U.S. flag

An official website of the United States government

Display Settings:

Format
Items per page
Sort by

Send to:

Choose Destination

Links from GEO Profiles

Items: 1 to 20 of 107

1.
Thrombospondin-1 is an endogenous substrate of cereblon responsible for immunomodulatory drug–induced thromboembolism
Kiwamu Hatakeyama, Yoshikane Kikushige, Daisuke Ishihara, Shunsuke Yamamoto, Gentaro Kawano, Taro Tochigi, Toshihiro Miyamoto, Teppei Sakoda, Andy Christoforou, Yuya Kunisaki, Mitsuhiro Fukata, Koji Kato, Takumi Ito, Hiroshi Handa, Koichi Akashi
Blood Adv. 2024 Feb 13; 8(3): 785–796. Published online 2024 Jan 3. doi: 10.1182/bloodadvances.2023010080
PMCID:
PMC10847748
AbstractArticlePDF–2.5M
2.
AZD7762 induces CRBN dependent BAG3 degradation through ubiquitin-proteasome pathway
Yanli Liao, Chao Yuan, Mi Huang, WenXia Si, Duanzhuo Li, Weibin Wu, Shifa Zhang, Runkun Wu, Yi Quan, Xin Yu, Shengjie Liao
Anticancer Drugs. 2024 Jan; 35(1): 46–54. Published online 2023 Jul 14. doi: 10.1097/CAD.0000000000001532
PMCID:
PMC10720835
AbstractArticlePDF–1.7M
3.
The CUL4B‐based E3 ubiquitin ligase regulates mitosis and brain development by recruiting phospho‐specific DCAFs
Anna Stier, Samuel Gilberto, Weaam I Mohamed, Lars N Royall, Jonne Helenius, Ivan Mikicic, Tatjana Sajic, Petra Beli, Daniel J Müller, Sebastian Jessberger, Matthias Peter
EMBO J. 2023 Sep; 42(17): e112847. Published online 2023 Jun 27. doi: 10.15252/embj.2022112847
PMCID:
PMC10476281
AbstractArticlePDF–2.6M
4.
The E3 ligase adapter cereblon targets the C-terminal cyclic imide degron
Saki Ichikawa, Hope A. Flaxman, Wenqing Xu, Nandini Vallavoju, Hannah C. Lloyd, Binyou Wang, Dacheng Shen, Matthew R. Pratt, Christina M. Woo
Nature. Author manuscript; available in PMC 2023 Jul 3.
Published in final edited form as: Nature. 2022 Oct; 610(7933): 775–782. Published online 2022 Oct 19. doi: 10.1038/s41586-022-05333-5
PMCID:
PMC10316063
AbstractArticlePDF–5.2M
5.
Autonomous Synthesis of Functional, Permanently Phosphorylated Proteins for Defining the Interactome of Monomeric 14-3-3ζ
Phillip Zhu, Stanislau Stanisheuski, Rachel Franklin, Amber Vogel, Cat Hoang Vesely, Patrick Reardon, Nikolai N. Sluchanko, Joseph S. Beckman, P. Andrew Karplus, Ryan A. Mehl, Richard B. Cooley
ACS Cent Sci. 2023 Apr 26; 9(4): 816–835. Published online 2023 Apr 10. doi: 10.1021/acscentsci.3c00191
PMCID:
PMC10141581
AbstractArticlePDF–9.1M
6.
HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation
Jingsheng Yuan, Tao Lv, Jian Yang, Zhenru Wu, Lvnan Yan, Jiayin Yang, Yujun Shi, Li Jiang
Cell Mol Gastroenterol Hepatol. 2023; 15(2): 307–325. Published online 2022 Oct 14. doi: 10.1016/j.jcmgh.2022.10.005
PMCID:
PMC9772558
AbstractArticlePDF–8.2M
7.
Molecular glue CELMoD compounds are regulators of cereblon conformation
Edmond R. Watson, Scott Novick, Mary E. Matyskiela, Philip P. Chamberlain, Andres H. de la Peña, Jinyi Zhu, Eileen Tran, Patrick R. Griffin, Ingrid E. Wertz, Gabriel C. Lander
