. 2017 Sep; 58(9): 1933.
PMCID:
PMC5454509
AbstractArticlePDF–1.4M
15.
β-Apo-10′-carotenoids Modulate Placental Microsomal Triglyceride Transfer Protein Expression and Function to Optimize Transport of Intact β-Carotene to the Embryo
Brianna K. Costabile, Youn-Kyung Kim, Jahangir Iqbal, Michael V. Zuccaro, Lesley Wassef, Sureshbabu Narayanasamy, Robert W. Curley, Jr., Earl H. Harrison, M. Mahmood Hussain, Loredana Quadro
J Biol Chem. 2016 Aug 26; 291(35): 18525–18535. Published online 2016 Jul 8. doi: 10.1074/jbc.M116.738336
PMCID:
PMC5000097
AbstractArticlePDF–1.1M
16.
Trehalose inhibits solute carrier 2A (SLC2A) proteins to induce autophagy and prevent hepatic steatosis
Brian J DeBosch, Monique R. Heitmeier, Allyson L. Mayer, Cassandra B. Higgins, Jan R. Crowley, Thomas E. Kraft, Maggie Chi, Elizabeth P. Newberry, Zhouji Chen, Brian N. Finck, Nicholas O. Davidson, Kevin E. Yarasheski, Paul W. Hruz, Kelle H. Moley
Sci Signal. Author manuscript; available in PMC 2017 Feb 23.
Published in final edited form as: Sci Signal. 2016; 9(416): ra21. Published online 2016 Feb 23. doi: 10.1126/scisignal.aac5472
PMCID:
PMC4816640
AbstractArticlePDF–1.4M
17.
Intestine-specific MTP and global ACAT2 deficiency lowers acute cholesterol absorption with chylomicrons and HDLs
Jahangir Iqbal, Mohamed Boutjdir, Lawrence L. Rudel, M. Mahmood Hussain
J Lipid Res. 2014 Nov; 55(11): 2261–2275. doi: 10.1194/jlr.M047951
PMCID:
PMC4617129
AbstractArticlePDF–1.2M
18.
Phosphatase and Tensin Homolog (PTEN) Regulates Hepatic Lipogenesis, Microsomal Triglyceride Transfer Protein, and the Secretion of Apolipoprotein B–Containing Lipoproteins
Wei Qiu, Lisa Federico, Mark Naples, Rita Kohen Avramoglu, Reza Meshkani, Jing Zhang, Julie Tsai, Mahmood Hussain, Kezhi Dai, Jahangir Iqbal, Christopher D. Kontos, Yasuo Horie, Akira Suzuki, Khosrow Adeli
Hepatology. Author manuscript; available in PMC 2015 Aug 21.
Published in final edited form as: Hepatology. 2008 Dec; 48(6): 1799–1809. doi: 10.1002/hep.22565
PMCID:
PMC4544759
AbstractArticlePDF–1.4M
19.
Chemokine receptors CXCR2 and CX3CR1 differentially regulate functional responses of bone-marrow endothelial progenitors during atherosclerotic plaque regression
Oana Herlea-Pana, Longbiao Yao, Janet Heuser-Baker, Qiongxin Wang, Qilong Wang, Constantin Georgescu, Ming-Hui Zou, Jana Barlic-Dicen
Cardiovasc Res. 2015 May 1; 106(2): 324–337. Published online 2015 Mar 12. doi: 10.1093/cvr/cvv111
PMCID:
PMC4481573
AbstractArticlePDF–1.4M
20.
Epigenome-Guided Analysis of the Transcriptome of Plaque Macrophages during Atherosclerosis Regression Reveals Activation of the Wnt Signaling Pathway
Stephen A. Ramsey, Yuliya Vengrenyuk, Prashanthi Menon, Irina Podolsky, Jonathan E. Feig, Alan Aderem, Edward A. Fisher, Elizabeth S. Gold
PLoS Genet. 2014 Dec; 10(12): e1004828. Published online 2014 Dec 4. doi: 10.1371/journal.pgen.1004828
PMCID:
PMC4256277
AbstractArticlePDF–1.0M

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