Science. Author manuscript; available in PMC 2022 Dec 1.
Published in final edited form as: Science. 2022 Nov 4; 378(6619): 549–553. Published online 2022 Nov 3. doi: 10.1126/science.add7574
PMCID:
PMC9714526
AbstractArticlePDF–1.3M
8.
CRBN is downregulated in lung cancer and negatively regulates TLR2, 4 and 7 stimulation in lung cancer cells
Mi‐Jeong Kim, Ji Su Lee, Ji Young Kim, Bongkum Choi, Juhee Son, Yoon Min, Soo‐Kyung Jeong, Duk‐Hwan Kim, Joo Sang Lee, Eunyoung Chun, Ki‐Young Lee
Clin Transl Med. 2022 Sep; 12(9): e1050. Published online 2022 Sep 27. doi: 10.1002/ctm2.1050
PMCID:
PMC9513676
ArticlePDF–3.6M
9.
The Casein kinase 1α agonist pyrvinium attenuates Wnt-mediated CK1α degradation via interaction with the E3 ubiquitin ligase component Cereblon
Chen Shen, Anmada Nayak, Leif R. Neitzel, Fan Yang, Bin Li, Charles H. Williams, Charles C. Hong, Yashi Ahmed, Ethan Lee, David J. Robbins
J Biol Chem. 2022 Aug; 298(8): 102227. Published online 2022 Jul 1. doi: 10.1016/j.jbc.2022.102227
PMCID:
PMC9352546
AbstractArticlePDF–1.6M
10.
E3 ubiquitin ligase RBX1 drives the metastasis of triple negative breast cancer through a FBXO45-TWIST1-dependent degradation mechanism
Jun Shao, Qian Feng, Weifan Jiang, Yuting Yang, Zhiqiang Liu, Liang Li, Wenlong Yang, Yufeng Zou
Aging (Albany NY) 2022 Jul 15; 14(13): 5493–5510. Published online 2022 Jul 8. doi: 10.18632/aging.204163
PMCID:
PMC9320552
AbstractArticlePDF–1.8M
11.
Cereblon regulates NK cell cytotoxicity and migration via Rac1 activation
Cinzia Fionda, Helena Stabile, Rosa Molfetta, Andrea Kosta, Giovanna Peruzzi, Silvia Ruggeri, Alessandra Zingoni, Cristina Capuano, Alessandra Soriani, Rossella Paolini, Angela Gismondi, Marco Cippitelli, Angela Santoni
Eur J Immunol. 2021 Nov; 51(11): 2607–2617. Published online 2021 Sep 18. doi: 10.1002/eji.202149269
PMCID:
PMC9291148
AbstractArticlePDF–1.6M
12.
OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization
Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti
Science. Author manuscript; available in PMC 2022 Sep 11.
Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983
PMCID:
PMC9119736
AbstractArticlePDF–3.3M
13.
Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mitophagy
Xin Sun, Yuhan Shu, Guiqin Ye, Caixia Wu, Mengting Xu, Ruilan Gao, Dongsheng Huang, Jianbin Zhang
Acta Pharm Sin B. 2022 Feb; 12(2): 838–852. Published online 2021 Jul 21. doi: 10.1016/j.apsb.2021.07.003
PMCID:
PMC8897022
AbstractArticlePDF–3.0M
14.
Role of cereblon in angiogenesis and in mediating the antiangiogenic activity of immunomodulatory drugs
Shaunna L. Beedie, Phoebe A. Huang, Emily M. Harris, Jonathan D. Strope, Christopher Mahony, Cindy H. Chau, Neil Vargesson, William D. Figg
FASEB J. Author manuscript; available in PMC 2022 Feb 7.
Published in final edited form as: FASEB J. 2020 Sep; 34(9): 11395–11404. Published online 2020 Jul 17. doi: 10.1096/fj.201903060RR
PMCID:
PMC8819519
AbstractArticlePDF–1.1M
15.
A proximity biotinylation-based approach to identify protein-E3 ligase interactions induced by PROTACs and molecular glues
Satoshi Yamanaka, Yuto Horiuchi, Saya Matsuoka, Kohki Kido, Kohei Nishino, Mayaka Maeno, Norio Shibata, Hidetaka Kosako, Tatsuya Sawasaki
Nat Commun. 2022; 13: 183. Published online 2022 Jan 10. doi: 10.1038/s41467-021-27818-z
PMCID:
PMC8748630
AbstractArticlePDF–2.8M
16.
PLZF and its fusion proteins are pomalidomide-dependent CRBN neosubstrates
Nobuyuki Shimizu, Tomoko Asatsuma-Okumura, Junichi Yamamoto, Yuki Yamaguchi, Hiroshi Handa, Takumi Ito
Commun Biol. 2021; 4: 1277. Published online 2021 Nov 11. doi: 10.1038/s42003-021-02801-y
PMCID:
PMC8586336
AbstractArticlePDF–2.1M
17.
Cereblon enhancer methylation and IMiD resistance in multiple myeloma
Larissa Haertle, Santiago Barrio, Umair Munawar, Seungbin Han, Xiang Zhou, Cornelia Vogt, Rafael Alonso Fernández, Max Bittrich, Yanira Ruiz-Heredia, Matteo Da Viá, Josip Zovko, Andoni Garitano-Trojaola, Niccolò Bolli, Anna Ruckdeschel, Thorsten Stühmer, Manik Chatterjee, Miriam Kull, Jan Krönke, Xabier Agirre, Jose I. Martin-Subero, Peter Raab, Hermann Einsele, Leo Rasche, Joaquin Martinez-Lopez, Thomas Haaf, K. Martin Kortüm
Blood. 2021 Nov 4; 138(18): 1721–1726. doi: 10.1182/blood.2020010452
PMCID:
PMC8569411
AbstractArticle
18.
Mutations in CRBN and other cereblon pathway genes are infrequently associated with acquired resistance to immunomodulatory drugs
J. R. Jones, A. Barber, Y-V Le Bihan, N. Weinhold, C. Ashby, B. A. Walker, C. P. Wardell, H. Wang, M. F. Kaiser, G. H. Jackson, F. E. Davies, R. Chopra, G. J. Morgan, C. Pawlyn
Leukemia. 2021; 35(10): 3017–3020. Published online 2021 Aug 9. doi: 10.1038/s41375-021-01373-4
PMCID:
PMC8478640
ArticlePDF–961K
19.
The E3 ubiquitin ligase component, Cereblon, is an evolutionarily conserved regulator of Wnt signaling
Chen Shen, Anmada Nayak, Leif R. Neitzel, Amber A. Adams, Maya Silver-Isenstadt, Leah M. Sawyer, Hassina Benchabane, Huilan Wang, Nawat Bunnag, Bin Li, Daniel T. Wynn, Fan Yang, Marta Garcia-Contreras, Charles H. Williams, Sivanesan Dakshanamurthy, Charles C. Hong, Nagi G. Ayad, Anthony J. Capobianco, Yashi Ahmed, Ethan Lee, David J. Robbins
Nat Commun. 2021; 12: 5263. Published online 2021 Sep 6. doi: 10.1038/s41467-021-25634-z
PMCID:
PMC8421366
AbstractArticlePDF–3.4M
20.
Regulation of AMPK Activity by CRBN Is Independent of the Thalidomide-CRL4CRBN Protein Degradation Axis
Seung-Joo Yang, Seungje Jeon, Jeong Won Baek, Kwang Min Lee, Chul-Seung Park
Pharmaceuticals (Basel) 2021 Jun; 14(6): 512. Published online 2021 May 26. doi: 10.3390/ph14060512
PMCID:
PMC8228114
AbstractArticlePDF–1.4M

Display Settings:

Format
Items per page
Sort by

Send to:

Choose Destination

Supplemental Content

Filter your results:

Find related data

Recent activity

You are here: NCBI > Literature > PubMed Central (PMC)
Support Center